Steve H. Fung, MD

Assistant Professor of Radiology, Academic Institute
Medical Director, MRI Core & Assistant Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. Steve H. Fung is a neuroradiologist at the Houston Methodist Hospital, Assistant Professor of Radiology at Weill Cornell Medical College, and Medical Director of the MRI Core at the Houston Methodist Research Institute. He graduated from the University of Texas at Austin with B.S., Highest Honors in Electrical Engineering and B.S., Highest Honors in Zoology (Neuroscience) with concentrations in mathematics and physics in 1995. He earned his M.D. from Harvard Medical School, Harvard/MIT Division of Health Sciences and Technology in 2000. His research includes work in electrophysiology, MRI, optics, ultrasound, signal and image processing. He was a postdoctoral fellow in molecular imaging at the National Institutes of Health, analyzing tumor microvasculature, modulating blood-brain barrier for enhanced drug delivery, refining and understanding limitations of various kinetic models used for estimating perfusion and permeability with dynamic contrast imaging. He was also a clinical fellow in neuroradiology at the Massachusetts General Hospital, where he worked in stroke-related research, including application of DTI in acute and chronic ischemic stroke and multivariate logistic model using CT perfusion to predict functional deficits and outcome, and clinical application of fMRI and DTI for presurgical planning. As a member of the Houston Methodist Research Institute, his research interests are in advanced MRI applications that can be applied broadly to a wide spectrum of CNS diseases, including cerebrovascular, neoplastic, and neurodegenerative diseases. He is a regular reviewer for several radiology and neuroradiology journals, including AJNR American Journal of Neuroradiology since 2008.

Description of Research

-Applying advanced MRI techniques to evaluate diseases of the central nervous system, including brain tumors, cerebrovascular disease/stroke, dementia/neurodegenerative diseases, and epilepsy, to grade severity of disease and predict outcome.

-Using ASL MRI to determine regional variation of cerebral perfusion and cerebrovascular reactivity in disease states and serial changes in perfusion in response to therapeutic intervention.
-Evaluating functional connectivity using task-based and resting state functional MRI in normal and disease states.
-Analyzing tumor microvasculature and modulating the blood brain barrier for enhanced drug delivery.
Understanding limitations of kinetic models for estimating perfusion and permeability.
-Developing techniques for molecular imaging, controlled drug release, and enhanced drug delivery.

Areas Of Expertise

Education & Training

Residency, The University of Texas Health Science Center at Houston
Research Fellowship, Imaging Sciences Training Program/National Institutes of Health
Internship, Harbor Hospital/Johns Hopkins University
MD, Harvard Medical School
Clinical Fellowship, Harvard Medical School

Obstructive hydrocephalus due to aqueductal stenosis from developmental venous anomaly draining bilateral medial thalami: a case report
Xian, Z, Fung, SH & Nakawah, MO 2020, Radiology Case Reports, vol. 15, no. 6, pp. 730-732.

Co-registration of MR and FDG-PET imaging for stereotactic radiotherapy planning; case report in a previously irradiated brain metastasis with recurrent tumor and radiation necrosis
Scranton, RA, Sadrameli, S, Butler, EB, Farach, A, Wang, H-C, Teh, BS, Tremont-Lukats, IW, Fung, SH, Zanotti-Fregonara, P & Rostomily, RC 2019, Practical Radiation Oncology.

One-Shot Generative Adversarial Learning for MRI Segmentation of Craniomaxillofacial Bony Structures
Chen, X, Lian, C, Wang, L, Deng, H, Fung, SH, Nie, D, Thung, K-H, Yap, P-T, Gateno, J, Xia, JJ & Shen, D 2019, IEEE Transactions on Medical Imaging.

Sleep-Disordered Breathing and Idiopathic Normal-Pressure Hydrocephalus: Recent Pathophysiological Advances
Roman, GC, Jackson, RE, Fung, SH, Zhang, YJ & Verma, A 2019, Current Neurology and Neuroscience Reports, vol. 19, no. 7, 39.

Reply: Letter to The Editor on “Idiopathic normal-pressure hydrocephalus and obstructive sleep apnea are frequently associated: A prospective cohort study” Journal of the Neurological Sciences 395 (2018) 164–168
Roman, GC, Verma, A, Zhang, YJ & Fung, SH 2019, Journal of the Neurological Sciences, vol. 397.

“Ears of the lynx” MRI sign is associated with SPG11 and SPG15 hereditary spastic paraplegia
Pascual, MB, De Bot, ST, Daniels, MR, França, MC, Toro, C, Riverol, M, Hedera, P, Bassi, MT, Bresolin, N, Van De Warrenburg, BP, Kremer, B, Nicolai, J, Charles, P, Xu, J, Singh, S, Patronas, NJ, Fung, SH, Gregory, MD & Masdeu, JC 2019, American Journal of Neuroradiology, vol. 40, no. 1, pp. 199-203.

Idiopathic normal-pressure hydrocephalus and obstructive sleep apnea are frequently associated: A prospective cohort study
Román, GC, Verma, AK, Zhang, YJ & Fung, SH 2018, Journal of the Neurological Sciences, vol. 395, pp. 164-168.

The long-term sequelae of palliative radiation therapy to lumbosacral spine using conventional PA-single portal technique
Hsiao, KY, Wang, HC, Fung, SH, Haque, WM, Butler, EB & Teh, BS 2018, Practical Radiation Oncology, vol. 8, no. 6, pp. 376-381.

Advanced neuroimaging in Balo's concentric sclerosis: MRI, MRS, DTI, and ASL perfusion imaging over 1 year
Yeo, CJJ, Hutton, GJ & Fung, SH 2018, Radiology Case Reports, vol. 13, no. 5, pp. 1030-1035.

Craniomaxillofacial Bony Structures Segmentation from MRI with Deep-Supervision Adversarial Learning
Zhao, M, Wang, L, Chen, J, Nie, D, Cong, Y, Ahmad, S, Ho, A, Yuan, P, Fung, SH, Deng, HH, Xia, JJ & Shen, D 2018, . in AF Frangi, G Fichtinger, JA Schnabel, C Alberola-López & C Davatzikos (eds), Medical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, 2018, Proceedings. vol. 11073, Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, Springer-Verlag, pp. 720-727, 21st International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2018, Granada, Spain, 9/16/18.

Transulcal parafascicular minimally invasive approach to deep and subcortical cavernomas: technical note
Scranton, RA, Fung, SH & Britz, GW 2016, Journal of Neurosurgery, vol. 125, no. 6, pp. 1360–1366.

Technical pitfalls of signal truncation in perfusion MRI of glioblastoma
Wong, KK, Fung, SH, New, PZ & Wong, STC 2016, Frontiers in Neurology, vol. 7, no. AUG, 121, pp. 121.

Paramagnetic Gd3+ labeled red blood cells for magnetic resonance angiography
Aryal, S, Stigliano, C, Key, J, Ramirez, M, Anderson, J, Karmonik, C, Fung, SH & Decuzzi, P 2016, Biomaterials, vol. 98, pp. 163-170.

Epithelioid glioblastoma presenting as massive intracerebral hemorrhage: Case report and review of the literature
Liebelt, B, Boghani, Z, Takei, H, Fung, SH & Britz, GW 2015, Surgical Neurology International, vol. 6, no. 3, pp. S97-S100.

Glioblastoma Presenting with Pure Alexia and Palinopsia Involving the Left Inferior Occipital Gyrus and Visual Word Form Area Evaluated with Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging Tractography
Huang, M, Baskin, DS & Fung, SH 2015, World Neurosurgery.

Quantifying cerebrovascular reactivity and identifying regions at risk from cerebrovascular steal with arterial spin labeling
Fung, SH, Diaz, O, Klucznik, RP, Zhang, Y, Britz, GW, Volpi, J, Thomas, AP & Chiu, D 2015, Interventional Neuroradiology, vol. 21S1.

Correlation of imaging with pathology
Fung, SH & Singh, SK 2015, . in A Rivera & H Takei (eds), Advances in Surgical Pathology: Brain Cancer. Lippencott Williams & Wilkins, Philadelphia, PA.

Functional magnetic resonance imaging during urodynamic testing identifies brain structures initiating micturition
Shy, M, Fung, SH, Boone, TB, Karmonik, C, Fletcher, SG & Khavari, R 2014, Journal of Urology, vol. 192, no. 4, pp. 1149-1154.

Diffusion tensor imaging in traumatic optic tract syndrome
Al-Zubidi, N, Ansari, W, Fung, SH & Lee, AG 2014, Journal of Neuro-Ophthalmology, vol. 34, no. 1, pp. 95-98.

Diffusion-weighted imaging in posterior ischemic optic neuropathy
Al-Zubidi, N, Stevens, S, Fung, SH & Lee, AG 2014, Canadian Journal of Ophthalmology, vol. 49, no. 1.

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