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Stephen T. Wong, PhD

John S. Dunn, Sr. Presidential Distinguished Chair in Biomedical Engineering, Full Member, Research Institute
Professor of Computer Science and Bioengineering in Oncology, Institute for Academic Medicine
Houston Methodist
Weill Cornell Medical College


stwong@houstonmethodist.org
Biography

Dr. Wong holds the John S. Dunn, Sr. Distinguished Endowed Chair in Biomedical Engineering; he is also a Professor of Radiology, Pathology, Laboratory Medicine, Neurology, and Neurosciences, the Associate Director of Translational Research at Methodist Cancer Center, and Chief of Medical Physics and Chief Research Information Officer at Houston Methodist Hospital. In addition, he serves as the Founding Director of the Ting Tsung and Wei Fong Chao Center for BRAIN (Bioinformatics Research and Imaging in the Neurosciences) and Founding Director of the Center for Modeling Cancer Development at Houston Methodist Research Institute. He also holds a dozen of other academic posts across institutions in Texas Medical Center as well as overseas universities and medical schools.

An internationally acclaimed bioengineer and imaging scientist, Dr. Stephen Wong has led teams that developed production automation for first very large scale integration (VLSI) 1MB computer memory chip and the largest online brokerage trading system, and contributed to the first hospital-wide digital radiology image management system in US academic medical centers.

Dr. Wong has more than twenty years of research and management experience in industry and academia, including Hewlett-Packard, AT&T Bell Laboratories, the Japanese Fifth Generation Computer Systems Project, Philips Medical Systems and Royal Philips Electronics, Charles Schwab, University of California - San Francisco/Berkeley, Harvard University and Houston Methodist Hospital. He received his senior executive education from the MIT Sloan School of Management, Stanford University Graduate School of Business and Columbia University Graduate School of Business. He holds many patents and has published over 300 peer-reviewed papers and four books. He also serves on and chairs NIH study panels, conference program committees, and the editorial boards of twelve scientific journals. As an international authority, he is sought as a speaker on medical imaging, systems biology, healthcare IT, drug development, biophotonics, clinical neuroscience and other related topics.

Description of Research

Dr. Wong's research focuses on understanding health and disease from a systems perspective in order to generate cost-effective strategies and solutions for disease management. His research approaches combine both experimental and high throughput biology with rigorous computational, bioinformatics, biophysics, and imaging methods to achieve a deep understanding of the functions of each component in biological systems and integration of them with multilevel systems analysis. For example, the consequences of genetic variation, cell-cell interactions and environmental factors are included to reflect the circumstances and microenvironments of the disease condition. Current research projects include pathway modeling and high throughput phenotyping approaches for target discovery and drug repurposing in combating neurological disorders and cancer, and for understanding the mechanisms of these diseases. Additional projects include reformulation of small molecule drugs using chemical biology approaches, the development of point-of-care molecular diagnosis and monitoring devices using biophotonics and nanotechnology techniques, and the development of label-free molecular image-guided cancer therapy platforms.

Areas Of Expertise

Bioinformatics Systems biology Biological and medical imaging Drug repositioning Drug combinations Image-guided therapy Translational biophotonics Molecular imaging Diagnosis Mechanisms of neurological disorders Mechanisms of cancer
Education & Training

Postdoctoral Fellowship, Japan Science and Technology Agency
MS, Lehigh University
PhD, Lehigh University
Postdoctoral Fellowship, National Science Foundation, ICOT, The Fifth Generation Computer Systems Project, MITI, Tokyo
Publications

Mammary precancerous stem and non-stem cells evolve into cancers of distinct subtypes
Bu, W, Liu, Z, Jiang, W, Nagi, C, Huang, S, Edwards, DP, Jo, E, Mo, Q, Creighton, CJ, Hilsenbeck, SG, Leavitt, AD, Lewis, MT, Wong, ST & Li, Y 2019, Cancer Research, vol. 79, no. 1, pp. 61-71. https://doi.org/10.1158/0008-5472.CAN-18-1087

The Modulatory Role of MicroRNA-873 in the Progression of KRAS-Driven Cancers
Mokhlis, HA, Bayraktar, R, Kabil, NN, Caner, A, Kahraman, N, Rodriguez-Aguayo, C, Zambalde, EP, Sheng, J, Karagoz, K, Kanlikilicer, P, Abdel Aziz, AAH, Abdelghany, TM, Ashour, AA, Wong, S, Gatza, ML, Calin, GA, Lopez-Berestein, G & Ozpolat, B 2019, Molecular Therapy - Nucleic Acids, vol. 14, pp. 301-317. https://doi.org/10.1016/j.omtn.2018.11.019

A Behavior-Modification, Clinical-Grade Mobile Application to Improve Breast Cancer Survivors' Accountability and Health Outcomes
Stubbins, R, He, T, Yu, X, Puppala, M, Ezeana, CF, Chen, S, Valdivia y Alvarado, M, Ensor, J, Rodriguez, A, Niravath, P, Chang, J, Wong, STC & Patel, T 2018, JCO Clinical Cancer Informatics, no. 2, pp. 1-11. https://doi.org/10.1200/CCI.18.00054

Systems biology-based drug repositioning identifies digoxin as a potential therapy for groups 3 and 4 medulloblastoma
Huang, L, Injac, SG, Cui, K, Braun, F, Lin, Q, Du, Y, Zhang, H, Kogiso, M, Lindsay, H, Zhao, S, Baxter, P, Adekunle, A, Man, TK, Zhao, H, Li, XN, Lau, CC & Wong, ST 2018, Science Translational Medicine, vol. 10, no. 464, eaat0150. https://doi.org/10.1126/scitranslmed.aat0150

Dual suppressive effect of miR-34A on the FOXM1/EEF2-kinase axis regulates triple-negative breast cancer growth and invasion
Bayraktar, R, Ivan, C, Bayraktar, E, Kanlikilicer, P, Kabil, NN, Kahraman, N, Mokhlis, HA, Karakas, D, Rodriguez-Aguayo, C, Arslan, A, Sheng, J, Wong, S, Lopez-Berestein, G, Calin, GA & Ozpolat, B 2018, Clinical Cancer Research, vol. 24, no. 17, pp. 4225-4241. https://doi.org/10.1158/1078-0432.CCR-17-1959

Two birds, one stone: Hesperetin alleviates chemotherapyinduced diarrhea and potentiates tumor inhibition
Yu, Y, Kong, R, Cao, H, Yin, Z, Liu, J, Nan, X, Phan, AT, Ding, T, Zhao, H & Wong, STC 2018, Oncotarget, vol. 9, no. 46, pp. 27958-27973. https://doi.org/10.18632/oncotarget.24563

Sustained adrenergic signaling promotes intratumoral innervation through BDNF induction
Allen, JK, Armaiz-Pena, GN, Nagaraja, AS, Sadaoui, NC, Ortiz, T, Dood, R, Ozcan, M, Herder, DM, Haemmerle, M, Gharpure, KM, Rupaimoole, R, Previs, RA, Wu, SY, Pradeep, S, Xu, X, Han, HD, Zand, B, Dalton, HJ, Taylor, M, Hu, W, Bottsford-Miller, J, Moreno-Smith, M, Kang, Y, Mangala, LS, Rodriguez-Aguayo, C, Sehgal, V, Spaeth, EL, Ram, PT, Wong, STC, Marini, FC, Lopez-Berestein, G, Cole, SW, Lutgendorf, SK, De Biasi, M & Sood, AK 2018, Cancer Research, vol. 78, no. 12, pp. 3233-3242. https://doi.org/10.1158/0008-5472.CAN-16-1701c

Is pathology prepared for the adoption of artificial intelligence?
Wong, ST 2018, Cancer Cytopathology, vol. 126, no. 6, pp. 373-375. https://doi.org/10.1002/cncy.21994

Systematic Identification of Druggable Epithelial-Stromal Crosstalk Signaling Networks in Ovarian Cancer
Yeung, T-L, Sheng, J, Leung, CS, Li, F, Kim, J, Ho, SY, Matzuk, MM, Lu, KH, Wong, STC & Mok, SC 2018, Journal of the National Cancer Institute. https://doi.org/10.1093/jnci/djy097

Evaluating the Therapeutic Relevance of Targeting TWIST1 Through Loss of Function Studies in Human Glioblastoma: AANS Annual Scientific Meeting, New Orleans, Louisiana, April 28-May 2, 2018
Mikheev, A, Mikheeva, SA, Severs, LJ, Funk, CC, Huang, L, Mcfaline-Figueroa, JL, Schwensen, J, Trapnell, C, Price, ND, Wong, ST & Rostomily, RC 2018, .

Integrative network analysis of multiple omics data of glioblastoma patients identifies driver dysregulated signaling associated with clinical outcome: AANS Annual Scientific Meeting, New Orleans, Louisiana, 28-May 2, 2018
Huang, L, Mikheev, A, Mikheeva, SA, Rostomily, RC & Wong, ST 2018, .

Targeting brain-adaptive cancer stem cells prohibits brain metastatic colonization of triple-negative breast cancer
Ren, D, Zhu, X, Kong, R, Zhao, Z, Sheng, J, Wang, J, Xu, X, Liu, J, Cui, K, Zhang, XHF, Zhao, H & Wong, STC 2018, Cancer Research, vol. 78, no. 8, pp. 2052-2064. https://doi.org/10.1158/0008-5472.CAN-17-2994

Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance
Leung, CS, Yeung, TL, Yip, KP, Wong, KK, Ho, SY, Mangala, LS, Sood, AK, Lopez-Berestein, G, Sheng, J, Wong, STC, Birrer, MJ & Mok, SC 2018, Journal of Clinical Investigation, vol. 128, no. 2, pp. 589-606. https://doi.org/10.1172/JCI95200

The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability
Wang, H, Tian, L, Liu, J, Goldstein, A, Bado, I, Zhang, W, Arenkiel, BR, Li, Z, Yang, M, Du, S, Zhao, H, Rowley, DR, Wong, STC, Gugala, Z & Zhang, XHF 2018, Cancer Cell. https://doi.org/10.1016/j.ccell.2018.10.002

Targeting TWIST1 through loss of function inhibits tumorigenicity of human glioblastoma
Mikheev, AM, Mikheeva, SA, Severs, LJ, Funk, CC, Huang, L, Mcfaline-Figueroa, JL, Schwensen, J, Trapnell, C, Price, ND, Wong, ST & Rostomily, RC 2018, Molecular Oncology. https://doi.org/10.1002/1878-0261.12320

Repositioning of Drug - New Indications for Marketed Drugs
Kong, R & Wong, ST 2017, . in Drug Selectivity: An Evolving Concept in Medicinal Chemistry. Wiley, pp. 55-78. https://doi.org/10.1002/9783527674381.ch3

Platelets reduce anoikis and promote metastasis by activating YAP1 signaling
Haemmerle, M, Taylor, ML, Gutschner, T, Pradeep, S, Cho, MS, Sheng, J, Lyons, YM, Nagaraja, AS, Dood, RL, Wen, Y, Mangala, LS, Hansen, JM, Rupaimoole, R, Gharpure, KM, Rodriguez-Aguayo, C, Yim, SY, Lee, JS, Ivan, C, Hu, W, Lopez-Berestein, G, Wong, ST, Karlan, BY, Levine, DA, Liu, J, Afshar-Kharghan, V & Sood, AK 2017, Nature communications, vol. 8, no. 1, 310. https://doi.org/10.1038/s41467-017-00411-z

Comparison of Direct Patient Care Costs and Quality Outcomes of the Teaching and Nonteaching Hospitalist Services at a Large Academic Medical Center
Perez Perez, JA, Awar, M, Nezamabadi, A, Ogunti, R, Puppala, M, Colton, L, Clewing, JM, Ketkar, S, Wong, STC & Robbins, RJ 2018, Academic medicine : journal of the Association of American Medical Colleges, pp. 491-497. https://doi.org/10.1097/ACM.0000000000002026

Combining deep learning and coherent anti-Stokes Raman scattering imaging for automated differential diagnosis of lung cancer
Weng, S, Xu, X, Li, J & Wong, STC 2017, Journal of Biomedical Optics, vol. 22, no. 10, 106017. https://doi.org/10.1117/1.JBO.22.10.106017

Role of platelet-derived Tgfß1 in the progression of ovarian cancer
Hu, Q, Hisamatsu, T, Haemmerle, M, Cho, MS, Pradeep, S, Rupaimoole, R, Rodriguez-Aguayo, C, Lopez-Berestein, G, Wong, STC, Sood, AK & Afshar-Kharghan, V 2017, Clinical Cancer Research, vol. 23, no. 18, pp. 5611-5621. https://doi.org/10.1158/1078-0432.CCR-16-3272