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Stephen T. Wong, PhD

John S. Dunn, Sr. Presidential Distinguished Chair in Biomedical Engineering, Full Member, Research Institute
Professor of Computer Science and Bioengineering in Oncology, Institute for Academic Medicine
Associate Director, Cores, Biostatistics and Bioinformatics
Houston Methodist
Weill Cornell Medical College

Dr. Wong holds the John S. Dunn, Sr. Distinguished Endowed Chair in Biomedical Engineering; he is also a Professor of Radiology, Pathology, Laboratory Medicine, Neurology, and Neurosciences, the Associate Director of Translational Research at Methodist Cancer Center, and Chief of Medical Physics and Chief Research Information Officer at Houston Methodist Hospital. In addition, he serves as the Founding Director of the Ting Tsung and Wei Fong Chao Center for BRAIN (Bioinformatics Research and Imaging in the Neurosciences) and Founding Director of the Center for Modeling Cancer Development at Houston Methodist Research Institute. He also holds a dozen of other academic posts across institutions in Texas Medical Center as well as overseas universities and medical schools.

An internationally acclaimed bioengineer and imaging scientist, Dr. Stephen Wong has led teams that developed production automation for first very large scale integration (VLSI) 1MB computer memory chip and the largest online brokerage trading system, and contributed to the first hospital-wide digital radiology image management system in US academic medical centers.

Dr. Wong has more than twenty years of research and management experience in industry and academia, including Hewlett-Packard, AT&T Bell Laboratories, the Japanese Fifth Generation Computer Systems Project, Philips Medical Systems and Royal Philips Electronics, Charles Schwab, University of California - San Francisco/Berkeley, Harvard University and Houston Methodist Hospital. He received his senior executive education from the MIT Sloan School of Management, Stanford University Graduate School of Business and Columbia University Graduate School of Business. He holds many patents and has published over 300 peer-reviewed papers and four books. He also serves on and chairs NIH study panels, conference program committees, and the editorial boards of twelve scientific journals. As an international authority, he is sought as a speaker on medical imaging, systems biology, healthcare IT, drug development, biophotonics, clinical neuroscience and other related topics.

Description of Research

Dr. Wong's research focuses on understanding health and disease from a systems perspective in order to generate cost-effective strategies and solutions for disease management. His research approaches combine both experimental and high throughput biology with rigorous computational, bioinformatics, biophysics, and imaging methods to achieve a deep understanding of the functions of each component in biological systems and integration of them with multilevel systems analysis. For example, the consequences of genetic variation, cell-cell interactions and environmental factors are included to reflect the circumstances and microenvironments of the disease condition. Current research projects include pathway modeling and high throughput phenotyping approaches for target discovery and drug repurposing in combating neurological disorders and cancer, and for understanding the mechanisms of these diseases. Additional projects include reformulation of small molecule drugs using chemical biology approaches, the development of point-of-care molecular diagnosis and monitoring devices using biophotonics and nanotechnology techniques, and the development of label-free molecular image-guided cancer therapy platforms.

Areas Of Expertise

Bioinformatics Systems biology Biological and medical imaging Drug repositioning Drug combinations Image-guided therapy Translational biophotonics Molecular imaging Diagnosis Mechanisms of neurological disorders Mechanisms of cancer
Education & Training

Postdoctoral Fellowship, Japan Science and Technology Agency
MS, Lehigh University
PhD, Lehigh University
Postdoctoral Fellowship, National Science Foundation, ICOT, The Fifth Generation Computer Systems Project, MITI, Tokyo

Driver network as a biomarker: systematic integration and network modeling of multi-omics data to derive driver signaling pathways for drug combination prediction
Huang, L, Brunell, D, Stephan, C, Mancuso, J, Yu, X, He, B, Thompson, TC, Zinner, R, Kim, J, Davies, P & Wong, ST 2019, Bioinformatics (Oxford, England), vol. 35, no. 19, pp. 3709-3717.

A multi-scale level set method based on local features for segmentation of images with intensity inhomogeneity
Min, H, Xia, L, Han, J, Wang, X, Pan, Q, Fu, H, Wang, H, Wong, ST & Li, H 2019, Pattern Recognition, vol. 91, pp. 69-85.

An image informatics pipeline for imaging mass cytometry to characterize the immune landscape in pre-and on-Treatment immune therapy and its application in recurrent platinium-resistant epithelial ovarian cancer
Zhu, Y, Yeung, TL, Sheng, J, Hinchcliff, EM, Burks, JK, Jazaeri, AA, Mok, SC & Wong, ST 2019, . in 2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings., 8834496, Institute of Electrical and Electronics Engineers Inc. 2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019, Chicago, United States, 5/19/19.

Clusterin impairs hepatic insulin sensitivity and adipocyte clusterin associates with cardiometabolic risk
Bradley, D, Blaszczak, A, Yin, Z, Liu, J, Joseph, JJ, Wright, V, Anandani, K, Needleman, B, Noria, S, Renton, D, Yearsley, M, Wong, ST & Hsueh, WA 2019, Diabetes Care, vol. 42, no. 3, pp. 466-475.

Prognostic gene discovery in glioblastoma patients using deep learning
Wong, K, Rostomily, RC & Wong, ST 2019, Cancers, vol. 11, no. 1, 53.

Mammary precancerous stem and non-stem cells evolve into cancers of distinct subtypes
Bu, W, Liu, Z, Jiang, W, Nagi, C, Huang, S, Edwards, DP, Jo, E, Mo, Q, Creighton, CJ, Hilsenbeck, SG, Leavitt, AD, Lewis, MT, Wong, ST & Li, Y 2019, Cancer Research, vol. 79, no. 1, pp. 61-71.

The Modulatory Role of MicroRNA-873 in the Progression of KRAS-Driven Cancers
Mokhlis, HA, Bayraktar, R, Kabil, NN, Caner, A, Kahraman, N, Rodriguez-Aguayo, C, Zambalde, EP, Sheng, J, Karagoz, K, Kanlikilicer, P, Abdel Aziz, AAH, Abdelghany, TM, Ashour, AA, Wong, S, Gatza, ML, Calin, GA, Lopez-Berestein, G & Ozpolat, B 2019, Molecular Therapy - Nucleic Acids, vol. 14, pp. 301-317.

Induction of N-Ras degradation by flunarizine-mediated autophagy
Zheng, ZY, Li, J, Li, F, Zhu, Y, Cui, K, Wong, ST, Chang, EC & Liao, YH 2018, Scientific Reports, vol. 8, no. 1, 16932.

A Behavior-Modification, Clinical-Grade Mobile Application to Improve Breast Cancer Survivors' Accountability and Health Outcomes
Stubbins, R, He, T, Yu, X, Puppala, M, Ezeana, CF, Chen, S, Valdivia y Alvarado, M, Ensor, J, Rodriguez, A, Niravath, P, Chang, J, Wong, STC & Patel, T 2018, JCO Clinical Cancer Informatics, no. 2, pp. 1-11.

Systems biology-based drug repositioning identifies digoxin as a potential therapy for groups 3 and 4 medulloblastoma
Huang, L, Injac, SG, Cui, K, Braun, F, Lin, Q, Du, Y, Zhang, H, Kogiso, M, Lindsay, H, Zhao, S, Baxter, P, Adekunle, A, Man, TK, Zhao, H, Li, XN, Lau, CC & Wong, ST 2018, Science Translational Medicine, vol. 10, no. 464, eaat0150.

Dual suppressive effect of miR-34A on the FOXM1/EEF2-kinase axis regulates triple-negative breast cancer growth and invasion
Bayraktar, R, Ivan, C, Bayraktar, E, Kanlikilicer, P, Kabil, NN, Kahraman, N, Mokhlis, HA, Karakas, D, Rodriguez-Aguayo, C, Arslan, A, Sheng, J, Wong, ST, Lopez-Berestein, G, Calin, GA & Ozpolat, B 2018, Clinical Cancer Research, vol. 24, no. 17, pp. 4225-4241.

Immune reprogramming via PD-1 inhibition enhances early-stage lung cancer survival
Markowitz, GJ, Havel, LS, Crowley, MJ, Ban, Y, Lee, SB, Thalappillil, JS, Narula, N, Bhinder, B, Elemento, O, Wong, ST, Gao, D, Altorki, NK & Mittal, V 2018, JCI insight, vol. 3, no. 13.

Sustained adrenergic signaling promotes intratumoral innervation through BDNF induction
Allen, JK, Armaiz-Pena, GN, Nagaraja, AS, Sadaoui, NC, Ortiz, T, Dood, R, Ozcan, M, Herder, DM, Haemmerle, M, Gharpure, KM, Rupaimoole, R, Previs, RA, Wu, SY, Pradeep, S, Xu, X, Han, HD, Zand, B, Dalton, HJ, Taylor, M, Hu, W, Bottsford-Miller, J, Moreno-Smith, M, Kang, Y, Mangala, LS, Rodriguez-Aguayo, C, Sehgal, V, Spaeth, EL, Ram, PT, Wong, ST, Marini, FC, Lopez-Berestein, G, Cole, SW, Lutgendorf, SK, De Biasi, M & Sood, AK 2018, Cancer Research, vol. 78, no. 12, pp. 3233-3242.

Two birds, one stone: Hesperetin alleviates chemotherapyinduced diarrhea and potentiates tumor inhibition
Yu, Y, Kong, R, Cao, H, Yin, Z, Liu, J, Nan, X, Phan, AT, Ding, T, Zhao, H & Wong, ST 2018, Oncotarget, vol. 9, no. 46, pp. 27958-27973.

Is pathology prepared for the adoption of artificial intelligence?
Wong, ST 2018, Cancer Cytopathology, vol. 126, no. 6, pp. 373-375.

Systematic Identification of Druggable Epithelial-Stromal Crosstalk Signaling Networks in Ovarian Cancer
Yeung, TL, Sheng, J, Leung, CS, Li, F, Kim, J, Ho, SY, Matzuk, MM, Lu, KH, Wong, ST & Mok, SC 2019, Journal of the National Cancer Institute, vol. 111, no. 3, pp. 272-282.

Evaluating the Therapeutic Relevance of Targeting TWIST1 Through Loss of Function Studies in Human Glioblastoma: AANS Annual Scientific Meeting, New Orleans, Louisiana, April 28-May 2, 2018
Mikheev, A, Mikheeva, SA, Severs, LJ, Funk, CC, Huang, L, Mcfaline-Figueroa, JL, Schwensen, J, Trapnell, C, Price, ND, Wong, ST & Rostomily, RC 2018, .

Integrative network analysis of multiple omics data of glioblastoma patients identifies driver dysregulated signaling associated with clinical outcome: AANS Annual Scientific Meeting, New Orleans, Louisiana, 28-May 2, 2018
Huang, L, Mikheev, A, Mikheeva, SA, Rostomily, RC & Wong, ST 2018, .

Targeting brain-adaptive cancer stem cells prohibits brain metastatic colonization of triple-negative breast cancer
Ren, D, Zhu, X, Kong, R, Zhao, Z, Sheng, J, Wang, J, Xu, X, Liu, J, Cui, K, Zhang, XHF, Zhao, H & Wong, ST 2018, Cancer Research, vol. 78, no. 8, pp. 2052-2064.

Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance
Leung, CS, Yeung, TL, Yip, KP, Wong, KK, Ho, SY, Mangala, LS, Sood, AK, Lopez-Berestein, G, Sheng, J, Wong, ST, Birrer, MJ & Mok, SC 2018, Journal of Clinical Investigation, vol. 128, no. 2, pp. 589-606.

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