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Stephen T. Wong, PhD

John S. Dunn, Sr. Presidential Distinguished Chair in Biomedical Engineering, Full Member, Research Institute
Professor of Computer Science and Bioengineering in Oncology, Academic Institute
Associate Director, Cores, Biostatistics and Bioinformatics
Houston Methodist
Weill Cornell Medical College


stwong@houstonmethodist.org
Biography

Dr. Wong holds the John S. Dunn, Sr. Distinguished Endowed Chair in Biomedical Engineering; he is also a Professor of Radiology, Pathology, Laboratory Medicine, Neurology, and Neurosciences, the Associate Director of Translational Research at Methodist Cancer Center, and Chief of Medical Physics and Chief Research Information Officer at Houston Methodist Hospital. In addition, he serves as the Founding Director of the Ting Tsung and Wei Fong Chao Center for BRAIN (Bioinformatics Research and Imaging in the Neurosciences) and Founding Director of the Center for Modeling Cancer Development at Houston Methodist Research Institute. He also holds a dozen of other academic posts across institutions in Texas Medical Center as well as overseas universities and medical schools.

An internationally acclaimed bioengineer and imaging scientist, Dr. Stephen Wong has led teams that developed production automation for first very large scale integration (VLSI) 1MB computer memory chip and the largest online brokerage trading system, and contributed to the first hospital-wide digital radiology image management system in US academic medical centers.

Dr. Wong has more than twenty years of research and management experience in industry and academia, including Hewlett-Packard, AT&T Bell Laboratories, the Japanese Fifth Generation Computer Systems Project, Philips Medical Systems and Royal Philips Electronics, Charles Schwab, University of California - San Francisco/Berkeley, Harvard University and Houston Methodist Hospital. He received his senior executive education from the MIT Sloan School of Management, Stanford University Graduate School of Business and Columbia University Graduate School of Business. He holds many patents and has published over 300 peer-reviewed papers and four books. He also serves on and chairs NIH study panels, conference program committees, and the editorial boards of twelve scientific journals. As an international authority, he is sought as a speaker on medical imaging, systems biology, healthcare IT, drug development, biophotonics, clinical neuroscience and other related topics.

Description of Research

Dr. Wong's research focuses on understanding health and disease from a systems perspective in order to generate cost-effective strategies and solutions for disease management. His research approaches combine both experimental and high throughput biology with rigorous computational, bioinformatics, biophysics, and imaging methods to achieve a deep understanding of the functions of each component in biological systems and integration of them with multilevel systems analysis. For example, the consequences of genetic variation, cell-cell interactions and environmental factors are included to reflect the circumstances and microenvironments of the disease condition. Current research projects include pathway modeling and high throughput phenotyping approaches for target discovery and drug repurposing in combating neurological disorders and cancer, and for understanding the mechanisms of these diseases. Additional projects include reformulation of small molecule drugs using chemical biology approaches, the development of point-of-care molecular diagnosis and monitoring devices using biophotonics and nanotechnology techniques, and the development of label-free molecular image-guided cancer therapy platforms.

Areas Of Expertise

Bioinformatics Systems biology Biological and medical imaging Drug repositioning Drug combinations Image-guided therapy Translational biophotonics Molecular imaging Diagnosis Mechanisms of neurological disorders Mechanisms of cancer
Education & Training

Postdoctoral Fellowship, Japan Science and Technology Agency
MS, Lehigh University
PhD, Lehigh University
Postdoctoral Fellowship, National Science Foundation, ICOT, The Fifth Generation Computer Systems Project, MITI, Tokyo
Publications

OCIAD1 contributes to neurodegeneration in Alzheimer’s disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages
Li, X, Wang, L, Cykowski, MD, He, T, Liu, T, Chakranarayan, J, Rivera, A, Zhao, H, Powell, SZ-E, Xia, W & Wong, ST 2020, EBioMedicine, vol. 2020: 51 .

Sepsis outcomes in solid organ transplant recipients
Gotur, DB, Masud, FN, Ezeana, CF, Nisar, T, Paranilam, J, Chen, S, Puppala, M, Wong, ST & Zimmerman, JL 2019, Transplant Infectious Disease. https://doi.org/10.1111/tid.13214

Anticancer immunotherapy by MFAP5 blockade inhibits fibrosis and enhances chemosensitivity in ovarian and pancreatic cancer
Yeung, TL, Leung, CS, Yip, KP, Sheng, J, Vien, L, Bover, LC, Birrer, MJ, Wong, ST & Mok, SC 2019, Clinical Cancer Research, vol. 25, no. 21, pp. 6417-6428. https://doi.org/10.1158/1078-0432.CCR-19-0187

Imatinib revives the therapeutic potential of metformin on ewing sarcoma by attenuating tumor hypoxic response and inhibiting convergent signaling pathways
Nan, X, Wang, J, Cheng, H, Yin, Z, Sheng, J, Qiu, B, Lau, CC, Yustein, JT, Zhao, H & Wong, STC 2019, Cancer Letters. https://doi.org/10.1016/j.canlet.2019.10.034

Driver network as a biomarker: systematic integration and network modeling of multi-omics data to derive driver signaling pathways for drug combination prediction
Huang, L, Brunell, D, Stephan, C, Mancuso, J, Yu, X, He, B, Thompson, TC, Zinner, R, Kim, J, Davies, P & Wong, ST 2019, Bioinformatics (Oxford, England), vol. 35, no. 19, pp. 3709-3717. https://doi.org/10.1093/bioinformatics/btz109

A multi-scale level set method based on local features for segmentation of images with intensity inhomogeneity
Min, H, Xia, L, Han, J, Wang, X, Pan, Q, Fu, H, Wang, H, Wong, ST & Li, H 2019, Pattern Recognition, vol. 91, pp. 69-85. https://doi.org/10.1016/j.patcog.2019.02.009

Epithelial-Mesenchymal Plasticity in Organotropism Metastasis and Tumor Immune Escape
Nan, X, Wang, J, Liu, HN, Wong, STC & Zhao, H 2019, journal of clinical medicine, vol. 8, no. 5. https://doi.org/10.3390/jcm8050747

An image informatics pipeline for imaging mass cytometry to characterize the immune landscape in pre-and on-Treatment immune therapy and its application in recurrent platinium-resistant epithelial ovarian cancer
Zhu, Y, Yeung, TL, Sheng, J, Hinchcliff, EM, Burks, JK, Jazaeri, AA, Mok, SC & Wong, ST 2019, . in 2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019 - Proceedings., 8834496, Institute of Electrical and Electronics Engineers Inc. 2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019, Chicago, United States, 5/19/19. https://doi.org/10.1109/BHI.2019.8834496

A Deep Learning-Based Decision Support Tool for Precision Risk Assessment of Breast Cancer
He, T, Puppala, M, Ezeana, CF, Huang, Y-S, Chou, P-H, Yu, X, Chen, S, Wang, L, Yin, Z, Danforth, RL, Ensor, J, Chang, J, Patel, T & Wong, STC 2019, JCO Clinical Cancer Informatics, vol. 3, pp. 1-12. https://doi.org/10.1200/CCI.18.00121

The Modulatory Role of MicroRNA-873 in the Progression of KRAS-Driven Cancers
Mokhlis, HA, Bayraktar, R, Kabil, NN, Caner, A, Kahraman, N, Rodriguez-Aguayo, C, Zambalde, EP, Sheng, J, Karagoz, K, Kanlikilicer, P, Abdel Aziz, AAH, Abdelghany, TM, Ashour, AA, Wong, S, Gatza, ML, Calin, GA, Lopez-Berestein, G & Ozpolat, B 2019, Molecular Therapy - Nucleic Acids, vol. 14, pp. 301-317. https://doi.org/10.1016/j.omtn.2018.11.019

Systematic Identification of Druggable Epithelial-Stromal Crosstalk Signaling Networks in Ovarian Cancer
Yeung, TL, Sheng, J, Leung, CS, Li, F, Kim, J, Ho, SY, Matzuk, MM, Lu, KH, Wong, ST & Mok, SC 2019, Journal of the National Cancer Institute, vol. 111, no. 3, pp. 272-282. https://doi.org/10.1093/jnci/djy097

Clusterin impairs hepatic insulin sensitivity and adipocyte clusterin associates with cardiometabolic risk
Bradley, D, Blaszczak, A, Yin, Z, Liu, J, Joseph, JJ, Wright, V, Anandani, K, Needleman, B, Noria, S, Renton, D, Yearsley, M, Wong, ST & Hsueh, WA 2019, Diabetes Care, vol. 42, no. 3, pp. 466-475. https://doi.org/10.2337/dc18-0870

Prognostic gene discovery in glioblastoma patients using deep learning
Wong, K, Rostomily, RC & Wong, ST 2019, Cancers, vol. 11, no. 1, 53. https://doi.org/10.3390/cancers11010053

Mammary precancerous stem and non-stem cells evolve into cancers of distinct subtypes
Bu, W, Liu, Z, Jiang, W, Nagi, C, Huang, S, Edwards, DP, Jo, E, Mo, Q, Creighton, CJ, Hilsenbeck, SG, Leavitt, AD, Lewis, MT, Wong, ST & Li, Y 2019, Cancer Research, vol. 79, no. 1, pp. 61-71. https://doi.org/10.1158/0008-5472.CAN-18-1087

Non-rigid Registration of White Matter Tractography Using Coherent Point Drift Algorithm
Wang, W, Liu, J, Wang, T, Hu, Z, Xia, L, Wang, H, Yang, L, Wong, ST, Zhang, X & Li, H 2019, . in D Zhu, J Yan, H Huang, L Shen, PM Thompson, C-F Westin, X Pennec, S Joshi, M Nielsen, S Sommer, T Fletcher & S Durrleman (eds), Multimodal Brain Image Analysis and Mathematical Foundations of Computational Anatomy - 4th International Workshop, MBIA 2019, and 7th International Workshop, MFCA 2019, Held in Conjunction with MICCAI 2019, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 11846 LNCS, Springer, pp. 3-11, 4th International Workshop on Multimodal Brain Image Analysis, MBAI 2019, and the 7th International Workshop on Mathematical Foundations of Computational Anatomy, MFCA 2019, held in conjunction with the 22nd International Conference on Medical Imaging and Computer Assisted Intervention, MICCAI 2019, Shenzhen, China, 10/17/19. https://doi.org/10.1007/978-3-030-33226-6_1

NIHSS Discrepancy and Reliability in Stroke Triage
Cummock, J, Wong, K, Wong, ST & Volpi, J 2019, Neurovascular and Neurodegenerative Diseases, Paris, France, 10/28/19 - 10/30/19, .

Induction of N-Ras degradation by flunarizine-mediated autophagy
Zheng, ZY, Li, J, Li, F, Zhu, Y, Cui, K, Wong, ST, Chang, EC & Liao, YH 2018, Scientific Reports, vol. 8, no. 1, 16932. https://doi.org/10.1038/s41598-018-35237-2

A Behavior-Modification, Clinical-Grade Mobile Application to Improve Breast Cancer Survivors' Accountability and Health Outcomes
Stubbins, R, He, T, Yu, X, Puppala, M, Ezeana, CF, Chen, S, Valdivia y Alvarado, M, Ensor, J, Rodriguez, A, Niravath, P, Chang, J, Wong, STC & Patel, T 2018, JCO Clinical Cancer Informatics, no. 2, pp. 1-11. https://doi.org/10.1200/CCI.18.00054

Systems biology-based drug repositioning identifies digoxin as a potential therapy for groups 3 and 4 medulloblastoma
Huang, L, Injac, SG, Cui, K, Braun, F, Lin, Q, Du, Y, Zhang, H, Kogiso, M, Lindsay, H, Zhao, S, Baxter, P, Adekunle, A, Man, TK, Zhao, H, Li, XN, Lau, CC & Wong, ST 2018, Science Translational Medicine, vol. 10, no. 464, eaat0150. https://doi.org/10.1126/scitranslmed.aat0150

Dual suppressive effect of miR-34A on the FOXM1/EEF2-kinase axis regulates triple-negative breast cancer growth and invasion
Bayraktar, R, Ivan, C, Bayraktar, E, Kanlikilicer, P, Kabil, NN, Kahraman, N, Mokhlis, HA, Karakas, D, Rodriguez-Aguayo, C, Arslan, A, Sheng, J, Wong, ST, Lopez-Berestein, G, Calin, GA & Ozpolat, B 2018, Clinical Cancer Research, vol. 24, no. 17, pp. 4225-4241. https://doi.org/10.1158/1078-0432.CCR-17-1959

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