Stephen H. Little, MD

John S. Dunn Chair in Clinical Cardiovascular Research and Education, DeBakey Heart & Vascular Center
Associate Professor of Clinical Cardiology, Institute for Academic Medicine
Assistant Member, Research Institute
Program Director, Cardiovascular Disease Fellowship, Department of Cardiology
Houston Methodist
Weill Cornell Medical College


Cardiovascular Disease Fellowship


Biography

Dr. Little, a cardiologist with the Houston Methodist DeBakey Heart & Vascular Center, is medical director of The Valve Clinic – a multidisciplinary medical clinic focused on the assessment and treatment of complex valvular heart disease. He also serves as Director of the Houston Methodist Valve Institute and is director of the Cardiovascular Hemodynamics Imaging Laboratory (CHIL).

Dr. Little’s recent research activities and peer-reviewed publications have focused on novel use of 3-D echocardiography for the quantification of native and prosthetic valve dysfunction as well as imaging guidance for percutaneous structural heart interventions. His team has created a robust in vitro flow system for multimodality functional valve imaging under tailored hemodynamic conditions. In collaboration with research scientists and mathematicians, Dr. Little’s research group creates complex heart valve constructs to address an increasingly important clinical need - To improve our understanding of heart valve dysfunction by employing multimodality imaging to better characterize and quantify these complex intra- cardiac flow conditions.

He received his medical degree from McMaster University and completed post graduate training in internal medicine and cardiology at the University of Western Ontario. Dr. Little completed research fellowships in echocardiography at the University of Ottawa Heart Institute and at Baylor College of Medicine, Houston. He is a fellow of the Royal College of Physicians and Surgeons of Canada, the American College of Cardiology, and the American Society of Echocardiography. Dr. Little serves on the Board of Directors for the American Society of Echocardiography as well as on ASE committees for Industry Relations, Public Relations, and writing groups.

Dr. Little has given more than 100 invited lectures nationally and internationally. He is an associate professor of clinical Medicine at Weill Cornell Medical College, and adjunct associate professor at Rice University, Dept. of Bioengineering.

Description of Research

After completing sub-specialty Cardiology training (Royal College of Physicians and Surgeon of Canada), Dr. Little completed a postdoctoral fellowship in echocardiography at the Ottawa Heart Institute. He then completed a second postdoctoral fellowship, under the supervision of Dr. W. Zoghbi at Baylor College of Medicine, Houston.  As an assistant  professor  in Canada, he continued to develop novel  strategies to visualize  the prosthetic valve function using 3D transesophageal echocardiography.  In 2007 he was recruited back to Houston to join the Cardiovascular Imaging Institute of the Methodist DeBakey Heart & Vascular Center. As medical director of the MDHVC Heart Valve Clinic, and as a cardiologist interpreting ~3000 patient echocardiograms/year, he has established research programs based on the multi-modality imaging of native and prosthetic valves. Over the last five years, he also leads a team to create a robust in vitro flow system to simulate simple and complex heart valve constructs. As a natural extension of his interest in valve disease and my expertise in 3D imaging, his research group has recently begun collaborations with research scientists and mathematicians to address an increasingly important clinical need - To improve our understanding of heart valve dysfunction by employing multimodality imaging to better characterize and quantity these complex intra- cardiac flow conditions.

Areas Of Expertise

Echocardiography Valvular disease Mitral regurgitation
Education & Training

Clinical Fellowship, Baylor College of Medicine
Residency, Western University
MD, McMaster University School of Medicine
Active Clinical Trials

Valve Clinic Registry

N/A

Publications

Three-Dimensional Printing and the Auricle: Predicting Future Events?
Little, SH & Saric, M 2019, Journal of the American Society of Echocardiography, vol. 32, no. 6, pp. 720-721. https://doi.org/10.1016/j.echo.2019.04.005

2019 AATS/ACC/ASE/SCAI/STS Expert Consensus Systems of Care Document: A Proposal to Optimize Care for Patients With Valvular Heart Disease: A Joint Report of the American Association for Thoracic Surgery, American College of Cardiology, American Society of Echocardiography, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons
Nishimura, RA, OGara, PT, Bavaria, JE, Brindis, RG, Carroll, JD, Kavinsky, CJ, Lindman, BR, Linderbaum, JA, Little, SH, Mack, MJ, Mauri, L, Miranda, WR, Shahian, DM & Sundt, TM 2019, Journal of the American Society of Echocardiography, vol. 32, no. 6, pp. 683-707. https://doi.org/10.1016/j.echo.2019.02.016

2019 AATS/ACC/ASE/SCAI/STS expert consensus systems of care document: A proposal to optimize care for patients with valvular heart disease: A joint report of the American Association for Thoracic Surgery, American College of Cardiology, American Society of Echocardiography, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons
Nishimura, RA, OGara, PT, Bavaria, JE, Brindis, RG, Carroll, JD, Kavinsky, CJ, Lindman, BR, Linderbaum, JA, Little, SH, Mack, MJ, Mauri, L, Miranda, WR, Shahian, DM & Sundt, TM 2019, Journal of Thoracic and Cardiovascular Surgery, vol. 157, no. 6, pp. e327-e354. https://doi.org/10.1016/j.jtcvs.2019.03.004

2019 AATS/ACC/ASE/SCAI/STS Expert Consensus Systems of Care Document: A Proposal to Optimize Care for Patients With Valvular Heart Disease: A Joint Report of the American Association for Thoracic Surgery, American College of Cardiology, American Society of Echocardiography, Society for Cardiovascular Angiography and Interventions, and The Society of Thoracic Surgeons
Nishimura, RA, OGara, PT, Bavaria, JE, Brindis, RG, Carroll, JD, Kavinsky, CJ, Lindman, BR, Linderbaum, JA, Little, SH, Mack, MJ, Mauri, L, Miranda, WR, Shahian, DM & Sundt, TM 2019, Annals of Thoracic Surgery, vol. 107, no. 6, pp. 1884-1910. https://doi.org/10.1016/j.athoracsur.2019.03.001

2019 AATS/ACC/ASE/SCAI/STS Expert Consensus Systems of Care Document: A Proposal to Optimize Care for Patients With Valvular Heart Disease: A Joint Report of the American Association for Thoracic Surgery, American College of Cardiology, American Society of Echocardiography, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons
Nishimura, RA, OGara, PT, Bavaria, JE, Brindis, RG, Carroll, JD, Kavinsky, CJ, Lindman, BR, Linderbaum, JA, Little, SH, Mack, MJ, Mauri, L, Miranda, WR, Shahian, DM & Sundt, TM 2019, Journal of the American College of Cardiology, vol. 73, no. 20, pp. 2609-2635. https://doi.org/10.1016/j.jacc.2018.10.007

Simultaneous Transfemoral Mitral and Tricuspid Valve in Ring Implantation: First Case Report with Edwards Sapien 3 Valve
Beg, F, Dadu, RT, Reardon, MJ, Little, SH, Kleiman, N & Barker, CM 2019, Methodist DeBakey cardiovascular journal, vol. 15, no. 2, pp. 149-151. https://doi.org/10.14797/mdcj-15-2-149

Diagnostic Value of 3-Dimensional Vena Contracta Area for the Quantification of Residual Mitral Regurgitation After MitraClip Procedure
Avenatti, E, Mackensen, GB, El-Tallawi, KC, Reisman, M, Gruye, L, Barker, CM & Little, SH 2019, JACC: Cardiovascular Interventions, vol. 12, no. 6, pp. 582-591. https://doi.org/10.1016/j.jcin.2018.12.006

Guidelines for the Evaluation of Valvular Regurgitation After Percutaneous Valve Repair or Replacement: A Report from the American Society of Echocardiography Developed in Collaboration with the Society for Cardiovascular Angiography and Interventions, Japanese Society of Echocardiography, and Society for Cardiovascular Magnetic Resonance
Zoghbi, WA, Asch, FM, Bruce, C, Gillam, LD, Grayburn, PA, Hahn, RT, Inglessis, I, Islam, AM, Lerakis, S, Little, SH, Siegel, RJ, Skubas, N, Slesnick, TC, Stewart, WJ, Thavendiranathan, P, Weissman, NJ, Yasukochi, S & Zimmerman, KG 2019, Journal of the American Society of Echocardiography. https://doi.org/10.1016/j.echo.2019.01.003

2019 AATS/ACC/ASE/SCAI/STS expert consensus systems of care document: A proposal to optimize care for patients with valvular heart disease: A Joint Report of the American Association for Thoracic Surgery, American College of Cardiology, American Society of Echocardiography, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons
Nishimura, RA, OGara, PT, Bavaria, JE, Brindis, RG, Carroll, JD, Kavinsky, CJ, Lindman, BR, Linderbaum, JA, Little, SH, Mack, MJ, Mauri, L, Miranda, WR, Shahian, DM & Sundt, TM 2019, Catheterization and Cardiovascular Interventions. https://doi.org/10.1002/ccd.28196

Intraventricular Vortex Interaction between Transmitral Flow and Paravalvular Leak
Morisawa, D, Falahatpisheh, A, Avenatti, E, Little, SH & Kheradvar, A 2018, Scientific Reports, vol. 8, no. 1, 15657. https://doi.org/10.1038/s41598-018-33648-9

3-Dimensional Modeling in Cardiovascular Disease: 3D Modeling as a Tool for Structural Heart Interventions
Vukicevic, M, Filippini, S & Little, SH 2018, . in 3-Dimensional Modeling in Cardiovascular Disease: 3D Modeling as a Tool for Structural Heart Interventions. Elsevier.

Quantifying Mitral Regurgitation: How Much Should We Lean on PISA?
Hung, J, Zeng, X & Little, SH 2018, Journal of the American Society of Echocardiography, vol. 31, no. 9, pp. 1000-1001. https://doi.org/10.1016/j.echo.2018.07.003

Myocardial Fibrosis in Patients With Primary Mitral Regurgitation With and Without Prolapse
Kitkungvan, D, Nabi, F, Kim, RJ, Bonow, RO, Khan, MA, Xu, J, Little, SH, Quinones, MA, Lawrie, GM, Zoghbi, WA & Shah, DJ 2018, Journal of the American College of Cardiology, vol. 72, no. 8, pp. 823-834. https://doi.org/10.1016/j.jacc.2018.06.048

Transcatheter Mitral Valve Replacement for Native and Failed Bioprosthetic Mitral Valves
Sarkar, K, Reardon, MJ, Little, SH, Barker, CM & Kleiman, NS 2018, Methodist DeBakey Cardiovascular Journal, vol. 13, no. 3, pp. 142-151. https://doi.org/10.14797/mdcj-13-3-142

Very Late Migration of Balloon-Expandable Transcatheter Aortic Valve
Kalra, A, Avenatti, E, Chinnadurai, P, Reardon, MJ, Kleiman, N, Little, SH & Barker, CM 2018, Journal of Invasive Cardiology, vol. 30, no. 4, pp. E28-E30.

Hemodynamic and echocardiographic comparison of the lotus and corevalve transcatheter aortic valves in patients with high and extreme surgical risk: An analysis from the REPRISE III randomized controlled trial
Asch, FM, Vannan, MA, Singh, S, Khandheria, B, Little, SH, Allocco, DJ, Meredith, IT, Feldman, TE, Reardon, MJ & Weissman, NJ 2018, Circulation, vol. 137, no. 24, pp. 2557-2567. https://doi.org/10.1161/CIRCULATIONAHA.118.034129, https://doi.org/10.1161/CIRCULATIONAHA.118.034

3D PRINTED MODELING OF RIGHT VENTRICLE AND TRICUSPID VALVE FROM CT IMAGES FOR STRUCTURAL HEART INTERVENTIONS
Vukicevic, M, El-Tallawi, KC, Avenatti, E, Chang, S-M, Barker, CM & Little, SH 2018, American College of Cardiology (ACC) 2018, Orlando, United States, 3/10/18 - 3/12/18, . https://doi.org/10.1016/S0735-1097(18)31893-X

Percutaneous Repair of Severe Eccentric Mitral Regurgitation Due to Medial Commissural Flail: Challenges for Imaging and Intervention
Avenatti, E, Vukicevic, M, El-Tallawi, KC, Barker, CM & Little, SH 2018, CASE (Philadelphia, Pa.), vol. 2, no. 1, pp. 2-5. https://doi.org/10.1016/j.case.2017.10.001

Transcatheter aortic valve replacement in patients with severe mitral or tricuspid regurgitation at extreme risk for surgery
Little, SH, Popma, JJ, Kleiman, NS, Deeb, GM, Gleason, TG, Yakubov, SJ, Checuti, S, OHair, D, Bajwa, T, Mumtaz, M, Maini, B, Hartman, A, Katz, S, Robinson, N, Petrossian, G, Heiser, J, Merhi, W, Moore, BJ, Li, S, Adams, DH & Reardon, MJ 2018, Journal of Thoracic and Cardiovascular Surgery. https://doi.org/10.1016/j.jtcvs.2017.11.108

Transcatheter Mitral Valve Repair Using the Edge-to-Edge Clip
Nyman, CB, Mackensen, GB, Jelacic, S, Little, SH, Smith, TW & Mahmood, F 2018, Journal of the American Society of Echocardiography. https://doi.org/10.1016/j.echo.2018.01.012

Live Chat Available