Stephen H. Little, MD, FRCPC, FACC, FASE

John S. Dunn Chair in Clinical Cardiovascular Research and Education, DeBakey Heart & Vascular Center
Professor of Cardiology, Academic Institute
Full Member, Research Institute
Program Director, Cardiovascular Disease Fellowship, Department of Cardiology
Houston Methodist
Weill Cornell Medical College

Cardiovascular Disease Fellowship


Dr. Little is a cardiologist with the Houston Methodist DeBakey Heart & Vascular Center and program director of the Cardiovascular Fellowship. In addition, he is director of Structural Heart for the Houston Methodist Hospital System, and medical director of the Valve Clinic. He also serves as director of the Cardiovascular Hemodynamics Imaging Laboratory (CHIL).

After completing sub-specialty Cardiology training at the Royal College of Physicians and Surgeon of Canada, Dr. Little completed a postdoctoral fellowship in echocardiography at the Ottawa Heart Institute. He then completed a postdoctoral fellowship, under the supervision of Dr. W. Zoghbi at Baylor College of Medicine, Houston.  In 2007 he was recruited back to Houston to join the Cardiovascular Imaging Institute of Houston Methodist DeBakey Heart & Vascular Center.

He is a fellow of the Royal College of Physicians and Surgeons of Canada, the American College of Cardiology, and the American Society of Echocardiography. For the American Society of Echocardiography, Dr. Little served on the Board of Directors, was chair of the guidelines committee, and is the current vice-president.

Dr. Little has given more than 150 invited lectures nationally and internationally. He is a Professor of Medicine at Weill Cornell Medical College and Adjunct Professor at Rice University, Dept. of Bioengineering.

Description of Research

Dr. Little’s recent research activities and peer-reviewed publications have focused on novel use of 3D echocardiography for the quantification of native and prosthetic valve dysfunction as well as imaging guidance for percutaneous structural heart interventions. His team has created a robust in vitro flow system for multimodality functional valve imaging under tailored hemodynamic conditions.

As principal investigator, Dr. Little leads Houston Methodists participation in the international Triluminate Clinical Trial of catheter-based therapy for tricuspid valve regurgitation and participates as a co-investigator in multiple other structural heart trials at Houston Methodist.

Areas Of Expertise

Echocardiography Valvular disease Mitral regurgitation
Education & Training

Clinical Fellowship, Baylor College of Medicine
Residency, Western University
MD, McMaster University School of Medicine

Reply: Management of Coronary Embolism in a Patient With Aortic Mechanical Prosthetic Heart Valve Thrombosis
Aoun, J & Little, SH 2021, , JACC: Case Reports, vol. 3, no. 1, pp. 169-170.

Impact of Myocardial Scar on Prognostic Implication of Secondary Mitral Regurgitation in Heart Failure
Tayal, B, Debs, D, Nabi, F, Malahfji, M, Little, SH, Reardon, M, Zoghbi, W, Kleiman, N & Shah, DJ 2021, , JACC: Cardiovascular Imaging, vol. 14, no. 4, pp. 812-822.

Utility of a Deep-Learning Algorithm to Guide Novices to Acquire Echocardiograms for Limited Diagnostic Use
Narang, A, Bae, R, Hong, H, Thomas, Y, Surette, S, Cadieu, C, Chaudhry, A, Martin, RP, McCarthy, PM, Rubenson, DS, Goldstein, S, Little, SH, Lang, RM, Weissman, NJ & Thomas, JD 2021, , JAMA Cardiology, vol. 6, no. 6, pp. 624-632.

Mitraclip after failed surgical mitral valve repair—an international multicenter study
Rahhab, Z, Lim, DS, Little, SH, Taramasso, M, Kuwata, S, Saccocci, M, Tamburino, C, Grasso, C, Frerker, C, Wißt, T, Garberich, R, Hausleiter, J, Braun, D, Avenatti, E, Delgado, V, Ussia, GP, Castriota, F, Nerla, R, Ince, H, Öner, A, Estevez-Loureiro, R, Latib, A, Regazzoli, D, Piazza, N, Alosaimi, H, de Jaegere, PPT, Bax, J, Dvir, D, Maisano, F, Sorajja, P, Reardon, MJ & Van Mieghem, NM 2021, , Journal of the American Heart Association, vol. 10, no. 7, e019236.

State of the Art: Transcatheter Edge-to-Edge Repair for Complex Mitral Regurgitation
Flint, N, Price, MJ, Little, SH, Mackensen, GB, Wunderlich, NC, Makar, M & Siegel, RJ 2021, , Journal of the American Society of Echocardiography.

QCA to guide treatment of inter-clip mitral regurgitation between two previously implanted MitraClips
Gupta, T, Faza, N, Joseph, D, Little, SH, Kleiman, NS, Wyler von Ballmoos, MC & Goel, SS 2021, , Cardiovascular Revascularization Medicine.

Interventional Echocardiography: A New Specialty Interest Group for American Society of Echocardiography
Hahn, RT, Rubenson, D, Mackensen, GB, Saric, M, Little, SH, Mahmood, F, Cole, SP & Quader, N 2020, , Journal of the American Society of Echocardiography, vol. 33, no. 12, pp. A10-A11.

Mechanical Prosthetic Aortic Valve Thrombosis Complicated by an Acute Coronary Syndrome During Fibrinolysis
Aoun, J, Assaker, JP, Faza, N, Kleiman, NS, Zacca, N & Little, SH 2020, , JACC: Case Reports, vol. 2, no. 14, pp. 2186-2190.

Natural History of Functional Tricuspid Regurgitation Quantified by Cardiovascular Magnetic Resonance
Zhan, Y, Debs, D, Khan, MA, Nguyen, DT, Graviss, EA, Khalaf, S, Little, SH, Reardon, MJ, Nagueh, S, Quiñones, MA, Kleiman, N, Zoghbi, WA & Shah, DJ 2020, , Journal of the American College of Cardiology, vol. 76, no. 11, pp. 1291-1301.

Mitral regurgitation: A contemporary review of percutaneous mitral valve repair and role of periprocedural imaging
Beg, F, Little, SH & Faza, NN 2020, , Current Opinion in Cardiology, vol. 35, no. 5, pp. 482-490.

Role of Teleproctoring in Challenging and Innovative Structural Interventions Amid the COVID-19 Pandemic and Beyond
Goel, SS, Greenbaum, AB, Patel, A, Little, SH, Parikh, R, Wyler von Ballmoos, MC, Lumsden, AB, Reardon, MJ & Kleiman, NS 2020, , JACC: Cardiovascular Interventions, vol. 13, no. 16, pp. 1945-1948.

Transcatheter Mitral Valve Repair with MitraClip for Severe Mitral Regurgitation and Cardiogenic Shock During the COVID-19 Pandemic
Chitturi, KR, Faza, NN, Little, SH, Kleiman, NS, Reardon, MJ & Goel, SS 2020, , Cardiovascular Revascularization Medicine, vol. 21, no. 8, pp. 950-953.

Functional assessment of bioprosthetic mitral valves by cardiovascular magnetic resonance: An in vitro validation and comparison to Doppler echocardiography
Maragiannis, D, Jackson, MS, Autry, K, Flores Arredondo, JH, Aggeli, C, Tousoulis, D, Zoghbi, WA, Shah, DJ & Little, SH 2020, , Journal of Cardiovascular Magnetic Resonance, vol. 22, no. 1, 55.

Patient-Specific Modeling for Structural Heart Intervention: Role of 3D Printing Today and Tomorrow CME
Vukicevic, M, Filippini, S & Little, SH 2020, , Methodist DeBakey cardiovascular journal, vol. 16, no. 2, pp. 130-137.

Patient-Specific 3-Dimensional Printed Modeling of the Tricuspid Valve for MitraClip Procedure Planning
Vukicevic, M, Faza, NN, Avenatti, E, Durai, PC, El-Tallawi, KC, Filippini, S, Chang, SM & Little, SH 2020, , Circulation: Cardiovascular Imaging, vol. 13, no. 7, e010376.

Role of 3-dimensional transesophageal echocardiography in guiding transcatheter mitral valve replacement
Faza, NN & Little, SH 2020, , Echocardiography, vol. 37, no. 6, pp. 945-953.

Proof of Concept: Echo Compatible Mock-Circulatory Flow Loop to Accurately Quantify Aortic Regurgitation in Patients with Left Ventricular Assist Devices
Kassi, M, Filippini, S, Agrawal, T, Bhimaraj, A, Guha, A, Trachtenberg, B, Kim, J, Fida, N, Hussain, I, Yousefzai, R & Little, S 2020, , The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, vol. 39, no. 4, pp. S415.

Intentional bioprosthetic tricuspid valve fracture to facilitate transcatheter valve-in-valve deployment
Karahalios, B, Breinholt, JP, Little, SH & Huie Lin, C 2021, , Catheterization and Cardiovascular Interventions, vol. 97, no. 2, pp. 361-364.

Impact of Stroke Volume Index and Left Ventricular Ejection Fraction on Mortality After Aortic Valve Replacement
Ito, S, Nkomo, VT, Orsinelli, DA, Lin, G, Cavalcante, J, Popma, JJ, Adams, DH, Checuti, SJ, Deeb, GM, Boulware, M, Huang, J, Little, SH, Cohen, SA, Reardon, MJ & Oh, JK 2020, , Mayo Clinic Proceedings, vol. 95, no. 1, pp. 69-76.

Imaging Guidance for Transcatheter Mitral Valve Intervention on Prosthetic Valves, Rings, and Annular Calcification
Little, SH, Bapat, V, Blanke, P, Guerrero, M, Rajagopal, V & Siegel, R 2021, , JACC: Cardiovascular Imaging, vol. 14, no. 1, pp. 22-40.