John S. Dunn Chair in Clinical Cardiovascular Research and Education, DeBakey Heart & Vascular Center
Associate Professor of Clinical Cardiology, Institute for Academic Medicine
Assistant Member, Research Institute
Program Director, Cardiovascular Disease Fellowship, Department of Cardiology
Weill Cornell Medical College
Dr. Little, a cardiologist with the Houston Methodist DeBakey Heart & Vascular Center, is medical director of The Valve Clinic – a multidisciplinary medical clinic focused on the assessment and treatment of complex valvular heart disease. He also serves as Director of the Houston Methodist Valve Institute and is director of the Cardiovascular Hemodynamics Imaging Laboratory (CHIL).
Dr. Little’s recent research activities and peer-reviewed publications have focused on novel use of 3-D echocardiography for the quantification of native and prosthetic valve dysfunction as well as imaging guidance for percutaneous structural heart interventions. His team has created a robust in vitro flow system for multimodality functional valve imaging under tailored hemodynamic conditions. In collaboration with research scientists and mathematicians, Dr. Little’s research group creates complex heart valve constructs to address an increasingly important clinical need - To improve our understanding of heart valve dysfunction by employing multimodality imaging to better characterize and quantify these complex intra- cardiac flow conditions.
He received his medical degree from McMaster University and completed post graduate training in internal medicine and cardiology at the University of Western Ontario. Dr. Little completed research fellowships in echocardiography at the University of Ottawa Heart Institute and at Baylor College of Medicine, Houston. He is a fellow of the Royal College of Physicians and Surgeons of Canada, the American College of Cardiology, and the American Society of Echocardiography. Dr. Little serves on the Board of Directors for the American Society of Echocardiography as well as on ASE committees for Industry Relations, Public Relations, and writing groups.
Dr. Little has given more than 100 invited lectures nationally and internationally. He is an associate professor of clinical Medicine at Weill Cornell Medical College, and adjunct associate professor at Rice University, Dept. of Bioengineering.
After completing sub-specialty Cardiology training (Royal College of Physicians and Surgeon of Canada), Dr. Little completed a postdoctoral fellowship in echocardiography at the Ottawa Heart Institute. He then completed a second postdoctoral fellowship, under the supervision of Dr. W. Zoghbi at Baylor College of Medicine, Houston. As an assistant professor in Canada, he continued to develop novel strategies to visualize the prosthetic valve function using 3D transesophageal echocardiography. In 2007 he was recruited back to Houston to join the Cardiovascular Imaging Institute of the Methodist DeBakey Heart & Vascular Center. As medical director of the MDHVC Heart Valve Clinic, and as a cardiologist interpreting ~3000 patient echocardiograms/year, he has established research programs based on the multi-modality imaging of native and prosthetic valves. Over the last five years, he also leads a team to create a robust in vitro flow system to simulate simple and complex heart valve constructs. As a natural extension of his interest in valve disease and my expertise in 3D imaging, his research group has recently begun collaborations with research scientists and mathematicians to address an increasingly important clinical need - To improve our understanding of heart valve dysfunction by employing multimodality imaging to better characterize and quantity these complex intra- cardiac flow conditions.