Stephen H. Little, MD, FRCPC, FACC, FASE

John S. Dunn Chair in Clinical Cardiovascular Research and Education, DeBakey Heart & Vascular Center
Professor of Cardiology, Academic Institute
Full Member, Research Institute
Program Director, Cardiovascular Disease Fellowship, Department of Cardiology
Houston Methodist
Weill Cornell Medical College


Cardiovascular Disease Fellowship


Biography

Dr. Little is a cardiologist with the Houston Methodist DeBakey Heart & Vascular Center and program director of the Cardiovascular Fellowship. In addition, he is director of Structural Heart for the Houston Methodist Hospital System, and medical director of the Valve Clinic. He also serves as director of the Cardiovascular Hemodynamics Imaging Laboratory (CHIL).

After completing sub-specialty Cardiology training at the Royal College of Physicians and Surgeon of Canada, Dr. Little completed a postdoctoral fellowship in echocardiography at the Ottawa Heart Institute. He then completed a postdoctoral fellowship, under the supervision of Dr. W. Zoghbi at Baylor College of Medicine, Houston.  In 2007 he was recruited back to Houston to join the Cardiovascular Imaging Institute of Houston Methodist DeBakey Heart & Vascular Center.

He is a fellow of the Royal College of Physicians and Surgeons of Canada, the American College of Cardiology, and the American Society of Echocardiography. For the American Society of Echocardiography, Dr. Little served on the Board of Directors, was chair of the guidelines committee, and is the current vice-president.

Dr. Little has given more than 150 invited lectures nationally and internationally. He is an associate professor of clinical Medicine at Weill Cornell Medical College, and adjunct associate professor at Rice University, Dept. of Bioengineering.

Description of Research

Dr. Little’s recent research activities and peer-reviewed publications have focused on novel use of 3D echocardiography for the quantification of native and prosthetic valve dysfunction as well as imaging guidance for percutaneous structural heart interventions. His team has created a robust in vitro flow system for multimodality functional valve imaging under tailored hemodynamic conditions.

As principal investigator, Dr. Little leads Houston Methodists participation in the international Triluminate Clinical Trial of catheter-based therapy for tricuspid valve regurgitation and participates as a co-investigator in multiple other structural heart trials at Houston Methodist.

Areas Of Expertise

Echocardiography Valvular disease Mitral regurgitation
Education & Training

Clinical Fellowship, Baylor College of Medicine
Residency, Western University
MD, McMaster University School of Medicine
Active Clinical Trials

Valve Clinic Registry

N/A

Publications

Natural History of Functional Tricuspid Regurgitation Quantified by Cardiovascular Magnetic Resonance
Zhan, Y, Debs, D, Khan, MA, Nguyen, DT, Graviss, EA, Khalaf, S, Little, SH, Reardon, MJ, Nagueh, S, Quiñones, MA, Kleiman, N, Zoghbi, WA & Shah, DJ 2020, , Journal of the American College of Cardiology, vol. 76, no. 11, pp. 1291-1301. https://doi.org/10.1016/j.jacc.2020.07.036

Mitral regurgitation: a contemporary review of percutaneous mitral valve repair and role of periprocedural imaging
Beg, F, Little, SH & Faza, NN 2020, , Current Opinion in Cardiology, vol. 35, no. 5, pp. 482-490. https://doi.org/10.1097/HCO.0000000000000765

Role of Teleproctoring in Challenging and Innovative Structural Interventions Amid the COVID-19 Pandemic and Beyond
Goel, SS, Greenbaum, AB, Patel, A, Little, SH, Parikh, R, Wyler von Ballmoos, MC, Lumsden, AB, Reardon, MJ & Kleiman, N 2020, , JACC: Cardiovascular Interventions, vol. 13, no. 16, pp. 1945-1948. https://doi.org/10.1016/j.jcin.2020.04.013

Intentional bioprosthetic tricuspid valve fracture to facilitate transcatheter valve-in-valve deployment
Karahalios, B, Breinholt, JP, Little, SH & Huie Lin, C 2020, , Catheterization and Cardiovascular Interventions. https://doi.org/10.1002/ccd.28837

Role of 3-dimensional transesophageal echocardiography in guiding transcatheter mitral valve replacement
Faza, NN & Little, SH 2020, Echocardiography. https://doi.org/10.1111/echo.14712

Transcatheter mitral valve repair with MitraClip for severe mitral regurgitation and cardiogenic shock during the COVID-19 pandemic
Chitturi, KR, Faza, NN, Little, SH, Kleiman, N, Reardon, MJ & Goel, SS 2020, Cardiovascular Revascularization Medicine. https://doi.org/10.1016/j.carrev.2020.05.030

Impact of Stroke Volume Index and Left Ventricular Ejection Fraction on Mortality After Aortic Valve Replacement
Ito, S, Nkomo, VT, Orsinelli, DA, Lin, G, Cavalcante, J, Popma, JJ, Adams, DH, Checuti, SJ, Deeb, GM, Boulware, M, Huang, J, Little, SH, Cohen, SA, Reardon, MJ & Oh, JK 2020, , Mayo Clinic Proceedings, vol. 95, no. 1, pp. 69-76. https://doi.org/10.1016/j.mayocp.2019.10.031

Imaging Guidance for Transcatheter Mitral Valve Intervention on Prosthetic Valves, Rings, and Annular Calcification
Little, SH, Bapat, V, Blanke, P, Guerrero, M, Rajagopal, V & Siegel, R 2020, , JACC: Cardiovascular Imaging. https://doi.org/10.1016/j.jcmg.2019.10.027

3D Printing, Computational Modeling, and Artificial Intelligence for Structural Heart Disease
Wang, DD, Qian, Z, Vukicevic, M, Engelhardt, S, Kheradvar, A, Zhang, C, Little, SH, Verjans, J, Comaniciu, D, ONeill, WW & Vannan, MA 2020, , JACC: Cardiovascular Imaging. https://doi.org/10.1016/j.jcmg.2019.12.022

Aortic Stenosis
Parker, JR & Little, SH 2019, Current Cardiovascular Risk Reports, vol. 13, no. 12, 38. https://doi.org/10.1007/s12170-019-0633-x

Core Competencies in Echocardiography for Imaging Structural Heart Disease Interventions: An Expert Consensus Statement
Hahn, RT, Mahmood, F, Kodali, S, Lang, R, Monaghan, M, Gillam, LD, Swaminathan, M, Bonow, RO, von Bardeleben, RS, Bax, JJ, Grayburn, P, Zoghbi, WA, Sengupta, PP, Chandrashekhar, Y & Little, SH 2019, , JACC: Cardiovascular Imaging, vol. 12, no. 12, pp. 2560-2570. https://doi.org/10.1016/j.jcmg.2019.10.008

Three-Dimensional Printing Applications in Percutaneous Structural Heart Interventions
Harb, SC, Rodriguez, LL, Vukicevic, M, Kapadia, SR & Little, SH 2019, Circulation: Cardiovascular Imaging, vol. 12, no. 10, e009014. https://doi.org/10.1161/CIRCIMAGING.119.009014

3D Cardiac Printing to Plan Transcatheter Closure of an Iatrogenic Primum Atrial Septal Defect
Rojas, SF, Vukicevic, M, Thakkar, AN, Little, SH & Lin, CH 2019, Structural Heart: The Journal of Heart Team , vol. 3, no. 6, pp. 512–513.

2019 AATS/ACC/ASE/SCAI/STS expert consensus systems of care document: A proposal to optimize care for patients with valvular heart disease: A Joint Report of the American Association for Thoracic Surgery, American College of Cardiology, American Society of Echocardiography, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons
Nishimura, RA, OGara, PT, Bavaria, JE, Brindis, RG, Carroll, JD, Kavinsky, CJ, Lindman, BR, Linderbaum, JA, Little, SH, Mack, MJ, Mauri, L, Miranda, WR, Shahian, DM & Sundt, TM 2019, Catheterization and Cardiovascular Interventions, vol. 94, no. 1, pp. 3-26. https://doi.org/10.1002/ccd.28196

Three-Dimensional Printing and the Auricle: Predicting Future Events?
Little, SH & Saric, M 2019, Journal of the American Society of Echocardiography, vol. 32, no. 6, pp. 720-721. https://doi.org/10.1016/j.echo.2019.04.005

2019 AATS/ACC/ASE/SCAI/STS Expert Consensus Systems of Care Document: A Proposal to Optimize Care for Patients With Valvular Heart Disease: A Joint Report of the American Association for Thoracic Surgery, American College of Cardiology, American Society of Echocardiography, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons
Nishimura, RA, OGara, PT, Bavaria, JE, Brindis, RG, Carroll, JD, Kavinsky, CJ, Lindman, BR, Linderbaum, JA, Little, SH, Mack, MJ, Mauri, L, Miranda, WR, Shahian, DM & Sundt, TM 2019, Journal of the American Society of Echocardiography, vol. 32, no. 6, pp. 683-707. https://doi.org/10.1016/j.echo.2019.02.016

2019 AATS/ACC/ASE/SCAI/STS expert consensus systems of care document: A proposal to optimize care for patients with valvular heart disease: A joint report of the American Association for Thoracic Surgery, American College of Cardiology, American Society of Echocardiography, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons
Nishimura, RA, OGara, PT, Bavaria, JE, Brindis, RG, Carroll, JD, Kavinsky, CJ, Lindman, BR, Linderbaum, JA, Little, SH, Mack, MJ, Mauri, L, Miranda, WR, Shahian, DM & Sundt, TM 2019, Journal of Thoracic and Cardiovascular Surgery, vol. 157, no. 6, pp. e327-e354. https://doi.org/10.1016/j.jtcvs.2019.03.004

2019 AATS/ACC/ASE/SCAI/STS Expert Consensus Systems of Care Document: A Proposal to Optimize Care for Patients With Valvular Heart Disease: A Joint Report of the American Association for Thoracic Surgery, American College of Cardiology, American Society of Echocardiography, Society for Cardiovascular Angiography and Interventions, and The Society of Thoracic Surgeons
Nishimura, RA, OGara, PT, Bavaria, JE, Brindis, RG, Carroll, JD, Kavinsky, CJ, Lindman, BR, Linderbaum, JA, Little, SH, Mack, MJ, Mauri, L, Miranda, WR, Shahian, DM & Sundt, TM 2019, , Annals of Thoracic Surgery, vol. 107, no. 6, pp. 1884-1910. https://doi.org/10.1016/j.athoracsur.2019.03.001

2019 AATS/ACC/ASE/SCAI/STS Expert Consensus Systems of Care Document: A Proposal to Optimize Care for Patients With Valvular Heart Disease: A Joint Report of the American Association for Thoracic Surgery, American College of Cardiology, American Society of Echocardiography, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons
Nishimura, RA, OGara, PT, Bavaria, JE, Brindis, RG, Carroll, JD, Kavinsky, CJ, Lindman, BR, Linderbaum, JA, Little, SH, Mack, MJ, Mauri, L, Miranda, WR, Shahian, DM & Sundt, TM 2019, Journal of the American College of Cardiology, vol. 73, no. 20, pp. 2609-2635. https://doi.org/10.1016/j.jacc.2018.10.007

Simultaneous Transfemoral Mitral and Tricuspid Valve in Ring Implantation: First Case Report with Edwards Sapien 3 Valve
Beg, F, Dadu, RT, Reardon, MJ, Little, SH, Kleiman, N & Barker, CM 2019, Methodist DeBakey cardiovascular journal, vol. 15, no. 2, pp. 149-151. https://doi.org/10.14797/mdcj-15-2-149