Stephen H. Little, MD

John S. Dunn Chair in Clinical Cardiovascular Research and Education, DeBakey Heart & Vascular Center
Associate Professor of Clinical Cardiology, Institute for Academic Medicine
Assistant Member, Research Institute
Program Director, Cardiovascular Disease Fellowship, Department of Cardiology
Houston Methodist
Weill Cornell Medical College

Cardiovascular Disease Fellowship


Dr. Little, a cardiologist with the Houston Methodist DeBakey Heart & Vascular Center, is medical director of The Valve Clinic – a multidisciplinary medical clinic focused on the assessment and treatment of complex valvular heart disease. He also serves as Director of the Houston Methodist Valve Institute and is director of the Cardiovascular Hemodynamics Imaging Laboratory (CHIL).

Dr. Little’s recent research activities and peer-reviewed publications have focused on novel use of 3-D echocardiography for the quantification of native and prosthetic valve dysfunction as well as imaging guidance for percutaneous structural heart interventions. His team has created a robust in vitro flow system for multimodality functional valve imaging under tailored hemodynamic conditions. In collaboration with research scientists and mathematicians, Dr. Little’s research group creates complex heart valve constructs to address an increasingly important clinical need - To improve our understanding of heart valve dysfunction by employing multimodality imaging to better characterize and quantify these complex intra- cardiac flow conditions.

He received his medical degree from McMaster University and completed post graduate training in internal medicine and cardiology at the University of Western Ontario. Dr. Little completed research fellowships in echocardiography at the University of Ottawa Heart Institute and at Baylor College of Medicine, Houston. He is a fellow of the Royal College of Physicians and Surgeons of Canada, the American College of Cardiology, and the American Society of Echocardiography. Dr. Little serves on the Board of Directors for the American Society of Echocardiography as well as on ASE committees for Industry Relations, Public Relations, and writing groups.

Dr. Little has given more than 100 invited lectures nationally and internationally. He is an associate professor of clinical Medicine at Weill Cornell Medical College, and adjunct associate professor at Rice University, Dept. of Bioengineering.

Description of Research

After completing sub-specialty Cardiology training (Royal College of Physicians and Surgeon of Canada), Dr. Little completed a postdoctoral fellowship in echocardiography at the Ottawa Heart Institute. He then completed a second postdoctoral fellowship, under the supervision of Dr. W. Zoghbi at Baylor College of Medicine, Houston.  As an assistant  professor  in Canada, he continued to develop novel  strategies to visualize  the prosthetic valve function using 3D transesophageal echocardiography.  In 2007 he was recruited back to Houston to join the Cardiovascular Imaging Institute of the Methodist DeBakey Heart & Vascular Center. As medical director of the MDHVC Heart Valve Clinic, and as a cardiologist interpreting ~3000 patient echocardiograms/year, he has established research programs based on the multi-modality imaging of native and prosthetic valves. Over the last five years, he also leads a team to create a robust in vitro flow system to simulate simple and complex heart valve constructs. As a natural extension of his interest in valve disease and my expertise in 3D imaging, his research group has recently begun collaborations with research scientists and mathematicians to address an increasingly important clinical need - To improve our understanding of heart valve dysfunction by employing multimodality imaging to better characterize and quantity these complex intra- cardiac flow conditions.

Areas Of Expertise

Echocardiography Valvular disease Mitral regurgitation
Education & Training

Clinical Fellowship, Baylor College of Medicine
Residency, Western University
MD, McMaster University School of Medicine
Active Clinical Trials

Valve Clinic Registry



Intraventricular Vortex Interaction between Transmitral Flow and Paravalvular Leak
Morisawa, D, Falahatpisheh, A, Avenatti, E, Little, SH & Kheradvar, A 2018, Scientific Reports, vol. 8, no. 1, 15657. DOI: 10.1038/s41598-018-33648-9

3-Dimensional Modeling in Cardiovascular Disease: 3D Modeling as a Tool for Structural Heart Interventions
Vukicevic, M, Filippini, S & Little, SH 2018, . in 3-Dimensional Modeling in Cardiovascular Disease: 3D Modeling as a Tool for Structural Heart Interventions. Elsevier.

Quantifying Mitral Regurgitation: How Much Should We Lean on PISA?
Hung, J, Zeng, X & Little, SH 2018, Journal of the American Society of Echocardiography, vol. 31, no. 9, pp. 1000-1001. DOI: 10.1016/j.echo.2018.07.003

Myocardial Fibrosis in Patients With Primary Mitral Regurgitation With and Without Prolapse
Kitkungvan, D, Nabi, F, Kim, RJ, Bonow, RO, Khan, MA, Xu, J, Little, SH, Quinones, MA, Lawrie, GM, Zoghbi, WA & Shah, DJ 2018, Journal of the American College of Cardiology, vol. 72, no. 8, pp. 823-834. DOI: 10.1016/j.jacc.2018.06.048

Transcatheter Mitral Valve Replacement for Native and Failed Bioprosthetic Mitral Valves
Sarkar, K, Reardon, MJ, Little, SH, Barker, CM & Kleiman, NS 2018, Methodist DeBakey Cardiovascular Journal, vol. 13, no. 3, pp. 142-151. DOI: 10.14797/mdcj-13-3-142

Very Late Migration of Balloon-Expandable Transcatheter Aortic Valve
Kalra, A, Avenatti, E, Chinnadurai, P, Reardon, MJ, Kleiman, NS, Little, SH & Barker, CM 2018, Journal of Invasive Cardiology, vol. 30, no. 4, pp. E28-E30.

Hemodynamic and echocardiographic comparison of the lotus and corevalve transcatheter aortic valves in patients with high and extreme surgical risk: An analysis from the REPRISE III randomized controlled trial
Asch, FM, Vannan, MA, Singh, S, Khandheria, B, Little, SH, Allocco, DJ, Meredith, IT, Feldman, TE, Reardon, MJ & Weissman, NJ 2018, Circulation, vol. 137, no. 24, pp. 2557-2567. DOI: 10.1161/CIRCULATIONAHA.118.034129, 10.1161/CIRCULATIONAHA.118.034

Vukicevic, M, El-Tallawi, KC, Avenatti, E, Chang, S-M, Barker, CM & Little, SH 2018, American College of Cardiology (ACC) 2018, Orlando, United States, 3/10/18 - 3/12/18, . DOI:

Percutaneous Repair of Severe Eccentric Mitral Regurgitation Due to Medial Commissural Flail: Challenges for Imaging and Intervention
Avenatti, E, Vukicevic, M, El-Tallawi, KC, Barker, CM & Little, SH 2018, CASE (Philadelphia, Pa.), vol. 2, no. 1, pp. 2-5. DOI: 10.1016/

Transcatheter aortic valve replacement in patients with severe mitral or tricuspid regurgitation at extreme risk for surgery
Little, SH, Popma, JJ, Kleiman, NS, Deeb, GM, Gleason, TG, Yakubov, SJ, Checuti, S, OHair, D, Bajwa, T, Mumtaz, M, Maini, B, Hartman, A, Katz, S, Robinson, N, Petrossian, G, Heiser, J, Merhi, W, Moore, BJ, Li, S, Adams, DH & Reardon, MJ 2018, Journal of Thoracic and Cardiovascular Surgery. DOI: 10.1016/j.jtcvs.2017.11.108

Transcatheter Mitral Valve Repair Using the Edge-to-Edge Clip
Nyman, CB, Mackensen, GB, Jelacic, S, Little, SH, Smith, TW & Mahmood, F 2018, Journal of the American Society of Echocardiography. DOI: 10.1016/j.echo.2018.01.012

Changes in Left Atrial Function After Transcutaneous Mitral Valve Repair
Avenatti, E, Little, SH, Barker, CM & Nagueh, SF 2018, American Journal of Cardiology. DOI: 10.1016/j.amjcard.2018.06.031

Four-dimensional flow cardiovascular magnetic resonance in aortic dissection: Assessment in an ex vivo model and preliminary clinical experience
de Beaufort, HW, Shah, DJ, Patel, AP, Jackson, MS, Spinelli, D, Yang, EY, Ghosn, MG, Autry, K, Igo, SR, Lumsden, AB, Little, SH, Trimarchi, S & Bismuth, J 2018, Journal of Thoracic and Cardiovascular Surgery. DOI: 10.1016/j.jtcvs.2018.06.022

Percutaneous repair for recurrent mitral regurgitation after surgical repair: a MitraClip experience
Avenatti, E, El Tallawi, KC, Vukicevic, M, Lawrie, GM, Barker, CM & Little, SH 2018, Structural Heart, vol. 00, no. 00, pp. 0-0. DOI: 10.1080/24748706.2017.1418544, 10.1080/24748706.2017.1418544

Will transcatheter aortic valve replacement echo surgical aortic valve replacement durability?
Little, SH & Reardon, MJ 2017, JAMA Cardiology, vol. 2, no. 11, pp. 1206-1207. DOI: 10.1001/jamacardio.2017.3307

Patient-specific 3D Valve Modeling for Structural Intervention
Vukicevic, M, Vekilov, D, Jane Grande-Allen, K & Little, SH 2017, Structural Heart: The Journal of Heart Team , vol. 1, no. 2, 10.1080/24748706.2017.1377363. DOI: 10.1080/24748706.2017.1377363

3D Experimental and Computational Analysis of Eccentric Mitral Regurgitant Jets in a Mock Imaging Heart Chamber
Wang, Y, Quaini, A, Canic, S, Vukicevic, M & Little, SH 2017, Cardiovascular Engineering and Technology, vol. 8, no. 4, pp. 419-438. DOI: 10.1007/s13239-017-0316-z

Emerging Transcatheter Options for Tricuspid Regurgitation
Kalra, A, Uberoi, AS, Latib, A, Khera, S, Little, SH, Bhatt, DL, Reardon, MJ, Kleiman, NS & Barker, CM 2017, Methodist DeBakey Cardiovascular Journal, vol. 13, no. 3, pp. 120-125. DOI: 10.14797/mdcj-13-3-120

Transcatheter Aortic Valve Replacement for Perceval Sutureless Aortic Valve Failure
Kalra, A, Reyes, M, Yang, EY, Little, SH, Nabi, F, Barker, CM, Ramchandani, M, Reul, RM, Reardon, MJ & Kleiman, NS 2017, Journal of Invasive Cardiology, vol. 29, no. 6, pp. E65-E66.

The use of transcatheter mitral valve system: Can we make mitral regurgitation better again?
Chamsi-Pasha, MA, Little, SH & Reardon, MJ 2017, Journal of Thoracic Disease, vol. 9, no. 5, pp. 1174-1177. DOI: 10.21037/jtd.2017.04.70