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Stephen B. Beres, PhD

Associate Professor of Pathology and Genomic Medicine, Institute for Academic Medicine
Associate Member, Research Institute
Houston Methodist


Publications

Integrated Analysis of Population Genomics, Transcriptomics and Virulence Provides Novel Insights into Serotype M28 Streptococcus pyogenes Pathogenesis
Kachroo, P, Eraso, JM, Beres, SB, Olsen, RJ, Zhu, L, Nasser, W, Bernard, PE, Cantu, CC, Saavedra, MO, Arredondo, MJ, Strope, B, Do, H, Kumaraswami, M, Vuopio, J, Gröndahl-Yli-Hannuksela, K, Kristinsson, K, Gottfredsson, M, Pesonen, M, Pensar, J, Davenport, E, Clark, A, Corander, J, Caugant, D, Gaini, S, Debess Magnussen, M, Kubiak, S, Nguyen, H, Long, SW, Porter, A, DeLeo, F & Musser, JM 2018, Nature genetics.

Gene fitness landscape of group A streptococcus during necrotizing myositis
Zhu, L, Olsen, RJ, Beres, SB, Eraso, JM, Saavedra, MO, Kubiak, S, Cantu, CC, Jenkins, L, Charbonneau, A, Waller, A & Musser, JM 2018, Journal of Clinical Investigation.

RocA Has Serotype-Specific Gene Regulatory and Pathogenesis Activities in Serotype M28 Group A Streptococcus
Bernard, PE, Kachroo, P, Zhu, L, Beres, SB, Eraso, JM, Kajani, Z, Long, SW, Musser, JM & Olsen, RJ 2018, Infection and immunity, vol. 86, no. 11. DOI: 10.1128/IAI.00467-18

Postpartum Group A Streptococcus Case Series: Reach Out to Infection Prevention!
Alexander, AJ, Myers, C, Beres, SB, Olsen, RJ, Musser, JM & Mangino, JE 2018, Open Forum Infectious Diseases, vol. 5, no. 7, pp. ofy159. DOI: 10.1093/ofid/ofy159

Genome sequence analysis of emm89 Streptococcus pyogenes strains causing infections in Scotland, 2010–2016
Beres, SB, Olsen, RJ, Saavedra, MO, Ure, R, Reynolds, A, Lindsay, DSJ, Smith, AJ & Musser, JM 2017, Journal of Medical Microbiology, vol. 66, no. 12, 000622, pp. 1765-1773. DOI: 10.1099/jmm.0.000622

Novel genes required for the fitness of Streptococcus pyogenes in human saliva
Zhu, L, Charbonneau, ARL, Waller, AS, Olsen, RJ, Beres, SB & Musser, JM 2017, mSphere, vol. 2, no. 6, e00460-17. DOI: 10.1128/mSphereDirect.00460-17

Rapid emergence of a new clone impacts the population at risk and increases the incidence of type emm89 group A Streptococcus invasive disease
Teatero, S, Coleman, BL, Beres, SB, Olsen, RJ, Kandel, C, Reynolds, O, Athey, TBT, Musser, JM, McGeer, A & Fittipaldi, N 2017, Open Forum Infectious Diseases, vol. 4, no. 2, ofx042. DOI: 10.1093/ofid/ofx042

Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis
Skwark, MJ, Croucher, NJ, Puranen, S, Chewapreecha, C, Pesonen, M, Xu, YY, Turner, P, Harris, SR, Beres, SB, Musser, JM, Parkhill, J, Bentley, SD, Aurell, E & Corander, J 2017, PLoS Genetics, vol. 13, no. 2, pp. e1006508. DOI: 10.1371/journal.pgen.1006508

Population genomic analysis of 1,777 extended-spectrum beta-lactamase-producing Klebsiella pneumoniae isolates, Houston, Texas: Unexpected abundance of clonal group 307
Long, SW, Olsen, RJ, Eagar, TN, Beres, SB, Zhao, P, Davis, JJ, Brettin, T, Xia, F & Musser, JM 2017, mBio, vol. 8, no. 3, e00489-17. DOI: 10.1128/mBio.00489-17

Case Series Description and Genomic Characterization of Invasive Group A Streptococcal Infections in Pediatric Patients
Bard, JD, Mongkolrattanothai, K, Kachroo, P, Beres, S & Olsen, RJ 2016, Pediatric Infectious Disease Journal. DOI: 10.1097/INF.0000000000001519

Genomic Characteristics Behind the Spread of Bacteremic Group A Streptococcus Type emm89 in Finland, 2004-2014
Latronico, F, Nasser, W, Puhakainen, K, Ollgren, J, Hyyryläinen, H-L, Beres, SB, Lyytikäinen, O, Jalava, J, Musser, JM & Vuopio, J 2016, Journal of Infectious Diseases, vol. 214, no. 12, pp. 1987-1995. DOI: 10.1093/infdis/jiw468

Genomic Landscape of Intrahost Variation in Group A Streptococcus: Repeated and Abundant Mutational Inactivation of the fabT Gene Encoding a Regulator of Fatty Acid Synthesis
Eraso, JM, Olsen, RJ, Beres, SB, Kachroo, P, Porter, AR, Nasser, W, Bernard, PE, DeLeo, FR & Musser, JM 2016, Infection and Immunity, vol. 84, no. 12, pp. 3268-3281. DOI: 10.1128/IAI.00608-16

Transcriptome remodeling contributes to epidemic disease caused by the human pathogen Streptococcus pyogenes
Beres, SB, Kachroo, P, Nasser, W, Olsen, RJ, Zhu, L, Flores, AR, de la Riva, I, Paez-Mayorga, J, Jimenez, FE, Cantu, C, Vuopio, J, Jalava, J, Kristinsson, KG, Gottfredsson, M, Corander, J, Fittipaldi, N, Di Luca, MC, Petrelli, D, Vitali, LA, Raiford, A, Jenkins, L & Musser, JM 2016, mBio, vol. 7, no. 3, e00403-16. DOI: 10.1128/mBio.00403-16

A molecular trigger for intercontinental epidemics of group A Streptococcus
Zhu, L, Olsen, RJ, Nasser, W, Beres, SB, Vuopio, J, Kristinsson, KG, Gottfredsson, M, Porter, AR, DeLeo, FR & Musser, JM 2015, The Journal of clinical investigation, vol. 125, no. 9, pp. 3545-3559. DOI: 10.1172/JCI82478

Comparative whole genome sequencing of community-associated methicillin-resistant Staphylococcus aureus sequence type 8 from primary care clinics in a Texas community
Lee, GC, Long, SW, Musser, JM, Beres, SB, Olsen, RJ, Dallas, SD, Nunez, YO & Frei, CR 2015, Pharmacotherapy, vol. 35, no. 2, pp. 220-228. DOI: 10.1002/phar.1536

The majority of 9,729 group A streptococcus strains causing disease secrete SpeB cysteine protease: Pathogenesis implications
Olsen, RJ, Raghuram, A, Cantu, C, Hartman, MH, Jimenez, FE, Lee, S, Ngo, A, Rice, KA, Saddington, D, Spillman, H, Valson, C, Flores, AR, Beres, SB, Wesley Long, S, Nasser, W & Musser, JM 2015, Infection and Immunity, vol. 83, no. 12, pp. 4750-4758. DOI: 10.1128/IAI.00989-15

Absence of Patient-to-Patient intrahospital transmission of staphylococcus aureus as determined by Whole-Genome sequencing
Wesley Long, S, Beres, SB, Olsen, RJ & Musser, JM 2014, mBio, vol. 5, no. 5, e01692-1. DOI: 10.1128/mBio.01692-14

Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences
Nasser, W, Beres, SB, Olsen, RJ, Dean, MA, Rice, KA, Long, SW, Kristinsson, KG, Gottfredsson, M, Vuopio, J, Raisanen, K, Caugant, DA, Steinbakk, M, Low, DE, McGeer, A, Darenberg, J, Henriques-Normark, B, Van Beneden, CA, Hoffmann, S & Musser, JM 2014, Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 17. DOI: 10.1073/pnas.1403138111

Clinical laboratory response to a mock outbreak of invasive bacterial infections: A preparedness study
Olsen, RJ, Fittipaldi, N, Kachroo, P, Sanson, MA, Long, SW, Como-Sabetti, KJ, Valson, C, Cantu, C, Lynfield, R, Van Beneden, C, Beres, SB & Musser, JM 2014, Journal of Clinical Microbiology, vol. 52, no. 12, pp. 4210-4216. DOI: 10.1128/JCM.02164-14

Asymptomatic carriage of group A streptococcus is associated with elimination of capsule production
Flores, AR, Jewell, BE, Olsen, RJ, Shelburne, SA, Fittipaldi, N, Beres, SB & Musser, JM 2014, Infection and Immunity, vol. 82, no. 9, pp. 3958-3967. DOI: 10.1128/IAI.01788-14