Stefano Casarin

Stefano Casarin, PhD

Assistant Research Professor of Surgery, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Description of Research

Vision - Dr. Casarin's Research focuses on the development of in silico models to guide pre-clinical and clinical research in a more robust and more effective fashion. Working side-by-side with biologist and clinicians, Dr. Casarin and his team aim to create data-integrated in silico platforms with the ultimate goal of prioritizing therapeutic approaches that will most likely succeed and de-prioritizing the ones that will most likely fail.

Active projects - The fields of interest of Dr. Casarin mostly include vascular, cancer, and transplants:

  1. Vascular: i) modeling of atherosclerotic plaque formation in superior femoral arteries; ii) modeling of restenosis phenomenon in vein graft bypasses during post-surgical vascular adaptation; iii) in silico platform to optimize the development of gene therapies to improve the life expectancy of vein graft bypasses
  2. Cancer: i) modeling of prostate cancer bone metastasis establishment, development, and response to therapeutic agents; ii) application of neural networks to the identification of cellular nuceli of interest in the phenomenon of foreign body response; iii) modeling of colon-rectal cancer development and metastatic spreading
  3. Transplant: clinical data-driven in silico platform to optimize the management of brain dead donor patients for solid organ transplantation.

Areas Of Expertise

Computational Biology
Education & Training

PhD, Université de La Rochelle
MS, Politecnico Di Milano
BS, Universita di Padova
Publications

Multiscale agent-based modeling of restenosis after percutaneous transluminal angioplasty: Effects of tissue damage and hemodynamics on cellular activity
Corti, A, Colombo, M, Migliavacca, F, Berceli, SA, Casarin, S, Rodriguez Matas, JF & Chiastra, C 2022, , Computers in Biology and Medicine, vol. 147, 105753. https://doi.org/10.1016/j.compbiomed.2022.105753

Enhancing Radium 223 treatment efficacy by anti-beta 1 integrin targeting
Paindelli, C, Casarin, S, Wang, F, Diaz-Gomez, L, Zhang, J, Mikos, AG, Logothetis, CJ, Friedl, P & Dondossola, E 2022, , Journal of Nuclear Medicine, vol. 63, no. 7. https://doi.org/10.2967/jnumed.121.262743

Deep Learning for Automated Analysis of Cellular and Extracellular Components of the Foreign Body Response in Multiphoton Microscopy Images
Sarti, M, Parlani, M, Diaz-Gomez, L, Mikos, AG, Cerveri, P, Casarin, S & Dondossola, E 2022, , Frontiers in Bioengineering and Biotechnology, vol. 9, 797555. https://doi.org/10.3389/fbioe.2021.797555

A predictive multiscale model of in-stent restenosis in femoral arteries: linking haemodynamics and gene expression with an agent-based model of cellular dynamics
Corti, A, Colombo, M, Rozowsky, JM, Casarin, S, He, Y, Carbonaro, D, Migliavacca, F, Matas, JFR, Berceli, SA & Chiastra, C 2022, , Journal of the Royal Society Interface, vol. 19, no. 188, 20210871. https://doi.org/10.1098/rsif.2021.0871

Baseline local hemodynamics as predictor of lumen remodeling at 1-year follow-up in stented superficial femoral arteries
Colombo, M, He, Y, Corti, A, Gallo, D, Casarin, S, Rozowsky, JM, Migliavacca, F, Berceli, S & Chiastra, C 2021, , Scientific Reports, vol. 11, no. 1, 1613. https://doi.org/10.1038/s41598-020-80681-8

Multiscale Computational Modeling of Vascular Adaptation: A Systems Biology Approach Using Agent-Based Models
Corti, A, Colombo, M, Migliavacca, F, Rodriguez Matas, JF, Casarin, S & Chiastra, C 2021, , Frontiers in Bioengineering and Biotechnology, vol. 9, 744560. https://doi.org/10.3389/fbioe.2021.744560

Enhancing Radium 223 treatment efficacy by anti-beta 1 integrin targeting
Paindelli, C, Casarin, S, Feng, W, Gomez, L-D, Zhang, J, Mikos, AG, Logothetis, CJ, Friedl, P & Dondossola, E 2021, , Journal of Nuclear Medicine. https://doi.org/10.2967/jnumed.121.262743

In silico deceased donor intervention research: A potential accelerant for progress
Hobeika, MJ, Casarin, S, Saharia, A, Mobley, C, Yi, S, McMillan, R, Mark Ghobrial, R & Gaber, AO 2021, , American Journal of Transplantation, vol. 21, no. 6, pp. 2231-2239. https://doi.org/10.1111/ajt.16482

In-Stent Restenosis Progression in Human Superficial Femoral Arteries: Dynamics of Lumen Remodeling and Impact of Local Hemodynamics
Colombo, M, He, Y, Corti, A, Gallo, D, Ninno, F, Casarin, S, Rozowsky, JM, Migliavacca, F, Berceli, S & Chiastra, C 2021, , Annals of Biomedical Engineering, vol. 49, no. 9, pp. 2349-2364. https://doi.org/10.1007/s10439-021-02776-1

Relationship between hemodynamics and in-stent restenosis in femoral arteries
Corti, A, Colombo, M, Migliavacca, F, Rodriguez Matas, JF, Casarin, S & Chiastra, C 2021, . in Biomaterials , Education and digital technology for patient management in vascular surgery.

An agent-based model of prostate Cancer bone metastasis progression and response to Radium223
Casarin, S & Dondossola, E 2020, , BMC Cancer, vol. 20, no. 1, 605. https://doi.org/10.1186/s12885-020-07084-w

A multiscale computational framework of in-stent restenosis: linking gene dynamics and hemodynamics to an agent-based model of cellular dynamics
Casarin, S, Chiastra, C, Migliavacca, F, Colombo, M, rozowsky, J, Berceli, S & he, Y 2020, , Summer Biomechanics, Bioengineering, and Biotransport Conference, 6/17/20 - 12/20/20.

Single gene therapies to improve the longevity of peripheral bypasses: a systems biology - multiscale modeling approach
Casarin, S, Garbey, M, rozowsky, J & Berceli, SA 2020, European Symposium of Vascular Surgery - Translational Meeting, Stockholm, Sweden, 4/2/20 - 4/3/20, .

In-stent restenosis in superficial femoral arteries: dynamic vessel remodeling and impact of local hemodynamics
Corti, A, Casarin, S, Colombo, M, Migliavacca, F, Chiastra, C, Rodriguez Matas, JF & Berceli, S 2020, , Summer Biomechanics, Bioengineering, and Biotransport Conference, 6/17/20 - 12/20/20.

Computational modeling of atherosclerosis: sensitivity analysis towards a quantitative calibration
Casarin, S, Corti, A, Chiastra, C, Colombo, M, Garbey, M & Migliavacca, F 2020, , Summer Biomechanics, Bioengineering, and Biotransport Conference, 6/17/20 - 12/20/20.

Towards a patient-specific multiscale framework of in-stent restenosis: integration of hemodynamics and gene expression with an agent-based model of cellular dynamics
Corti, A, Casarin, S, rozowsky, J, Colombo, M, Migliavacca, F, Rodriguez Matas, JF, Berceli, S & Chiastra, C 2020, , Virtual Physiological Human , 8/24/20 - 8/28/20.

A fully coupled computational fluid dynamics – agent-based model of atherosclerotic plaque development: Multiscale modeling framework and parameter sensitivity analysis
Corti, A, Chiastra, C, Colombo, M, Garbey, M, Migliavacca, F & Casarin, S 2020, , Computers in Biology and Medicine, vol. 118, 103623. https://doi.org/10.1016/j.compbiomed.2020.103623

An in silico model of prostate cancer bone metastasis growth and response to Radium223
Casarin, S & Dondossola, E 2020, , European Conference of Mathematical and Theoretical Biology, 8/31/20 - 9/4/20.

An in silico model of prostate cancer bone metastasis growth and response to Radium223
Casarin, S & Dondossola, E 2020, , 8th Annual Houston Methodist Cancer Symposium, 8/7/20.

Patient specific multiscale model of in-stent restenosis: integrating hemodynamics, gene expression and cellular dynamics
Corti, A, Casarin, S, Colombo, M, rozowsky, J, Berceli, S, Chiastra, C & Migliavacca, F 2020, , International CAE Conference, 11/30/20 - 12/4/20.