Sonia Villapol

Sonia Villapol, PhD

Assistant Professor of Neurosurgery, Academic Institute
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College


VILLAPOL Lab


Phone:
713.363.9208


svillapol@houstonmethodist.org
Biography

Dr. Villapol graduated from the University of Santiago of Compostela, Spain in 2003 with a bachelor’s degree in Molecular Biology and Biotechnology. She received her Master´s degree and Ph.D. in Neuroscience from the Autonomous University of Barcelona, Spain in 2007. She worked as a postdoctoral fellow at CNRS in the University Pierre and Marie Curie VI and at INSERM in Paris, France (2007-2010); and at National Institute of Health (NIH) and Center for Neuroscience and Regenerative Medicine at Uniformed Services University (USUHS) in Bethesda, MD (2010-2014). Following her postdoctoral research work, Dr. Villapol joined the Department of Neuroscience at Georgetown University (Washington, D.C.) as a Research Assistant Professor in May 2014. In July 2018, she started as an Assistant Professor to the Center for Neuroregeneration at Houston Methodist Research Institute. Dr. Villapol has received extramural research funding as Principal Investigator from NIH, and she serves as an Associate Editor for Cellular and Molecular Neurobiology (Springer Journal), and Review Editor for Frontiers in Neurotrauma. She has published over 40 articles in peer reviewer journals and book chapters. 

Description of Research

Dr. Villapol´s research interests have been mainly focused on elucidating the mechanisms of neurodegeneration, neuroinflammation or neurogenesis via several models of brain injury (traumatic brain injury or cerebral ischemia), and how inflammatory mediators connect the brain with the periphery.

Villapol lab focus is the pursuit of novel neurorestorative treatments for debilitating brain injuries to open the door to alternative therapies that repair and recovery in the damaged brain through the periphery.

 

Research Interests:

  • Cerebral ischemia and traumatic brain injury
  • Neuroinflammation and neurodegeneration
  • Sex and gender differences in response to brain damage
  • Brain-Liver axis ~ Brain-gut-microbiome axis ~ Brain-Periphery axis
  • Glia activation
  • Neuroprotection and Neurorestoration

 

Research Methods:

  • Animal models of brain injury
  • Immunohistochemistry and microscopy analysis
  • Protein analysis
  • DNA and RNA purification
  • Sequence analysis

 

Areas Of Expertise

Stroke Inflammation Microbiome Immune activation Cerebral blood flow (CBF) Traumatic brain injury (TBI) Microglia Ischemia Apoptosis
Education & Training

PhD, Autonomous University of Barcelona
Publications

Fecal Microbiota Transplantation Derived from Alzheimer’s Disease Mice Worsens Brain Trauma Outcomes in Wild-Type Controls
Soriano, S, Curry, K, Wang, Q, Chow, E, Treangen, TJ & Villapol, S 2022, , International journal of molecular sciences, vol. 23, no. 9, 4476. https://doi.org/10.3390/ijms23094476

COVID-SCORE Spain: public perceptions of key government COVID-19 control measures
White, TM, Cash-Gibson, L, Martin-Moreno, JM, Matesanz, R, Crespo, J, Alfonso-Sanchez, JL, Villapol, S, El-Mohandes, A & Lazarus, JV 2021, , European Journal of Public Health, vol. 31, no. 5, pp. 1095-1102. https://doi.org/10.1093/eurpub/ckab066

COVID-SCORE Spain: public perceptions of key government COVID-19 control measures
White, TM, Cash-Gibson, L, Martin-Moreno, JM, Matesanz, R, Crespo, J, Alfonso-Sanchez, JL, Villapol, S, El-Mohandes, A & Lazarus, JV 2021, , European Journal of Public Health, vol. 31, no. 5, pp. 1095-1102. https://doi.org/10.1093/eurpub/ckab066

COVID-SCORE Spain: public perceptions of key government COVID-19 control measures
White, TM, Cash-Gibson, L, Martin-Moreno, JM, Matesanz, R, Crespo, J, Alfonso-Sanchez, JL, Villapol, S, El-Mohandes, A & Lazarus, JV 2021, , European Journal of Public Health, vol. 31, no. 5, pp. 1095-1102. https://doi.org/10.1093/eurpub/ckab066

A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage
Sadaf, H, Desai, VR, Misra, V, Golanov, E, Hegde, ML, Villapol, S, Karmonik, C, Regnier-Golanov, A, Sayenko, D, Horner, PJ, Krencik, R, Weng, YL, Vahidy, FS & Britz, GW 2021, , Annals of Clinical and Translational Neurology. https://doi.org/10.1002/acn3.51443

More than 50 long-term effects of COVID-19: a systematic review and meta-analysis
Lopez-Leon, S, Wegman-Ostrosky, T, Perelman, C, Sepulveda, R, Rebolledo, PA, Cuapio, A & Villapol, S 2021, , Scientific Reports, vol. 11, no. 1, 16144, pp. 16144. https://doi.org/10.1038/s41598-021-95565-8

Biomimetic Nanoparticles as a Theranostic Tool for Traumatic Brain Injury
Zinger, A, Soriano, S, Baudo, G, De Rosa, E, Taraballi, F & Villapol, S 2021, , Advanced Functional Materials, vol. 31, no. 30, pp. 2100722. https://doi.org/10.1002/adfm.202100722

Vaccinate fast but leave no one behind: a call to action for COVID-19 vaccination in Spain
Lazarus, JV, Bassat, Q, Crespo, J, Fanjul, G, Garcia-Basteiro, AL, Hoyos, ML, Mateos, C, Gutierrez, JM, Naniche, D, Oliu-Barton, M, Rabin, KH, Vilasanjuan, R, Villapol, S & Martin-Moreno, JM 2021, , Communications Medicine, vol. 1, no. 1. https://doi.org/10.1038/s43856-021-00014-2

Natural tannin extracts supplementation for COVID-19 patients (TanCOVID): a structured summary of a study protocol for a randomized controlled trial
Molino, S, Pisarevsky, A, Mingorance, FL, Vega, P, Stefanolo, JP, Repetti, J, Ludueña, G, Pepa, P, Olmos, JI, Fermepin, MR, Uehara, T, Villapol, S, Savidge, T, Treangen, T, Viciani, E, Castagnetti, A & Piskorz, MM 2021, , Trials, vol. 22, no. 1, 310, pp. 310. https://doi.org/10.1186/s13063-021-05281-x

SARS-CoV-2 genomic diversity and the implications for qRT-PCR diagnostics and transmission
Sapoval, N, Mahmoud, M, Jochum, MD, Liu, Y, Elworth, RAL, Wang, Q, Albin, D, Ogilvie, HA, Lee, MD, Villapol, S, Hernandez, KM, Maljkovic Berry, I, Foox, J, Beheshti, A, Ternus, K, Aagaard, KM, Posada, D, Mason, CE, Sedlazeck, FJ & Treangen, TJ 2021, , Genome Research, vol. 31, no. 4, pp. 635-644. https://doi.org/10.1101/gr.268961.120

More Than 50 Long-Term Effects of COVID-19: A Systematic Review and Meta-Analysis
Lopez-Leon, S, Wegman-Ostrosky, T, Perelman, C, Sepulveda, R, Rebolledo, P, Cuapio, A & Villapol, S 2021, , Research square. https://doi.org/10.21203/rs.3.rs-266574/v1

More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis
Lopez-Leon, S, Wegman-Ostrosky, T, Perelman, C, Sepulveda, R, Rebolledo, PA, Cuapio, A & Villapol, S 2021, , medRxiv. https://doi.org/10.1101/2021.01.27.21250617

Biomimetic Nanoparticles as a Theranostic Tool for Traumatic Brain Injury
Zinger, A, Soriano, S, Baudo, G, De Rosa, E, Taraballi, F & Villapol, S 2021, , Advanced Functional Materials, vol. 31, no. 30, 2100722, pp. 2100722. https://doi.org/10.1002/adfm.202100722, https://doi.org/10.1002/adfm.202100722

A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage
Sadaf, H, Desai, VR, Misra, V, Golanov, E, Hegde, ML, Villapol, S, Karmonik, C, Regnier-Golanov, A, Sayenko, D, Horner, PJ, Krencik, R, Weng, YL, Vahidy, FS & Britz, GW 2021, , Annals of Clinical and Translational Neurology, vol. 8, no. 11, pp. 2211-2221. https://doi.org/10.1002/acn3.51443, https://doi.org/10.1002/acn3.51443, https://doi.org/doi: 10.1002/acn3.51443

Are angiotensin receptor blockers protecting the brain from Covid-19?.
Villapol, S & Saavedra, JM 2021, , Annals of Neurology.

Alterations to the gut microbiome after sport-related concussion and subconcussive impacts in a collegiate football players cohort
Soriano, S, Curry, K, Sadrameli, SS, Qi "Maria", W, Nute, M, Reeves , E, Kabir, R, Wiese, JR, Criswell, A, Schodrof, S, Britz, GW, Gadhia, RR, Podell, K, Treangen , T & Villapol, S 2021, , medRxiv. https://doi.org/doi:10.1101/2021.07.10.21260292

Fecal microbiota transplantation derived from Alzheimer's disease mice worsens brain trauma outcomes in young C57BL/6 mice
Soriano, S, Curry, K, Qi "Maria", W, Chow, E, Treangen, TJ & Villapol, S 2021, , bioRxiv. https://doi.org/doi:10.1101/2021.11.23.469725

A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage.
Villapol, S 2021, , Annals of Clinical and Translational Neurology. https://doi.org/doi: 10.1002/acn3.51443

Vaccinate fast but leave no one behind: a call to action for COVID-19 vaccination in Spain: Communications Medicine volume 1, Article number: 12 (2021).
Villapol, S 2021, , Communications Medicine, vol. volume 1, no. 12.

Emu: Species-Level Microbial Community Profiling for Full-Length Nanopore 16S Reads
Curry, KD, Wang, Q, Nute, MG, Tyshaieva, A, Reeves, E, Soriano, S, Graeber, E, Finzer, P, Mendling, W, Wu, Q, Savidge, T, Villapol, S, Dilthey, A & Treangen, TJ 2021, , bioRxiv. https://doi.org/10.1101/2021.05.02.442339