Siddhartha Ganguly VIEW CLINICAL PROFILE

Siddhartha Ganguly, MD, FACP

Carol Cockrell Curran Distinguished Centennial Chair in Hematologic Oncology, Dr. Mary and Ron Neal Cancer Center
Professor of Clinical Medicine, Academic Institute
Houston Methodist
Weill Cornell Medical College


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Biography

Dr. Ganguly is a board-certified hematologist specializing in the clinical care and research of hematological malignancies, cellular therapeutics, and bone marrow transplantation. Dr. Ganguly was a A. Drue Jennings endowed professor of medical oncology at the University of Kansas Cancer Center in Westwood, Kansas where he was also the Deputy Director of the Division of Hematological Malignancies and Cellular Therapeutics, the Associate Director of Blood and Marrow Transplantation Program, and the Director of Lymphoma and Myeloma Program.

Dr. Ganguly received his undergraduate degree from Calcutta Medical College and his medical degree from the Department of Internal Medicine, Post Graduate, Institute of Medical Education and Research in India. Additionally, he completed his residency in internal medicine and fellowship in hematology at Baylor College of Medicine and concluded another fellowship in bone marrow transplantation at Baylor College of Medicine, Center for Cell and Gene Therapy.

Active Clinical Trials

A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma

NCT06208150


Iberdomide Versus Observation Off Therapy After Idecabtagene Vicleucel CAR-T for Multiple Myeloma

NCT06179888


Open Label, Multi-center, Phase 1b/2 Clinical Trial to Evaluate the Safety and Efficacy of Autologous CAR BCMA T Cells (CT053) in Patients With Relapsed and/or Refractory Multiple Myeloma (LUMMICAR STUDY 2)

NCT03915184


A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma

NCT05455320

Publications

Leukocyte immunoglobulin-like receptor B1 (LILRB1) protects human multiple myeloma cells from ferroptosis by maintaining cholesterol homeostasis
Xian, M, Wang, Q, Xiao, L, Zhong, L, Xiong, W, Ye, L, Su, P, Zhang, C, Li, Y, Orlowski, RZ, Zhan, F, Ganguly, S, Zu, Y, Qian, J & Yi, Q 2024, , Nature Communications, vol. 15, no. 1, 5767. https://doi.org/10.1038/s41467-024-50073-x

Outcomes of patients with primary central nervous system lymphoma following CD19-targeted chimeric antigen receptor T-cell therapy
Mercadal, S, Ahn, KW, Allbee-Johnson, M, Ganguly, S, Geethakumari, PR, Hong, S, Malone, A, Murthy, H, Pawarode, A, Sica, AR, Solh, M, Ustun, C, Shadman, M, Sauter, CS, Hamadani, M, Herrera, AF & Lee, CJ 2024, , Haematologica. https://doi.org/10.3324/haematol.2024.285613

TACTUM: Trends in Access to Cellular Therapies in Multiple Myeloma, Perspectives of Treating Versus Referring Physicians
Atallah, R, Ahmed, N, Ayoobkhan, F, Saif, MSI, Logan, E, Shrestha, A, Anwer, F, Mahmoudjafari, Z, Mushtaq, MU, Hashmi, H, Ganguly, S, McGuirk, J, Shebli, A, Abdallah, AO, Banerjee, R & Alkharabsheh, O 2024, , Transplantation and Cellular Therapy, vol. 30, no. 9, pp. 925.e1-925.e6. https://doi.org/10.1016/j.jtct.2024.05.011

Editor's Note: Superior Efficacy of a Combined Epigenetic Therapy against Human Mantle Cell Lymphoma Cells
Fiskus, W, Rao, R, Balusu, R, Ganguly, S, Tao, J, Sotomayor, E, Mudunuru, U, Smith, JE, Hembruff, SL, Atadja, P, Marquez, VE & Bhalla, K 2024, , Clinical Cancer Research, vol. 30, no. 9, pp. 1994. https://doi.org/10.1158/1078-0432.CCR-24-0856

Development of therapeutic monoclonal antibodies against DKK1 peptide-HLA-A2 complex to treat human cancers
Qian, J, Wang, Q, Xiao, L, Xiong, W, Xian, M, Su, P, Yang, M, Zhang, C, Li, Y, Zhong, L, Ganguly, S, Zu, Y & Yi, Q 2024, , Journal for immunotherapy of cancer, vol. 12, no. 1, e008145. https://doi.org/10.1136/jitc-2023-008145

LILRB3 Modulates Acute Myeloid Leukemia Progression and Acts as an Effective Target for CAR T-cell Therapy
Mai, S, Hodges, A, Chen, HM, Zhang, J, Wang, YL, Liu, Y, Nakatsu, F, Wang, X, Fang, J, Xu, Y, Davidov, V, Kang, K, Pingali, SR, Ganguly, S, Suzuki, M, Konopleva, M, Prinzing, B, Zu, Y, Gottschalk, S, Lu, Y, Chen, SH & Pan, PY 2023, , Cancer research, vol. 83, no. 24, pp. 4047-4062. https://doi.org/10.1158/0008-5472.CAN-22-2483

Cell-free DNA 5-hydroxymethylcytosine is highly sensitive for MRD assessment in acute myeloid leukemia
Shao, J, Shah, S, Ganguly, S, Zu, Y, He, C & Li, Z 2023, , Clinical Epigenetics, vol. 15, no. 1, 134. https://doi.org/10.1186/s13148-023-01547-0

Racial and Socioeconomic Disparities in Long-Term Outcomes in =1 Year Allogeneic Hematopoietic Cell Transplantation Survivors: A CIBMTR Analysis
Blue, BJ, Brazauskas, R, Chen, K, Patel, J, Zeidan, AM, Steinberg, A, Ballen, K, Kwok, J, Rotz, SJ, Perez, MAD, Kelkar, AH, Ganguly, S, Wingard, JR, Lad, D, Sharma, A, Badawy, SM, Lazarus, HM, Hashem, H, Szwajcer, D, Knight, JM, Bhatt, NS, Page, K, Beattie, S, Arai, Y, Liu, H, Arnold, SD, Freytes, CO, Abid, MB, Beitinjaneh, A, Farhadfar, N, Wirk, B, Winestone, LE, Agrawal, V, Preussler, JM, Seo, S, Hashmi, S, Lehmann, L, Wood, WA, Rangarajan, HG, Saber, W & Majhail, NS 2023, , Transplantation and Cellular Therapy, vol. 29, no. 11, pp. 709.e1-709.e11. https://doi.org/10.1016/j.jtct.2023.07.013

A simple prognostic system in patients with myelofibrosis undergoing allogeneic stem cell transplantation: a CIBMTR/EBMT analysis
Tamari, R, McLornan, DP, Ahn, KW, Estrada-Merly, N, Hernández-Boluda, JC, Giralt, S, Palmer, J, Gale, RP, DeFilipp, Z, Marks, DI, van der Poel, M, Verdonck, LF, Battiwalla, M, Diaz, MA, Gupta, V, Ali, H, Litzow, MR, Lazarus, HM, Gergis, U, Bashey, A, Liesveld, J, Hashmi, S, Pu, JJ, Beitinjaneh, A, Bredeson, C, Rizzieri, D, Savani, BN, Abid, MB, Ganguly, S, Agrawal, V, Bacher, VU, Wirk, B, Jain, T, Cutler, C, Aljurf, M, Kindwall-Keller, T, Kharfan-Dabaja, MA, Hildebrandt, GC, Pawarode, A, Solh, MM, Yared, JA, Grunwald, MR, Nathan, S, Nishihori, T, Seo, S, Scott, BL, Nakamura, R, Oran, B, Czerw, T, Yakoub-Agha, I & Saber, W 2023, , Blood Advances, vol. 7, no. 15, pp. 3993-4002. https://doi.org/10.1182/bloodadvances.2023009886

Association between the choice of the conditioning regimen and outcomes of allogeneic hematopoietic cell transplantation for myelofibrosis
Murthy, GSG, Kim, S, Estrada-Merly, N, Abid, MB, Aljurf, M, Assal, A, Badar, T, Badawy, SM, Ballen, K, Beitinjaneh, A, Cerny, J, Chhabra, S, DeFilipp, Z, Dholaria, B, Perez, MAD, Farhan, S, Freytes, CO, Gale, RP, Ganguly, S, Gupta, V, Grunwald, MR, Hamad, N, Hildebrandt, GC, Inamoto, Y, Jain, T, Jamy, O, Juckett, M, Kalaycio, M, Krem, MM, Lazarus, HM, Litzow, M, Munker, R, Murthy, HS, Nathan, S, Nishihori, T, Ortí, G, Patel, SS, van der Poel, M, Rizzieri, DA, Savani, BN, Seo, S, Solh, M, Verdonck, LF, Wirk, B, Yared, JA, Nakamura, R, Oran, B, Scott, B & Saber, W 2023, , Haematologica, vol. 108, no. 7, pp. 1900-1908. https://doi.org/10.3324/haematol.2022.281958

Lenalidomide maintenance following high-dose therapy and autologous haematopoietic stem cell transplantation in chemo-resistant or high-risk non-Hodgkin lymphoma: A phase I/II study
Vose, JM, Ganguly, S, Bierman, PJ, Bociek, RG, Lunning, M, Lyden, L, Meza, JL, Caimi, PF & Armitage, JO 2023, , British Journal of Haematology, vol. 202, no. 1, pp. 116-121. https://doi.org/10.1111/bjh.18821

Classification of Acute Myeloid Leukemia by Cell-Free DNA 5-Hydroxymethylcytosine
Shao, J, Shah, S, Ganguly, S, Zu, Y, He, C & Li, Z 2023, , Genes, vol. 14, no. 6, 1180. https://doi.org/10.3390/genes14061180

Long term outcomes in older patients with primary central nervous system lymphoma: an analysis of the Texas Cancer Registry
Burns, EA, Sanchez, CG, Mathur, S, Guerrero, C, Muhsen, IN, Sarfraz, H, Hu, CCA, Tang, CHA, Shah, SS, Tremont, IW, Teh, B, Ganguly, S & Pingali, SRK 2023, , Annals of Hematology, vol. 102, no. 5, pp. 1111-1120. https://doi.org/10.1007/s00277-023-05140-6

The mutational landscape in chronic myelomonocytic leukemia and its impact on allogeneic hematopoietic cell transplantation outcomes: a Center for Blood and Marrow Transplantation Research (CIBMTR) analysis
Mei, M, Pillai, R, Kim, S, Estrada-Merly, N, Afkhami, M, Yang, L, Meng, Z, Abid, MB, Aljurf, M, Bacher, U, Beitinjaneh, A, Bredeson, C, Cahn, JY, Cerny, J, Copelan, E, Cutler, C, DeFilipp, Z, Perez, MAD, Farhadfar, N, Freytes, CO, Gadalla, SM, Ganguly, S, Gale, RP, Gergis, U, Grunwald, MR, Hamilton, BK, Hashmi, S, Hildebrandt, GC, Lazarus, HM, Litzow, M, Munker, R, Murthy, HS, Nathan, S, Nishihori, T, Patel, SS, Rizzieri, D, Seo, S, Shah, MV, Solh, M, Verdonck, LF, Vij, R, Sobecks, RM, Oran, B, Scott, BL, Saber, W & Nakamura, R 2023, , Haematologica, vol. 108, no. 1, pp. 150-160. https://doi.org/10.3324/haematol.2021.280203

Correction to: Impact of pre-transplant induction and consolidation cycles on AML allogeneic transplant outcomes: a CIBMTR analysis in 3113AML patients
Boyiadzis, M, Zhang, MJ, Chen, K, Abdel-Azim, H, Abid, MB, Aljurf, M, Bacher, U, Badar, T, Badawy, SM, Battiwalla, M, Bejanyan, N, Bhatt, VR, Brown, VI, Castillo, P, Cerny, J, Copelan, EA, Craddock, C, Dholaria, B, Perez, MAD, Ebens, CL, Gale, RP, Ganguly, S, Gowda, L, Grunwald, MR, Hashmi, S, Hildebrandt, GC, Iqbal, M, Jamy, O, Kharfan-Dabaja, MA, Khera, N, Lazarus, HM, Lin, R, Modi, D, Nathan, S, Nishihori, T, Patel, SS, Pawarode, A, Saber, W, Sharma, A, Solh, M, Wagner, JL, Wang, T, Williams, KM, Winestone, LE, Wirk, B, Zeidan, A, Hourigan, CS, Litzow, M, Kebriaei, P, de Lima, M, Page, K & Weisdorf, DJ 2023, , Leukemia, vol. 37, no. 5, pp. 1173. https://doi.org/10.1038/s41375-023-01814-2

From bench to bedside: the history and progress of CAR T cell therapy
Mitra, A, Barua, A, Huang, L, Ganguly, S, Feng, Q & He, B 2023, , Frontiers in immunology, vol. 14, 1188049, pp. 1188049. https://doi.org/10.3389/fimmu.2023.1188049

Long-term outcomes in patients with Burkitt lymphoma older than 65 years: an analysis of the Texas Cancer Registry
Burns, EA, Wilson, JJ, Mathur, S, Kieser, R, Gong, Z, Hu, CCA, Tang, CHA, Petkova, J, Yuen, C, Mai, H, Shah, S, Rice, L, Ganguly, S & Pingali, SR 2023, , Annals of Hematology, vol. 102, no. 10, pp. 2753-2763. https://doi.org/10.1007/s00277-023-05328-w

Allogeneic hematopoietic cell transplantation for blastic plasmacytoid dendritic cell neoplasm: a CIBMTR analysis
Murthy, HS, Zhang, MJ, Chen, K, Ahmed, S, Deotare, U, Ganguly, S, Kansagra, A, Michelis, FV, Nishihori, T, Patnaik, M, Abid, MB, Aljurf, M, Arai, Y, Bacher, U, Badar, T, Badawy, SM, Ballen, K, Battiwalla, M, Beitinjaneh, A, Bejanyan, N, Bhatt, VR, Brown, VI, Martino, R, Cahn, JY, Castillo, P, Cerny, J, Chhabra, S, Copelan, E, Daly, A, Dholaria, B, Perez, MAD, Freytes, CO, Grunwald, MR, Hashmi, S, Hildebrandt, GC, Jamy, O, Joseph, J, Kanakry, CG, Khera, N, Krem, MM, Kuwatsuka, Y, Lazarus, HM, Lekakis, LJ, Liu, H, Modi, D, Munshi, PN, Mussetti, A, Palmisiano, N, Patel, SS, Rizzieri, DA, Seo, S, Shah, MV, Sharma, A, Sohl, M, Solomon, SR, Ulrickson, M, Ustun, C, van der Poel, M, Verdonck, LF, Wagner, JL, Wang, T, Wirk, B, Zeidan, A, Litzow, M, Kebriaei, P, Hourigan, CS, Weisdorf, DJ, Saber, W & Kharfan-Dabaja, MA 2023, , Blood Advances, vol. 7, no. 22, pp. 7007-7016. https://doi.org/10.1182/bloodadvances.2023011308

“Waitlist mortality” is high for myeloma patients with limited access to BCMA therapy
Ahmed, N, Wesson, W, Mushtaq, MU, Bansal, R, AbdelHakim, H, Bromert, S, Appenfeller, A, Ghazal, BA, Singh, A, Abhyankar, S, Ganguly, S, McGuirk, J, Abdallah, AO & Shune, L 2023, , Frontiers in Oncology, vol. 13, 1206715. https://doi.org/10.3389/fonc.2023.1206715

Real-World Evidence of Axicabtagene Ciloleucel for the Treatment of Large B Cell Lymphoma in the United States
Jacobson, CA, Locke, FL, Ma, L, Asubonteng, J, Hu, ZH, Siddiqi, T, Ahmed, S, Ghobadi, A, Miklos, DB, Lin, Y, Perales, MA, Lunning, MA, Herr, MM, Hill, BT, Ganguly, S, Dong, H, Nikiforow, S, Hooper, M, Kawashima, J, Xu, H & Pasquini, MC 2022, , Transplantation and Cellular Therapy, vol. 28, no. 9, pp. 581.e1-581.e8. https://doi.org/10.1016/j.jtct.2022.05.026

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