Sherif Nagueh, MD

Professor of Cardiology, Academic Institute
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


In 1996, Dr. Nagueh joined the Section of Cardiology in the Department of Medicine at the Baylor College of Medicine as an Assistant Professor. He was promoted in 2001 to an Associate Professor, and became the T.L.L Temple/William H. Spencer, MD Chair in Clinical Cardiology there in 2004. Dr. Nagueh assumed his positions at Houston Methodist in 2005.

Description of Research

Dr. Nagueh´s research career has been in the field of echocardiography. He has authored or co-authored over 100 manuscripts in peer reviewed journals and four book chapters. His research interest has been in the evaluation of diastolic function with tissue Doppler and its application in hypertrophic cardiomyopathy, particularly in patients undergoing alcohol septal ablation.

Areas Of Expertise

Alcohol septal ablation Echocardiography Diastolic function Doppler
Education & Training

Residency, Baylor College of Medicine
MD, University of Cairo
Active Clinical Trials

HCMR - Novel



Loperamide Toxicity Revealing Apical Hypertrophic Cardiomyopathy
Khan, N, Chitturi, KR, Hatcher, C, Clewing, M & Nagueh, SF 2021, , Methodist DeBakey cardiovascular journal, vol. 17, no. 1, pp. 65-67.

Heart failure with preserved ejection fraction: Insights into diagnosis and pathophysiology
Nagueh, SF 2021, , Cardiovascular Research, vol. 117, no. 4, pp. 999-1014.

Hemodynamic determinants of left atrial strain in patients with hypertrophic cardiomyopathy: A combined echocardiography and CMR study
Tayal, B, Malahfji, M, Buergler, JM, Shah, DJ & Nagueh, SF 2021, , PLoS ONE, vol. 16, no. 2 February, e0245934.

Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity
HCMR Investigators 2021, , Nature Genetics, vol. 53, no. 2, pp. 135-142.

Extracellular Volume in Primary Mitral Regurgitation
Kitkungvan, D, Yang, EY, El Tallawi, KC, Nagueh, SF, Nabi, F, Khan, MA, Nguyen, DT, Graviss, EA, Lawrie, GM, Zoghbi, WA, Bonow, RO, Quinones, MA & Shah, DJ 2021, , JACC: Cardiovascular Imaging, vol. 14, no. 6, pp. 1146-1160.

Aortic Stenosis and Diastolic Dysfunction: Partners in Crime
Klein, AL, Ramchand, J & Nagueh, SF 2020, , Journal of the American College of Cardiology, vol. 76, no. 25, pp. 2952-2955.

Left atrial dysfunction in sickle cell anemia is associated with diffuse myocardial fibrosis, increased right ventricular pressure and reduced exercise capacity
Alsaied, T, Niss, O, Tretter, JT, Powell, AW, Chin, C, Fleck, RJ, Cnota, JF, Malik, P, Quinn, CT, Nagueh, SM, Taylor, MD & Mazur, WM 2020, , Scientific Reports, vol. 10, no. 1, 1767.

Examining the impact of inducible ischemia on myocardial fibrosis and exercise capacity in hypertrophic cardiomyopathy
Malahfji, M, Senapati, A, Debs, D, Angulo, C, Zhan, Y, Nagueh, SF & Shah, DJ 2020, , Scientific Reports, vol. 10, no. 1, 15977.

Myocardial scar and mortality in chronic aortic regurgitation
Malahfji, M, Senapati, A, Tayal, B, Nguyen, DT, Graviss, EA, Nagueh, SF, Reardon, MJ, Quinones, M, Zoghbi, WA & Shah, DJ 2020, , Journal of the American Heart Association, vol. 9, no. 23, e018731.

Retrospective evaluation of echocardiographic variables for prediction of heart failure hospitalization in heart failure with preserved versus reduced ejection fraction: A single center experience
Hammond, MM, Shen, C, Li, S, Kazi, DS, Sabe, MA, Reshad Garan, A, Markson, LJ, Manning, WJ, Klein, AL, Nagueh, SF & Strom, JB 2020, , PLoS ONE, vol. 15, no. 12 December, e0244379.

Diastology: 2020-A practical guide
Nagueh, SF 2020, , Echocardiography, vol. 37, no. 11, pp. 1919-1925.

Transcatheter Aortic Valve Replacement and Left Ventricular Geometry: Survival and Gender Differences
Truong, VT, Mazur, W, Broderick, J, Egnaczyk, GF, Kereiakes, DJ, Sarembock, IJ, Choo, JK, Shreenivas, S, Nagueh, SF, Bartone, C & Chung, ES 2020, , Journal of the American Society of Echocardiography, vol. 33, no. 11, pp. 1357-1362.e2.

The Authors Reply:
Nagueh, SF 2020, , JACC: Cardiovascular Imaging, vol. 13, no. 10.

Left atrial strain and diastolic function abnormalities in obese and type 2 diabetic adolescents and young adults
Steele, JM, Urbina, EM, Mazur, WM, Khoury, PR, Nagueh, SF, Tretter, JT & Alsaied, T 2020, , Cardiovascular Diabetology, vol. 19, no. 1, 163.

Natural History of Functional Tricuspid Regurgitation Quantified by Cardiovascular Magnetic Resonance
Zhan, Y, Debs, D, Khan, MA, Nguyen, DT, Graviss, EA, Khalaf, S, Little, SH, Reardon, MJ, Nagueh, S, Quiñones, MA, Kleiman, N, Zoghbi, WA & Shah, DJ 2020, , Journal of the American College of Cardiology, vol. 76, no. 11, pp. 1291-1301.

Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial
Olivotto, I, Oreziak, A, Barriales-Villa, R, Abraham, TP, Masri, A, Garcia-Pavia, P, Saberi, S, Lakdawala, NK, Wheeler, MT, Owens, A, Kubanek, M, Wojakowski, W, Jensen, MK, Gimeno-Blanes, J, Afshar, K, Myers, J, Hegde, SM, Solomon, SD, Sehnert, AJ, Zhang, D, Li, W, Bhattacharya, M, Edelberg, JM, Waldman, CB, Lester, SJ, Wang, A, Ho, CY, Jacoby, D, Bartunek, J, Bondue, A, Van Craenenbroeck, E, Zemanek, D, Jensen, M, Mogensen, J, Thune, JJ, Charron, P, Hagege, A, Lairez, O, Trochu, JN, Axthelm, C, Duengen, HD, Frey, N, Mitrovic, V, Preusch, M, Schulz-Menger, J, Seidler, T, Arad, M, Halabi, M, Katz, A, Monakier, D, Paz, O, Viskin, S, Zwas, D, Brunner-La Rocca, HP, Michels, M, Dudek, D, Oko-Sarnowska, Z, Cardim, N, Pereira, H, García Pavia, P, Gimeno Blanes, J, Hidalgo Urbano, R, Rincón Diaz, LM, Elliott, P, Yousef, Z, Abraham, T, Alvarez, P, Bach, R, Becker, R, Choudhury, L, Fermin, D, Jefferies, J, Kramer, C, Lakdawala, N, Lester, S, Marian, A, Maurer, M, Nagueh, S, Owens, D, Rader, F, Sherrid, M, Shirani, J, Symanski, J, Turer, A, Wever-Pinzon, O, Wong, T & Yamani, M 2020, , The Lancet, vol. 396, no. 10253, pp. 759-769.

Diagnostic Algorithms for Heart Failure With Preserved Ejection Fraction
Nagueh, SF 2020, , JACC: Heart Failure, vol. 8, no. 8, pp. 654-656.

Comparison of Echocardiographic Assessment of Tricuspid Regurgitation Against Cardiovascular Magnetic Resonance
Zhan, Y, Senapati, A, Vejpongsa, P, Xu, J, Shah, DJ & Nagueh, S 2020, , JACC: Cardiovascular Imaging, vol. 13, no. 7, pp. 1461-1471.

Left and right atrial speckle tracking: Comparison of three methods of time reference gating
Palmer, C, Truong, VT, Klas, B, Wolking, S, Ornella, A, Young, M, Ngo, TNM, Tretter, JT, Nagueh, SF & Mazur, W 2020, , Echocardiography, vol. 37, no. 7, pp. 1021-1029.

Examining the Relationship and Prognostic Implication of Diabetic Status and Extracellular Matrix Expansion by Cardiac Magnetic Resonance
Khan, MA, Yang, EY, Nguyen, DT, Nabi, F, Hinojosa, J, Jabel, M, Nagueh, SF, Graviss, EA & Shah, DJ 2020, , Circulation: Cardiovascular Imaging, vol. 13, no. 7, e011000.