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S. Wesley Long, MD, PhD

Associate Professor of Pathology and Genomic Medicine, Academic Institute
Associate Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College

Clinical Informatics Fellowship

Dr. Long received his MD degree in 2007 from The University of Texas Medical Branch (UTMB) in Galveston TX, where he also earned a PhD in Experimental Pathology. While at UTMB, he was the recipient of a McLaughlin Fellowship for Immunity and Infectious Disease and a Sealy Center for Vaccine Development fellowship. After finishing his doctoral studies, Dr. Long completed a clinical pathology residency at Houston Methodist. He currently serves as a member of the Editorial Board for Archives of Pathology and Laboratory Medicine. Dr. Long joined Houston Methodist Hospital in 2011, and received his faculty appointment at the Weill Cornell Medical College in 2012. 

Description of Research

Dr. Long’s research centers on functional genomics of multidrug-resistant bacterial strains to identify novel drug targets. He is currently focusing his work on MRSA (methicillin-resistant Staphylococcus aureus) and Klebsiella pneumoniae, both of which readily acquire resistance to several different types of antibiotics and are prevalent in the hospital setting.

Education & Training

MD, University of Texas Medical Branch at Galveston
Residency, The Methodist Hospital

Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization
Salazar, E, Kuchipudi, SV, Christensen, PA, Eagar, T, Yi, X, Zhao, P, Jin, Z, Long, SW, Olsen, RJ, Chen, J, Castillo, B, Leveque, C, Towers, D, Lavinder, J, Gollihar, J, Cardona, J, Ippolito, G, Nissly, R, Bird, I, Greenawalt, D, Rossi, RM, Gontu, A, Srinivasan, S, Poojary, I, Cattadori, IM, Hudson, PJ, Josleyn, NM, Prugar, L, Huie, K, Herbert, A, Bernard, DW, Dye, JM, Kapur, V & Musser, JM 2020, , Journal of Clinical Investigation, vol. 130, no. 12, pp. 6728-6738.

Predicting ß-lactam resistance using whole genome sequencing in Klebsiella pneumoniae: the challenge of ß-lactamase inhibitors
Hujer, AM, Long, SW, Olsen, RJ, Taracila, MA, Rojas, LJ, Musser, JM & Bonomo, RA 2020, , Diagnostic Microbiology and Infectious Disease, vol. 98, no. 3, 115149.

Molecular architecture of early dissemination and massive second wave of the SARS-CoV-2 virus in a major metropolitan area
Long, SW, Olsen, RJ, Christensen, PA, Bernard, DW, Davis, JJ, Shukla, M, Nguyen, M, Saavedra, MO, Yerramilli, P, Pruitt, L, Subedi, S, Kuo, HC, Hendrickson, H, Eskandari, G, Nguyen, HAT, Long, JH, Kumaraswami, M, Goike, J, Boutz, D, Gollihar, J, McLellan, JS, Chou, CW, Javanmardi, K, Finkelstein, IJ & Musser, JM 2020, , mBio, vol. 11, no. 6, e02707-20, pp. 1-30.

Carbapenems drive the collateral resistance to ceftaroline in cystic fibrosis patients with MRSA
Varela, MC, Roch, M, Taglialegna, A, Long, SW, Saavedra, MO, Rose, WE, Davis, JJ, Hoffman, LR, Hernandez, RE, Rosato, RR & Rosato, AE 2020, , Communications Biology, vol. 3, no. 1, 599.

Pathology Trainee Redeployment and Education During the COVID-19 Pandemic: An Institutional Experience
Monroig-Bosque, PDC, Hsu, JW, Lin, MS, Shehabeldin, AN, Rogers, JT, Kim, CF, Kalsekar, AG, Jin, Z, Cara, LR, Barbieri, AN, El-Zaatari, Z, Eskandari, G, Sheu, TG, Tomsula, JA, Long, SW, Zieske, AW, Leveque, CM, Salazar, E, Mody, DR, Schwartz, MR, Cykowski, MD, Yi, X, Powell, SZ & Thomas, JS 2020, , Academic Pathology, vol. 7.

Convalescent plasma anti-SARS-CoV-2 spike protein ectodomain and receptor binding domain IgG correlate with virus neutralization
Salazar, E, Kuchipudi, SV, Christensen, PA, Eagar, T, Yi, X, Zhao, P, Jin, Z, Long, SW, Olsen, RJ, Chen, J, Castillo, B, Leveque, C, Towers, D, Lavinder, JJ, Gollihar, J, Cardona, JA, Ippolito, GC, Nissly, RH, Bird, I, Greenawalt, D, Rossi, RM, Gontu, A, Srinivasan, S, Poojary, I, Cattadori, IM, Hudson, P, Josleyn, NM, Prugar, L, Huie, KE, Herbert, AS, Bernard, DW, Dye, JM, Kapur, V & Musser, JM 2020, , The Journal of clinical investigation.

Treatment of Coronavirus Disease 2019 (COVID-19) Patients with Convalescent Plasma
Salazar, E, Perez, KK, Ashraf, M, Chen, J, Castillo, B, Christensen, PA, Eubank, T, Bernard, DW, Eagar, TN, Long, SW, Subedi, S, Olsen, RJ, Leveque, C, Schwartz, MR, Dey, M, Chavez-East, C, Rogers, J, Shehabeldin, A, Joseph, D, Williams, G, Thomas, K, Masud, F, Talley, C, Dlouhy, KG, Lopez, BV, Hampton, C, Lavinder, J, Gollihar, JD, Maranhao, AC, Ippolito, GC, Saavedra, MO, Cantu, CC, Yerramilli, P, Pruitt, L & Musser, JM 2020, , American Journal of Pathology, vol. 190, no. 8, pp. 1680-1690.

Role of Rapid Diagnostics in Diagnosis and Management of Patients With Sepsis
Eubank, TA, Long, SW & Perez, KK 2020, The Journal of infectious diseases, vol. 222, no. Supplement_2, pp. S103-S109.

Human infections caused by clonally related african clade (clade III) strains of candida auris in the greater houston region
Long, SW, Saavedra, MO, Christensen, PA, Musser, JM & Olsena, RJ 2020, , Journal of Clinical Microbiology, vol. 58, no. 7, e02063-19.

Applications of Artificial Intelligence in Clinical Microbiology Diagnostic Testing
Smith, KP, Wang, H, Durant, TJS, Mathison, BA, Sharp, SE, Kirby, JE, Long, SW & Rhoads, DD 2020, , Clinical Microbiology Newsletter, vol. 42, no. 8, pp. 61-70.

Development and evaluation of a novel protein-based assay for specific detection of KPC ß-lactamases from Klebsiella pneumoniae clinical isolates
Lu, S, Soeung, V, Nguyen, HAT, Long, SW, Musser, JM & Palzkill, T 2020, , mSphere, vol. 5, no. 1, e00918.

Integrated analysis of population genomics, transcriptomics and virulence provides novel insights into Streptococcus pyogenes pathogenesis
Kachroo, P, Eraso, JM, Beres, SB, Olsen, RJ, Zhu, L, Nasser, W, Bernard, PE, Cantu, CC, Saavedra, MO, Arredondo, MJ, Strope, B, Do, H, Kumaraswami, M, Vuopio, J, Gröndahl-Yli-Hannuksela, K, Kristinsson, KG, Gottfredsson, M, Pesonen, M, Pensar, J, Davenport, ER, Clark, AG, Corander, J, Caugant, DA, Gaini, S, Magnussen, MD, Kubiak, SL, Nguyen, HAT, Long, SW, Porter, AR, DeLeo, FR & Musser, JM 2019, , Nature Genetics, vol. 51, no. 3, pp. 548-559.

Draft Genome Sequence of Candida auris Strain LOM, a Human Clinical Isolate from Greater Metropolitan Houston, Texas
Wesley Long, S, Olsen, RJ, Nguyen, HAT, Saavedra, MO & Musser, JM 2019, , Microbiology Resource Announcements, vol. 8, no. 25, e00532-19.

RocA has serotype-specific gene regulatory and pathogenesis activities in serotype M28 Group A streptococcus
Bernard, PE, Kachroo, P, Zhu, L, Beres, SB, Eraso, JM, Kajani, Z, Long, SW, Musser, JM & Olsen, RJ 2018, , Infection and Immunity, vol. 86, no. 11, e00467-18.

Using machine learning to predict antimicrobial MICs and associated genomic features for nontyphoidal Salmonella
Nguyen, M, Long, SW, McDermott, PF, Olsen, RJ, Olson, R, Stevens, RL, Tyson, GH, Zhao, S & Davisa, JJ 2019, , Journal of Clinical Microbiology, vol. 57, no. 2, e01260.

Chlorhexidine bathing and Clostridium difficile infection in a surgical intensive care unit
Bui, LN, Swan, JT, Shirkey, BA, Olsen, RJ, Long, SW & Graviss, EA 2018, , The Journal of surgical research, vol. 228, pp. 107-111.

Real-time Communication with Health Care Providers through an Online Respiratory Pathogen Laboratory Report
Christensen, PA, Olsen, RJ, Perez, KK, Cernoch, PL & Wesley Long, S 2018, , Open Forum Infectious Diseases, vol. 5, no. 12.

Developing an in silico minimum inhibitory concentration panel test for Klebsiella pneumonia
Nguyen, M, Brettin, T, Long, SW, Musser, JM, Olsen, RJ, Olson, R, Shukla, M, Stevens, RL, Xia, F, Yoo, H & Davis, JJ 2018, , Scientific Reports, vol. 8, no. 1, 421.

Houston Methodist Variant Viewer: An Application to Support Clinical Laboratory Interpretation of Next-generation Sequencing Data for Cancer
Christensen, PA, Ni, Y, Bao, F, Hendrickson, HL, Greenwood, M, Thomas, JS, Long, SW & Olsen, RJ 2017, , Journal of Pathology Informatics, vol. 8, no. 1, A25.

Whole-genome sequencing of a human clinical isolate of emm28 Streptococcus pyogenes causing necrotizing fasciitis acquired contemporaneously with Hurricane Harvey
Long, SW, Kachroo, P, Musser, JM & Olsen, RJ 2017, , Genome Announcements, vol. 5, no. 45, e01269-17.