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S. Wesley Long

S. Wesley Long, MD, PhD

Associate Professor of Pathology and Genomic Medicine, Academic Institute
Associate Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Clinical Informatics Fellowship


swlong@houstonmethodist.org
Biography

Dr. Long received his MD degree in 2007 from The University of Texas Medical Branch (UTMB) in Galveston TX, where he also earned a PhD in Experimental Pathology. While at UTMB, he was the recipient of a McLaughlin Fellowship for Immunity and Infectious Disease and a Sealy Center for Vaccine Development fellowship. After finishing his doctoral studies, Dr. Long completed a clinical pathology residency at Houston Methodist. He currently serves as a member of the Editorial Board for Archives of Pathology and Laboratory Medicine. Dr. Long joined Houston Methodist Hospital in 2011, and received his faculty appointment at the Weill Cornell Medical College in 2012. 

Description of Research

Dr. Long’s research centers on functional genomics of multidrug-resistant bacterial strains to identify novel drug targets. He is currently focusing his work on MRSA (methicillin-resistant Staphylococcus aureus) and Klebsiella pneumoniae, both of which readily acquire resistance to several different types of antibiotics and are prevalent in the hospital setting.

Education & Training

MD, University of Texas Medical Branch at Galveston
Residency, Houston Methodist
Publications

Klebsiella pneumoniae clinical isolates with features of both multidrug-resistance and hypervirulence have unexpectedly low virulence
Kochan, TJ, Nozick, SH, Valdes, A, Mitra, SD, Cheung, BH, Lebrun-Corbin, M, Medernach, RL, Vessely, MB, Mills, JO, Axline, CMR, Nelson, JA, VanGosen, EM, Ward, TJ, Ozer, EA, van Duin, D, Chen, L, Kreiswirth, BN, Long, SW, Musser, JM, Bulman, ZP, Wunderink, RG & Hauser, AR 2023, , Nature Communications, vol. 14, no. 1, 7962. https://doi.org/10.1038/s41467-023-43802-1

Integrating genomics, transcriptomics and virulence to study Streptococcus dysgalactiae subspecies equisimilis (SDSE) strains causing severe infections in humans
Eraso, JM, Beres, SB, Olsen, RJ, Long, SW, Gadd, R, Boukthir, S, Faili, A, Kayal, S & Musser, JM 2023, , Tissue, Matrix & Pathobiology Meeting, Salt lake City, United States, 10/22/23 - 10/25/23.

Creation and Evaluation of a Clinical Informatics Match: Initial Findings
Hron, JD, Lehmann, CU, Long, SW, Pageler, NM, Kannry, J, Levy, B & Leu, MG 2023, , Applied Clinical Informatics, vol. 14, no. 5, pp. 973-980. https://doi.org/10.1055/s-0043-1777000

Analysis of the Genomics and Mouse Virulence of an Emergent Clone of Streptococcus dysgalactiae Subspecies equisimilis
Beres, SB, Olsen, RJ, Wesley Long, S, Eraso, JM, Boukthir, S, Faili, A, Kayal, S & Musser, JM 2023, , Microbiology Spectrum, vol. 11, no. 2. https://doi.org/10.1128/spectrum.04550-22

Evaluation of computerized clinical decision support system to reduce unnecessary nasal methicillin-resistant Staphylococcus aureus (MRSA) polymerase chain reaction (PCR) testing
Huynh, DN, Shah, PJ, Greenlee, SB, Long, SW & Alsafadi, MY 2023, , Infection Control and Hospital Epidemiology. https://doi.org/10.1017/ice.2023.256

Proceedings of the Clinical Microbiology Open 2018 and 2019 - a Discussion about Emerging Trends, Challenges, and the Future of Clinical Microbiology
the American Society for Microbiology (ASM) Clinical and Public Health Microbiology Committee and the ASM Corporate Council 2022, , Journal of Clinical Microbiology, vol. 60, no. 7, pp. e0009222. https://doi.org/10.1128/jcm.00092-22

Signals of Significantly Increased Vaccine Breakthrough, Decreased Hospitalization Rates, and Less Severe Disease in Patients with Coronavirus Disease 2019 Caused by the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2 in Houston, Texas
Christensen, PA, Olsen, RJ, Long, SW, Snehal, R, Davis, JJ, Ojeda Saavedra, M, Reppond, K, Shyer, MN, Cambric, J, Gadd, R, Thakur, RM, Batajoo, A, Mangham, R, Pena, S, Trinh, T, Kinskey, JC, Williams, G, Olson, R, Gollihar, J & Musser, JM 2022, , American Journal of Pathology, vol. 192, no. 4, pp. 642-652. https://doi.org/10.1016/j.ajpath.2022.01.007

Delta Variants of SARS-CoV-2 Cause Significantly Increased Vaccine Breakthrough COVID-19 Cases in Houston, Texas
Christensen, PA, Olsen, RJ, Long, SW, Subedi, S, Davis, JJ, Hodjat, P, Walley, DR, Kinskey, JC, Ojeda Saavedra, M, Pruitt, L, Reppond, K, Shyer, MN, Cambric, J, Gadd, R, Thakur, RM, Batajoo, A, Mangham, R, Pena, S, Trinh, T, Yerramilli, P, Nguyen, M, Olson, R, Snehal, R, Gollihar, J & Musser, JM 2022, , American Journal of Pathology, vol. 192, no. 2, pp. 320-331. https://doi.org/10.1016/j.ajpath.2021.10.019

Classification of cervical biopsy free-text diagnoses through linear-classifier based natural language processing
Hsu, JWC, Christensen, P, Ge, Y & Long, SW 2022, , Journal of Pathology Informatics, vol. 13, 100123, pp. 100123. https://doi.org/10.1016/j.jpi.2022.100123

Analysis of the ARTIC Version 3 and Version 4 SARS-CoV-2 Primers and Their Impact on the Detection of the G142D Amino Acid Substitution in the Spike Protein
Davis, JJ, Wesley Long, S, Christensen, PA, Olsen, RJ, Olson, R, Shukla, M, Subedi, S, Stevens, R & Musser, JM 2021, , Microbiology Spectrum, vol. 9, no. 3, e01803. https://doi.org/10.1128/SPECTRUM.01803-21

Trajectory of Growth of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants in Houston, Texas, January through May 2021, Based on 12,476 Genome Sequences
Olsen, RJ, Christensen, PA, Long, SW, Subedi, S, Hodjat, P, Olson, R, Nguyen, M, Davis, JJ, Yerramilli, P, Saavedra, MO, Pruitt, L, Reppond, K, Shyer, MN, Cambric, J, Gadd, R, Thakur, RM, Batajoo, A, Finkelstein, IJ, Gollihar, J & Musser, JM 2021, , American Journal of Pathology, vol. 191, no. 10, pp. 1754-1773. https://doi.org/10.1016/j.ajpath.2021.07.002

The reemergence of seasonal respiratory viruses in Houston, Texas, after Relaxing COVID-19 restrictions
Hodjat, P, Christensen, PA, Subedi, S, Bernard, DW, Olsen, RJ & Long, SW 2021, , Microbiology Spectrum, vol. 9, no. 2, e00430-21. https://doi.org/10.1128/Spectrum.00430-21

Role of rapid diagnostics in diagnosis and management of patients with sepsis
Eubank, TA, Long, SW & Perez, KK 2021, , Journal of Infectious Diseases, vol. 222, no. Supplement_2, pp. S103-S109. https://doi.org/10.1093/INFDIS/JIAA263

Sequence Analysis of 20,453 Severe Acute Respiratory Syndrome Coronavirus 2 Genomes from the Houston Metropolitan Area Identifies the Emergence and Widespread Distribution of Multiple Isolates of All Major Variants of Concern
Long, SW, Olsen, RJ, Christensen, PA, Subedi, S, Olson, R, Davis, JJ, Saavedra, MO, Yerramilli, P, Pruitt, L, Reppond, K, Shyer, MN, Cambric, J, Finkelstein, IJ, Gollihar, J & Musser, JM 2021, , American Journal of Pathology, vol. 191, no. 6, pp. 983-992. https://doi.org/10.1016/j.ajpath.2021.03.004

Implementing flowDensity for automated analysis of bone marrow lymphocyte population
Eskandari, G, Subedi, S, Christensen, P, Olsen, RJ, Zu, Y & Long, SW 2021, , Journal of Pathology Informatics, vol. 12, no. 1. https://doi.org/10.4103/JOPI.JOPI_12_21

The ongoing threat of methicillin-resistant staphylococcus aureus
Long, SW 2020, , Journal of Infectious Diseases, vol. 222, no. 12, pp. 1943-1945. https://doi.org/10.1093/infdis/jiaa260

Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization
Salazar, E, Kuchipudi, SV, Christensen, PA, Eagar, T, Yi, X, Zhao, P, Jin, Z, Long, SW, Olsen, RJ, Chen, J, Castillo, B, Leveque, C, Towers, D, Lavinder, J, Gollihar, J, Cardona, J, Ippolito, G, Nissly, R, Bird, I, Greenawalt, D, Rossi, RM, Gontu, A, Srinivasan, S, Poojary, I, Cattadori, IM, Hudson, PJ, Josleyn, NM, Prugar, L, Huie, K, Herbert, A, Bernard, DW, Dye, JM, Kapur, V & Musser, JM 2020, , Journal of Clinical Investigation, vol. 130, no. 12, pp. 6728-6738. https://doi.org/10.1172/JCI141206

Predicting ß-lactam resistance using whole genome sequencing in Klebsiella pneumoniae: the challenge of ß-lactamase inhibitors
Hujer, AM, Long, SW, Olsen, RJ, Taracila, MA, Rojas, LJ, Musser, JM & Bonomo, RA 2020, , Diagnostic Microbiology and Infectious Disease, vol. 98, no. 3, 115149. https://doi.org/10.1016/j.diagmicrobio.2020.115149

Molecular architecture of early dissemination and massive second wave of the SARS-CoV-2 virus in a major metropolitan area
Long, SW, Olsen, RJ, Christensen, PA, Bernard, DW, Davis, JJ, Shukla, M, Nguyen, M, Saavedra, MO, Yerramilli, P, Pruitt, L, Subedi, S, Kuo, HC, Hendrickson, H, Eskandari, G, Nguyen, HAT, Long, JH, Kumaraswami, M, Goike, J, Boutz, D, Gollihar, J, McLellan, JS, Chou, CW, Javanmardi, K, Finkelstein, IJ & Musser, JM 2020, , mBio, vol. 11, no. 6, e02707-20, pp. 1-30. https://doi.org/10.1128/mBio.02707-20

Carbapenems drive the collateral resistance to ceftaroline in cystic fibrosis patients with MRSA
Varela, MC, Roch, M, Taglialegna, A, Long, SW, Saavedra, MO, Rose, WE, Davis, JJ, Hoffman, LR, Hernandez, RE, Rosato, RR & Rosato, AE 2020, , Communications Biology, vol. 3, no. 1, 599. https://doi.org/10.1038/s42003-020-01313-5