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S. Wesley Long, MD, PhD

Assistant Professor of Pathology and Genomic Medicine, Institute for Academic Medicine
Houston Methodist
Weill Cornell Medical College

Dr. Long received his MD degree in 2007 from The University of Texas Medical Branch (UTMB) in Galveston TX, where he also earned a PhD in Experimental Pathology. While at UTMB, he was the recipient of a McLaughlin Fellowship for Immunity and Infectious Disease and a Sealy Center for Vaccine Development fellowship. After finishing his doctoral studies, Dr. Long completed a clinical pathology residency at Houston Methodist. He currently serves as a member of the Editorial Board for Archives of Pathology and Laboratory Medicine. Dr. Long joined Houston Methodist Hospital in 2011, and received his faculty appointment at the Weill Cornell Medical College in 2012. 

Description of Research

Dr. Long’s research centers on functional genomics of multidrug-resistant bacterial strains to identify novel drug targets. He is currently focusing his work on MRSA (methicillin-resistant Staphylococcus aureus) and Klebsiella pneumoniae, both of which readily acquire resistance to several different types of antibiotics and are prevalent in the hospital setting.

Education & Training

MD, University of Texas Medical Branch at Galveston
Residency, The Methodist Hospital

Chlorhexidine bathing and Clostridium difficile infection in a surgical intensive care unit
Bui, LN, Swan, JT, Shirkey, BA, Olsen, RJ, Long, SW & Graviss, EA 2018, The Journal of surgical research, vol. 228, pp. 107-111. DOI: 10.1016/j.jss.2018.02.063

Developing an in silico minimum inhibitory concentration panel test for Klebsiella pneumonia
Nguyen, M, Brettin, T, Long, SW, Musser, JM, Olsen, RJ, Olson, R, Shukla, M, Stevens, RL, Xia, F, Yoo, H & Davis, JJ 2018, Scientific Reports, vol. 8, no. 1, 421. DOI: 10.1038/s41598-017-18972-w

Whole-genome sequencing of a human clinical isolate of emm28 Streptococcus pyogenes causing necrotizing fasciitis acquired contemporaneously with Hurricane Harvey
Long, SW, Kachroo, P, Musser, JM & Olsen, RJ 2017, Genome Announcements, vol. 5, no. 45, e01269-17. DOI: 10.1128/genomeA.01269-17

Houston Methodist Variant Viewer: An Application to Support Clinical Laboratory Interpretation of Next-generation Sequencing Data for Cancer
Christensen, PA, Ni, Y, Bao, F, Hendrickson, HL, Greenwood, M, Thomas, JS, Long, SW & Olsen, RJ 2017, Journal of Pathology Informatics, vol. 8, no. 1, A25. DOI: 10.4103/jpi.jpi_48_17

Whole-genome sequencing of a human clinical isolate of the novel species Klebsiella quasivariicola sp. nov.
Wesley Long, S, Linson, SE, Saavedra, MO, Cantu, C, Davis, JJ, Brettin, T & Olsen, RJ 2017, Genome Announcements, vol. 5, no. 42, e01057-17. DOI: 10.1128/genomeA.01057-17

Wholegenome sequencing of human clinical Klebsiella pneumoniae isolates reveals misidentification and misunderstandings of Klebsiella pneumoniae, Klebsiella variicola, and Klebsiella quasipneumoniae
Long, SW, Linson, SE, Saavedra, MO, Cantu, C, Davis, JJ, Brettin, T & Olsen, RJ 2017, mSphere, vol. 2, no. 4, e00290-17. DOI: 10.1128/mSpheredirect.00290-17

Population genomic analysis of 1,777 extended-spectrum beta-lactamase-producing Klebsiella pneumoniae isolates, Houston, Texas: Unexpected abundance of clonal group 307
Long, SW, Olsen, RJ, Eagar, TN, Beres, SB, Zhao, P, Davis, JJ, Brettin, T, Xia, F & Musser, JM 2017, mBio, vol. 8, no. 3, e00489-17. DOI: 10.1128/mBio.00489-17 An Open Source, Whole Slide Image-based Pathology Education System
Christensen, PA, Lee, NE, Thrall, MJ, Powell, SZ, Chevez-Barrios, P & Long, SW 2017, Journal of Pathology Informatics, vol. 8, no. 10, pp. 10. DOI: 10.4103/jpi.jpi_72_16

Comparative whole genome sequencing of community-associated methicillin-resistant Staphylococcus aureus sequence type 8 from primary care clinics in a Texas community
Lee, GC, Long, SW, Musser, JM, Beres, SB, Olsen, RJ, Dallas, SD, Nunez, YO & Frei, CR 2015, Pharmacotherapy, vol. 35, no. 2, pp. 220-228. DOI: 10.1002/phar.1536

Improving positive blood culture removal time significantly decreases total processing time
Salazar, E, Divatia, M, Cernoch, PL, Olsen, RJ, Long, SW, Land, GA, Davis, JR & Musser, JM 2015, Archives of Pathology and Laboratory Medicine, vol. 139, no. 2, pp. 199-203. DOI: 10.5858/arpa.2013-0681-OA

The majority of 9,729 group A streptococcus strains causing disease secrete SpeB cysteine protease: Pathogenesis implications
Olsen, RJ, Raghuram, A, Cantu, C, Hartman, MH, Jimenez, FE, Lee, S, Ngo, A, Rice, KA, Saddington, D, Spillman, H, Valson, C, Flores, AR, Beres, SB, Wesley Long, S, Nasser, W & Musser, JM 2015, Infection and Immunity, vol. 83, no. 12, pp. 4750-4758. DOI: 10.1128/IAI.00989-15

PBP2a mutations causing high-level ceftaroline resistance in clinical methicillin-resistant Staphylococcus aureus isolates
Long, SW, Olsen, RJ, Mehta, SC, Palzkill, T, Cernoch, PL, Perez, KK, Musick, WL, Rosato, AE & Musser, JM 2014, Antimicrobial agents and chemotherapy, vol. 58, no. 11, pp. 6668-6674. DOI: 10.1128/AAC.03622-14

Absence of Patient-to-Patient intrahospital transmission of staphylococcus aureus as determined by Whole-Genome sequencing
Wesley Long, S, Beres, SB, Olsen, RJ & Musser, JM 2014, mBio, vol. 5, no. 5, e01692-1. DOI: 10.1128/mBio.01692-14

Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences
Nasser, W, Beres, SB, Olsen, RJ, Dean, MA, Rice, KA, Long, SW, Kristinsson, KG, Gottfredsson, M, Vuopio, J, Raisanen, K, Caugant, DA, Steinbakk, M, Low, DE, McGeer, A, Darenberg, J, Henriques-Normark, B, Van Beneden, CA, Hoffmann, S & Musser, JM 2014, Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 17. DOI: 10.1073/pnas.1403138111

Clinical laboratory response to a mock outbreak of invasive bacterial infections: A preparedness study
Olsen, RJ, Fittipaldi, N, Kachroo, P, Sanson, MA, Long, SW, Como-Sabetti, KJ, Valson, C, Cantu, C, Lynfield, R, Van Beneden, C, Beres, SB & Musser, JM 2014, Journal of Clinical Microbiology, vol. 52, no. 12, pp. 4210-4216. DOI: 10.1128/JCM.02164-14

Identification of point mutations in clinical staphylococcus aureus strains that produce small-colony variants auxotrophic for menadione
Dean, MA, Olsen, RJ, Wesley Long, S, Rosato, AE & Musser, JM 2014, Infection and Immunity, vol. 82, no. 4, pp. 1600-1605. DOI: 10.1128/IAI.01487-13

A genomic day in the life of a clinical microbiology laboratory
Long, SW, Williams, D, Valson, C, Cantu, CC, Cernoch, P, Musser, JM & Olsen, RJ 2013, Journal of Clinical Microbiology, vol. 51, no. 4, pp. 1272-1277. DOI: 10.1128/JCM.03237-12

Bacterial genomics in infectious disease and the clinical pathology laboratory
Olsen, RJ, Long, SW & Musser, JM 2012, Archives of Pathology and Laboratory Medicine, vol. 136, no. 11, pp. 1414-1422. DOI: 10.5858/arpa.2012-0025-RA

Strategy for rapid identification and antibiotic susceptibility testing of gram-negative bacteria directly recovered from positive blood cultures using the Bruker MALDI biotyper and the BD phoenix system
Wimmer, JL, Long, SW, Cernoch, P, Land, GA, Davis, JR, Musser, JM & Olsen, RJ 2012, Journal of Clinical Microbiology, vol. 50, no. 7, pp. 2452-2454. DOI: 10.1128/JCM.00409-12

Rapidly progressive, fatal, inhalation anthrax-like infection in a human: Case report, pathogen genome sequencing, pathology, and coordinated response
Wright, AM, Beres, SB, Consamus, EN, Long, SW, Flores, AR, Barrios, R, Richter, GS, Oh, SY, Garufi, G, Maier, H, Drews, AL, Stockbauer, KE, Cernoch, P, Schneewind, O, Olsen, RJ & Musser, JM 2011, Archives of Pathology and Laboratory Medicine, vol. 135, no. 11, pp. 1447-1459. DOI: 10.5858/arpa.2011-0362-SA