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Sankar Mitra, PhD

Professor of Radiation Oncology, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Research Lab


Biography

Dr. Mitra had a brillient academic career at Calcutta University, India from which he received MS in Biochemitry in 1959.After earning a Ph.D. from the University of Wisconsin in 1964, Dr. Mitra did postdoctoral research in Arthur Kornberg’s laboratory at Stanford Medical School. He then returned to India to join Bose Institute, Calcutta, as an assistant professor in 1966, and became an associate professor in 1971. He came back to the U.S. in 1971 to join the Biology Division of Oak Ridge National Laboratory as a senior research investigator and subsequently became leader of the Nucleic Acid Enzymology Group. He also served as an adjunct professor of the University of Tennessee Graduate School of Biomedical Sciences. Dr. Mitra moved to the newly created Sealy Center for Molecular Science at the University of Texas Medical Branch (UTMB), Galveston, TX in 1992 as professor of Biochemistry & Molecular Biology, and later as senior scientist in the Sealy Center for Molecular Medicine. After his retirement from UTMB in 2013, he joined Houston Methodist Research Institute as a full member in Radiation Oncology. He was elected a fellow of AAAS in 1989 and as a fellow of the Japan Society for Promotion of Science, participating in lecture tours in Japan in 1991, 1999, and 2008.He was awarded Mark Brothers of Indiana Prize in 2009. Dr. Mitra has been continuously funded by NIH since 1982 and has been serving on various NIH and other  review panels.

Description of Research

Working in the broad area of genome damage, its repair, and its influence in carcinogenesis and cancer therapy, Dr. Mitra has made several seminal discoveries during his tenure at Oak Ridge National Laboratory, including the characterization of the E. coli repair protein for the mutagenic DNA base O-6 methylguanine produced by mutagens and anticancer alkylating agents, the naming of the repair protein MGMT, and the cloning of human MGMT. More recently, Dr. Mitra’s group characterized a new family of DNA repair proteins that they named NEILs for oxidative genome damage. The recent research focus of Dr. Mitra’s group is enhancement of chemo/radiation sensitivity of tumor cells using targeted DNA repair inhibitors. After the early studies on MGMT inhibition, his current research aims to identify inhibitors for repair pathways for oxidative/radiation damage.

Areas Of Expertise

Genome damage Repair Cancer mechanisms Cancer therapy
Education & Training

Postdoctoral Fellowship, Stanford University Medical School
Research Doctorate, Department of Biochemistry University of Wisconsin Madison 6
MS, University of Calcutta
Research Fellowship, Department of Biochemistry, University of Calcutta
University Fellow, Department of Biochemistry, University of Wisconsin, Madison,WI
PhD, University of Wisconsin-Madison
Publications

Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
Wang, H, Guo, W, Mitra, J, Hegde, PM, Vandoorne, T, Eckelmann, BJ, Mitra, S, Tomkinson, AE, Van Den Bosch, L & Hegde, ML 2018, Nature communications, vol. 9, no. 1, 3683. DOI: 10.1038/s41467-018-06111-6

Metal Nanoparticle Radiosensitization and Immunotherapy as a Therapeutic Strategy for Non-Small Cell Lung Cancers
Hirsch, M, Vighetto, V, Di Marzio, N, Ferraro, F, Pandey, A, Liu, H, Xuan Chua, CY, Mitra, S, Sikora, AG, Halas, NJ, Filgueira, CS & Grattoni, A 2018, NanoX Symposium, Houston, United States, 9/21/18 - 9/21/18, .

Metal Nanoparticle Radiosensitization and Immunotherapy as a Therapeutic Strategy for Non-Small Cell Lung Cancers
Hirsch, M, Vighetto, V, Di Marzio, N, Ferraro, F, Pandey, A, Liu, H, Xuan Chua, CY, Mitra, S, Sikora, AG, Halas, NJ, Filgueira, CS & Grattoni, A 2018, 6th Annual Houston Methodist Cancer Symposium, Houston, United States, 8/17/18 - 8/17/18, .

Radiosensitization of Gold Nanoparticles as a Therapeutic for Non-Small Cell Lung Cancers
Hirsch, M, Vighetto, V, Di Marzio, N, Ferraro, F, Pathak, R, Pandey, A, Liu, H-C, Villanueva, M, Chua, CYX, Mitra, S, Sikora, AG, Halas, NJ, Filgueira, CS & Grattoni, A 2018, 2018 Methodist Association for Professional Affairs (MAPTA) Summer Symposium, 8/3/18, .

Radio-enhancement of Gold Nanoparticles In Ovo and In Vivo as a Therapeutic for Lung Cancer
Vighetto, V, Di Marzio, N, Ferraro, F, Hirsch, M, Pathak, RR, Pandey, A, Villanueva, M, Liu, H-C, Chua, CYX, Mitra, S, Sikora, AG, Filgueira, CS, Halas, NJ & Grattoni, A 2018, GCC NMR and Cell Tracking Symposium, Houston, United States, 5/16/18 - 5/16/18, .

A novel in ovo system to treat lung cancer
Vighetto, V, Di Marzio, N, Ferraro, F, Hirsch, M, Pathak, R, Pandey, A, Villanueva, M, Liu, H-C, Chua, CYX, Mitra, S, Sikora, AG, Filgueira, CS, Halas, NJ & Grattoni, A 2018, Kavli Foundation Workshop “Sensing the Future: The Future of Sensing”, Houston, United States, 5/7/18, .

A novel in ovo system to treat lung cancer
Vighetto, V, Di Marzio, N, Ferraro, F, Pathak, R, Pandey, A, Villanueva, M, Rhudy, JR, Mitra, S, Sikora, AG, Filgueira, CS, Halas, NJ & Grattoni, A 2018, Lasker lecture & Biomedical Imaging Symposium, Houston, United States, 4/26/18, .

Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress
Sengupta, S, Yang, C, Hegde, ML, Hegde, PM, Mitra, J, Pandey, A, Dutta, A, Datarwala, AT, Bhakat, KK & Mitra, S 2018, DNA Repair, vol. 66-67, pp. 1-10. DOI: 10.1016/j.dnarep.2018.04.001

SMAD4 gene mutation renders pancreatic cancer resistance to radiotherapy through promotion of autophagy
Wang, F, Xia, X, Yang, C, Shen, J, Mai, J, Kim, HC, Kirui, D, Kang, Y, Fleming, JB, Koay, EJ, Mitra, S, Ferrari, M & Shen, H 2018, Clinical Cancer Research, vol. 24, no. 13, pp. 3176-3185. DOI: 10.1158/1078-0432.CCR-17-3435

A novel in ovo system to treat lung cancer
Vighetto, V, Di Marzio, N, Ferraro, F, Pathak, R, Pandey, A, Villanueva, M, Rhudy, JR, Mitra, S, Sikora, A, Filgueira, CS, Halas, NJ & Grattoni, A 2018, 2018 Department of Nanomedicine Symposium, Houston, United States, 2/28/18, .

A Novel In Ovo System to Treat Lung Cancer
Vighetto, V, Di Marzio, N, Ferraro, F, Pathak, R, Pandey, A, Villanueva, M, Rhudy, JR, Mitra, S, Sikora, A, Filgueira, CS, Halas, NJ & Grattoni, A 2018, MAPTA Winter Science Symposium, Houston, United States, 12/1/16, .

A Novel Intratumoral Delivery System to Treat Lung Cancer
Ferraro, F, Pathak, R, Pandey, A, Nixon, A, Rhudy, JR, Mitra, S, Sikora, AG, Filgueira, CS, Halas, NJ & Grattoni, A 2017, Houston Methodist Cancer Symposium, 8/12/16, .

Chromatin-Bound Oxidized a-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson's Disease
Vasquez, V, Mitra, J, Hegde, PM, Pandey, A, Sengupta, S, Mitra, S, Rao, SK & Hegde, ML 2017, Journal of Alzheimers Disease, vol. 60, no. s1, pp. S133-S150. DOI: 10.3233/JAD-170342

Pre-Replicative Repair of Oxidized Bases Maintains Fidelity in Mammalian Genomes: The Cowcatcher Role of NEIL1 DNA Glycosylase
Rangaswamy, S, Pandey, A, Mitra, S & Hegde, ML 2017, Genes, vol. 8, no. 7. DOI: 10.3390/genes8070175

Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis
Wang, H, Peng, B, Pandita, RK, Engler, DA, Matsunami, RK, Xu, X, Hegde, PM, Butler, EB, Pandita, TK, Mitra, S, Xu, B & Hegde, ML 2017, Oncotarget, vol. 8, no. 30, pp. 48671-48687. DOI: 10.18632/oncotarget.16225

DNA damage responses in central nervous system and age-associated neurodegeneration
Hegde, ML, Bohr, VA & Mitra, S 2017, Mechanisms of Ageing and Development, vol. 161, pp. 1-3. DOI: 10.1016/j.mad.2017.01.010

Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex
Dutta, A, Eckelmann, B, Adhikari, S, Ahmed, KM, Sengupta, S, Pandey, A, Hegde, PM, Tsai, M-S, Tainer, JA, Weinfeld, M, Hegde, ML & Mitra, S 2016, Nucleic acids research, vol. 45, no. 5, pp. 2585-2599. DOI: 10.1093/nar/gkw1262

Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A
Yang, C, Sengupta, S, Hegde, PM, Mitra, J, Jiang, S, Holey, B, Sarker, AH, Tsai, M-S, Hegde, ML & Mitra, S 2016, Nucleic acids research, vol. 45, no. 2, pp. 739-748. DOI: 10.1093/nar/gkw1024

Depletion of tyrosyl DNA phosphodiesterase 2 activity enhances etoposide-mediated double-strand break formation and cell killing
Kont, YS, Dutta, A, Mallisetty, A, Mathew, J, Minas, T, Kraus, C, Dhopeshwarkar, P, Kallakury, B, Mitra, S, Üren, A & Adhikari, S 2016, DNA Repair, vol. 43, pp. 38-47. DOI: 10.1016/j.dnarep.2016.04.009

Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions
Hegde, ML, Dutta, A, Yang, C, Mantha, AK, Hegde, PM, Pandey, A, Sengupta, S, Yu, Y, Calsou, P, Chen, D, Lees-Miller, SP & Mitra, S 2016, Oncotarget. DOI: 10.18632/oncotarget.9914