Roderic I. Pettigrew

Roderic I. Pettigrew, MD, PhD

Adjunct Professor of Nanomedicine, Academic Institute
Adjunct Professor of Radiology, Academic Institute
Full Affiliate Member, Research Institute
Houston Methodist


EnMed


Biography

Roderic Ivan Pettigrew, PhD, MD is the Robert A. Welch Professor of Medicine, and serves as CEO of Engineering Health (EnHealth) and executive dean for Engineering Medicine (EnMed) at Texas A&M and Houston Methodist Hospital where he is Adjunct Professor of Nanomedicine. He was the founding Director of the US National Institute of Biomedical Imaging and Bioengineering (NIBIB) of the NIH [2002-2017], oversaw $5 billion in research investments and is credited with building it into the signature NIH institute for emerging medical technologies. Of note, under Dr Pettigrew’s leadership, NIBIB produced more patents per appropriated dollar than any other institute or federal agency returning $30 per each $1 invested in research or 3000% (5 x the already remarkable NIH Average of 600%). On the 10th anniversary of NIBIB, the U.S. Senate unanimously passed a resolution commending the institute for its leadership and impact in improving the nation’s health through technological innovation.

His newest undertaking is EnHealth, the world’s first initiative to holistically integrate engineering into all of the colleges of a university that are a part of the health care enterprise. EnMed is the first constituent initiative, creating a new school that integrates engineering into medical training to develop a new kind of engineering-minded physician, or Physicianeer, who invents solutions to healthcare problems.  Of note, an invention is required of each EnMed graduate who will earn both MD and MEng degrees in 4years.

Dr. Pettigrew’s expertise is in health technologies emerging from the convergence of the life sciences, the physical sciences and engineering.  An MIT graduate (PhD ’77) who finished his medical training at UCSD (’83), he is known internationally for his pioneering work involving four-dimensional imaging of the cardiovascular system using magnetic resonance (MRI). His current knowledge base also includes nanotechnology, regenerative medicine, and point-of-care technologies. He has been elected to membership in the National Academy of Medicine, the National Academy of Engineering, the National Academy of Inventors and the National Academy of Sciences, India. Other awards include the Pierre Galletti Award (highest honor) of the American Institute of Medical and Biological Engineering, the Inaugural Gold Medal of the Academy of Radiology Research, the Distinguished Service Medal of the International Society of Magnetic Resonance in Medicine, the Spirit of the Heart Award of the ABC, the Pritzker Distinguished Achievement Award of the Biomedical Engineering Society, the Gold Medal of the Radiological Society of North America, and the Arthur M. Bueche Award of the National Academy of Engineering.

Current advisory service includes the Phil and Penny Knight Institute for Accelerating Scientific Impact External Advisory Board, the Stand Up To Cancer Scientific Advisory Board and the Allen Institute Scientific Advisory Board.

Areas Of Expertise

EnHealth EnMed
Publications

At the nexus of science, engineering, and medicine: Pasteur's quadrant reconsidered
Pettigrew, RI & Cooke, JP 2022, , PNAS nexus, vol. 1, no. 3, pp. pgac092. https://doi.org/10.1093/pnasnexus/pgac092

Liquid Drug Delivery Approaches for the Treatment of Occlusive Arterial Disease: A Systematic Review
Todd, M, Nair, PK, Ohayon, J, Pettigrew, RI & Yazdani, SK 2022, , Journal of Endovascular Therapy. https://doi.org/10.1177/15266028221120755

Blood Pressure Estimation using a Single Channel Bio-Impedance Ring Sensor
Osman, D, Jankovic, M, Sel, K, Pettigrew, RI & Jafari, R 2022, . in 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 2022-July, Institute of Electrical and Electronics Engineers Inc. pp. 4286-4290, 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022, Glasgow, United Kingdom, 7/11/22. https://doi.org/10.1109/EMBC48229.2022.9871653

Precision delivery of liquid therapy into the arterial wall for the treatment of peripheral arterial disease
Atigh, MK, Goel, E, Erwin, M, Greer, R, Ohayon, J, Pettigrew, RI & Yazdani, SK 2021, , Scientific Reports, vol. 11, no. 1, 18676. https://doi.org/10.1038/s41598-021-98063-z

Evidence generation and reproducibility in cell and gene therapy research: A call to action
Abou-el-Enein, M, Angelis, A, Appelbaum, FR, Andrews, NC, Bates, SE, Bierman, AS, Brenner, MK, Cavazzana, M, Caligiuri, MA, Clevers, H, Cooke, E, Daley, GQ, Dzau, VJ, Ellis, LM, Fineberg, HV, Goldstein, LSB, Gottschalk, S, Hamburg, MA, Ingber, DE, Kohn, DB, Krainer, AR, Maus, MV, Marks, P, Mummery, CL, Pettigrew, RI, Rutter, JL, Teichmann, SA, Terzic, A, Urnov, FD, Williams, DA, Wolchok, JD, Lawler, M, Turtle, CJ, Bauer, G & Ioannidis, JPA 2021, , Molecular Therapy - Methods and Clinical Development, vol. 22, pp. 11-14. https://doi.org/10.1016/j.omtm.2021.06.012

RNA therapeutics for cardiovascular disease
Boada, C, Sukhovershin, R, Pettigrew, R & Cooke, JP 2021, , Current Opinion in Cardiology, vol. 36, no. 3, pp. 256-263. https://doi.org/10.1097/HCO.0000000000000850

Impact of malapposed and overlapping stents on hemodynamics: A 2d parametric computational fluid dynamics study
Lagache, M, Coppel, R, Finet, G, Derimay, F, Pettigrew, RI, Ohayon, J & Malvè, M 2021, , Mathematics, vol. 9, no. 8, 795. https://doi.org/10.3390/math9080795

The Limitless Future of RNA Therapeutics
Damase, TR, Sukhovershin, R, Boada, C, Taraballi, F, Pettigrew, RI & Cooke, JP 2021, , Frontiers in Bioengineering and Biotechnology, vol. 9, 628137. https://doi.org/10.3389/fbioe.2021.628137

Coronary artery calcium scoring: an evidence-based guide for primary care physicians
Cheong, BYC, Wilson, JM, Spann, SJ, Pettigrew, RI, Preventza, OA & Muthupillai, R 2021, , Journal of Internal Medicine, vol. 289, no. 3, pp. 309-324. https://doi.org/10.1111/joim.13176

Emergent biomechanical factors predicting vulnerable coronary atherosclerotic plaque rupture
Peña, E, Cilla, M, Latorre, ÁT, Martínez, MA, Gómez, A, Ohayon, J, Pettigrew, RI & Finet, G 2021, . in Biomechanics of Coronary Atherosclerotic Plaque: From Model to Patient. Elsevier, pp. 361-380. https://doi.org/10.1016/B978-0-12-817195-0.00016-0

Intravascular ultrasound imaging of human coronary atherosclerotic plaque: Novel morpho-elastic biomarkers of instability
Gómez, A, Tacheau, A, Ohayon, J, Le Floch, S, Pettigrew, RI, Cloutier, G & Finet, G 2021, . in Biomechanics of Coronary Atherosclerotic Plaque: From Model to Patient. Elsevier, pp. 465-489. https://doi.org/10.1016/B978-0-12-817195-0.00020-2

Biomechanics of Coronary Atherosclerotic Plaque
Ohayon, J, Finet, G & Pettigrew, RI 2021, . in Biomechanics of Coronary Atherosclerotic Plaque: From Model to Patient. Elsevier, pp. 1-653. https://doi.org/10.1016/C2017-0-03308-6

Preface
Ohayon, J, Finet, G & Pettigrew, RI 2021, . in Biomechanics of Coronary Atherosclerotic Plaque: From Model to Patient. Elsevier, pp. xxxi-xxxii. https://doi.org/10.1016/B978-0-12-817195-0.05001-0

Importance of residual stress and basal tone in healthy and pathological human coronary arteries
Martiel, JL, Ohayon, J, Finet, G, Holzapfel, GA, Stuber, M, Matsumoto, T & Pettigrew, RI 2021, . in Biomechanics of Coronary Atherosclerotic Plaque: From Model to Patient. Elsevier, pp. 433-461. https://doi.org/10.1016/B978-0-12-817195-0.00019-6

A new reduced-order model to assess the true fractional flow reserve of a left main coronary artery stenosis with downstream lesions and collateral circulations: an in vitro study
Lagache, M, Coppel, R, Ohayon, J, Finet, G, Malvè, M & Pettigrew, RI 2021, . in Biomechanics of Coronary Atherosclerotic Plaque: From Model to Patient. Elsevier, pp. 273-295. https://doi.org/10.1016/B978-0-12-817195-0.00012-3

Hemodynamic disturbance due to serial stenosis in human coronary bifurcations: a computational fluid dynamics study
Malvè, M, Finet, G, Lagache, M, Ohayon, J, Coppel, R & Pettigrew, RI 2021, . in Biomechanics of Coronary Atherosclerotic Plaque: From Model to Patient. Elsevier, pp. 225-250. https://doi.org/10.1016/B978-0-12-817195-0.00010-X

Modeling-based UV-C decontamination of N95 masks optimized to avoid undertreatment
Sears, AP, Ohayon, J, Shutov, AD & Pettigrew, RI 2020, , Unknown Journal. https://doi.org/10.1101/2020.10.30.20223354

Achieving healthy human longevity: A global grand challenge
Dzau, VJ, Finkelman, EM, Balatbat, CA, Verdin, EM & Pettigrew, RI 2020, , Science translational medicine, vol. 12, no. 566, eabd3816. https://doi.org/10.1126/scitranslmed.abd3816

Caveats on modeling of nuclear biomechanics
Walther, BK, Mojiri, A, Ohayon, J, Cooke, JP & Pettigrew, RI 2020, , Molecular Biology of the Cell, vol. 31, no. 22, pp. 2421-2422. https://doi.org/10.1091/MBC.E20-05-0281

Clinician Cognition and Artificial Intelligence in Medicine
Feaster, WW, Maher, K, Lee, J, Gearhart, A, Young, AS, Cummings, A, Vorhies, B, Yoo, C, Pettigrew, RI, Mathur, P, Papay, F, Cummings, KC, Baker, H, Char, D, Seals, K, Meyer, A, Holbrook, PR, Rutledge, GW, Feinman, T, Agha-Mir-Salim, L, Celi, LA, Miolane, N, Axelrod, DM, Klaus, S, Callahan, A, Shah, NH, Gaffar, S & Entezam, L 2020, . in Intelligence-Based Medicine: Artificial Intelligence and Human Cognition in Clinical Medicine and Healthcare. Elsevier, pp. 193-266. https://doi.org/10.1016/B978-0-12-823337-5.00007-X