Roderic I. Pettigrew

Roderic I. Pettigrew, MD, PhD

Adjunct Professor of Nanomedicine, Academic Institute
Adjunct Professor of Radiology, Academic Institute
Full Affiliate Member, Research Institute
Houston Methodist



Roderic Ivan Pettigrew, PhD, MD is the Robert A. Welch Professor of Medicine, and serves as CEO of Engineering Health (EnHealth) and executive dean for Engineering Medicine (EnMed) at Texas A&M and Houston Methodist Hospital where he is Adjunct Professor of Nanomedicine. He was the founding Director of the US National Institute of Biomedical Imaging and Bioengineering (NIBIB) of the NIH [2002-2017], oversaw $5 billion in research investments and is credited with building it into the signature NIH institute for emerging medical technologies. Of note, under Dr Pettigrew’s leadership, NIBIB produced more patents per appropriated dollar than any other institute or federal agency returning $30 per each $1 invested in research or 3000% (5 x the already remarkable NIH Average of 600%). On the 10th anniversary of NIBIB, the U.S. Senate unanimously passed a resolution commending the institute for its leadership and impact in improving the nation’s health through technological innovation.

His newest undertaking is EnHealth, the world’s first initiative to holistically integrate engineering into all of the colleges of a university that are a part of the health care enterprise. EnMed is the first constituent initiative, creating a new school that integrates engineering into medical training to develop a new kind of engineering-minded physician, or Physicianeer, who invents solutions to healthcare problems.  Of note, an invention is required of each EnMed graduate who will earn both MD and MEng degrees in 4years.

Dr. Pettigrew’s expertise is in health technologies emerging from the convergence of the life sciences, the physical sciences and engineering.  An MIT graduate (PhD ’77) who finished his medical training at UCSD (’83), he is known internationally for his pioneering work involving four-dimensional imaging of the cardiovascular system using magnetic resonance (MRI). His current knowledge base also includes nanotechnology, regenerative medicine, and point-of-care technologies. He has been elected to membership in the National Academy of Medicine, the National Academy of Engineering, the National Academy of Inventors and the National Academy of Sciences, India. Other awards include the Pierre Galletti Award (highest honor) of the American Institute of Medical and Biological Engineering, the Inaugural Gold Medal of the Academy of Radiology Research, the Distinguished Service Medal of the International Society of Magnetic Resonance in Medicine, the Spirit of the Heart Award of the ABC, the Pritzker Distinguished Achievement Award of the Biomedical Engineering Society, the Gold Medal of the Radiological Society of North America, and the Arthur M. Bueche Award of the National Academy of Engineering.

Current advisory service includes the Phil and Penny Knight Institute for Accelerating Scientific Impact External Advisory Board, the Stand Up To Cancer Scientific Advisory Board and the Allen Institute Scientific Advisory Board.

Areas Of Expertise

EnHealth EnMed

Precision delivery of liquid therapy into the arterial wall for the treatment of peripheral arterial disease
Atigh, MK, Goel, E, Erwin, M, Greer, R, Ohayon, J, Pettigrew, RI & Yazdani, SK 2021, , Scientific Reports, vol. 11, no. 1, 18676.

Evidence generation and reproducibility in cell and gene therapy research: A call to action
Abou-el-Enein, M, Angelis, A, Appelbaum, FR, Andrews, NC, Bates, SE, Bierman, AS, Brenner, MK, Cavazzana, M, Caligiuri, MA, Clevers, H, Cooke, E, Daley, GQ, Dzau, VJ, Ellis, LM, Fineberg, HV, Goldstein, LSB, Gottschalk, S, Hamburg, MA, Ingber, DE, Kohn, DB, Krainer, AR, Maus, MV, Marks, P, Mummery, CL, Pettigrew, RI, Rutter, JL, Teichmann, SA, Terzic, A, Urnov, FD, Williams, DA, Wolchok, JD, Lawler, M, Turtle, CJ, Bauer, G & Ioannidis, JPA 2021, , Molecular Therapy - Methods and Clinical Development, vol. 22, pp. 11-14.

RNA therapeutics for cardiovascular disease
Boada, C, Sukhovershin, R, Pettigrew, R & Cooke, JP 2021, , Current Opinion in Cardiology, vol. 36, no. 3, pp. 256-263.

Impact of malapposed and overlapping stents on hemodynamics: A 2d parametric computational fluid dynamics study
Lagache, M, Coppel, R, Finet, G, Derimay, F, Pettigrew, RI, Ohayon, J & Malvè, M 2021, , Mathematics, vol. 9, no. 8, 795.

The Limitless Future of RNA Therapeutics
Damase, TR, Sukhovershin, R, Boada, C, Taraballi, F, Pettigrew, RI & Cooke, JP 2021, , Frontiers in Bioengineering and Biotechnology, vol. 9, 628137.

Coronary artery calcium scoring: an evidence-based guide for primary care physicians
Cheong, BYC, Wilson, JM, Spann, SJ, Pettigrew, RI, Preventza, OA & Muthupillai, R 2021, , Journal of Internal Medicine, vol. 289, no. 3, pp. 309-324.

Modeling-based UV-C decontamination of N95 masks optimized to avoid undertreatment
Sears, AP, Ohayon, J, Shutov, AD & Pettigrew, RI 2020, , Unknown Journal.

Achieving healthy human longevity: A global grand challenge
Dzau, VJ, Finkelman, EM, Balatbat, CA, Verdin, EM & Pettigrew, RI 2020, , Science translational medicine, vol. 12, no. 566, eabd3816.

Caveats on modeling of nuclear biomechanics
Walther, BK, Mojiri, A, Ohayon, J, Cooke, JP & Pettigrew, RI 2020, , Molecular Biology of the Cell, vol. 31, no. 22, pp. 2421-2422.

Clinician Cognition and Artificial Intelligence in Medicine
Feaster, WW, Maher, K, Lee, J, Gearhart, A, Young, AS, Cummings, A, Vorhies, B, Yoo, C, Pettigrew, RI, Mathur, P, Papay, F, Cummings, KC, Baker, H, Char, D, Seals, K, Meyer, A, Holbrook, PR, Rutledge, GW, Feinman, T, Agha-Mir-Salim, L, Celi, LA, Miolane, N, Axelrod, DM, Klaus, S, Callahan, A, Shah, NH, Gaffar, S & Entezam, L 2020, . in Intelligence-Based Medicine: Artificial Intelligence and Human Cognition in Clinical Medicine and Healthcare. Elsevier, pp. 193-266.

Influence of Collaterals on True FFR Prediction for a Left Main Stenosis with Concomitant Lesions: An In Vitro Study
Coppel, R, Lagache, M, Finet, G, Rioufol, G, Gómez, A, Dérimay, F, Malvé, M, Yazdani, SK, Pettigrew, RI & Ohayon, J 2019, , Annals of Biomedical Engineering, vol. 47, no. 6, pp. 1409-1421.

Single-Molecule Force Measurement Guides the Design of Multivalent Ligands with Picomolar Affinity
Yang, Z, Jiang, S, Li, F, Qiu, Y, Gu, J, Pettigrew, RI, Ferrari, M, Hamilton, DJ & Li, Z 2019, , Angewandte Chemie - International Edition, vol. 58, no. 16, pp. 5272-5276.

Intraluminal Ultrasonic Palpation Imaging Technique Revisited for Anisotropic Characterization of Healthy and Atherosclerotic Coronary Arteries: A Feasibility Study
Gómez, A, Tacheau, A, Finet, G, Lagache, M, Martiel, JL, Floch, SL, Yazdani, SK, Elias-Zuñiga, A, Pettigrew, RI, Cloutier, G & Ohayon, J 2019, , Ultrasound in Medicine and Biology, vol. 45, no. 1, pp. 35-49.

Experimental Bench for Hemodynamic Study of Coronary Artery with Serial Stenoses: Fractional Flow Reserve Assessment
Coppel, R, Gomez, AL, Finet, G, Mauro, M, Pettigrew, RI, Ohayon, J & Lagache, M 2017, , Computer Methods in Biomechanics and Biomedical Engineering, vol. 20, pp. 45-46.

An intravascular ultrasound anisotropic elasticity-palpography technique for in vivo coronary atherosclerotic plaque detection and characterization
Gomez, A, Tacheau, A, Finet, G, Coppel, RD, Lagache, M, Martiel, JL, Le Floc’h, S, Pettigrew, RI, Cloutier, G & Ohayon, J 2017, , Computer Methods in Biomechanics and Biomedical Engineering, vol. 20, pp. 97-98.

Epidural Spinal Stimulation to Improve Bladder, Bowel, and Sexual Function in Individuals with Spinal Cord Injuries: A Framework for Clinical Research
Pettigrew, RI, Heetderks, WJ, Kelley, CA, Peng, GCY, Krosnick, SH, Jakeman, LB, Egan, KD & Marge, M 2017, , IEEE Transactions on Biomedical Engineering, vol. 64, no. 2, 7827212, pp. 253-262.

Arterial Wall Stiffness and Atherogenesis in Human Coronaries
Ohayon, J, Yazdani, SK, Malvè, M, Gharib, AM, Garcia, A, Finet, G & Pettigrew, RI 2017, . in Biomechanics of Living Organs: Hyperelastic Constitutive Laws for Finite Element Modeling. Elsevier, pp. 193-213.

Special Section Guest Editorial: Positron Emission Tomography: History, Current Status, and Future Prospects
Pelc, NJ, Kinahan, PE & Pettigrew, RI 2017, , Journal of Medical Imaging, vol. 4, no. 1, 011001.

Continuous Blood Pressure Measurement From Invasive to Unobtrusive: Celebration of 200th Birth Anniversary of Carl Ludwig
Ding, XR, Zhao, N, Yang, GZ, Pettigrew, RI, Lo, B, Miao, F, Li, Y, Liu, J & Zhang, YT 2016, , IEEE Journal of Biomedical and Health Informatics, vol. 20, no. 6, 7676313, pp. 1455-1465.

Basic science: Bedrock of progress
Collins, FS, Anderson, JM, Austin, CP, Battey, JF, Birnbaum, LS, Briggs, JP, Clayton, JA, Cuthbert, B, Eisinger, RW, Fauci, AS, Gallin, JI, Gibbons, GH, Glass, RI, Gottesman, MM, Gray, PA, Green, ED, Greider, FB, Hodes, R, Hudson, KL, Humphreys, B, Katz, SI, Koob, GF, Koroshetz, WJ, Lauer, MS, Lorsch, JR, Lowy, DR, McGowan, JJ, Murray, DM, Nakamura, R, Norris, A, Perez-Stable, EJ, Pettigrew, RI, Riley, WT, Rodgers, GP, Sieving, PA, Somerman, MJ, Spong, CY, Tabak, LA, Volkow, ND & Wilder, EL 2016, , Science, vol. 351, no. 6280, pp. 1405.