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Roderic I. Pettigrew, MD, PhD

Adjunct Professor of Nanomedicine, Academic Institute
Full Affiliate Member, Research Institute
Houston Methodist


EnMed


Biography

Roderic Ivan Pettigrew, PhD, MD is the Robert A. Welch Professor of Medicine, and serves as CEO of Engineering Health (EnHealth) and executive dean for Engineering Medicine (EnMed) at Texas A&M and Houston Methodist Hospital where he is Adjunct Professor of Nanomedicine. He was the founding Director of the US National Institute of Biomedical Imaging and Bioengineering (NIBIB) of the NIH [2002-2017], oversaw $5 billion in research investments and is credited with building it into the signature NIH institute for emerging medical technologies. Of note, under Dr Pettigrew’s leadership, NIBIB produced more patents per appropriated dollar than any other institute or federal agency returning $30 per each $1 invested in research or 3000% (5 x the already remarkable NIH Average of 600%). On the 10th anniversary of NIBIB, the U.S. Senate unanimously passed a resolution commending the institute for its leadership and impact in improving the nation’s health through technological innovation.

His newest undertaking is EnHealth, the world’s first initiative to holistically integrate engineering into all of the colleges of a university that are a part of the health care enterprise. EnMed is the first constituent initiative, creating a new school that integrates engineering into medical training to develop a new kind of engineering-minded physician, or Physicianeer, who invents solutions to healthcare problems.  Of note, an invention is required of each EnMed graduate who will earn both MD and MEng degrees in 4years.

Dr. Pettigrew’s expertise is in health technologies emerging from the convergence of the life sciences, the physical sciences and engineering.  An MIT graduate (PhD ’77) who finished his medical training at UCSD (’83), he is known internationally for his pioneering work involving four-dimensional imaging of the cardiovascular system using magnetic resonance (MRI). His current knowledge base also includes nanotechnology, regenerative medicine, and point-of-care technologies. He has been elected to membership in the National Academy of Medicine, the National Academy of Engineering, the National Academy of Inventors and the National Academy of Sciences, India. Other awards include the Pierre Galletti Award (highest honor) of the American Institute of Medical and Biological Engineering, the Inaugural Gold Medal of the Academy of Radiology Research, the Distinguished Service Medal of the International Society of Magnetic Resonance in Medicine, the Spirit of the Heart Award of the ABC, the Pritzker Distinguished Achievement Award of the Biomedical Engineering Society, the Gold Medal of the Radiological Society of North America, and the Arthur M. Bueche Award of the National Academy of Engineering.

Current advisory service includes the Phil and Penny Knight Institute for Accelerating Scientific Impact External Advisory Board, the Stand Up To Cancer Scientific Advisory Board and the Allen Institute Scientific Advisory Board.

Areas Of Expertise

EnHealth EnMed
Publications

Influence of Collaterals on True FFR Prediction for a Left Main Stenosis with Concomitant Lesions: An In Vitro Study
Coppel, R, Lagache, M, Finet, G, Rioufol, G, Gómez, A, Dérimay, F, Malvé, M, Yazdani, SK, Pettigrew, RI & Ohayon, J 2019, , Annals of Biomedical Engineering, vol. 47, no. 6, pp. 1409-1421. https://doi.org/10.1007/s10439-019-02235-y

Single-Molecule Force Measurement Guides the Design of Multivalent Ligands with Picomolar Affinity
Yang, Z, Jiang, S, Li, F, Qiu, Y, Gu, J, Pettigrew, RI, Ferrari, M, Hamilton, DJ & Li, Z 2019, , Angewandte Chemie - International Edition, vol. 58, no. 16, pp. 5272-5276. https://doi.org/10.1002/anie.201814347

Intraluminal Ultrasonic Palpation Imaging Technique Revisited for Anisotropic Characterization of Healthy and Atherosclerotic Coronary Arteries: A Feasibility Study
Gómez, A, Tacheau, A, Finet, G, Lagache, M, Martiel, JL, Floch, SL, Yazdani, SK, Elias-Zuñiga, A, Pettigrew, RI, Cloutier, G & Ohayon, J 2019, , Ultrasound in Medicine and Biology, vol. 45, no. 1, pp. 35-49. https://doi.org/10.1016/j.ultrasmedbio.2018.08.020

Experimental Bench for Hemodynamic Study of Coronary Artery with Serial Stenoses: Fractional Flow Reserve Assessment
Coppel, R, Gomez, AL, Finet, G, Mauro, M, Pettigrew, RI, Ohayon, J & Lagache, M 2017, , Computer Methods in Biomechanics and Biomedical Engineering, vol. 20, pp. 45-46. https://doi.org/10.1080/10255842.2017.1382853

An intravascular ultrasound anisotropic elasticity-palpography technique for in vivo coronary atherosclerotic plaque detection and characterization
Gomez, A, Tacheau, A, Finet, G, Coppel, RD, Lagache, M, Martiel, JL, Le Floc’h, S, Pettigrew, RI, Cloutier, G & Ohayon, J 2017, , Computer Methods in Biomechanics and Biomedical Engineering, vol. 20, pp. 97-98. https://doi.org/10.1080/10255842.2017.1382879

Epidural Spinal Stimulation to Improve Bladder, Bowel, and Sexual Function in Individuals with Spinal Cord Injuries: A Framework for Clinical Research
Pettigrew, RI, Heetderks, WJ, Kelley, CA, Peng, GCY, Krosnick, SH, Jakeman, LB, Egan, KD & Marge, M 2017, , IEEE Transactions on Biomedical Engineering, vol. 64, no. 2, 7827212, pp. 253-262. https://doi.org/10.1109/TBME.2016.2637301

Arterial Wall Stiffness and Atherogenesis in Human Coronaries
Ohayon, J, Yazdani, SK, Malvè, M, Gharib, AM, Garcia, A, Finet, G & Pettigrew, RI 2017, . in Biomechanics of Living Organs: Hyperelastic Constitutive Laws for Finite Element Modeling. Elsevier, pp. 193-213. https://doi.org/10.1016/B978-0-12-804009-6.00009-2

Special Section Guest Editorial: Positron Emission Tomography: History, Current Status, and Future Prospects
Pelc, NJ, Kinahan, PE & Pettigrew, RI 2017, Journal of Medical Imaging, vol. 4, no. 1, 011001. https://doi.org/10.1117/1.JMI.4.1.011001

Continuous Blood Pressure Measurement From Invasive to Unobtrusive: Celebration of 200th Birth Anniversary of Carl Ludwig
Ding, XR, Zhao, N, Yang, GZ, Pettigrew, RI, Lo, B, Miao, F, Li, Y, Liu, J & Zhang, YT 2016, , IEEE Journal of Biomedical and Health Informatics, vol. 20, no. 6, 7676313, pp. 1455-1465. https://doi.org/10.1109/JBHI.2016.2620995

Basic science: Bedrock of progress
Collins, FS, Anderson, JM, Austin, CP, Battey, JF, Birnbaum, LS, Briggs, JP, Clayton, JA, Cuthbert, B, Eisinger, RW, Fauci, AS, Gallin, JI, Gibbons, GH, Glass, RI, Gottesman, MM, Gray, PA, Green, ED, Greider, FB, Hodes, R, Hudson, KL, Humphreys, B, Katz, SI, Koob, GF, Koroshetz, WJ, Lauer, MS, Lorsch, JR, Lowy, DR, McGowan, JJ, Murray, DM, Nakamura, R, Norris, A, Perez-Stable, EJ, Pettigrew, RI, Riley, WT, Rodgers, GP, Sieving, PA, Somerman, MJ, Spong, CY, Tabak, LA, Volkow, ND & Wilder, EL 2016, , Science, vol. 351, no. 6280. https://doi.org/10.1126/science.351.6280.1405-a

The Imaging Modulography Technique Revisited for High-Definition Intravascular Ultrasound: Theoretical Framework
Tacheau, A, Le Floch, S, Finet, G, Doyley, MM, Pettigrew, RI, Cloutier, G & Ohayon, J 2016, , Ultrasound in Medicine and Biology, vol. 42, no. 3, pp. 727-741. https://doi.org/10.1016/j.ultrasmedbio.2015.11.015

Engineering as a new frontier for translational medicine
Chien, S, Bashir, R, Nerem, RM & Pettigrew, R 2015, , Science translational medicine, vol. 7, no. 281, 281fs13. https://doi.org/10.1126/scitranslmed.aaa4325

An intravascular coronary plaque elasticity reconstruction method using limited depth penetration ultrasound signals
Tacheau, A, Le Floc’h, S, Finet, G, Doyley, MM, Pettigrew, RI, Cloutier, G & Ohayon, J 2015, , Computer Methods in Biomechanics and Biomedical Engineering, vol. 18, pp. 2066-2067. https://doi.org/10.1080/10255842.2015.1069604

A new finite element method for inverse problems in structural analysis: application to atherosclerotic plaque elasticity reconstruction
Bouvier, A, Deleaval, F, Doyley, MM, Tacheau, A, Finet, G, Floch, SL, Cloutier, G, Pettigrew, RI & Ohayon, J 2014, , Computer Methods in Biomechanics and Biomedical Engineering, vol. 17, no. SUPP1, pp. 16-17. https://doi.org/10.1080/10255842.2014.931071

Brain initiative to transform human imaging
Pettigrew, RI 2014, , Science translational medicine, vol. 6, no. 244, 244ed16. https://doi.org/10.1126/scitranslmed.3009695

Foreword
Pettigrew, RI 2014, . in Magnetic Resonance Elastography. vol. 9781493915750, Springer New York, pp. vii. https://doi.org/10.1007/978-1-4939-1575-0

Effects of mechanical properties and atherosclerotic artery size on biomechanical plaque disruption - Mouse vs. human
Riou, LM, Broisat, A, Ghezzi, C, Finet, G, Rioufol, G, Gharib, AM, Pettigrew, RI & Ohayon, J 2014, , Journal of Biomechanics, vol. 47, no. 4, pp. 765-772. https://doi.org/10.1016/j.jbiomech.2014.01.020

Biomechanics of atherosclerotic coronary plaque: Site, stability and in vivo elasticity modeling
Ohayon, J, Finet, G, Le Floch, S, Cloutier, G, Gharib, AM, Heroux, J & Pettigrew, RI 2014, , Annals of Biomedical Engineering, vol. 42, no. 2, pp. 269-279. https://doi.org/10.1007/s10439-013-0888-1

NIH Workshop on Clinical Translation of Molecular Imaging Probes and Technology—Meeting Report
Liu, CH, Sastre, A, Conroy, R, Seto, B & Pettigrew, RI 2014, , Molecular Imaging and Biology, vol. 16, no. 5, pp. 595-604. https://doi.org/10.1007/s11307-014-0746-z

Tortuosity of Coronary Bifurcation as a Potential Local Risk Factor for Atherosclerosis: CFD Steady State Study Based on In Vivo Dynamic CT Measurements
Malvè, M, Gharib, AM, Yazdani, SK, Finet, G, Martínez, MA, Pettigrew, RI & Ohayon, J 2014, , Annals of Biomedical Engineering, vol. 43, no. 1, pp. 82-93. https://doi.org/10.1007/s10439-014-1056-y