Roberto Barrios, MD

Professor of Pathology and Genomic Medicine, Academic Institute
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. Barrios received his first academic appointment at the Universidad Nacional Autonoma de Mexico as Assistant Professor of Histology and Pathology in the Department of Chemistry in 1978. In 1982, he was promoted to full Professor in the Department of Cell Biology, and elected Head of the Department of Electron Microscopy at the same institution. He then became Chairman of the Department of Pathology at the Mexican Cardiology Institute and later Chairman of Pathology at the National Institute for Respiratory Diseases in Mexico City. He was visiting professor from 1990 through 1992 in Dr. Michael Lieberman’s laboratory at Baylor College of Medicine, conducting molecular biology studies. In 1992, Dr. Barrios was appointed Associate Professor in the Department of Pathology at Baylor College of Medicine, where he led numerous conferences and lectures for medical students. In 2004, he assumed his positions at Houston Methodist Hospital as Professor of Pathology and Laboratory Medicine at Weill Cornell Medical College.

Description of Research

Dr. Barrios has worked with experimental pathology projects for the last twenty-eight years, while at the same time his primary area of interest in diagnostic pathology has been pulmonary and renal pathology. His current projects include the study of interstitial lung diseases and pulmonary neoplasms. His collaborations in experimental pathology are related to oncogenesis and oxygen toxicity.



Areas Of Expertise

Pulmonary Renal Pathology
Education & Training

MD, Facultad De Medicina - Instituto Tech.
Residency, Case Western Reserve University
Clinical Fellowship, McGill University

Papillary Fibroelastoma Incidentally Found on Left Atrial Wall During Minimally Invasive Aortic Valve Replacement
Abri, QA, El Nihum, LI, Zubair, MM, Barrios, R, Reardon, MJ & Ramchandani, M 2022, , Texas Heart Institute Journal, vol. 49, no. 4, e217725.

Extracellular Signal-Regulated Kinase 1 Alone Is Dispensable for Hyperoxia-Mediated Alveolar and Pulmonary Vascular Simplification in Neonatal Mice
Menon, RT, Thapa, S, Shrestha, AK, Barrios, R & Shivanna, B 2022, , Antioxidants, vol. 11, no. 6, 1130.

Hidden in Plain Sight: Discovering Giant Cell Aortopathy During Surgical Mitral Valve Repair
Khan, NA, Li, D, Newstrom, E, Barrios, R & Attar, M 2022, , JACC: Case Reports, vol. 4, no. 9, pp. 529-532.

Erratum: Newborn Mice Lacking the Gene for Cyp1a1 Are More Susceptible to Oxygen-Mediated Lung Injury, and Are Rescued by Postnatal ß-Naphthoflavone Administration: Implications for Bronchopulmonary Dysplasia in Premature Infants (Toxicological Sciences (2017) 157:1 (260-271) DOI: 10.1093/toxsci/kfx036)
Maturu, P, Wei-Liang, Y, Jiang, W, Wang, L, Lingappan, K, Barrios, R, Liang, Y, Moorthy, B & Couroucli, XI 2022, , Toxicological Sciences, vol. 187, no. 1, pp. 187.

Progression of pulmonary veno-occlusive disease without pulmonary hypertension
Beshay, S, Humbert, M, Barrios, R & Sahay, S 2022, , Pulmonary Circulation, vol. 12, no. 1, e12046.

Atypical Presentation of Marantic Endocarditis
Manian, N, Arunachalam, P, El Nihum, LI, Al Abri, Q, Barrios, R, Chamsi-Pasha, M & Ramchandani, M 2022, , Methodist DeBakey cardiovascular journal, vol. 18, no. 1, pp. 45-47.

Adrenomedullin Deficiency Potentiates Lipopolysaccharide-Induced Experimental Bronchopulmonary Dysplasia in Neonatal Mice
Shrestha, AK, Menon, RT, Yallampalli, C, Barrios, R & Shivanna, B 2021, , American Journal of Pathology, vol. 191, no. 12, pp. 2080-2090.

Endothelial adenosine monophosphate-activated protein kinase-alpha1 deficiency potentiates hyperoxia-induced experimental bronchopulmonary dysplasia and pulmonary hypertension
Elsaie, A, Menon, RT, Shrestha, AK, Gowda, SH, Varghese, NP, Barrios, RJ, Blanco, CL, Konduri, GG & Shivanna, B 2021, , Antioxidants, vol. 10, no. 12, 1913.

Vancomycin-Associated Tubular Casts and Vancomycin Nephrotoxicity
Tantranont, N, Luque, Y, Hsiao, M, Haute, C, Gaber, L, Barrios, R, Adrogue, HE, Niasse, A & Truong, LD 2021, , Kidney International Reports, vol. 6, no. 7, pp. 1912-1922.

A Japanese-American female with rapidly progressive interstitial lung disease associated with clinically amyopathic dermatomyositis
Takada, T, Asakawa, K & Barrios, R 2021, , Clinical Rheumatology, vol. 40, no. 3, pp. 1159-1165.

Interactive and independent effects of early lipopolysaccharide and hyperoxia exposure on developing murine lungs
Shrestha, AK, Menon, RT, El-Saie, A, Barrios, R, Reynolds, C & Shivanna, B 2020, , American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 319, no. 6, pp. L981-L996.

Prevalence, Characteristics, and Outcomes of Incidental IgA Glomerular Deposits in Donor Kidneys
Gaber, LW, Khan, FN, Graviss, EA, Nguyen, DT, Moore, LW, Truong, LD, Barrios, RJ & Suki, WN 2020, , Kidney International Reports, vol. 5, no. 11, pp. 1914-1924.

Prevalence, Characteristics, and Outcomes of Incidental IgA Glomerular Deposits in Donor Kidneys
Gaber, LW, Khan, FN, Graviss, EA, Nguyen, DT, Moore, LW, Truong, LD, Barrios, RJ & Suki, WN 2020, , Kidney International Reports, vol. 5, no. 11, pp. 1914-1924.

A novel BMPR2 mutation with widely disparate heritable pulmonary arterial hypertension clinical phenotype
Oriaku, I, LeSieur, MN, Nichols, WC, Barrios, R, Elliott, CG & Frost, A 2020, , Pulmonary Circulation, vol. 10, no. 3.

Tie-2 cre-mediated deficiency of extracellular signal-regulated kinase 2 potentiates experimental bronchopulmonary dysplasia-associated pulmonary hypertension in neonatal mice
Menon, RT, Shrestha, AK, Barrios, R, Reynolds, C & Shivanna, B 2020, , International journal of molecular sciences, vol. 21, no. 7, 2408.

Adrenomedullin Is Necessary to Resolve Hyperoxia-Induced Experimental Bronchopulmonary Dysplasia and Pulmonary Hypertension in Mice
Menon, RT, Shrestha, AK, Reynolds, CL, Barrios, R, Caron, KM & Shivanna, B 2020, , American Journal of Pathology, vol. 190, no. 3, pp. 711-722.

Micropapillary adenocarcinoma of lung: Morphological criteria and diagnostic reproducibility among pulmonary pathologists
Monroig-Bosque, PDC, Morales-Rosado, JA, Roden, AC, Churg, A, Barrios, R, Cagle, P, Ge, Y, Allen, TC, Smith, ML, Larsen, BT, Sholl, LM, Beasley, MB, Borczuk, A, Raparia, K, Ayala, A, Tazelaar, HD, Miller, R, Kalhor, N, Moran, CA & Ro, JY 2019, , Annals of Diagnostic Pathology, vol. 41, pp. 43-50.

Cardiac Afferent Denervation Abolishes Ganglionated Plexi and Sympathetic Responses to Apnea: Implications for Atrial Fibrillation
Tavares, L, Rodríguez-Mañero, M, Kreidieh, B, Ibarra-Cortez, SH, Chen, J, Wang, S, Markovits, J, Barrios, R & Valderrábano, M 2019, , Circulation: Arrhythmia and Electrophysiology, vol. 12, no. 6, e006942.

Consequences of early postnatal lipopolysaccharide exposure on developing lungs in mice
Shrestha, AK, Bettini, ML, Menon, RT, Gopal, VYN, Huang, S, Edwards, DP, Pammi, M, Barrios, R & Shivanna, B 2019, , American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 316, no. 1, pp. L229-L244.

Retraction: Inactivation of the quinone oxidoreductases NQO1 and NQO2 strongly elevates the incidence and multiplicity of chemically induced skin tumors (Cancer Research (2010) 70 (1006–1014))
Shen, J, Barrios, RJ & Jaiswal, AK 2018, , Cancer research, vol. 78, no. 21, pp. 6345.