Roberto Barrios, MD

Professor of Pathology and Genomic Medicine, Institute for Academic Medicine
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. Barrios received his first academic appointment at the Universidad Nacional Autonoma de Mexico as Assistant Professor of Histology and Pathology in the Department of Chemistry in 1978. In 1982, he was promoted to full Professor in the Department of Cell Biology, and elected Head of the Department of Electron Microscopy at the same institution. He then became Chairman of the Department of Pathology at the Mexican Cardiology Institute and later Chairman of Pathology at the National Institute for Respiratory Diseases in Mexico City. He was visiting professor from 1990 through 1992 in Dr. Michael Lieberman’s laboratory at Baylor College of Medicine, conducting molecular biology studies. In 1992, Dr. Barrios was appointed Associate Professor in the Department of Pathology at Baylor College of Medicine, where he led numerous conferences and lectures for medical students. In 2004, he assumed his positions at Houston Methodist Hospital as Professor of Pathology and Laboratory Medicine at Weill Cornell Medical College.

Description of Research

Dr. Barrios has worked with experimental pathology projects for the last twenty-eight years, while at the same time his primary area of interest in diagnostic pathology has been pulmonary and renal pathology. His current projects include the study of interstitial lung diseases and pulmonary neoplasms. His collaborations in experimental pathology are related to oncogenesis and oxygen toxicity.



Areas Of Expertise

Renal Pathology Pulmonary
Education & Training

MD, Facultad De Medicina - Instituto Tech.
Residency, Case Western Reserve University
Clinical Fellowship, McGill University

Clinical and pathologic outcomes of incidental IgA glomerular deposits (IgAGD) in donated kidneys in an ethnically diverse region of the USA
Gaber, LW, Khan, F, Barrios, R, Truong, L, Graviss, E, Nguyen, DTM & Suki, W 2018, Transplantation, vol. 102.

Hyperoxia disrupts extracellular signal-regulated kinases 1/2-induced angiogenesis in the developing lungs
Menon, RT, Shrestha, AK, Barrios, R & Shivanna, B 2018, International Journal of Molecular Sciences, vol. 19, no. 5, 1525. DOI: 10.3390/ijms19051525

Hypersensitivity pneumonitis: A perspective from members of the pulmonary pathology society
Miller, R, Allen, TC, Barrios, RJ, Beasley, MB, Burke, L, Cagle, PT, Capelozzi, VL, Ge, Y, Hariri, LP, Kerr, KM, Khoor, A, Larsen, BT, Mark, EJ, Matsubara, O, Mehrad, M, Mino-Kenudson, M, Raparia, K, Roden, AC, Russell, P, Schneider, F, Sholl, LM & Smith, ML 2018, Archives of Pathology and Laboratory Medicine, vol. 142, no. 1, pp. 120-126. DOI: 10.5858/arpa.2017-0138-SA

Long-term pulmonary and cardiovascular morbidities of neonatal hyperoxia exposure in mice
Menon, RT, Shrestha, AK, Reynolds, CL, Barrios, R & Shivanna, B 2018, International Journal of Biochemistry and Cell Biology, vol. 94, pp. 119-124. DOI: 10.1016/j.biocel.2017.12.001

Programmed death ligand-1 (pd-l1) expression in either tumor cells or tumor-infiltrating immune cells correlates with solid and high-grade lung adenocarcinomas
Driver, BR, Miller, RA, Miller, T, Deavers, M, Gorman, B, Mody, D, Ge, Y, Barrios, R, Bernicker, E, Kim, M & Cagle, PT 2017, Archives of Pathology and Laboratory Medicine, vol. 141, no. 11, pp. 1529-1532. DOI: 10.5858/arpa.2017-0028-OA

Colon adenocarcinoma after jejunoileal bypass for morbid obesity
Morris, L, Beketaev, I, Barrios, R & Reardon, P 2017, Journal of surgical case reports, vol. 2017, no. 11, pp. rjx214. DOI: 10.1093/jscr/rjx214

Involvement of the Bufadienolides in the Detection and Therapy of the Acute Respiratory Distress Syndrome
Abbas, MMK, Patel, B, Chen, Q, Jiang, W, Moorthy, B, Barrios, R & Puschett, JB 2017, Lung, vol. 195, no. 3, pp. 323-332. DOI: 10.1007/s00408-017-9989-1

Newborn mice lacking the gene for Cyp1a1 are more susceptible to oxygen-mediated lung injury, and are rescued by postnatal b-naphthoflavone administration: Implications for bronchopulmonary dysplasia in premature infants
Maturu, P, Wei-Liang, Y, Jiang, W, Wang, L, Lingappan, K, Barrios, R, Liang, Y, Moorthy, B & Couroucli, XI 2017, Toxicological Sciences, vol. 157, no. 1, pp. 260-271. DOI: 10.1093/toxsci/kfx036

Diagnosis of Acute Cellular Rejection and Antibody-Mediated Rejection on Lung Transplant Biopsies: A Perspective From Members of the Pulmonary Pathology Society
Roden, AC, Aisner, DL, Allen, TC, Aubry, MC, Barrios, RJ, Beasley, MB, Cagle, PT, Capelozzi, VL, Dacic, S, Ge, Y, Hariri, LP, Lantuejoul, S, Miller, RA, Mino-Kenudson, M, Moreira, AL, Raparia, K, Rekhtman, N, Sholl, L, Smith, ML, Tsao, MS, Vivero, M, Yatabe, Y & Yi, ES 2016, Archives of Pathology and Laboratory Medicine. DOI: 10.5858/arpa.2016-0459-SA

Hypertrophic Cardiomyopathy with Unusual Extensive Scarring Pattern: Danon Disease
Le, DD, Alvarez, P, Barrios, R, Arriaga, M, Cherry, M, Shah, D & Lin, CH 2016, Methodist DeBakey Cardiovascular Journal, vol. 12, no. 4, pp. 227-229. DOI: 10.14797/mdcj-12-4-227

Phenotypic assessment of pulmonary hypertension using high-resolution echocardiography is feasible in neonatal mice with experimental bronchopulmonary dysplasia and pulmonary hypertension: A step toward preventing chronic obstructive pulmonary disease
Reynolds, CL, Zhang, S, Shrestha, AK, Barrios, R & Shivanna, B 2016, International journal of chronic obstructive pulmonary disease, vol. 11, no. 1, pp. 1597-1605. DOI: 10.2147/COPD.S109510

Folate Receptor a Expression Level Correlates With Histologic Grade in Lung Adenocarcinoma
Driver, BR, Barrios, R, Ge, Y, Haque, A, Tacha, D & Cagle, PT 2016, Archives of Pathology and Laboratory Medicine, vol. 140, no. 7, pp. 682-685. DOI: 10.5858/arpa.2015-0431-OA

Impact of recent developments in lung cancer on the practice of pathology
Cagle, PT, Allen, TC, Bernicker, EH, Ge, Y, Haque, A & Barrios, R 2016, Archives of Pathology and Laboratory Medicine, vol. 140, no. 4, pp. 322-325. DOI: 10.5858/arpa.2015-0535-SA

Intravascular carcinomatosis of central nervous system due to metastatic inflammatory breast cancer: A case report
Takei, H, Rouah, E & Barrios, R 2015, Neuropathology, vol. 35, no. 5, pp. 456-461. DOI: 10.1111/neup.12206

Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury
Wang, L, Lingappan, K, Jiang, W, Couroucli, XI, Welty, SE, Shivanna, B, Barrios, R, Wang, G, Firoze Khan, M, Gonzalez, FJ, Jackson Roberts, L & Moorthy, B 2015, Free Radical Biology and Medicine, vol. 82, pp. 147-159. DOI: 10.1016/j.freeradbiomed.2015.01.019

Increased susceptibility to hyperoxic lung injury and alveolar simplification in newborn rats by prenatal administration of benzo[a]pyrene
Thakur, VS, Liang, YW, Lingappan, K, Jiang, W, Wang, L, Barrios, R, Zhou, G, Guntupalli, B, Shivanna, B, Maturu, P, Welty, SE, Moorthy, B & Couroucli, XI 2014, Toxicology Letters, vol. 230, no. 2, pp. 322-332. DOI: 10.1016/j.toxlet.2014.03.006

Double lung transplantation for diffuse idiopathic pulmonary neuroendocrine cell hyperplasia
Zhou, H, Ge, Y, Janssen, B, Peterson, A, Takei, H, Haque, A, Barrios, R & Cagle, P 2014, Journal of Bronchology and Interventional Pulmonology, vol. 21, no. 4, pp. 342-345.

Magnetically guided recellularization of decellularized stented porcine pericardium-derived aortic valve for TAVI
Ghodsizad, A, Bordel, V, Wiedensohler, H, Elbanayosy, A, Koerner, MMA, Gonzalez Berjon, JM, Barrios, R, Farag, M, Zeriouh, M, Loebe, M, Noon, GPE, Koegler, G, Karck, M & Ruhparwar, A 2014, ASAIO Journal, vol. 60, no. 5, pp. 582-586. DOI: 10.1097/MAT.0000000000000110

High proportion of patients with end-stage heart failure regardless of aetiology demonstrates anti-cardiac antibody deposition in failing myocardium: Humoral activation, a potential contributor of disease progression
Youker, KA, Assad-Kottner, C, Cordero-Reyes, AM, Trevino, AR, Flores-Arredondo, JH, Barrios, R, Fernandez-Sada, E, Estep, JD, Bhimaraj, A & Torre-Amione, G 2014, European Heart Journal, vol. 35, no. 16, pp. 1061-1068. DOI: 10.1093/eurheartj/eht506

Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: Evidence for protective role of CYP1A1 against oxidative stress
Lingappan, K, Jiang, W, Wang, L, Wang, G, Couroucli, XI, Shivanna, B, Welty, SE, Barrios, R, Khan, MF, Nebert, DW, Roberts, LJ & Moorthy, B 2014, Toxicological Sciences, vol. 141, no. 1, kfu106, pp. 68-77. DOI: 10.1093/toxsci/kfu106