Roberto Barrios, MD

Professor of Pathology and Genomic Medicine, Academic Institute
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. Barrios received his first academic appointment at the Universidad Nacional Autonoma de Mexico as Assistant Professor of Histology and Pathology in the Department of Chemistry in 1978. In 1982, he was promoted to full Professor in the Department of Cell Biology, and elected Head of the Department of Electron Microscopy at the same institution. He then became Chairman of the Department of Pathology at the Mexican Cardiology Institute and later Chairman of Pathology at the National Institute for Respiratory Diseases in Mexico City. He was visiting professor from 1990 through 1992 in Dr. Michael Lieberman’s laboratory at Baylor College of Medicine, conducting molecular biology studies. In 1992, Dr. Barrios was appointed Associate Professor in the Department of Pathology at Baylor College of Medicine, where he led numerous conferences and lectures for medical students. In 2004, he assumed his positions at Houston Methodist Hospital as Professor of Pathology and Laboratory Medicine at Weill Cornell Medical College.

Description of Research

Dr. Barrios has worked with experimental pathology projects for the last twenty-eight years, while at the same time his primary area of interest in diagnostic pathology has been pulmonary and renal pathology. His current projects include the study of interstitial lung diseases and pulmonary neoplasms. His collaborations in experimental pathology are related to oncogenesis and oxygen toxicity.



Areas Of Expertise

Renal Pathology Pulmonary
Education & Training

MD, Facultad De Medicina - Instituto Tech.
Residency, Case Western Reserve University
Clinical Fellowship, McGill University

Adrenomedullin Is Necessary to Resolve Hyperoxia-Induced Experimental Bronchopulmonary Dysplasia and Pulmonary Hypertension in Mice
Menon, RT, Shrestha, AK, Reynolds, CL, Barrios, R, Caron, KM & Shivanna, B 2020, American Journal of Pathology, vol. 190, no. 3, pp. 711-722.

Micropapillary adenocarcinoma of lung: Morphological criteria and diagnostic reproducibility among pulmonary pathologists
Monroig-Bosque, PDC, Morales-Rosado, JA, Roden, AC, Churg, A, Barrios, R, Cagle, PT, Ge, Y, Allen, TC, Smith, ML, Larsen, BT, Sholl, LM, Beasley, MB, Borczuk, A, Raparia, K, Ayala, A, Tazelaar, HD, Miller, R, Kalhor, N, Moran, CA & Ro, J 2019, Annals of Diagnostic Pathology, vol. 41, pp. 43-50.

Cardiac Afferent Denervation Abolishes Ganglionated Plexi and Sympathetic Responses to Apnea
Tavares, L, Rodríguez-Mañero, M, Kreidieh, B, Ibarra-Cortez, SH, Chen, J, Wang, S, Markovits, J, Barrios, R & Valderrábano, M 2019, Circulation. Arrhythmia and electrophysiology, vol. 12, no. 6, pp. e006942.

Consequences of early postnatal lipopolysaccharide exposure on developing lungs in mice
Shrestha, AK, Bettini, ML, Menon, RT, Gopal, VYN, Huang, S, Edwards, DP, Pammi, M, Barrios, R & Shivanna, B 2019, American journal of physiology. Lung cellular and molecular physiology, vol. 316, no. 1, pp. L229-L244.

Retraction: Inactivation of the quinone oxidoreductases NQO1 and NQO2 strongly elevates the incidence and multiplicity of chemically induced skin tumors (Cancer Research (2010) 70 (1006–1014))
Shen, J, Barrios, R & Jaiswal, AK 2018, Cancer Research, vol. 78, no. 21.

Retraction: NRH:Quinone Oxidoreductase 2-Deficient Mice Are Highly Susceptible to Radiation-induced B-Cell Lymphomas
Iskander, K, Barrios, R & Jaiswal, AK 2018, Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 24, no. 21.

Clinical and pathologic outcomes of incidental IgA glomerular deposits (IgAGD) in donated kidneys in an ethnically diverse region of the USA
Gaber, LW, Khan, F, Barrios, R, Truong, L, Graviss, E, Nguyen, DTM & Suki, W 2018, Transplantation, vol. 102.

Hyperoxia disrupts extracellular signal-regulated kinases 1/2-induced angiogenesis in the developing lungs
Menon, RT, Shrestha, AK, Barrios, R & Shivanna, B 2018, International Journal of Molecular Sciences, vol. 19, no. 5, 1525.

Long-term pulmonary and cardiovascular morbidities of neonatal hyperoxia exposure in mice
Menon, RT, Shrestha, AK, Reynolds, CL, Barrios, R & Shivanna, B 2018, International Journal of Biochemistry and Cell Biology, vol. 94, pp. 119-124.

Hypersensitivity pneumonitis: A perspective from members of the pulmonary pathology society
Miller, R, Allen, TC, Barrios, R, Beasley, MB, Burke, L, Cagle, PT, Capelozzi, VL, Ge, Y, Hariri, LP, Kerr, KM, Khoor, A, Larsen, BT, Mark, EJ, Matsubara, O, Mehrad, M, Mino-Kenudson, M, Raparia, K, Roden, AC, Russell, P, Schneider, F, Sholl, LM & Smith, ML 2018, Archives of Pathology and Laboratory Medicine, vol. 142, no. 1, pp. 120-126.

Colon adenocarcinoma after jejunoileal bypass for morbid obesity
Morris, L, Beketaev, I, Barrios, R & Reardon, P 2017, Journal of surgical case reports, vol. 2017, no. 11, pp. rjx214.

Programmed death ligand-1 (pd-l1) expression in either tumor cells or tumor-infiltrating immune cells correlates with solid and high-grade lung adenocarcinomas
Driver, BR, Miller, RA, Miller, T, Deavers, M, Gorman, B, Mody, D, Ge, Y, Barrios, R, Bernicker, E, Kim, M & Cagle, PT 2017, Archives of Pathology and Laboratory Medicine, vol. 141, no. 11, pp. 1529-1532.

Involvement of the Bufadienolides in the Detection and Therapy of the Acute Respiratory Distress Syndrome
Abbas, MMK, Patel, B, Chen, Q, Jiang, W, Moorthy, B, Barrios, R & Puschett, JB 2017, Lung, vol. 195, no. 3, pp. 323-332.

Newborn mice lacking the gene for Cyp1a1 are more susceptible to oxygen-mediated lung injury, and are rescued by postnatal b-naphthoflavone administration: Implications for bronchopulmonary dysplasia in premature infants
Maturu, P, Wei-Liang, Y, Jiang, W, Wang, L, Lingappan, K, Barrios, R, Liang, Y, Moorthy, B & Couroucli, XI 2017, Toxicological Sciences, vol. 157, no. 1, pp. 260-271.

Diseases of Small Airways
Barrios, R 2017, . in Pulmonary Pathology: A Volume in the Series: Foundations in Diagnostic Pathology. Elsevier, pp. 427-444.

Other Interstitial Lung Diseases
Barrios, R, Rassaei, N & Zander, DS 2017, . in Pulmonary Pathology: A Volume in the Series: Foundations in Diagnostic Pathology. Elsevier, pp. 347-373.

Diagnosis of Acute Cellular Rejection and Antibody-Mediated Rejection on Lung Transplant Biopsies: A Perspective From Members of the Pulmonary Pathology Society
Roden, AC, Aisner, DL, Allen, TC, Aubry, MC, Barrios, RJ, Beasley, MB, Cagle, PT, Capelozzi, VL, Dacic, S, Ge, Y, Hariri, LP, Lantuejoul, S, Miller, RA, Mino-Kenudson, M, Moreira, AL, Raparia, K, Rekhtman, N, Sholl, L, Smith, ML, Tsao, MS, Vivero, M, Yatabe, Y & Yi, ES 2016, Archives of Pathology and Laboratory Medicine.

Hypertrophic Cardiomyopathy with Unusual Extensive Scarring Pattern: Danon Disease
Le, DD, Alvarez, P, Barrios, R, Arriaga, M, Cherry, M, Shah, D & Lin, CH 2016, Methodist DeBakey Cardiovascular Journal, vol. 12, no. 4, pp. 227-229.

Phenotypic assessment of pulmonary hypertension using high-resolution echocardiography is feasible in neonatal mice with experimental bronchopulmonary dysplasia and pulmonary hypertension: A step toward preventing chronic obstructive pulmonary disease
Reynolds, CL, Zhang, S, Shrestha, AK, Barrios, R & Shivanna, B 2016, International journal of chronic obstructive pulmonary disease, vol. 11, no. 1, pp. 1597-1605.

Folate Receptor a Expression Level Correlates With Histologic Grade in Lung Adenocarcinoma
Driver, BR, Barrios, R, Ge, Y, Haque, A, Tacha, D & Cagle, PT 2016, Archives of Pathology and Laboratory Medicine, vol. 140, no. 7, pp. 682-685.

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