Robert C. Rostomily, MD

John S. “Steve” Dunn, Jr. and Dagmar Dunn Pickens Gipe Chair in Brain Tumor Research, Department of Neurosurgery
Professor of Neurosurgery, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Rostomily Lab - Glioblastoma Research


Publications

The validity of 18F-GE180 as a TSPO imaging agent
Zanotti Fregonara, P, Veronese, M, Pascual, MB, Rostomily, RC, Turkheimer, F & Masdeu, JC 2019, European Journal of Nuclear Medicine and Molecular Imaging. https://doi.org/10.1007/s00259-019-4268-4

Prognostic gene discovery in glioblastoma patients using deep learning
Wong, K, Rostomily, RC & Wong, ST 2019, Cancers, vol. 11, no. 1, 53. https://doi.org/10.3390/cancers11010053

Kinome and phosphoproteome of high-grade meningiomas reveal AKAP12 as a central regulator of aggressiveness and its possible role in progression
Parada, CA, Osbun, J, Kaur, S, Yakkioui, Y, Shi, M, Pan, C, Busald, T, Karasozen, Y, Gonzalez-Cuyar, LF, Rostomily, RC, Zhang, J & Ferreira, M 2018, Scientific Reports, vol. 8, no. 1, 2098. https://doi.org/10.1038/s41598-018-19308-y

An anatomic transcriptional atlas of human glioblastoma
Puchalski, RB, Shah, N, Miller, J, Dalley, R, Nomura, SR, Yoon, JG, Smith, KA, Lankerovich, M, Bertagnolli, D, Bickley, K, Boe, AF, Brouner, K, Butler, S, Caldejon, S, Chapin, M, Datta, S, Dee, N, Desta, T, Dolbeare, T, Dotson, N, Ebbert, A, Feng, D, Feng, X, Fisher, M, Gee, G, Goldy, J, Gourley, L, Gregor, BW, Gu, G, Hejazinia, N, Hohmann, J, Hothi, P, Howard, R, Joines, K, Kriedberg, A, Kuan, L, Lau, C, Lee, F, Lee, H, Lemon, T, Long, F, Mastan, N, Mott, E, Murthy, C, Ngo, K, Olson, E, Reding, M, Riley, Z, Rosen, D, Sandman, D, Shapovalova, N, Slaughterbeck, CR, Sodt, A, Stockdale, G, Szafer, A, Wakeman, W, Wohnoutka, PE, White, SJ, Marsh, D, Rostomily, RC, Ng, L, Dang, C, Jones, A, Keogh, B, Gittleman, HR, Barnholtz-Sloan, JS, Cimino, PJ, Uppin, MS, Dirk Keene, C, Farrokhi, FR, Lathia, JD, Berens, ME, Iavarone, A, Bernard, A, Lein, E, Phillips, JW, Rostad, SW, Cobbs, C, Hawrylycz, MJ & Foltz, GD 2018, Science, vol. 360, no. 6389, pp. 660-663. https://doi.org/10.1126/science.aaf2666

Targeting TWIST1 through loss of function inhibits tumorigenicity of human glioblastoma
Mikheev, AM, Mikheeva, SA, Severs, LJ, Funk, CC, Huang, L, Mcfaline-Figueroa, JL, Schwensen, J, Trapnell, C, Price, ND, Wong, ST & Rostomily, RC 2018, Molecular Oncology. https://doi.org/10.1002/1878-0261.12320

Cranial chordoma: A new preoperative grading system
Da Silva, HB, Straus, D, Barber, JK, Rostomily, RC, Ferreira, M & Sekhar, LN 2018, Clinical neurosurgery, vol. 83, no. 3, pp. 403-415. https://doi.org/10.1093/neuros/nyx423

Twist1 mediated regulation of glioma tumorigenicity is dependent on mode of mouse neural progenitor transformation
Mikheev, AM, Mikheeva, SA, Tokita, M, Severs, LJ & Rostomily, RC 2017, Oncotarget, vol. 8, no. 64, pp. 107716-107729. https://doi.org/10.18632/oncotarget.22593

Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy
Pollak, J, Rai, KG, Funk, CC, Arora, S, Lee, E, Zhu, J, Price, ND, Paddison, PJ, Ramirez, J-M & Rostomily, RC 2017, PLoS ONE, vol. 12, no. 3, pp. e0172884. https://doi.org/10.1371/journal.pone.0172884

Fragment Length of Circulating Tumor DNA
Underhill, HR, Kitzman, JO, Hellwig, S, Welker, NC, Daza, R, Baker, DN, Gligorich, KM, Rostomily, RC, Bronner, MP & Shendure, J 2016, PLoS Genetics, vol. 12, no. 7, pp. e1006162. https://doi.org/10.1371/journal.pgen.1006162

Outcomes in Reoperated Low-Grade Gliomas
Ramakrishna, R, Hebb, A, Barber, J, Rostomily, R & Silbergeld, D 2015, Neurosurgery, vol. 77, no. 2, pp. 175-184. https://doi.org/10.1227/NEU.0000000000000753

O(6)-methylguanine-DNA methyltransferase activity is associated with response to alkylating agent therapy and with MGMT promoter methylation in glioblastoma and anaplastic glioma
Bobola, MS, Alnoor, M, Chen, JY-S, Kolstoe, DD, Silbergeld, DL, Rostomily, RC, Blank, A, Chamberlain, MC & Silber, JR 2015, Aging, vol. 3, pp. 1-10. https://doi.org/10.1016/j.bbacli.2014.11.003

Novel targeted therapies in chordoma: An update
Di Maio, S, Yip, S, Al Zhrani, GA, Alotaibi, FE, Al Turki, A, Kong, E & Rostomily, RC 2015, Therapeutics and Clinical Risk Management, vol. 11, pp. 873-883. https://doi.org/10.2147/TCRM.S50526

Multivalent display of pendant pro-apoptotic peptides increases cytotoxic activity
Chu, DSH, Bocek, MJ, Shi, J, Ta, A, Ngambenjawong, C, Rostomily, RC & Pun, SH 2015, Journal of Controlled Release, vol. 205, pp. 155-61. https://doi.org/10.1016/j.jconrel.2015.01.013

Periostin is a novel therapeutic target that predicts and regulates glioma malignancy
Mikheev, AM, Mikheeva, SA, Trister, AD, Tokita, MJ, Emerson, SN, Parada, CA, Born, DE, Carnemolla, B, Frankel, S, Kim, DH, Oxford, RG, Kosai, Y, Tozer-Fink, KR, Manning, TC, Silber, JR & Rostomily, RC 2015, Neuro-Oncology, vol. 17, no. 3, pp. 372-382. https://doi.org/10.1093/neuonc/nou161

Parallel microfluidic chemosensitivity testing on individual slice cultures
Chang, TC, Mikheev, AM, Huynh, W, Monnat, RJ, Rostomily, RC & Folch, A 2014, Lab on a Chip - Miniaturisation for Chemistry and Biology, vol. 14, no. 23, pp. 4540-4551. https://doi.org/10.1039/c4lc00642a

Deep sequencing of multiple regions of glial tumors reveals spatial heterogeneity for mutations in clinically relevant genes
Kumar, A, Boyle, EA, Tokita, M, Mikheev, AM, Sanger, MC, Girard, E, Silber, JR, Gonzalez-Cuyar, LF, Hiatt, JB, Adey, A, Lee, C, Kitzman, JO, Born, DE, Silbergeld, DL, Olson, JM, Rostomily, RC & Shendure, J 2014, Genome biology, vol. 15, no. 12, pp. 530. https://doi.org/10.1186/s13059-014-0530-z

Patient-specific metrics of invasiveness reveal significant prognostic benefit of resection in a predictable subset of gliomas
Baldock, AL, Ahn, S, Rockne, R, Johnston, S, Neal, M, Corwin, D, Clark-Swanson, K, Sterin, G, Trister, AD, Malone, H, Ebiana, V, Sonabend, AM, Mrugala, M, Rockhill, JK, Silbergeld, DL, Lai, A, Cloughesy, T, McKhann, GM, Bruce, JN, Rostomily, RC, Canoll, P & Swanson, KR 2014, PLoS ONE, vol. 9, no. 10, e99057. https://doi.org/10.1371/journal.pone.0099057

Seed, soil, and beyond: The basic biology of brain metastasis
Ramakrishna, R & Rostomily, R 2013, Surgical Neurology International, vol. 4, no. SUPPL4. https://doi.org/10.4103/2152-7806.111303

The impact of age on oncogenic potential: Tumor-initiating cells and the brain microenvironment
Stoll, EA, Horner, PJ & Rostomily, RC 2013, Aging Cell, vol. 12, no. 5, pp. 733-741. https://doi.org/10.1111/acel.12104

A rare case of gamma knife-induced smoking cessation in a patient with a vestibular schwannoma
Ramakrishna, R, Rostomily, RC & Rockhill, J 2013, British Journal of Neurosurgery, vol. 27, no. 2, pp. 251-252. https://doi.org/10.3109/02688697.2012.725873