Robert C. Rostomily, MD

John S. “Steve” Dunn, Jr. and Dagmar Dunn Pickens Gipe Chair in Brain Tumor Research, Department of Neurosurgery
Professor of Neurosurgery, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Rostomily Lab - Glioblastoma Research


Publications

Kinome and phosphoproteome of high-grade meningiomas reveal AKAP12 as a central regulator of aggressiveness and its possible role in progression
Parada, CA, Osbun, J, Kaur, S, Yakkioui, Y, Shi, M, Pan, C, Busald, T, Karasozen, Y, Gonzalez-Cuyar, LF, Rostomily, R, Zhang, J & Ferreira, M 2018, Scientific Reports, vol. 8, no. 1, 2098. DOI: 10.1038/s41598-018-19308-y

An anatomic transcriptional atlas of human glioblastoma
Puchalski, RB, Shah, N, Miller, J, Dalley, R, Nomura, SR, Yoon, JG, Smith, KA, Lankerovich, M, Bertagnolli, D, Bickley, K, Boe, AF, Brouner, K, Butler, S, Caldejon, S, Chapin, M, Datta, S, Dee, N, Desta, T, Dolbeare, T, Dotson, N, Ebbert, A, Feng, D, Feng, X, Fisher, M, Gee, G, Goldy, J, Gourley, L, Gregor, BW, Gu, G, Hejazinia, N, Hohmann, J, Hothi, P, Howard, R, Joines, K, Kriedberg, A, Kuan, L, Lau, C, Lee, F, Lee, H, Lemon, T, Long, F, Mastan, N, Mott, E, Murthy, C, Ngo, K, Olson, E, Reding, M, Riley, Z, Rosen, D, Sandman, D, Shapovalova, N, Slaughterbeck, CR, Sodt, A, Stockdale, G, Szafer, A, Wakeman, W, Wohnoutka, PE, White, SJ, Marsh, D, Rostomily, RC, Ng, L, Dang, C, Jones, A, Keogh, B, Gittleman, HR, Barnholtz-Sloan, JS, Cimino, PJ, Uppin, MS, Dirk Keene, C, Farrokhi, FR, Lathia, JD, Berens, ME, Iavarone, A, Bernard, A, Lein, E, Phillips, JW, Rostad, SW, Cobbs, C, Hawrylycz, MJ & Foltz, GD 2018, Science, vol. 360, no. 6389, pp. 660-663. DOI: 10.1126/science.aaf2666

Targeting TWIST1 through loss of function inhibits tumorigenicity of human glioblastoma
Mikheev, AM, Mikheeva, SA, Severs, LJ, Funk, CC, Huang, L, Mcfaline-Figueroa, JL, Schwensen, J, Trapnell, C, Price, ND, Wong, S & Rostomily, RC 2018, Molecular Oncology. DOI: 10.1002/1878-0261.12320

Twist1 mediated regulation of glioma tumorigenicity is dependent on mode of mouse neural progenitor transformation
Mikheev, AM, Mikheeva, SA, Tokita, M, Severs, LJ & Rostomily, RC 2017, Oncotarget, vol. 8, no. 64, pp. 107716-107729. DOI: 10.18632/oncotarget.22593

Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy
Pollak, J, Rai, KG, Funk, CC, Arora, S, Lee, E, Zhu, J, Price, ND, Paddison, PJ, Ramirez, J-M & Rostomily, RC 2017, PLoS ONE, vol. 12, no. 3, pp. e0172884. DOI: 10.1371/journal.pone.0172884

Fragment Length of Circulating Tumor DNA
Underhill, HR, Kitzman, JO, Hellwig, S, Welker, NC, Daza, R, Baker, DN, Gligorich, KM, Rostomily, RC, Bronner, MP & Shendure, J 2016, PLoS Genetics, vol. 12, no. 7, pp. e1006162. DOI: 10.1371/journal.pgen.1006162

Improvement in Visual Fields After Treatment of Intracranial Meningioma With Bevacizumab
Ly, KI, Hamilton, SR, Rostomily, RC, Rockhill, JK & Mrugala, MM 2015, Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, vol. 35, no. 4, pp. 382-6. DOI: 10.1097/WNO.0000000000000253

Safety and Efficacy of Preoperative Embolization of Intracranial Hemangioblastomas
Ene, CI, Xu, D, Morton, RP, Emerson, S, Levitt, MR, Barber, J, Rostomily, RC, Ghodke, BV, Hallam, DK, Albuquerque, FC, McDougall, CG, Sekhar, LN, Ferreira, M, Kim, LJ & Chang, SW 2015, Neurosurgery. DOI: 10.1227/NEU.0000000000001014

Outcomes in Reoperated Low-Grade Gliomas
Ramakrishna, R, Hebb, A, Barber, J, Rostomily, R & Silbergeld, D 2015, Neurosurgery, vol. 77, no. 2, pp. 175-184. DOI: 10.1227/NEU.0000000000000753

O(6)-methylguanine-DNA methyltransferase activity is associated with response to alkylating agent therapy and with MGMT promoter methylation in glioblastoma and anaplastic glioma
Bobola, MS, Alnoor, M, Chen, JY-S, Kolstoe, DD, Silbergeld, DL, Rostomily, RC, Blank, A, Chamberlain, MC & Silber, JR 2015, Aging, vol. 3, pp. 1-10. DOI: 10.1016/j.bbacli.2014.11.003

Novel targeted therapies in chordoma: An update
Di Maio, S, Yip, S, Al Zhrani, GA, Alotaibi, FE, Al Turki, A, Kong, E & Rostomily, RC 2015, Therapeutics and Clinical Risk Management, vol. 11, pp. 873-883. DOI: 10.2147/TCRM.S50526

Multivalent display of pendant pro-apoptotic peptides increases cytotoxic activity
Chu, DSH, Bocek, MJ, Shi, J, Ta, A, Ngambenjawong, C, Rostomily, RC & Pun, SH 2015, Journal of Controlled Release, vol. 205, pp. 155-61. DOI: 10.1016/j.jconrel.2015.01.013

Periostin is a novel therapeutic target that predicts and regulates glioma malignancy
Mikheev, AM, Mikheeva, SA, Trister, AD, Tokita, MJ, Emerson, SN, Parada, CA, Born, DE, Carnemolla, B, Frankel, S, Kim, DH, Oxford, RG, Kosai, Y, Tozer-Fink, KR, Manning, TC, Silber, JR & Rostomily, RC 2015, Neuro-Oncology, vol. 17, no. 3, pp. 372-382. DOI: 10.1093/neuonc/nou161

Parallel microfluidic chemosensitivity testing on individual slice cultures
Chang, TC, Mikheev, AM, Huynh, W, Monnat, RJ, Rostomily, RC & Folch, A 2014, Lab on a Chip - Miniaturisation for Chemistry and Biology, vol. 14, no. 23, pp. 4540-4551. DOI: 10.1039/c4lc00642a

Deep sequencing of multiple regions of glial tumors reveals spatial heterogeneity for mutations in clinically relevant genes
Kumar, A, Boyle, EA, Tokita, M, Mikheev, AM, Sanger, MC, Girard, E, Silber, JR, Gonzalez-Cuyar, LF, Hiatt, JB, Adey, A, Lee, C, Kitzman, JO, Born, DE, Silbergeld, DL, Olson, JM, Rostomily, RC & Shendure, J 2014, Genome biology, vol. 15, no. 12, pp. 530. DOI: 10.1186/s13059-014-0530-z

Patient-specific metrics of invasiveness reveal significant prognostic benefit of resection in a predictable subset of gliomas
Baldock, AL, Ahn, S, Rockne, R, Johnston, S, Neal, M, Corwin, D, Clark-Swanson, K, Sterin, G, Trister, AD, Malone, H, Ebiana, V, Sonabend, AM, Mrugala, M, Rockhill, JK, Silbergeld, DL, Lai, A, Cloughesy, T, McKhann, GM, Bruce, JN, Rostomily, RC, Canoll, P & Swanson, KR 2014, PLoS ONE, vol. 9, no. 10, e99057. DOI: 10.1371/journal.pone.0099057

Hypertriglyceridemia, lipemia, and elevated liver enzymes associated with prolonged propofol anesthesia for craniotomy
Bowdle, A, Richebe, P, Lee, L, Rostomily, R & Gabikian, P 2014, Therapeutic Drug Monitoring, vol. 36, no. 5, pp. 556-559. DOI: 10.1097/FTD.0000000000000073

Hemangiopericytoma: Radical resection remains the cornerstone of therapy
Ramakrishna, R, Rostomily, R, Sekhar, L, Rockhill, J & Ferreira, M 2014, Journal of Clinical Neuroscience, vol. 21, no. 4, pp. 612-615. DOI: 10.1016/j.jocn.2013.08.006

A case of nodular fasciitis causing compressive optic neuropathy
Gupta, D, Tailor, TD, Keene, CD, Rostomily, RC & Jian-Amadi, A 2014, Ophthalmic plastic and reconstructive surgery, vol. 30, no. 2. DOI: 10.1097/IOP.0b013e31829bb265

The impact of age on oncogenic potential: Tumor-initiating cells and the brain microenvironment
Stoll, EA, Horner, PJ & Rostomily, RC 2013, Aging Cell, vol. 12, no. 5, pp. 733-741. DOI: 10.1111/acel.12104