Reginald F. Munden

Reginald F. Munden, MD, DMD, MBA

Adjunct Professor of Radiology, Academic Institute
Full Affiliate Member, Research Institute
Houston Methodist


Dr. Munden earned his D.M.D. in 1982 and his M.D. in 1990 from the Medical University of South Carolina in Charleston. After dental school, he was in private practice for 3 years and served as an assistant professor of dentistry at the Medical University of South Carolina Dental School for 3 years. After medical school, he remained in Charleston for his residency in Diagnostic Radiology. In 1994, Dr. Munden moved to Boston where he completed a Fellowship in Thoracic Radiology. 

Dr. Munden is a member of and serves in leadership positions in a number of national and international radiology organizations, including the World Congress of Thoracic Imaging, Society of Thoracic Radiology, Radiological Society of North America (RSNA), American Roentgen Ray Society, American College of Radiology (ACR), American College of Radiology Imaging Network (ACRIN), and the Radiation Therapy Oncology Group. Currently, he serves as Chair of Chest Scientific Committee of the RSNA, and is a member of the ACRIN Executive Committee of the National Lung Screening Trial and the ACR Practice Guidelines for CT Screening of Lung Cancer.


Description of Research

Dr. Munden has been extensively involved in evaluating the role of imaging (including chest radiographs, CT, and PET/CT) in lung cancer and other thoracic malignancies. He has extensive experience in the application and translation of imaging research for evaluating lung cancer, esophageal cancer, and other thoracic malignancies. He has a special interest in assessing the tumor response to therapy and lung cancer screening. He has participated in over 40 clinical trials and served as the National Lung Screening Trial (NLST) site PI for the MD Anderson Cancer Center (MDACC). This site participated in targeted recruitment of underrepresented populations for the NLST and has significant experience in recruitment for lung cancer screening. His interest in screening continues with further evaluation and publication of NLST data, development of recommendations and guidelines for lung cancer screening, and biomarker utilization for screening and assessing the value of lung cancer screening.

Areas Of Expertise

Lung cancer Esophageal cancer Thoracic imaging
Education & Training

MBA, Auburn University

Enhancing diagnostic precision for acute chest syndrome in sickle cell disease: insights from dual-energy CT lung perfusion mapping
Chamberlin, JH, Ogbonna, A, Abrol, S, Maisuria, D, Miller, E, McGuire, A, Knight, H, O’Doherty, J, Baruah, D, Schoepf, UJ, Munden, RF & Kabakus, IM 2024, , Emergency Radiology, vol. 31, no. 1, 31, pp. 73-82.

Virtual Noncontrast Reconstructions on Contrast-Enhanced Dual-Energy CT for the Differentiation of Vertebral Venous Congestion and Sclerotic Metastasis
McGuire, AM, Chamberlin, J, Baruah, D, Munden, RF & Kabakus, IM 2024, , American Journal of Roentgenology, vol. 222, no. 1, e2330152, pp. e2330152.

Optimisation of virtual monoenergetic reconstructions for the diagnosis of pulmonary embolism using photon-counting detector computed tomography angiography
Chamberlin, JH, Toth, A, Hinen, S, O’Doherty, J, Baruah, D, Maisuria, D, McGuire, A, Knight, H, Joseph Schoepf, U, Munden, RF & Kabakus, IM 2024, , Polish Journal of Radiology, vol. 89, no. 1, pp. e63-e69.

Comparison of the characteristics of the population eligible for lung cancer screening under 2013 and population newly eligible under 2021 US Preventive Services Task Force recommendations
Yell, N, Eberth, JM, Alberg, AJ, Hung, P, Schootman, M, McLain, AC & Munden, RF 2024, , Cancer Causes and Control.

Ultra-high-resolution photon-counting detector computed tomography of the lungs: Phantom and clinical assessment of radiation dose and image quality
Chamberlin, JH, Smith, CD, Maisuria, D, Parrish, J, van Swol, E, Mah, E, Emrich, T, Schoepf, UJ, Varga-Szemes, A, ODoherty, J, Munden, RF, Tipnis, SV, Baruah, D & Kabakus, IM 2023, , Clinical Imaging, vol. 104, 110008.

ACR Appropriateness Criteria® Incidentally Detected Indeterminate Pulmonary Nodule
Expert Panel on Thoracic Imaging 2023, , Journal of the American College of Radiology, vol. 20, no. 11S, pp. S455-S470.

Reduction of beam hardening artifact in photon-counting computed tomography: Using low-energy threshold polyenergetic reconstruction
McGuire, AM, Smith, CD, Chamberlin, JH, Maisuria, D, Tóth, A, Schoepf, UJ, ODoherty, J, Munden, RF, Burt, J, Baruah, D & Kabakus, IM 2023, , Journal of cardiovascular computed tomography, vol. 17, no. 5, pp. 356-357.

Incidentalomas in chest CT
Munden, R 2023, , British Journal of Radiology, vol. 96, no. 1142, 20211368.

A transformer-based deep-learning approach for classifying brain metastases into primary organ sites using clinical whole-brain MRI images
Lyu, Q, Namjoshi, SV, McTyre, E, Topaloglu, U, Barcus, R, Chan, MD, Cramer, CK, Debinski, W, Gurcan, MN, Lesser, GJ, Lin, HK, Munden, RF, Pasche, BC, Sai, KKS, Strowd, RE, Tatter, SB, Watabe, K, Zhang, W, Wang, G & Whitlow, CT 2022, , Patterns, vol. 3, no. 11, 100613, pp. 100613.

Artificial Intelligence Tool for Assessment of Indeterminate Pulmonary Nodules Detected with CT
Kim, RY, Oke, JL, Pickup, LC, Munden, RF, Dotson, TL, Bellinger, CR, Cohen, A, Simoff, MJ, Massion, PP, Filippini, C, Gleeson, FV & Vachani, A 2022, , Radiology, vol. 304, no. 3, pp. 683-691.

Managing Incidental Findings on Thoracic CT: Lung Findings. A White Paper of the ACR Incidental Findings Committee
Munden, RF, Black, WC, Hartman, TE, MacMahon, H, Ko, JP, Dyer, DS, Naidich, D, Rossi, SE, McAdams, HP, Goodman, EM, Brown, K, Kent, M, Carter, BW, Chiles, C, Leung, AN, Boiselle, PM, Kazerooni, EA, Berland, LL & Pandharipande, PV 2021, , Journal of the American College of Radiology, vol. 18, no. 9, pp. 1267-1279.

SMARCA4 mutations in KRAS-mutant lung adenocarcinoma: a multi-cohort analysis
Liu, L, Ahmed, T, Petty, WJ, Grant, S, Ruiz, J, Lycan, TW, Topaloglu, U, Chou, PC, Miller, LD, Hawkins, GA, Alexander-Miller, MA, O’Neill, SS, Powell, BL, D’Agostino, RB, Munden, RF, Pasche, B & Zhang, W 2021, , Molecular Oncology, vol. 15, no. 2, pp. 462-472.

Assessing the accuracy of a deep learning method to risk stratify indeterminate pulmonary nodules
Massion, PP, Antic, S, Ather, S, Arteta, C, Brabec, J, Chen, H, Declerck, J, Dufek, D, Hickes, W, Kadir, T, Kunst, J, Landman, BA, Munden, RF, Novotny, P, Peschl, H, Pickup, LC, Santos, C, Smith, GT, Talwar, A & Gleeson, F 2020, , American journal of respiratory and critical care medicine, vol. 202, no. 2, pp. 241-249.

Effect of a Patient Decision Aid on Lung Cancer Screening Decision-Making by Persons Who Smoke: A Randomized Clinical Trial
Volk, RJ, Lowenstein, LM, Leal, VB, Escoto, KH, Cantor, SB, Munden, RF, Rabius, VA, Bailey, L, Cinciripini, PM, Lin, H, Housten, AJ, Luckett, PG, Esparza, A, Godoy, MC & Bevers, TB 2020, , JAMA Network Open, vol. 3, no. 1, pp. e1920362.

Micronodules Detected on Computed Tomography During the National Lung Screening Trial: Prevalence and Relation to Positive Studies and Lung Cancer
Munden, RF, Chiles, C, Boiselle, PM, Sicks, JRD, Aberle, DR & Gatsonis, CA 2019, , Journal of Thoracic Oncology, vol. 14, no. 9, pp. 1538-1546.

Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2?T-type voltage-gated calcium channels and Ca2+ influx
Jimenez, H, Wang, M, Zimmerman, JW, Pennison, MJ, Sharma, S, Surratt, T, Xu, ZX, Brezovich, I, Absher, D, Myers, RM, DeYoung, B, Caudell, DL, Chen, D, Lo, HW, Lin, HK, Godwin, DW, Olivier, M, Ghanekar, A, Chen, K, Miller, LD, Gong, Y, Capstick, M, DAgostino, RB, Munden, R, Merle, P, Barbault, A, Blackstock, AW, Bonkovsky, HL, Yang, GY, Jin, G, Liu, L, Zhang, W, Watabe, K, Blackman, CF & Pasche, BC 2019, , EBioMedicine, vol. 44, pp. 209-224.

A national survey of primary care physicians: Perceptions and practices of low-dose CT lung cancer screening
Eberth, JM, McDonnell, KK, Sercy, E, Khan, S, Strayer, SM, Dievendorf, AC, Munden, RF & Vernon, SW 2018, , Preventive Medicine Reports, vol. 11, pp. 93-99.

Randomized trial of a patient-centered decision aid for promoting informed decisions about lung cancer screening: Implementation of a PCORI study protocol and lessons learned
Lowenstein, LM, Escoto, KH, Leal, VB, Bailey, L, Bevers, TB, Cantor, SB, Cinciripini, PM, E. Jacobs, L, Esparza, A, Godoy, MC, Housten, AJ, Lin, H, Luckett, P, Munden, RF, Rabius, V & Volk, RJ 2018, , Contemporary Clinical Trials, vol. 72, pp. 26-34.

The epidemiology of lung cancer
de Groot, PM, Wu, CC, Carter, BW & Munden, RF 2018, , Translational Lung Cancer Research, vol. 7, no. 3, pp. 220-233.

Extrapulmonary neoplasms in lung cancer screening
Godoy, MCB, White, CS, Erasmus, JJ, Wu, CC, Truong, MT, Munden, RF & Chiles, C 2018, , Translational Lung Cancer Research, vol. 7, no. 3, pp. 368-375.