Reginald F. Munden

Reginald F. Munden, MD, DMD, MBA

Adjunct Professor of Radiology, Academic Institute
Full Affiliate Member, Research Institute
Houston Methodist


Dr. Munden earned his D.M.D. in 1982 and his M.D. in 1990 from the Medical University of South Carolina in Charleston. After dental school, he was in private practice for 3 years and served as an assistant professor of dentistry at the Medical University of South Carolina Dental School for 3 years. After medical school, he remained in Charleston for his residency in Diagnostic Radiology. In 1994, Dr. Munden moved to Boston where he completed a Fellowship in Thoracic Radiology. 

Dr. Munden is a member of and serves in leadership positions in a number of national and international radiology organizations, including the World Congress of Thoracic Imaging, Society of Thoracic Radiology, Radiological Society of North America (RSNA), American Roentgen Ray Society, American College of Radiology (ACR), American College of Radiology Imaging Network (ACRIN), and the Radiation Therapy Oncology Group. Currently, he serves as Chair of Chest Scientific Committee of the RSNA, and is a member of the ACRIN Executive Committee of the National Lung Screening Trial and the ACR Practice Guidelines for CT Screening of Lung Cancer.


Description of Research

Dr. Munden has been extensively involved in evaluating the role of imaging (including chest radiographs, CT, and PET/CT) in lung cancer and other thoracic malignancies. He has extensive experience in the application and translation of imaging research for evaluating lung cancer, esophageal cancer, and other thoracic malignancies. He has a special interest in assessing the tumor response to therapy and lung cancer screening. He has participated in over 40 clinical trials and served as the National Lung Screening Trial (NLST) site PI for the MD Anderson Cancer Center (MDACC). This site participated in targeted recruitment of underrepresented populations for the NLST and has significant experience in recruitment for lung cancer screening. His interest in screening continues with further evaluation and publication of NLST data, development of recommendations and guidelines for lung cancer screening, and biomarker utilization for screening and assessing the value of lung cancer screening.

Areas Of Expertise

Lung cancer Esophageal cancer Thoracic imaging
Education & Training

MBA, Auburn University

Incidentalomas in chest CT
Munden, R 2023, , British Journal of Radiology, vol. 96, no. 1142, 20211368.

A transformer-based deep-learning approach for classifying brain metastases into primary organ sites using clinical whole-brain MRI images
Lyu, Q, Namjoshi, SV, McTyre, E, Topaloglu, U, Barcus, R, Chan, MD, Cramer, CK, Debinski, W, Gurcan, MN, Lesser, GJ, Lin, HK, Munden, RF, Pasche, BC, Sai, KKS, Strowd, RE, Tatter, SB, Watabe, K, Zhang, W, Wang, G & Whitlow, CT 2022, , Patterns, vol. 3, no. 11, 100613, pp. 100613.

Artificial Intelligence Tool for Assessment of Indeterminate Pulmonary Nodules Detected with CT
Kim, RY, Oke, JL, Pickup, LC, Munden, RF, Dotson, TL, Bellinger, CR, Cohen, A, Simoff, MJ, Massion, PP, Filippini, C, Gleeson, FV & Vachani, A 2022, , Radiology, vol. 304, no. 3, pp. 683-691.

Managing Incidental Findings on Thoracic CT: Lung Findings. A White Paper of the ACR Incidental Findings Committee
Munden, RF, Black, WC, Hartman, TE, MacMahon, H, Ko, JP, Dyer, DS, Naidich, D, Rossi, SE, McAdams, HP, Goodman, EM, Brown, K, Kent, M, Carter, BW, Chiles, C, Leung, AN, Boiselle, PM, Kazerooni, EA, Berland, LL & Pandharipande, PV 2021, , Journal of the American College of Radiology, vol. 18, no. 9, pp. 1267-1279.

SMARCA4 mutations in KRAS-mutant lung adenocarcinoma: a multi-cohort analysis
Liu, L, Ahmed, T, Petty, WJ, Grant, S, Ruiz, J, Lycan, TW, Topaloglu, U, Chou, PC, Miller, LD, Hawkins, GA, Alexander-Miller, MA, O’Neill, SS, Powell, BL, D’Agostino, RB, Munden, RF, Pasche, B & Zhang, W 2021, , Molecular Oncology, vol. 15, no. 2, pp. 462-472.

Assessing the accuracy of a deep learning method to risk stratify indeterminate pulmonary nodules
Massion, PP, Antic, S, Ather, S, Arteta, C, Brabec, J, Chen, H, Declerck, J, Dufek, D, Hickes, W, Kadir, T, Kunst, J, Landman, BA, Munden, RF, Novotny, P, Peschl, H, Pickup, LC, Santos, C, Smith, GT, Talwar, A & Gleeson, F 2020, , American journal of respiratory and critical care medicine, vol. 202, no. 2, pp. 241-249.

Effect of a Patient Decision Aid on Lung Cancer Screening Decision-Making by Persons Who Smoke: A Randomized Clinical Trial
Volk, RJ, Lowenstein, LM, Leal, VB, Escoto, KH, Cantor, SB, Munden, RF, Rabius, VA, Bailey, L, Cinciripini, PM, Lin, H, Housten, AJ, Luckett, PG, Esparza, A, Godoy, MC & Bevers, TB 2020, , JAMA Network Open, vol. 3, no. 1, pp. e1920362.

Micronodules Detected on Computed Tomography During the National Lung Screening Trial: Prevalence and Relation to Positive Studies and Lung Cancer
Munden, RF, Chiles, C, Boiselle, PM, Sicks, JRD, Aberle, DR & Gatsonis, CA 2019, , Journal of Thoracic Oncology, vol. 14, no. 9, pp. 1538-1546.

Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2?T-type voltage-gated calcium channels and Ca2+ influx
Jimenez, H, Wang, M, Zimmerman, JW, Pennison, MJ, Sharma, S, Surratt, T, Xu, ZX, Brezovich, I, Absher, D, Myers, RM, DeYoung, B, Caudell, DL, Chen, D, Lo, HW, Lin, HK, Godwin, DW, Olivier, M, Ghanekar, A, Chen, K, Miller, LD, Gong, Y, Capstick, M, DAgostino, RB, Munden, R, Merle, P, Barbault, A, Blackstock, AW, Bonkovsky, HL, Yang, GY, Jin, G, Liu, L, Zhang, W, Watabe, K, Blackman, CF & Pasche, BC 2019, , EBioMedicine, vol. 44, pp. 209-224.

A national survey of primary care physicians: Perceptions and practices of low-dose CT lung cancer screening
Eberth, JM, McDonnell, KK, Sercy, E, Khan, S, Strayer, SM, Dievendorf, AC, Munden, RF & Vernon, SW 2018, , Preventive Medicine Reports, vol. 11, pp. 93-99.

Randomized trial of a patient-centered decision aid for promoting informed decisions about lung cancer screening: Implementation of a PCORI study protocol and lessons learned
Lowenstein, LM, Escoto, KH, Leal, VB, Bailey, L, Bevers, TB, Cantor, SB, Cinciripini, PM, E. Jacobs, L, Esparza, A, Godoy, MC, Housten, AJ, Lin, H, Luckett, P, Munden, RF, Rabius, V & Volk, RJ 2018, , Contemporary Clinical Trials, vol. 72, pp. 26-34.

The epidemiology of lung cancer
de Groot, PM, Wu, CC, Carter, BW & Munden, RF 2018, , Translational Lung Cancer Research, vol. 7, no. 3, pp. 220-233.

Extrapulmonary neoplasms in lung cancer screening
Godoy, MCB, White, CS, Erasmus, JJ, Wu, CC, Truong, MT, Munden, RF & Chiles, C 2018, , Translational Lung Cancer Research, vol. 7, no. 3, pp. 368-375.

Lung cancer screening: The path forward
Chiles, C & Munden, RF 2018, , Translational Lung Cancer Research, vol. 7, no. 3, pp. 216-229.

The cytokinesis-blocked micronucleus assay as a novel biomarker for selection of lung cancer screening participants
El-Zein, RA, Etzel, CJ & Munden, RF 2018, , Translational Lung Cancer Research, vol. 7, no. 3, pp. 336-346.

Screening for lung cancer: Lexicon for communicating with health care providers
Carter, BW, Lichtenberger, JP, Wu, CC & Munden, RF 2018, , American Journal of Roentgenology, vol. 210, no. 3, pp. 473-479.

Incidental Findings on Lung Cancer Screening: Significance and Management
Tsai, EB, Chiles, C, Carter, BW, Godoy, MCB, Shroff, GS, Munden, RF, Truong, MT & Wu, CC 2018, , Seminars in Ultrasound, CT and MRI.

The Incentive Dilemma: Intrinsic Motivation and Workplace Performance
Itri, JN, Bruno, MA, Lalwani, N, Munden, RF & Tappouni, R 2019, , Journal of the American College of Radiology, vol. 16, no. 1, pp. 39-44.

Managing Incidental Findings on Thoracic CT: Mediastinal and Cardiovascular Findings. A White Paper of the ACR Incidental Findings Committee
Munden, RF, Carter, BW, Chiles, C, MacMahon, H, Black, WC, Ko, JP, McAdams, HP, Rossi, SE, Leung, AN, Boiselle, PM, Kent, MS, Brown, K, Dyer, DS, Hartman, TE, Goodman, EM, Naidich, DP, Kazerooni, EA, Berland, LL & Pandharipande, PV 2018, , Journal of the American College of Radiology, vol. 15, no. 8, pp. 1087-1096.

Conventional Imaging of Lung Cancer
de Groot, PM, Carter, BW & Munden, RF 2018, . in IASLC Thoracic Oncology. Elsevier, pp. 199-218.e3.