Randall J. Olsen, MD, PhD

Associate Professor of Clinical Pathology and Genomic Medicine, Institute for Academic Medicine
Associate Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Research Lab


RJOlsen@houstonmethodist.org
Biography

After completing his fellowship in hematopathology, Dr. Olsen became an Instructor in Houston Methodist Research Institute. He was recently awarded a Fellow-to-Faculty transition award from the American Heart Association to investigate virulence genetics in group A Streptococcus. The study will focus on why certain strains are more capable of causing necrotizing fasciitis, or the devastating “flesh eating” disease. He is a member of several professional societies.

Description of Research

The research in Dr. Olsen’s laboratory is focused on studying the molecular pathogenesis of invasive group A Streptococcus (GAS) infections such as necrotizing fasciitis (NF, also termed the “flesh eating infection”). During the past several years, there have been marked advances in the study of GAS genetics and epidemiology, but overall knowledge of the key molecular pathways and host-pathogen interactions mediating GAS virulence in invasive deep soft tissue infections remains largely incomplete. Previous studies in the Musser laboratory suggest that the metal transporter of the Streptococcus regulator (mtsR) regulatory gene and/or the genes under its control (the “mtsR Axis”) may play an important role in GAS NF. Dr. Olsen’s laboratory uses an integrated molecular approach to study the “mtsR Axis” in GAS NF. Affymetrix GAS gene expression microarray analysis, Luminex-based human serum protein profiling, tissue microarray examination, flow cytometric analysis, in vivo molecular imaging, quantitative microbial culture, and in vitro immunologic assays will be used for the detailed study of specimens derived from preclinical models and human patients. The long-term goal is to leverage knowledge gained to aid the development of new diagnostic tools, vaccine strategies, and therapeutic agents that will significantly improve patient care.

Areas Of Expertise

Group A Streptococcus Necrotizing fasciitis Invasive infection Pathogen-host interactions Microbial virulence
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, The Methodist Hospital
PhD, University of Nebraska
MD, University of Nebraska Medical School, Omaha, NE
Research Fellowship, Houston Methodist Hospital
Publications

Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway
Do, H, Makthal, N, VanderWal, AR, Saavedra, MO, Olsen, RJ, Musser, JM & Kumaraswami, M 2019, Nature Communications, vol. 10, no. 1, 2586. https://doi.org/10.1038/s41467-019-10556-8

Integrated analysis of population genomics, transcriptomics and virulence provides novel insights into Streptococcus pyogenes pathogenesis
Kachroo, P, Eraso, JM, Beres, SB, Olsen, RJ, Zhu, L, Nasser, W, Bernard, PE, Cantu, CC, Saavedra, MO, Arredondo, MJ, Strope, B, Do, H, Kumaraswami, M, Vuopio, J, Gröndahl-Yli-Hannuksela, K, Kristinsson, KG, Gottfredsson, M, Pesonen, M, Pensar, J, Davenport, ER, Clark, AG, Corander, J, Caugant, DA, Gaini, S, Magnussen, MD, Kubiak, SL, Nguyen, HAT, Long, SW, Porter, AR, DeLeo, FR & Musser, JM 2019, Nature Genetics, vol. 51, no. 3, pp. 548-559. https://doi.org/10.1038/s41588-018-0343-1

Gene fitness landscape of group A streptococcus during necrotizing myositis
Zhu, L, Olsen, RJ, Beres, SB, Eraso, JM, Saavedra, MO, Kubiak, SL, Cantu, CC, Jenkins, L, Charbonneau, ARL, Waller, AS & Musser, JM 2019, The Journal of clinical investigation, vol. 129, no. 2, pp. 887-901. https://doi.org/10.1172/JCI124994

HPV status in women with high-grade dysplasia on cervical biopsy and preceding negative HPV tests
Ge, Y, Mody, RR, Olsen, RJ, Zhou, H, Luna, E, Armylagos, D, Puntachart, N, Hendrickson, H, Schwartz, MR & Mody, DR 2019, Journal of the American Society of Cytopathology. https://doi.org/10.1016/j.jasc.2019.01.001

From bench to bedside: Evaluation of AHCC supplementation to modulate the host immunity to clear high-risk human papillomavirus infections
Smith, JA, Mathew, L, Gaikwad, A, Rech, B, Burney, MN, Faro, JP, Lucci, JA, Bai, Y, Olsen, RJ & Byrd, TT 2019, Frontiers in Oncology, vol. 9, no. MAR, 173. https://doi.org/10.3389/fonc.2019.00173

A review of the FDA-approved molecular testing platforms for human papillomavirus
Salazar, KL, Duhon, DJ, Olsen, RJ & Thrall, MJ 2019, Journal of the American Society of Cytopathology. https://doi.org/10.1016/j.jasc.2019.06.001

Draft Genome Sequence of Candida auris Strain LOM, a Human Clinical Isolate from Greater Metropolitan Houston, Texas
Long, SW, Olsen, RJ, Nguyen, HAT, Saavedra, MO & Musser, JM 2019, Microbiology Resource Announcements, vol. 8, no. 25, e00532-19. https://doi.org/10.1128/MRA.00532-19

RocA Has Serotype-Specific Gene Regulatory and Pathogenesis Activities in Serotype M28 Group A Streptococcus
Bernard, PE, Kachroo, P, Zhu, L, Beres, SB, Eraso, JM, Kajani, Z, Long, SW, Musser, JM & Olsen, RJ 2018, Infection and immunity, vol. 86, no. 11, e00467-18. https://doi.org/10.1128/IAI.00467-18

Using machine learning to predict antimicrobial MICs and associated genomic features for nontyphoidal Salmonella
Nguyen, M, Long, SW, McDermott, PF, Olsen, RJ, Olson, R, Stevens, RL, Tyson, GH, Zhao, S & Davisa, JJ 2019, Journal of Clinical Microbiology, vol. 57, no. 2, e01260. https://doi.org/10.1128/JCM.01260-18

Chlorhexidine bathing and Clostridium difficile infection in a surgical intensive care unit
Bui, LN, Swan, JT, Shirkey, BA, Olsen, RJ, Long, SW & Graviss, EA 2018, The Journal of surgical research, vol. 228, pp. 107-111. https://doi.org/10.1016/j.jss.2018.02.063

Postpartum Group A Streptococcus Case Series: Reach Out to Infection Prevention!
Alexander, AJ, Myers, C, Beres, SB, Olsen, RJ, Musser, JM & Mangino, JE 2018, Open Forum Infectious Diseases, vol. 5, no. 7, pp. ofy159. https://doi.org/10.1093/ofid/ofy159

Human Papillomavirus-Driven Squamous Lesions: High-Risk Genotype Found in Conjunctival Papillomas, Dysplasia, and Carcinoma
Moyer, AB, Roberts, J, Olsen, RJ & Chévez-Barrios, P 2018, The American Journal of dermatopathology, vol. 40, no. 7, pp. 486-490. https://doi.org/10.1097/DAD.0000000000001139

Signaling by a conserved quorum sensing pathway contributes to growth ex vivo and oropharyngeal colonization of human pathogen group A streptococcus
Makthal, N, Do, H, VanderWal, AR, Olsen, RJ, Musser, JM & Kumaraswami, M 2018, Infection and Immunity, vol. 86, no. 5, e00169-18. https://doi.org/10.1128/IAI.00169-18

Creutzfeldt astrocytes may be seen in IDH-wildtype glioblastoma and retain expression of DNA repair and chromatin binding proteins
Ballester, LY, Boghani, Z, Baskin, DS, Britz, GW, Olsen, R, Fuller, GN, Powell, SZ & Cykowski, MD 2018, Brain Pathology, vol. 28, no. 6, pp. 1012-1019. https://doi.org/10.1111/bpa.12604

Next-generation sequencing identifies gene mutations that are predictive of malignancy in residual needle rinses collected from fine-needle aspirations of thyroid nodules
Fuller, MY, Mody, DR, Hull, A, Pepper, K, Hendrickson, H & Olsen, RJ 2018, Archives of Pathology and Laboratory Medicine, vol. 142, no. 2, pp. 178-183. https://doi.org/10.5858/arpa.2017-0136-OA

Updates in Polycythemia Vera
Nagrale, V, Olsen, RJ & Zu, Y 2018, . in C-CJ Chang & R Ohgami (eds), Precision Molecular Pathology of Myeloid Neoplasms. 1st edn, vol. 12, Springer, Switzerland, pp. 115-139. https://doi.org/10.1007/978-3-319-62146-3

Real-time Communication with Health Care Providers through an Online Respiratory Pathogen Laboratory Report
Christensen, PA, Olsen, RJ, Perez, KK, Cernoch, PL & Long, SW 2018, Open Forum Infectious Diseases, vol. 5, no. 12. https://doi.org/10.1093/ofid/ofy322

Genome sequence analysis of emm89 Streptococcus pyogenes strains causing infections in Scotland, 2010–2016
Beres, SB, Olsen, RJ, Saavedra, MO, Ure, R, Reynolds, A, Lindsay, DSJ, Smith, AJ & Musser, JM 2017, Journal of Medical Microbiology, vol. 66, no. 12, 000622, pp. 1765-1773. https://doi.org/10.1099/jmm.0.000622

Developing an in silico minimum inhibitory concentration panel test for Klebsiella pneumonia
Nguyen, M, Brettin, T, Long, SW, Musser, JM, Olsen, RJ, Olson, R, Shukla, M, Stevens, RL, Xia, F, Yoo, H & Davis, JJ 2018, Scientific Reports, vol. 8, no. 1, 421. https://doi.org/10.1038/s41598-017-18972-w

Pancreas metastases from papillary thyroid carcinoma: A review of the literature
Davidson, M, Olsen, RJ, Ewton, AA & Robbins, RJ 2017, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, vol. 23, no. 12, pp. 1425-1429. https://doi.org/10.4158/EP-2017-0001

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