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Rajarajan Amirthalingam Thandavarayan, M.Pharm, PhD

Assistant Research Professor of Cardiology, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


ramirthalingamthandavarayan@houstonmethodist.org
Publications

4-Hydroxy-2-nonenal, a lipid peroxidation product, as a biomarker in diabetes and its complications: challenges and opportunities
Dham, D, Roy, B, Gowda, A, Pan, G, Sridhar, A, Zeng, X, Thandavarayan, RA & Palaniyandi, SS 2021, , Free Radical Research. https://doi.org/10.1080/10715762.2020.1866756

SARS–CoV-2 Mediated Hyperferritinemia and Cardiac Arrest: Preliminary Insights
VasanthiDharmalingam, P, Karuppagounder, V, Watanabe, K, Karmouty-Quintana, H, Palaniyandi, SS, Guha, A & Thandavarayan, RA 2021, , Drug Discovery Today. https://doi.org/10.1016/j.drudis.2021.01.014

Emerging mechanisms of pulmonary vasoconstriction in SARS-CoV-2-induced acute respiratory distress syndrome (ARDS) and potential therapeutic targets
Karmouty-Quintana, H, Thandavarayan, RA, Keller, SP, Sahay, S, Pandit, LM & Akkanti, B 2020, , International journal of molecular sciences, vol. 21, no. 21, 8081, pp. 1-21. https://doi.org/10.3390/ijms21218081

Brain adaptations of insulin signaling kinases, GLUT 3, p-BADser155 and nitrotyrosine expression in various hypoglycemic models of mice
Pitchaimani, V, Arumugam, S, Thandavarayan, RA, Karuppagounder, V, Afrin, MR, Sreedhar, R, Harima, M, Nakamura, M, Watanabe, K, Kodama, S, Fujihara, K & Sone, H 2020, , Neurochemistry International, vol. 137, 104745. https://doi.org/10.1016/j.neuint.2020.104745

Pathophysiology of Acute and Chronic Right Heart Failure
Thandavarayan, RA, Chitturi, KR & Guha, A 2020, , Cardiology Clinics, vol. 38, no. 2, pp. 149-160. https://doi.org/10.1016/j.ccl.2020.01.009

3,4-Dihydroxybenzalacetone (DBL) Prevents Aging-Induced Myocardial Changes in Senescence-Accelerated Mouse-Prone 8 (SAMP8) Mice
Giridharan, VV, Karupppagounder, V, Arumugam, S, Nakamura, Y, Guha, A, Barichello, T, Quevedo, J, Watanabe, K, Konishi, T & Thandavarayan, RA 2020, Cells, vol. 9, no. 3. https://doi.org/10.3390/cells9030597

Single-cell RNA sequencing analysis of SARS-CoV-2 entry receptors in human organoids
Mahalingam, R, Dharmalingam, P, Santhanam, A, Kotla, S, Davuluri, G, Karmouty-Quintana, H, Ashrith, G & Thandavarayan, RA 2021, , Journal of Cellular Physiology, vol. 236, no. 4, pp. 2950-2958. https://doi.org/10.1002/jcp.30054

Role of Endothelial and Mesenchymal Cell Transitions in Heart Failure and Recovery Thereafter
Wang, G, Cruz, AS, Youker, K, Marcos-Abdala, HG, Thandavarayan, RA, Cooke, JP, Torre-Amione, G, Chen, K & Bhimaraj, A 2020, , Frontiers in Genetics, vol. 11, pp. 609262. https://doi.org/10.3389/fgene.2020.609262

Dysfunction of iPSC-derived endothelial cells in human Hutchinson–Gilford progeria syndrome
Matrone, G, Thandavarayan, RA, Walther, BK, Meng, S, Mojiri, A & Cooke, JP 2019, , Cell Cycle, vol. 18, no. 19, pp. 2495-2508. https://doi.org/10.1080/15384101.2019.1651587

Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema
Collum, SD, Molina, JG, Hanmandlu, A, Bi, W, Pedroza, M, Mertens, TCJ, Wareing, N, Wei, W, Wilson, C, Sun, W, Rajadas, J, Bollyky, PL, Philip, KM, Ren, D, Amirthalingam Thandavarayan, R, Bruckner, BA, Xia, Y, Blackburn, MR & Karmouty-Quintana, H 2019, , DMM Disease Models and Mechanisms, vol. 12, no. 5, dmm038711. https://doi.org/10.1242/dmm.038711

Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation
Weng, T, Ko, J, Masamha, CP, Xia, Z, Xiang, Y, Chen, NY, Molina, JG, Collum, S, Mertens, TC, Luo, F, Philip, K, Davies, J, Huang, J, Wilson, C, Thandavarayan, RA, Bruckner, BA, Jyothula, SSK, Volcik, KA, Li, L, Han, L, Li, W, Assassi, S, Karmouty-Quintana, H, Wagner, EJ & Blackburn, MR 2019, , Journal of Clinical Investigation, vol. 129, no. 5, pp. 1984-1999. https://doi.org/10.1172/JCI122106

Correction: Type-2 diabetic aldehyde dehydrogenase 2 mutant mice (ALDH 22) exhibiting heart failure with preserved ejection fraction phenotype can be determined by exercise stress echocardiography (PLoS ONE (2018) 13: 4 (e0195796) DOI: 10.1371/journal.pone.0195796)
Pan, G, Munukutla, S, Kar, A, Gardinier, J, Thandavarayan, RA & Palaniyandi, SS 2018, , PLoS ONE, vol. 13, no. 8, e0203581. https://doi.org/10.1371/journal.pone.0203581

Transflammation: How Innate Immune Activation and Free Radicals Drive Nuclear Reprogramming
Meng, S, Chanda, P, Thandavarayan, RA & Cooke, JP 2018, , Antioxidants and Redox Signaling, vol. 29, no. 2, pp. 205-218. https://doi.org/10.1089/ars.2017.7364

Small molecule disruption of G protein ß? subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats
Karuppagounder, V, Bajpai, A, Meng, S, Arumugam, S, Sreedhar, R, Giridharan, VV, Guha, A, Bhimaraj, A, Youker, KA, Palaniyandi, SS, Karmouty-Quintana, H, Kamal, F, Spiller, KL, Watanabe, K & Thandavarayan, RA 2018, , PLoS ONE, vol. 13, no. 7, e0200697. https://doi.org/10.1371/journal.pone.0200697

Type-2 diabetic aldehyde dehydrogenase 2 mutant mice (ALDH 22) exhibiting heart failure with preserved ejection fraction phenotype can be determined by exercise stress echocardiography
Pan, G, Munukutla, S, Kar, A, Gardinier, J, Thandavarayan, RA & Palaniyandi, SS 2018, , PLoS ONE, vol. 13, no. 4, e0195796. https://doi.org/10.1371/journal.pone.0195796

In search of suitable extraction technique for large scale commercial production of bioactive fraction for the treatment of diabetes: The case Diospyros melanoxylon Roxb
Harun Al Rashid, M, Majumder, S, Mandal, V, Mandal, SC & Amirthalingam Thandavarayan, R 2019, , Journal of Traditional and Complementary Medicine, vol. 9, no. 2, pp. 106-118. https://doi.org/10.1016/j.jtcme.2017.11.003

Transflammation: Innate immune signaling in nuclear reprogramming
Meng, S, Chanda, P, Thandavarayan, RA & Cooke, JP 2017, , Advanced Drug Delivery Reviews, vol. 120, pp. 133-141. https://doi.org/10.1016/j.addr.2017.09.010

Preparation and characterization of PLGA loaded nanoparticles obtained from D. Melanoxylon Roxb. Leaves for their antiproliferative and antidiabetic activity
Al Rashid, MH, Bharadwaj, PVPD, Mandal, V, Pal, M, Mandal, SC & Thandavarayan, RA 2017, , International Journal of Green Pharmacy, vol. 11, no. 3, pp. S438-S447.

The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging
Karuppagounder, V, Arumugam, S, Babu, SS, Palaniyandi, SS, Watanabe, K, Cooke, JP & Amirthalingam Thandavarayan, R 2017, , Ageing Research Reviews, vol. 35, pp. 291-296. https://doi.org/10.1016/j.arr.2016.10.006

Significance of Japanese Kampo Medicine in Supportive Care of Heart Failure/Function
Joladarashi, D, Thandavarayan, RA & Krishnamurthy, P 2017, . in Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation. Elsevier, pp. 47-57. https://doi.org/10.1016/B978-0-12-809398-6.00006-8