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Rajarajan Amirthalingam Thandavarayan, M.Pharm, PhD

Assistant Research Professor of Cardiology, Institute for Academic Medicine
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


ramirthalingamthandavarayan@houstonmethodist.org
Publications

Dysfunction of iPSC-derived endothelial cells in human Hutchinson–Gilford progeria syndrome
Matrone, G, Amirthalingam Thandavarayan, R, Walther, BK, Meng, S, Mojiri, A & Cooke, JP 2019, Cell Cycle, vol. 18, no. 19, pp. 2495-2508. https://doi.org/10.1080/15384101.2019.1651587

Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema
Collum, SD, Molina, JG, Hanmandlu, A, Bi, W, Pedroza, M, Mertens, TCJ, Wareing, N, Wei, W, Wilson, C, Sun, W, Rajadas, J, Bollyky, PL, Philip, KM, Ren, D, Amirthalingam Thandavarayan, R, Bruckner, BA, Xia, Y, Blackburn, MR & Karmouty-Quintana, H 2019, DMM Disease Models and Mechanisms, vol. 12, no. 5, dmm038711. https://doi.org/10.1242/dmm.038711

In search of suitable extraction technique for large scale commercial production of bioactive fraction for the treatment of diabetes: The case Diospyros melanoxylon Roxb
Harun Al Rashid, M, Majumder, S, Mandal, V, Mandal, SC & Amirthalingam Thandavarayan, R 2019, Journal of Traditional and Complementary Medicine, vol. 9, no. 2, pp. 106-118. https://doi.org/10.1016/j.jtcme.2017.11.003

Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation
Weng, T, Ko, J, Masamha, CP, Xia, Z, Xiang, Y, Chen, NY, Molina, JG, Collum, S, Mertens, TC, Luo, F, Philip, K, Davies, J, Huang, J, Wilson, C, Amirthalingam Thandavarayan, R, Bruckner, BA, Jyothula, SS, Volcik, KA, Li, L, Han, L, Li, W, Assassi, S, Karmouty-Quintana, H, Wagner, EJ & Blackburn, MR 2019, The Journal of clinical investigation, vol. 130. https://doi.org/10.1172/JCI122106

Correction: Type-2 diabetic aldehyde dehydrogenase 2 mutant mice (ALDH 22) exhibiting heart failure with preserved ejection fraction phenotype can be determined by exercise stress echocardiography (PLoS ONE (2018) 13: 4 (e0195796) DOI: 10.1371/journal.pone.0195796)
Pan, G, Munukutla, S, Kar, A, Gardinier, J, Amirthalingam Thandavarayan, R & Palaniyandi, SS 2018, PLoS ONE, vol. 13, no. 8, e0203581. https://doi.org/10.1371/journal.pone.0203581

Transflammation: How Innate Immune Activation and Free Radicals Drive Nuclear Reprogramming
Meng, S, Chanda, P, Amirthalingam Thandavarayan, R & Cooke, JP 2018, Antioxidants and Redox Signaling, vol. 29, no. 2, pp. 205-218. https://doi.org/10.1089/ars.2017.7364

Small molecule disruption of G protein ß? subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats
Karuppagounder, V, Bajpai, A, Meng, S, Arumugam, S, Sreedhar, R, Giridharan, VV, Guha, A, Bhimaraj, A, Youker, KA, Palaniyandi, SS, Karmouty-Quintana, H, Kamal, F, Spiller, KL, Watanabe, K & Amirthalingam Thandavarayan, R 2018, PLoS ONE, vol. 13, no. 7, e0200697. https://doi.org/10.1371/journal.pone.0200697

Type-2 diabetic aldehyde dehydrogenase 2 mutant mice (ALDH 22) exhibiting heart failure with preserved ejection fraction phenotype can be determined by exercise stress echocardiography
Pan, G, Munukutla, S, Kar, A, Gardinier, J, Amirthalingam Thandavarayan, R & Palaniyandi, SS 2018, PLoS ONE, vol. 13, no. 4, e0195796. https://doi.org/10.1371/journal.pone.0195796

Transflammation: Innate immune signaling in nuclear reprogramming
Meng, S, Chanda, P, Amirthalingam Thandavarayan, R & Cooke, JP 2017, Advanced Drug Delivery Reviews, vol. 120, pp. 133-141. https://doi.org/10.1016/j.addr.2017.09.010

Preparation and characterization of PLGA loaded nanoparticles obtained from D. Melanoxylon Roxb. Leaves for their antiproliferative and antidiabetic activity
Al Rashid, MH, Bharadwaj, PVPD, Mandal, V, Pal, M, Mandal, SC & Amirthalingam Thandavarayan, R 2017, International Journal of Green Pharmacy, vol. 11, no. 3, pp. S438-S447.

The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging
Karuppagounder, V, Arumugam, S, Babu, SS, Palaniyandi, SS, Watanabe, K, Cooke, JP & Amirthalingam Thandavarayan, R 2017, Ageing Research Reviews, vol. 35, pp. 291-296. https://doi.org/10.1016/j.arr.2016.10.006

Japanese Kampo Medicine for Aging-Related Neurological Diseases
Giridharan, VV, Amirthalingam Thandavarayan, R, Konishi, T & Quedevo, J 2017, . in Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation. Elsevier, pp. 75-88. https://doi.org/10.1016/B978-0-12-809398-6.00009-3

Significance of Japanese Kampo Medicine in Supportive Care of Heart Failure/Function
Joladarashi, D, Amirthalingam Thandavarayan, R & Krishnamurthy, P 2017, . in Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation. Elsevier, pp. 47-57. https://doi.org/10.1016/B978-0-12-809398-6.00006-8

Kampo Medicine for Hypertension and Related Disorders
Babu, SS, Amirthalingam Thandavarayan, R & Krishnamurthy, P 2017, . in Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation. Elsevier, pp. 59-67. https://doi.org/10.1016/B978-0-12-809398-6.00007-X

Comparative effects of torasemide and furosemide on gap junction proteins and cardiac fibrosis in a rat model of dilated cardiomyopathy
Watanabe, K, Sreedhar, R, Amirthalingam Thandavarayan, R, Karuppagounder, V, Giridharan, VV, Antony, S, Harima, M, Nakamura, M, Suzuki, K, Suzuki, H, Sone, H & Arumugam, S 2017, BioFactors, vol. 43, no. 2, pp. 187-194. https://doi.org/10.1002/biof.1332

Lipid-polymer hybrid nanoparticle-mediated therapeutics delivery: Advances and challenges
Bose, RJC, Ravikumar, R, Karuppagounder, V, Bennet, D, Rangasamy, S & Amirthalingam Thandavarayan, R 2017, Drug Discovery Today. https://doi.org/10.1016/j.drudis.2017.05.015

Newer insights into the role of miRNA a tiny genetic tool in psychiatric disorders: focus on post-traumatic stress disorder
Giridharan, VV, Thandavarayan, RA, Fries, GR, Walss-Bass, C, Barichello, T, Justice, NJ, Reddy, MK & Quevedo, J 2016, Translational psychiatry, vol. 6, no. 11, pp. e954. https://doi.org/10.1038/tp.2016.220

MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes
Suresh Babu, S, Amirthalingam Thandavarayan, R, Joladarashi, D, Jeyabal, P, Krishnamurthy, S, Bhimaraj, A, Youker, KA & Krishnamurthy, P 2016, Scientific Reports, vol. 6, 36207. https://doi.org/10.1038/srep36207

Cardiac mitochondrial respiratory dysfunction and tissue damage in chronic hyperglycemia correlate with reduced aldehyde dehydrogenase-2 activity
Mali, VR, Pan, G, Deshpande, M, Amirthalingam Thandavarayan, R, Xu, J, Yang, XP & Palaniyandi, SS 2016, PLoS ONE, vol. 11, no. 10, e0163158. https://doi.org/10.1371/journal.pone.0163158

Erratum to “Hypothalamic glucagon signaling in fasting hypoglycemia” (Life Sci. (2016) 153 (118–123))
Pitchaimani, V, Arumugam, S, Amirthalingam Thandavarayan, R, Karuppagounder, V, Afrin, MR, Sreedhar, R, Harima, M, Suzuki, H, Miyashita, S, Suzuki, K, Nakamura, M, Ueno, K & Watanabe, K 2016, Life Sciences, vol. 160, pp. 1. https://doi.org/10.1016/j.lfs.2016.07.003

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