Rajarajan Amirthalingam Thandavarayan

Rajarajan Amirthalingam Thandavarayan, M.Pharm, PhD

Assistant Research Professor of Cardiology, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


ramirthalingamthandavarayan@houstonmethodist.org
Publications

3'UTR shortening of profibrotic genes and reversibility of fibrosis in patients with end-stage right ventricular failure
Neupane, R, Cieslik, KA, Youker, K, Palaniyandi, SS, Guha, A & Thandavarayan, RA 2022, , Clinical and translational medicine, vol. 12, no. 9, pp. e1017. https://doi.org/10.1002/ctm2.1017

Aldehyde Dehydrogenase 2 Activator Augments the Beneficial Effects of Empagliflozin in Mice with Diabetes-Associated HFpEF
Pan, G, Roy, B, Giri, S, Lanfear, DE, Thandavarayan, RA, Guha, A, Ortiz, PA & Palaniyandi, SS 2022, , International journal of molecular sciences, vol. 23, no. 18, 10439. https://doi.org/10.3390/ijms231810439

3’UTR shortening of HAS2 promotes hyaluronan hyper-synthesis and bioenergetic dysfunction in pulmonary hypertension
Tseng, V, Collum, SD, Allawzi, A, Crotty, K, Yeligar, S, Trammell, A, Ryan Smith, M, Kang, BY, Sutliff, RL, Ingram, JL, Jyothula, SSSK, Thandavarayan, RA, Huang, HJ, Nozik, ES, Wagner, EJ, Michael Hart, C & Karmouty-Quintana, H 2022, , Matrix Biology, vol. 111, pp. 53-75. https://doi.org/10.1016/j.matbio.2022.06.001

Aldehyde dehydrogenase 2 augments adiponectin signaling in coronary angiogenesis in HFpEF associated with diabetes
Roy, B, Pan, G, Giri, S, Thandavarayan, RA & Palaniyandi, SS 2022, , FASEB Journal, vol. 36, no. 8, e22440. https://doi.org/10.1096/fj.202200498R

Effect of heat-moisture treated brown rice crackers on postprandial flow-mediated dilation in adults with mild endothelial dysfunction
Watanabe, K, Hirayama, M, Arumugam, S, Sugawara, M, Kato, H, Nakamura, S, Ohtsubo, K, Matsumoto, H, Nomi, Y, Homma, N, Fujii, Y, Murohashi, N, A Thandavarayan, R, Suzuki, H, Fujihara, K, Kodama, S & Sone, H 2022, , Heliyon, vol. 8, no. 8, e10284. https://doi.org/10.1016/j.heliyon.2022.e10284

An In Vitro Platform to Study Reversible Endothelial-to-Mesenchymal Transition
Krishnamoorthi, MK, Thandavarayan, RA, Youker, KA & Bhimaraj, A 2022, , Frontiers in Pharmacology, vol. 13, 912660, pp. 912660. https://doi.org/10.3389/fphar.2022.912660

Sine oculis homeobox homolog 1 plays a critical role in pulmonary fibrosis
Wilson, C, Mertens, TCJ, Shivshankar, P, Bi, W, Collum, SD, Wareing, N, Ko, J, Weng, T, Naikawadi, RP, Wolters, PJ, Maire, P, Jyothula, SSK, Thandavarayan, RA, Ren, D, Elrod, ND, Wagner, EJ, Huang, HJ, Dickey, BF, Ford, HL & Karmouty-Quintana, H 2022, , JCI insight, vol. 7, no. 10, e142984. https://doi.org/10.1172/jci.insight.142984

Cleavage stimulating factor 64 depletion mitigates cardiac fibrosis through alternative polyadenylation
Neupane, R, Youker, K, Yalamanchili, HK, Cieslik, KA, Karmouty-quintana, H, Guha, A & Thandavarayan, RA 2022, , Biochemical and Biophysical Research Communications, vol. 597, pp. 109-114. https://doi.org/10.1016/j.bbrc.2022.01.093

Effects of intracardiac delivery of aldehyde dehydrogenase 2 gene in myocardial salvage
Pan, G, Roy, B, Harding, P, Lanigan, T, Hilgarth, R, Thandavarayan, RA & Palaniyandi, SS 2022, , Gene Therapy. https://doi.org/10.1038/s41434-022-00345-2

Transcriptomic and Epigenetic Profiling of Fibroblasts in Idiopathic Pulmonary Fibrosis
Hanmandlu, A, Zhu, L, Mertens, TCJ, Collum, S, Bi, W, Xiong, F, Wang, R, Amirthalingam, RT, Ren, D, Han, L, Jyothula, SSSK, Li, W, Zheng, WJ & Karmouty-Quintana, H 2022, , American Journal of Respiratory Cell and Molecular Biology, vol. 66, no. 1, pp. 53-63. https://doi.org/10.1165/rcmb.2020-0437OC

Role of Endothelial and Mesenchymal Cell Transitions in Heart Failure and Recovery Thereafter
Wang, G, Cruz, AS, Youker, K, Marcos-Abdala, HG, Thandavarayan, RA, Cooke, JP, Torre-Amione, G, Chen, K & Bhimaraj, A 2021, , Frontiers in Genetics, vol. 11, 609262, pp. 609262. https://doi.org/10.3389/fgene.2020.609262

4-Hydroxy-2-nonenal, a lipid peroxidation product, as a biomarker in diabetes and its complications: challenges and opportunities
Dham, D, Roy, B, Gowda, A, Pan, G, Sridhar, A, Zeng, X, Thandavarayan, RA & Palaniyandi, SS 2021, , Free Radical Research, vol. 55, no. 5, pp. 547-561. https://doi.org/10.1080/10715762.2020.1866756

SARS–CoV-2 Mediated Hyperferritinemia and Cardiac Arrest: Preliminary Insights
VasanthiDharmalingam, P, Karuppagounder, V, Watanabe, K, Karmouty-Quintana, H, Palaniyandi, SS, Guha, A & Thandavarayan, RA 2021, , Drug Discovery Today, vol. 26, no. 5, pp. 1265-1274. https://doi.org/10.1016/j.drudis.2021.01.014

Histamine 2 receptors in cardiovascular biology: A friend for the heart
Saheera, S, Potnuri, AG, Guha, A, Palaniyandi, SS & Thandavarayan, RA 2022, , Drug Discovery Today, vol. 27, no. 1, pp. 234-245. https://doi.org/10.1016/j.drudis.2021.08.008

Right ventricular failure: a comorbidity or a clinical emergency?
Das, P, Thandavarayan, RA, Watanabe, K, Velayutham, R & Arumugam, S 2022, , Heart Failure Reviews, vol. 27, no. 5, pp. 1779-1793. https://doi.org/10.1007/s10741-021-10192-9

Emerging roles of alternative cleavage and polyadenylation (APA) in human disease
Dharmalingam, P, Mahalingam, R, Yalamanchili, HK, Weng, T, Karmouty-Quintana, H, Guha, A & A. Thandavarayan, R 2022, , Journal of Cellular Physiology, vol. 237, no. 1, pp. 149-160. https://doi.org/10.1002/jcp.30549

STK35 Gene Therapy Attenuates Endothelial Dysfunction and Improves Cardiac Function in Diabetes
Joladarashi, D, Zhu, Y, Willman, M, Nash, K, Cimini, M, Thandavarayan, RA, Youker, KA, Song, X, Ren, D, Li, J, Kishore, R, Krishnamurthy, P & Wang, L 2021, , Frontiers in cardiovascular medicine, vol. 8, pp. 798091. https://doi.org/10.3389/fcvm.2021.798091

Le Carbone prevents liver damage in non-alcoholic steatohepatitis-hepatocellular carcinoma mouse model via AMPKa-SIRT1 signaling pathway activation
Afrin, MR, Arumugam, S, Pitchaimani, V, Karuppagounder, V, Thandavarayan, RA, Harima, M, Hossain, CF, Suzuki, K, Sone, H, Matsubayashi, Y & Watanabe, K 2021, , Heliyon, vol. 7, no. 1, pp. e05888. https://doi.org/10.1016/j.heliyon.2020.e05888

Emerging mechanisms of pulmonary vasoconstriction in SARS-CoV-2-induced acute respiratory distress syndrome (ARDS) and potential therapeutic targets
Karmouty-Quintana, H, Thandavarayan, RA, Keller, SP, Sahay, S, Pandit, LM & Akkanti, B 2020, , International journal of molecular sciences, vol. 21, no. 21, 8081, pp. 1-21. https://doi.org/10.3390/ijms21218081

Brain adaptations of insulin signaling kinases, GLUT 3, p-BADser155 and nitrotyrosine expression in various hypoglycemic models of mice
Pitchaimani, V, Arumugam, S, Thandavarayan, RA, Karuppagounder, V, Afrin, MR, Sreedhar, R, Harima, M, Nakamura, M, Watanabe, K, Kodama, S, Fujihara, K & Sone, H 2020, , Neurochemistry International, vol. 137, 104745. https://doi.org/10.1016/j.neuint.2020.104745