Rajarajan Amirthalingam Thandavarayan, M.Pharm, PhD

Assistant Research Professor of Cardiology, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College

ramirthalingamthandavarayan@houstonmethodist.org

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Publications

3,4-Dihydroxybenzalacetone (DBL) Prevents Aging-Induced Myocardial Changes in Senescence-Accelerated Mouse-Prone 8 (SAMP8) Mice

Giridharan, VV, Karupppagounder, V, Arumugam, S, Nakamura, Y, Guha, A, Barichello, T, Quevedo, J, Watanabe, K, Konishi, T & Thandavarayan, RA 2020, Cells, vol. 9, no. 3. https://doi.org/10.3390/cells9030597

Pathophysiology of Acute and Chronic Right Heart Failure

Thandavarayan, RA, Chitturi, KR & Guha, A 2020, Cardiology Clinics. https://doi.org/10.1016/j.ccl.2020.01.009

Dysfunction of iPSC-derived endothelial cells in human Hutchinson–Gilford progeria syndrome

Matrone, G, Amirthalingam Thandavarayan, R, Walther, BK, Meng, S, Mojiri, A & Cooke, JP 2019, Cell Cycle, vol. 18, no. 19, pp. 2495-2508. https://doi.org/10.1080/15384101.2019.1651587

Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema

Collum, SD, Molina, JG, Hanmandlu, A, Bi, W, Pedroza, M, Mertens, TCJ, Wareing, N, Wei, W, Wilson, C, Sun, W, Rajadas, J, Bollyky, PL, Philip, KM, Ren, D, Amirthalingam Thandavarayan, R, Bruckner, BA, Xia, Y, Blackburn, MR & Karmouty-Quintana, H 2019, DMM Disease Models and Mechanisms, vol. 12, no. 5, dmm038711. https://doi.org/10.1242/dmm.038711

In search of suitable extraction technique for large scale commercial production of bioactive fraction for the treatment of diabetes: The case Diospyros melanoxylon Roxb

Harun Al Rashid, M, Majumder, S, Mandal, V, Mandal, SC & Amirthalingam Thandavarayan, R 2019, Journal of Traditional and Complementary Medicine, vol. 9, no. 2, pp. 106-118. https://doi.org/10.1016/j.jtcme.2017.11.003

Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation

Weng, T, Ko, J, Masamha, CP, Xia, Z, Xiang, Y, Chen, NY, Molina, JG, Collum, S, Mertens, TC, Luo, F, Philip, K, Davies, J, Huang, J, Wilson, C, Amirthalingam Thandavarayan, R, Bruckner, BA, Jyothula, SS, Volcik, KA, Li, L, Han, L, Li, W, Assassi, S, Karmouty-Quintana, H, Wagner, EJ & Blackburn, MR 2019, The Journal of clinical investigation, vol. 130. https://doi.org/10.1172/JCI122106

Correction: Type-2 diabetic aldehyde dehydrogenase 2 mutant mice (ALDH 22) exhibiting heart failure with preserved ejection fraction phenotype can be determined by exercise stress echocardiography (PLoS ONE (2018) 13: 4 (e0195796) DOI: 10.1371/journal.pone.0195796)

Pan, G, Munukutla, S, Kar, A, Gardinier, J, Amirthalingam Thandavarayan, R & Palaniyandi, SS 2018, PLoS ONE, vol. 13, no. 8, e0203581. https://doi.org/10.1371/journal.pone.0203581

Transflammation: How Innate Immune Activation and Free Radicals Drive Nuclear Reprogramming

Meng, S, Chanda, P, Amirthalingam Thandavarayan, R & Cooke, JP 2018, Antioxidants and Redox Signaling, vol. 29, no. 2, pp. 205-218. https://doi.org/10.1089/ars.2017.7364

Small molecule disruption of G protein ß? subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats

Karuppagounder, V, Bajpai, A, Meng, S, Arumugam, S, Sreedhar, R, Giridharan, VV, Guha, A, Bhimaraj, A, Youker, KA, Palaniyandi, SS, Karmouty-Quintana, H, Kamal, F, Spiller, KL, Watanabe, K & Amirthalingam Thandavarayan, R 2018, PLoS ONE, vol. 13, no. 7, e0200697. https://doi.org/10.1371/journal.pone.0200697

Type-2 diabetic aldehyde dehydrogenase 2 mutant mice (ALDH 22) exhibiting heart failure with preserved ejection fraction phenotype can be determined by exercise stress echocardiography

Pan, G, Munukutla, S, Kar, A, Gardinier, J, Amirthalingam Thandavarayan, R & Palaniyandi, SS 2018, PLoS ONE, vol. 13, no. 4, e0195796. https://doi.org/10.1371/journal.pone.0195796

Transflammation: Innate immune signaling in nuclear reprogramming

Meng, S, Chanda, P, Amirthalingam Thandavarayan, R & Cooke, JP 2017, Advanced Drug Delivery Reviews, vol. 120, pp. 133-141. https://doi.org/10.1016/j.addr.2017.09.010

Preparation and characterization of PLGA loaded nanoparticles obtained from D. Melanoxylon Roxb. Leaves for their antiproliferative and antidiabetic activity

Al Rashid, MH, Bharadwaj, PVPD, Mandal, V, Pal, M, Mandal, SC & Amirthalingam Thandavarayan, R 2017, International Journal of Green Pharmacy, vol. 11, no. 3, pp. S438-S447.

The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging

Karuppagounder, V, Arumugam, S, Babu, SS, Palaniyandi, SS, Watanabe, K, Cooke, JP & Amirthalingam Thandavarayan, R 2017, Ageing Research Reviews, vol. 35, pp. 291-296. https://doi.org/10.1016/j.arr.2016.10.006

Significance of Japanese Kampo Medicine in Supportive Care of Heart Failure/Function

Joladarashi, D, Amirthalingam Thandavarayan, R & Krishnamurthy, P 2017, . in Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation. Elsevier, pp. 47-57. https://doi.org/10.1016/B978-0-12-809398-6.00006-8

Kampo Medicine for Hypertension and Related Disorders

Babu, SS, Amirthalingam Thandavarayan, R & Krishnamurthy, P 2017, . in Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation. Elsevier, pp. 59-67. https://doi.org/10.1016/B978-0-12-809398-6.00007-X

Japanese Kampo Medicine for Aging-Related Neurological Diseases

Giridharan, VV, Amirthalingam Thandavarayan, R, Konishi, T & Quedevo, J 2017, . in Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation. Elsevier, pp. 75-88. https://doi.org/10.1016/B978-0-12-809398-6.00009-3

Comparative effects of torasemide and furosemide on gap junction proteins and cardiac fibrosis in a rat model of dilated cardiomyopathy

Watanabe, K, Sreedhar, R, Amirthalingam Thandavarayan, R, Karuppagounder, V, Giridharan, VV, Antony, S, Harima, M, Nakamura, M, Suzuki, K, Suzuki, H, Sone, H & Arumugam, S 2017, BioFactors, vol. 43, no. 2, pp. 187-194. https://doi.org/10.1002/biof.1332

Lipid-polymer hybrid nanoparticle-mediated therapeutics delivery: Advances and challenges

Bose, RJC, Ravikumar, R, Karuppagounder, V, Bennet, D, Rangasamy, S & Amirthalingam Thandavarayan, R 2017, Drug Discovery Today. https://doi.org/10.1016/j.drudis.2017.05.015

Newer insights into the role of miRNA a tiny genetic tool in psychiatric disorders: focus on post-traumatic stress disorder

Giridharan, VV, Thandavarayan, RA, Fries, GR, Walss-Bass, C, Barichello, T, Justice, NJ, Reddy, MK & Quevedo, J 2016, Translational psychiatry, vol. 6, no. 11, pp. e954. https://doi.org/10.1038/tp.2016.220

MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes

Suresh Babu, S, Amirthalingam Thandavarayan, R, Joladarashi, D, Jeyabal, P, Krishnamurthy, S, Bhimaraj, A, Youker, KA & Krishnamurthy, P 2016, Scientific Reports, vol. 6, 36207. https://doi.org/10.1038/srep36207

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