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Raghav Shroff, PhD

Assistant Research Professor of Pathology and Genomic Medicine, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist


Publications

SARS-COV-2 Omicron variants conformationally escape a rare quaternary antibody binding mode
Goike, J, Hsieh, CL, Horton, AP, Gardner, EC, Zhou, L, Bartzoka, F, Wang, N, Javanmardi, K, Hebert, A, Abbasi, SA, Xie, X, Xia, H, Shi, PY, Renberg, R, Segall-Shapiro, T, Terrace, CI, Wu, W, Shroff, R, Byrom, M, Ellington, AD, Marcotte, EM, Musser, JM, Kuchipudi, SV, Kapur, V, Georgiou, G, Weaver, S, Dye, JM, Boutz, DR, McLellan, JS & Gollihar, JD 2023, , Communications Biology, vol. 6, 1250, pp. 1250. https://doi.org/10.1038/s42003-023-05649-6

DLPacker: Deep learning for prediction of amino acid side chain conformations in proteins
Misiura, M, Shroff, R, Thyer, R & Kolomeisky, AB 2022, , Proteins: Structure, Function and Bioinformatics, vol. 90, no. 6, pp. 1278-1290. https://doi.org/10.1002/prot.26311

Machine learning-aided engineering of hydrolases for PET depolymerization
Lu, H, Diaz, DJ, Czarnecki, NJ, Zhu, C, Kim, W, Shroff, R, Acosta, DJ, Alexander, BR, Cole, HO, Zhang, Y, Lynd, NA, Ellington, AD & Alper, HS 2022, , Nature, vol. 604, no. 7907, pp. 662-667. https://doi.org/10.1038/s41586-022-04599-z

Recovery of Information Stored in Modified DNA with an Evolved Polymerase
Shroff, R, Ellefson, JW, Wang, SS, Boulgakov, AA, Hughes, RA & Ellington, AD 2022, , ACS Synthetic Biology, vol. 11, no. 2, pp. 554-561. https://doi.org/10.1021/acssynbio.1c00575

Improved Bst DNA Polymerase Variants Derived via a Machine Learning Approach
Paik, I, Ngo, PHT, Shroff, R, Diaz, DJ, Maranhao, AC, Walker, DJF, Bhadra, S & Ellington, AD 2023, , Biochemistry, vol. 62, no. 2, pp. 410-418. https://doi.org/10.1021/acs.biochem.1c00451

Evolving Bacterial Fitness with an Expanded Genetic Code
Tack, DS, Cole, AC, Shroff, R, Morrow, BR & Ellington, AD 2018, , Scientific Reports, vol. 8, no. 1, 3288. https://doi.org/10.1038/s41598-018-21549-w

Evolution of a Thermophilic Strand-Displacing Polymerase Using High-Temperature Isothermal Compartmentalized Self-Replication
Milligan, JN, Shroff, R, Garry, DJ & Ellington, AD 2018, , Biochemistry, vol. 57, no. 31, pp. 4607-4619. https://doi.org/10.1021/acs.biochem.8b00200

Custom selenoprotein production enabled by laboratory evolution of recoded bacterial strains
Thyer, R, Shroff, R, Klein, DR, DOelsnitz, S, Cotham, VC, Byrom, M, Brodbelt, JS & Ellington, AD 2018, , Nature Biotechnology, vol. 36, no. 7, pp. 624-631. https://doi.org/10.1038/nbt.4154

Microbiota and metatranscriptome changes accompanying the onset of gingivitis
Nowicki, EM, Shroff, R, Singleton, JA, Renaud, DE, Wallace, D, Drury, J, Zirnheld, J, Colleti, B, Ellington, AD, Lamont, RJ, Scott, DA & Whiteley, M 2018, , mBio, vol. 9, no. 2, e00575-18. https://doi.org/10.1128/mBio.00575-18

Characterizing bacterial gene circuit dynamics with optically programmed gene expression signals
Olson, EJ, Hartsough, LA, Landry, BP, Shroff, R & Tabor, JJ 2014, , Nature Methods, vol. 11, no. 4, pp. 449-455. https://doi.org/10.1038/nmeth.2884

Fragile X AGG analysis provides new risk predictions for 45-69 repeat alleles
Nolin, SL, Sah, S, Glicksman, A, Sherman, SL, Allen, E, Berry-Kravis, E, Tassone, F, Yrigollen, C, Cronister, A, Jodah, M, Ersalesi, N, Dobkin, C, Brown, WT, Shroff, R, Latham, GJ & Hadd, AG 2013, , American Journal of Medical Genetics, Part A, vol. 161, no. 4, pp. 771-778. https://doi.org/10.1002/ajmg.a.35833