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Philip J. Horner, PhD

Professor of Neuroregeneration, Institute for Academic Medicine
Full Member, Research Institute
Scientific Director, Center for Neuroregeneration
Houston Methodist
Weill Cornell Medical College


Horner Lab - Neuroplasticity & Repair


pjhorner@houstonmethodist.org
Biography

Philip J. Horner, Ph.D., received a Ph.D. in physiology from Ohio State University in 1995. He did post-doctoral training with Dr. Fred H. Gage and became a staff scientist in the Lab of Genetics at the Salk Institute in 1998. In 2001, Dr. Horner joined the faculty of the Department of Neurological Surgery at the University of Washington in Seattle. He directed a laboratory at the UW South Lake Union Campus and was a member of the Institute for Stem Cell and Regenerative Medicine. In 2015, Dr. Horner became the Scientific Director of the Center for Neuroregenerative Medicine and the Co-Director, Center for Regenerative and Restorative Neurosurgery at the Houston Methodist Research Institute in Houston Texas. Dr. Horner’s research focuses on the role of glial and neural progenitor cells in the regeneration of the injured and aging nervous system.

Description of Research

The Horner lab is focused on the interaction between glial and neural cells following central nervous system challenge and specifically: 1) mechanisms of adult stem cell-derived lesion remodeling/repair and 2) role of gliogenesis and gliosis in neural degeneration. Over the past decades, researchers have observed that the human brain and spinal cord retain a population of stem cells with the capacity to replace neurons and glia. However, during normal aging and following trauma or disease, the brain and spinal cord stem cells fail to replace needed circuitry. The Horner lab has been developing approaches to modify and amplify the fate of neural stem cells to increase cellular repair after spinal cord and brain injury. Together with electrical stimulation, the lab has shown that regeneration of neural circuitry offers hope for repair nervous system. Together with clinical research partners at Houston Methodist and our global partners, the Horner lab seeks to move from bench to bedside by engineering new neural circuits in people with chronic paralysis in order to restore hand function.  Neural regeneration strategies are also being applied to stroke, head injury, glaucoma and motor/cognitive decline associated with aging. 

Areas Of Expertise

Stroke Neural stem cells Myelin Optogenetics Neural trauma Regeneration Spinal cord Multiple sclerosis
Education & Training

MS, The Ohio State University
PhD, The Ohio State University
Postdoctoral Fellowship, The Salk Institute for Biological Studies
BS, University of Nevada, Reno
Publications

µBRAINS: Microassembly of Bioengineered, Rapid, All-Inducible Neural System for Injury Modeling and Neuroregeneration Screening
Krencik, RC, Patel, RAG, Cvetkovic, C, Hogan, MK, Muir, M, Basu, N, Shetty, A & Horner, PJ 2020, Mission Connect Annual Scientific Symposium 2018, Houston, United States, 11/30/18 - 11/30/18, .

Development of a protocol to assess cell internalization and tissue uptake of magnetic nanoparticles by AC Biosusceptometry
Quini, CC, Próspero, AG, Kondiles, BR, Chaboub, L, Hogan, MK, Baffa, O, Bakuzis, AF, Horner, PJ & Miranda, JRA 2019, Journal of Magnetism and Magnetic Materials, vol. 473, pp. 527-533. https://doi.org/10.1016/j.jmmm.2018.10.064

Navigable Myelin Compaction Atlas Reflects Healthy Human Aging: Implications For Injured Nerve Fiber Mapping
Hoffman, KA, Wolfe, T, Quini, C, Hogan, MK, Kondiles, BR, Chaboub, L, Huang, M, Desai, VR & Horner, PJ 2018, Mission Connect Annual Scientific Symposium 2018, Houston, United States, 11/30/18 - 11/30/18, .

Wireless Stimulation of the Ventral Spinal Cord to Facilitate Recovery After Spinal Cord Injury
Hogan, MK, Barber, SM, Kondiles, BR, Krencik, RC, Yu, C & Horner, PJ 2018, Mission Connect Annual Scientific Symposium 2018, Houston, United States, 11/30/18 - 11/30/18, .

Optogenetic surface stimulation of the rat cervical spinal cord
Mondello, SE, Sunshine, MD, Fischedick, AE, Dreyer, SJ, Horwitz, GD, Anikeeva, P, Horner, PJ & Moritz, CT 2018, Journal of neurophysiology, vol. 120, no. 2, pp. 795-811. https://doi.org/10.1152/jn.00461.2017

Controlled Release of Thrombin-Inhibitor from Injectable Hydrogel Modulates Gliosis After Spinal Cord Injury
Hogan, MK, Zhao, T, Kondiles, BR, Sellers, DL, Pun, SH & Horner, PJ 2018, Neurotrauma 2018 Conference, 8/11/18 - 8/16/18, .

Neural Activity and Regeneration
Hogan, MK, Barber, SM, Kondiles, BR, Krencik, RC, Yu, C & Horner, PJ 2018, 2018 Methodist Association for Professional Affairs (MAPTA) Summer Symposium, 8/3/18, .

Electro-magnetic stimulation and exercise training combined with implantation of neuralized-pluripotent stem cells (NiPSCs) immediately after spinal cord injury in rats.
Arvanian, VL, Petrosyan, HA, Liang, L, Alessi, V, Ballas, N, Kondiles, BR & Horner, PJ 2018, 2018 Forum of Neuroscience, Germany, 7/7/18 - 7/11/18, .

Activation of Hypoxia Responses in Aging Mouse Glioma Model: AANS Annual Scientific Meeting, New Orleans, Louisiana, April 28-May 2, 2018
Mikheeva, SA, Horner, PJ, Rostomily, RC & Mikheev, A 2018, .

Differential Effects of Neuregulin-1 Isoforms on Myelin Regeneration Following a Spinal Cord Injury
Salazar, BH, Lasiene, J, Jacobson, BE & Horner, PJ 2018, AANS 2018, New Orleans, United States, 4/28/18 - 5/2/18, .

Potential Therapeutic Effects of Injectable Hydrogel for Controlled Release of Thrombin-Inhibitor Following Spinal Cord Injury
Hogan, MK, Zhao, T, Kondiles, BR, Sellers, DL, Horner, PJ & Pun, SH 2018, AANS 2018, New Orleans, United States, 4/28/18 - 5/2/18, .

Systematic three-dimensional coculture methods to rapidly recapitulate complex interactions between human astrocytes and neurons.
Krencik, RC, Seo, K, van Asperen, JV, Basu, N, Cvetkovic, C, Barlas, S, Chen, R, Ludwig, C, Wang, C, Ward, ME, Gan, L & Horner, PJ 2018, AANS 2018, New Orleans, United States, 4/28/18 - 5/2/18, .

Histologic and MRI Analysis of Myelin in a Swine White Matter Injury Model
Chaboub, L, Huang, M, Kondiles, BR, Hogan, MK, Desai, V, Wolfe, T & Horner, PJ 2018, Myelin Gordon Research Conference , 3/18/18 - 3/23/18, .

Characterization of RNA’s collected from Central Nervous System Myelin Development
Lee, TH, Barbosa, Z, Campa-Carranza, JN, Viswanath, D & Horner, PJ 2018, .

A pilot examination of region specific myelin compaction by MRI in human aging
Kondiles, BR, Hogan, MK, Steele, WJ, Boghani, Z, Quini, C, Wolfe, T & Horner, PJ 2018, Myelin Gordon Research Conference , 3/18/18 - 3/23/18, .

Neurostimulation induced medicine (nSIM) device. Minimally invasive neurostimulation device for direct electrical stimulation of vagus nerve via sympathetic ganglia to modulate brain and immune function for the alleviation of brain damage due to injury, stroke or surgical complications.
Golanov, EV, Horner, PJ, Britz, GW & Wolfe, T 2018, .

Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes
Krencik, R, Seo, K, van Asperen, JV, Basu, N, Cvetkovic, C, Barlas, S, Chen, R, Ludwig, C, Wang, C, Ward, ME, Gan, L, Horner, PJ, Rowitch, DH & Ullian, EM 2017, Stem Cell Reports, vol. 9, no. 6, pp. 1745-1753. https://doi.org/10.1016/j.stemcr.2017.10.026

Age-related accumulation of phosphorylated mitofusin 2 protein in retinal ganglion cells correlates with glaucoma progression
Nivison, MP, Ericson, NG, Green, VM, Bielas, JH, Campbell, JS & Horner, PJ 2017, Experimental Neurology, vol. 296, pp. 49-61. https://doi.org/10.1016/j.expneurol.2017.07.001

Myelin plasticity, neural activity, and traumatic neural injury
Kondiles, BR & Horner, PJ 2018, Developmental Neurobiology, vol. 78, no. 2, pp. 108-122. https://doi.org/10.1002/dneu.22540

Tunable, Injectable Hydrogels Based on Peptide-Cross-Linked, Cyclized Polymer Nanoparticles for Neural Progenitor Cell Delivery
Zhao, T, Sellers, DL, Cheng, Y, Horner, PJ & Pun, SH 2017, Biomacromolecules, vol. 18, no. 9, pp. 2723-2731. https://doi.org/10.1021/acs.biomac.7b00510

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