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Paul Rees, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Paul Rees received his Ph.D. in physics from Cardiff University. He calculated the optical properties of semiconductor lasers and the measured spontaneous emissions from laser diodes under operating conditions. He was a research fellow in the physics department at Trinity College, Dublin, Ireland, where he studied self-pulsation in laser diodes and the theory of many-body effects in wide band-gap semiconductors. He later joined the School of Informatics, University of Wales, Bangor, UK, where he was appointed senior lecturer.

In 2005, Dr. Rees was appointed as the chair of nanotechnology in the newly-formed Multidisciplinary Nanotechnology Centre at Swansea University. As an Full Affiliate Member of Houston Methodist Research Institute, Dr. Rees collaborates with the nanomedicine department to study the uptake of micro and nanoparticles by biological cells. Dr. Rees also participates as a mentor for the graduate exchange training program between the Houston Methodist Academy and Swansea University.

Description of Research

Dr. Rees’ research focuses on the uptake of micro and nanoparticles by biological cells using high throughput imaging techniques such as imaging flow cytometry and multi-field imaging microscopy, the biological process of particle uptake, and the study of dose responses for drug molecules deliv-ered by particulate delivery vectors.

Areas Of Expertise

Laser diodes Nonlinear systems and chaos Simulation of cell mitosis Colloidal quantum dot fluorophores
Education & Training

PhD, Cardiff University
Postdoctoral Fellowship, Trinity College Dublin

Application of automated electron microscopy imaging and machine learning to characterise and quantify nanoparticle dispersion in aqueous media
Ilett, M, Wills, J, Rees, P, Sharma, S, Micklethwaite, S, Brown, A, Brydson, R & Hondow, N 2020, Journal of Microscopy, vol. 279, no. 3, pp. 177-184.

A Murine Oral-Exposure Model for Nano- and Micro-Particulates: Demonstrating Human Relevance with Food-Grade Titanium Dioxide
Riedle, S, Wills, JW, Miniter, M, Otter, DE, Singh, H, Brown, AP, Micklethwaite, S, Rees, P, Jugdaohsingh, R, Roy, NC, Hewitt, RE & Powell, JJ 2020, Small, vol. 16, no. 21, 2000486.

Label-Free Leukemia Monitoring by Computer Vision
Doan, M, Case, M, Masic, D, Hennig, H, McQuin, C, Caicedo, J, Singh, S, Goodman, A, Wolkenhauer, O, Summers, H, Jamieson, D, Delft, FV, Filby, A, Carpenter, AE, Rees, P & Irving, J 2020, Cytometry Part A, vol. 97, no. 4, pp. 407-414.

Compositional analysis of the associations between 24-h movement behaviours and cardio-metabolic risk factors in overweight and obese adults with pre-diabetes from the PREVIEW study: Cross-sectional baseline analysis
Swindell, N, Rees, P, Fogelholm, M, Drummen, M, MacDonald, I, Martinez, JA, Navas-Carretero, S, Handjieva-Darlenska, T, Boyadjieva, N, Bogdanov, G, Poppitt, SD, Gant, N, Silvestre, MP, Brand-Miller, J, Schlicht, W, Muirhead, R, Brodie, S, Tikkanen, H, Jalo, E, Westerterp-Plantenga, M, Adam, T, Vestentoft, PS, Larsen, TM, Raben, A & Stratton, G 2020, International Journal of Behavioral Nutrition and Physical Activity, vol. 17, no. 1, 29.

Diffusion Mapping of Eosinophil-Activation State
Piasecka, J, Thornton, CA, Rees, P & Summers, H 2020, Cytometry Part A, vol. 97, no. 3, pp. 253-258.

Copper nanoparticles have negligible direct antibacterial impact
Bastos, CAP, Faria, N, Wills, J, Malmberg, P, Scheers, N, Rees, P & Powell, JJ 2020, NanoImpact, vol. 17, 100192.

Activity mapping of children in play using multivariate analysis of movement events
Rocha, JN, Barnes, CM, Rees, P, Clark, CT, Stratton, G & Summers, H 2020, Medicine and science in sports and exercise, vol. 52, no. 1, pp. 259-266.

Image-Based Cell Profiling Enables Quantitative Tissue Microscopy in Gastroenterology
Wills, JW, Robertson, J, Summers, H, Miniter, M, Barnes, C, Hewitt, RE, Keita, ÅV, Söderholm, JD, Rees, P & Powell, JJ 2020, Cytometry Part A.

The origin of heterogeneous nanoparticle uptake by cells
Rees, P, Wills, JW, Brown, MR, Barnes, CM & Summers, H 2019, Nature Communications, vol. 10, no. 1, 2341.

Bilayer graphene nanoribbons junction with aligned holes exhibiting high ZT values
Deng, S, Li, L & Rees, P 2019, Carbon, vol. 155, pp. 438-444.

Graphene/MoXY Heterostructures Adjusted by Interlayer Distance, External Electric Field, and Strain for Tunable Devices
Deng, S, Li, L & Rees, P 2019, ACS Applied Nano Materials, vol. 2, no. 6, pp. 3977-3988.

Noisy Cell-Size-Correlated Expression of Cyclin B Drives Probabilistic Cell-Size Homeostasis in Fission Yeast
Patterson, JO, Rees, P & Nurse, P 2019, Current Biology, vol. 29, no. 8, pp. 1379-1386.e4.

Modifying the electrical properties of graphene by reversible point-ripple formation
Alyobi, MMM, Barnett, CJ, Rees, P & Cobley, RJ 2019, , Carbon, vol. 143, pp. 762-768.

Elucidating effects of reaction rates on dynamics of the lac circuit in Escherichia coli
Atitey, K, Loskot, P & Rees, P 2019, , BioSystems, vol. 175, pp. 1-10.

Label-Free Identification of White Blood Cells Using Machine Learning
Nassar, M, Doan, M, Filby, A, Wolkenhauer, O, Fogg, DK, Piasecka, J, Thornton, CA, Carpenter, AE, Summers, H, Rees, P & Hennig, H 2019, Cytometry Part A, vol. 95, no. 8, pp. 836-842.

Inferring distributions from observed mRNA and protein copy counts in genetic circuits
Atitey, K, Loskot, P & Rees, P 2019, Biomedical Physics and Engineering Express, vol. 5, no. 1, 015022.

Investigating FlowSight® imaging flow cytometry as a platform to assess chemically induced micronuclei using human lymphoblastoid cells in vitro
Verma, JR, Harte, DSG, Shah, UK, Summers, H, Thornton, CA, Doak, SH, Jenkins, GJS, Rees, P, Wills, JW & Johnson, GE 2018, , Mutagenesis, vol. 33, no. 4, pp. 283-289.

Inter-personal and critical-thinking capabilities in those about to enter qualified social work: A six-centre study
Sheppard, M, Charles, M, Rees, P, Wheeler, M & Williams, R 2018, , British Journal of Social Work, vol. 48, no. 7, pp. 1855-1873.

Determining the Transcription Rates Yielding Steady-State Production of mRNA in the Lac Genetic Switch of Escherichia coli
Atitey, K, Loskot, P & Rees, P 2018, , Journal of Computational Biology, vol. 25, no. 9, pp. 1023-1039.

Objective profiling of varied human motion based on normative assessment of magnetometer time series data
Barnes, CM, Clark, CCT, Rees, P, Stratton, G & Summers, H 2018, Physiological Measurement, vol. 39, no. 4, 045007.