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Paul Rees, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Biography

Paul Rees received his Ph.D. in physics from Cardiff University. He calculated the optical properties of semiconductor lasers and the measured spontaneous emissions from laser diodes under operating conditions. He was a research fellow in the physics department at Trinity College, Dublin, Ireland, where he studied self-pulsation in laser diodes and the theory of many-body effects in wide band-gap semiconductors. He later joined the School of Informatics, University of Wales, Bangor, UK, where he was appointed senior lecturer.

In 2005, Dr. Rees was appointed as the chair of nanotechnology in the newly-formed Multidisciplinary Nanotechnology Centre at Swansea University. As an Full Affiliate Member of Houston Methodist Research Institute, Dr. Rees collaborates with the nanomedicine department to study the uptake of micro and nanoparticles by biological cells. Dr. Rees also participates as a mentor for the graduate exchange training program between the Houston Methodist Academy and Swansea University.

Description of Research

Dr. Rees’ research focuses on the uptake of micro and nanoparticles by biological cells using high throughput imaging techniques such as imaging flow cytometry and multi-field imaging microscopy, the biological process of particle uptake, and the study of dose responses for drug molecules deliv-ered by particulate delivery vectors.

Areas Of Expertise

Laser diodes Nonlinear systems and chaos Simulation of cell mitosis Colloidal quantum dot fluorophores
Education & Training

PhD, Cardiff University
Postdoctoral Fellowship, Trinity College Dublin
Publications

The origin of heterogeneous nanoparticle uptake by cells
Rees, P, Wills, JW, Brown, MR, Barnes, CM & Summers, H 2019, Nature Communications, vol. 10, no. 1, 2341. https://doi.org/10.1038/s41467-019-10112-4

Noisy Cell-Size-Correlated Expression of Cyclin B Drives Probabilistic Cell-Size Homeostasis in Fission Yeast
Patterson, JO, Rees, P & Nurse, P 2019, Current Biology, vol. 29, no. 8, pp. 1379-1386.e4. https://doi.org/10.1016/j.cub.2019.03.011

Modifying the electrical properties of graphene by reversible point-ripple formation
Alyobi, MMM, Barnett, CJ, Rees, P & Cobley, RJ 2019, Carbon, vol. 143, pp. 762-768. https://doi.org/10.1016/j.carbon.2018.11.076

Elucidating effects of reaction rates on dynamics of the lac circuit in Escherichia coli
Atitey, K, Loskot, P & Rees, P 2019, BioSystems, vol. 175, pp. 1-10. https://doi.org/10.1016/j.biosystems.2018.11.003

Inferring distributions from observed mRNA and protein copy counts in genetic circuits
Atitey, K, Loskot, P & Rees, P 2019, Biomedical Physics and Engineering Express, vol. 5, no. 1, 015022. https://doi.org/10.1088/2057-1976/aaef5c

Label-Free Identification of White Blood Cells Using Machine Learning
Nassar, M, Doan, M, Filby, A, Wolkenhauer, O, Fogg, DK, Piasecka, J, Thornton, CA, Carpenter, AE, Summers, H, Rees, P & Hennig, H 2019, Cytometry Part A. https://doi.org/10.1002/cyto.a.23794

Investigating FlowSight® imaging flow cytometry as a platform to assess chemically induced micronuclei using human lymphoblastoid cells in vitro
Verma, JR, Harte, DSG, Shah, UK, Summers, H, Thornton, CA, Doak, SH, Jenkins, GJS, Rees, P, Wills, JW & Johnson, GE 2018, Mutagenesis, vol. 33, no. 4, pp. 283-289. https://doi.org/10.1093/mutage/gey021

Inter-personal and critical-thinking capabilities in those about to enter qualified social work: A six-centre study
Sheppard, M, Charles, M, Rees, P, Wheeler, M & Williams, R 2018, British Journal of Social Work, vol. 48, no. 7, pp. 1855-1873. https://doi.org/10.1093/bjsw/bcx143

Determining the Transcription Rates Yielding Steady-State Production of mRNA in the Lac Genetic Switch of Escherichia coli
Atitey, K, Loskot, P & Rees, P 2018, Journal of Computational Biology, vol. 25, no. 9, pp. 1023-1039. https://doi.org/10.1089/cmb.2018.0055

Objective profiling of varied human motion based on normative assessment of magnetometer time series data
Barnes, CM, Clark, CCT, Rees, P, Stratton, G & Summers, H 2018, Physiological Measurement, vol. 39, no. 4, 045007. https://doi.org/10.1088/1361-6579/aab9de

The association between imported factors and prisoners’ mental health: Implications for adaptation and intervention
Bowler, N, Phillips, C & Rees, P 2018, International Journal of Law and Psychiatry, vol. 57, pp. 61-66. https://doi.org/10.1016/j.ijlp.2018.01.001

Organic matter identifies the nano-mechanical properties of native soil aggregates
Gazze, SA, Hallin, I, Quinn, G, Dudley, E, Matthews, GP, Rees, P, Van Keulen, G, Doerr, SH & Francis, LW 2018, Nanoscale, vol. 10, no. 2, pp. 520-525. https://doi.org/10.1039/c7nr07070e

Diagnostic Potential of Imaging Flow Cytometry
Doan, M, Vorobjev, I, Rees, P, Filby, A, Wolkenhauer, O, Goldfeld, AE, Lieberman, J, Barteneva, N, Carpenter, AE & Hennig, H 2018, Trends in Biotechnology. https://doi.org/10.1016/j.tibtech.2017.12.008

Characterizing Nanoparticles in Biological Matrices: Tipping Points in Agglomeration State and Cellular Delivery in Vitro
Wills, JW, Summers, H, Hondow, N, Sooresh, A, Meissner, KE, White, PA, Rees, P, Brown, A & Doak, SH 2017, ACS Nano, vol. 11, no. 12, pp. 11986-12000. https://doi.org/10.1021/acsnano.7b03708

Reconstructing cell cycle and disease progression using deep learning
Eulenberg, P, Köhler, N, Blasi, T, Filby, A, Carpenter, AE, Rees, P, Theis, FJ & Wolf, FA 2017, Nature communications, vol. 8, no. 1, 463. https://doi.org/10.1038/s41467-017-00623-3

Data-analysis strategies for image-based cell profiling
Caicedo, JC, Cooper, S, Heigwer, F, Warchal, S, Qiu, P, Molnar, C, Vasilevich, AS, Barry, JD, Bansal, HS, Kraus, O, Wawer, M, Paavolainen, L, Herrmann, MD, Rohban, M, Hung, J, Hennig, H, Concannon, J, Smith, I, Clemons, PA, Singh, S, Rees, P, Horvath, P, Linington, RG & Carpenter, AE 2017, Nature Methods, vol. 14, no. 9, pp. 849-863. https://doi.org/10.1038/nmeth.4397

Theories underpinning kinship care
Pratchett, RC & Rees, P 2017, . in Children, Young People and Care. Taylor and Francis Inc. pp. 44-57. https://doi.org/10.4324/9781315686752

Spatially-resolved profiling of carbon nanotube uptake across cell lines
Summers, H, Rees, P, Wang, JTW & Al-Jamal, KT 2017, Nanoscale, vol. 9, no. 20, pp. 6800-6807. https://doi.org/10.1039/c7nr01561e

Dot state properties of 1.3 µm low-loss InAs quantum dot lasers grown directly on Si
Elliott, SN, Shutts, S, Sobiesierski, A, Rees, P, Smowton, PM, Tang, M, Wu, J & Liu, HY 2016, . in 2016 International Semiconductor Laser Conference, ISLC 2016., 7765701, Institute of Electrical and Electronics Engineers Inc. 2016 International Semiconductor Laser Conference, ISLC 2016, Kobe, Japan, 9/12/16.

Generation of an in vitro 3D PDAC stroma rich spheroid model
Ware, MJ, Keshishian, V, Law, JJ, Ho, JC, Favela, CA, Rees, P, Smith, B, Mohammad, S, Hwang, RF, Rajapakshe, K, Coarfa, C, Huang, S, Edwards, DP, Corr, SJ, Godin, B & Curley, SA 2016, Biomaterials, vol. 108, pp. 129-142. https://doi.org/10.1016/j.biomaterials.2016.08.041

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