Paul Christensen

Paul Christensen, MD

Assistant Professor of Clinical Pathology & Genomic Medicine, Academic Institute
Assistant Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Christensen received his MD from the University of Texas Health Science Center at Houston in 2014. He then completed his anatomic and clinical pathology residency and fellowships in clinical informatics and clinical chemistry, all at Houston Methodist Hospital. Upon completion, he was appointed as a staff pathologist.

Dr. Christensen’s clinical focus is informatics and analytics. He developed the Houston Methodist Respiratory Pathogen Epidemiology Snapshot and is an Emerging Technologies and Techniques section editor for the journal Archives of Pathology & Laboratory Medicine. Dr. Christensen is a member of the Texas Society of Pathologists, the College of American Pathologists, the Academy of Clinical Laboratory Physicians and Scientists, and the American Medical Informatics Association.

Description of Research

Dr. Christensen’s research focuses on the generation and use of real-time data to improve laboratory and hospital operations.

Areas Of Expertise

Pathology Analytics Clinical Informatics Clinical Chemistry
Publications

Accuracy-Based Glomerular Filtration Rate Assessment by Plasma Iohexol Clearance in Kidney Transplant Donors
Jin, Z, Huang, R, Christensen, P, Bertholf, RL & Yi, X 2023, , Journal of Clinical Medicine, vol. 12, no. 18, 6054. https://doi.org/10.3390/jcm12186054

Prognostic Significance of Size, Location, and Number of Lymph Node Metastases in Endometrial Carcinoma
Tran, L, Christensen, P, Barroeta, JE, Hunter, K, Sookram, J, McGregor, SM, Wilkinson, N, Orsi, NM & Lastra, RR 2023, , International Journal of Gynecological Pathology, vol. 42, no. 4, pp. 376-389. https://doi.org/10.1097/PGP.0000000000000897

A retrospective analysis of molecular testing in cytologically indeterminate thyroid nodules with histologic correlation: Experience at a heterogenous multihospital system
Sura, GH, Thrall, MJ, Rogers, J, Hodjat, P, Christensen, P, Cubb, TD, Khadra, HS, Thomas, JS & Jacobi, EM 2024, , Diagnostic Cytopathology, vol. 52, no. 2, pp. 82-92. https://doi.org/10.1002/dc.25250

Signals of Significantly Increased Vaccine Breakthrough, Decreased Hospitalization Rates, and Less Severe Disease in Patients with Coronavirus Disease 2019 Caused by the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2 in Houston, Texas
Christensen, PA, Olsen, RJ, Long, SW, Snehal, R, Davis, JJ, Ojeda Saavedra, M, Reppond, K, Shyer, MN, Cambric, J, Gadd, R, Thakur, RM, Batajoo, A, Mangham, R, Pena, S, Trinh, T, Kinskey, JC, Williams, G, Olson, R, Gollihar, J & Musser, JM 2022, , American Journal of Pathology, vol. 192, no. 4, pp. 642-652. https://doi.org/10.1016/j.ajpath.2022.01.007

Delta Variants of SARS-CoV-2 Cause Significantly Increased Vaccine Breakthrough COVID-19 Cases in Houston, Texas
Christensen, PA, Olsen, RJ, Long, SW, Subedi, S, Davis, JJ, Hodjat, P, Walley, DR, Kinskey, JC, Ojeda Saavedra, M, Pruitt, L, Reppond, K, Shyer, MN, Cambric, J, Gadd, R, Thakur, RM, Batajoo, A, Mangham, R, Pena, S, Trinh, T, Yerramilli, P, Nguyen, M, Olson, R, Snehal, R, Gollihar, J & Musser, JM 2022, , American Journal of Pathology, vol. 192, no. 2, pp. 320-331. https://doi.org/10.1016/j.ajpath.2021.10.019

Classification of cervical biopsy free-text diagnoses through linear-classifier based natural language processing
Hsu, JWC, Christensen, P, Ge, Y & Long, SW 2022, , Journal of Pathology Informatics, vol. 13, 100123, pp. 100123. https://doi.org/10.1016/j.jpi.2022.100123

A 57-year-old woman with falls, slurred speech, and abnormal MRI signal in the pons, middle cerebellar peduncles, and cerebellum
Holloman, A, Panchal, S, Mistry, E, Monroig-Bosque, P, Christensen, P, Lai, E & Cykowski, M 2022, , Brain Pathology, vol. 32, no. 4, e13072, pp. e13072. https://doi.org/10.1111/bpa.13072

Analysis of the ARTIC Version 3 and Version 4 SARS-CoV-2 Primers and Their Impact on the Detection of the G142D Amino Acid Substitution in the Spike Protein
Davis, JJ, Wesley Long, S, Christensen, PA, Olsen, RJ, Olson, R, Shukla, M, Subedi, S, Stevens, R & Musser, JM 2021, , Microbiology Spectrum, vol. 9, no. 3, e01803. https://doi.org/10.1128/SPECTRUM.01803-21

Real-world Assessment of 2879 COVID-19 Patients Treated With Monoclonal Antibody Therapy: A Propensity Score-Matched Cohort Study
Cooper, MH, Christensen, PA, Salazar, E, Perez, KK, Graviss, EA, Nguyen, D, Musser, JM, Huang, HJ & Liebl, MG 2021, , Open Forum Infectious Diseases, vol. 8, no. 11, ofab512, pp. ofab512. https://doi.org/10.1093/ofid/ofab512, https://doi.org/10.1093/ofid/ofab512

Real-world Assessment of 2879 COVID-19 Patients Treated With Monoclonal Antibody Therapy: A Propensity Score-Matched Cohort Study
Cooper, MH, Christensen, PA, Salazar, E, Perez, KK, Graviss, EA, Nguyen, D, Musser, JM, Huang, HJ & Liebl, MG 2021, , Open Forum Infectious Diseases, vol. 8, no. 11, pp. ofab512. https://doi.org/10.1093/ofid/ofab512

The reemergence of seasonal respiratory viruses in Houston, Texas, after Relaxing COVID-19 restrictions
Hodjat, P, Christensen, PA, Subedi, S, Bernard, DW, Olsen, RJ & Long, SW 2021, , Microbiology Spectrum, vol. 9, no. 2, e00430-21. https://doi.org/10.1128/Spectrum.00430-21

Trajectory of Growth of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants in Houston, Texas, January through May 2021, Based on 12,476 Genome Sequences
Olsen, RJ, Christensen, PA, Long, SW, Subedi, S, Hodjat, P, Olson, R, Nguyen, M, Davis, JJ, Yerramilli, P, Saavedra, MO, Pruitt, L, Reppond, K, Shyer, MN, Cambric, J, Gadd, R, Thakur, RM, Batajoo, A, Finkelstein, IJ, Gollihar, J & Musser, JM 2021, , American Journal of Pathology, vol. 191, no. 10, pp. 1754-1773. https://doi.org/10.1016/j.ajpath.2021.07.002

Limited window for donation of convalescent plasma with high live-virus neutralizing antibody titers for COVID-19 immunotherapy
Gontu, A, Srinivasan, S, Salazar, E, Nair, MS, Nissly, RH, Greenawalt, D, Bird, IM, Herzog, CM, Ferrari, MJ, Poojary, I, Katani, R, Lindner, SE, Minns, AM, Rossi, R, Christensen, PA, Castillo, B, Chen, J, Eagar, TN, Yi, X, Zhao, P, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J, Kuchipudi, SV, Musser, JM & Kapur, V 2021, , Communications Biology, vol. 4, no. 1, 267. https://doi.org/10.1038/s42003-021-01813-y

Identifying possible germline variants from tumor-only sequencing of hematological malignancies
Shao, J, Subedi, S, Pepper, K, Badgett, S, Christensen, PA, Hendrickson, HL, Thomas, JS, Olsen, RJ & Li, Z 2021, , Leukemia and Lymphoma, vol. 62, no. 2, pp. 482-485. https://doi.org/10.1080/10428194.2020.1832665

Implementing flowDensity for automated analysis of bone marrow lymphocyte population
Eskandari, G, Subedi, S, Christensen, P, Olsen, RJ, Zu, Y & Long, SW 2021, , Journal of Pathology Informatics, vol. 12, no. 1. https://doi.org/10.4103/JOPI.JOPI_12_21

Sequence Analysis of 20,453 Severe Acute Respiratory Syndrome Coronavirus 2 Genomes from the Houston Metropolitan Area Identifies the Emergence and Widespread Distribution of Multiple Isolates of All Major Variants of Concern
Long, SW, Olsen, RJ, Christensen, PA, Subedi, S, Olson, R, Davis, JJ, Saavedra, MO, Yerramilli, P, Pruitt, L, Reppond, K, Shyer, MN, Cambric, J, Finkelstein, IJ, Gollihar, J & Musser, JM 2021, , American Journal of Pathology, vol. 191, no. 6, pp. 983-992. https://doi.org/10.1016/j.ajpath.2021.03.004

Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization
Salazar, E, Kuchipudi, SV, Christensen, PA, Eagar, T, Yi, X, Zhao, P, Jin, Z, Long, SW, Olsen, RJ, Chen, J, Castillo, B, Leveque, C, Towers, D, Lavinder, J, Gollihar, J, Cardona, J, Ippolito, G, Nissly, R, Bird, I, Greenawalt, D, Rossi, RM, Gontu, A, Srinivasan, S, Poojary, I, Cattadori, IM, Hudson, PJ, Josleyn, NM, Prugar, L, Huie, K, Herbert, A, Bernard, DW, Dye, JM, Kapur, V & Musser, JM 2020, , Journal of Clinical Investigation, vol. 130, no. 12, pp. 6728-6738. https://doi.org/10.1172/JCI141206

Treatment of Coronavirus Disease 2019 Patients with Convalescent Plasma Reveals a Signal of Significantly Decreased Mortality
Salazar, E, Christensen, PA, Graviss, EA, Nguyen, DT, Castillo, B, Chen, J, Lopez, BV, Eagar, TN, Yi, X, Zhao, P, Rogers, J, Shehabeldin, A, Joseph, D, Leveque, C, Olsen, RJ, Bernard, DW, Gollihar, J & Musser, JM 2020, , American Journal of Pathology, vol. 190, no. 11, pp. 2290-2303. https://doi.org/10.1016/j.ajpath.2020.08.001

Molecular architecture of early dissemination and massive second wave of the SARS-CoV-2 virus in a major metropolitan area
Long, SW, Olsen, RJ, Christensen, PA, Bernard, DW, Davis, JJ, Shukla, M, Nguyen, M, Saavedra, MO, Yerramilli, P, Pruitt, L, Subedi, S, Kuo, HC, Hendrickson, H, Eskandari, G, Nguyen, HAT, Long, JH, Kumaraswami, M, Goike, J, Boutz, D, Gollihar, J, McLellan, JS, Chou, CW, Javanmardi, K, Finkelstein, IJ & Musser, JM 2020, , mBio, vol. 11, no. 6, e02707-20, pp. 1-30. https://doi.org/10.1128/mBio.02707-20

Treatment of Coronavirus Disease 2019 (COVID-19) Patients with Convalescent Plasma
Salazar, E, Perez, KK, Ashraf, M, Chen, J, Castillo, B, Christensen, PA, Eubank, T, Bernard, DW, Eagar, TN, Long, SW, Subedi, S, Olsen, RJ, Leveque, C, Schwartz, MR, Dey, M, Chavez-East, C, Rogers, J, Shehabeldin, A, Joseph, D, Williams, G, Thomas, K, Masud, F, Talley, C, Dlouhy, KG, Lopez, BV, Hampton, C, Lavinder, J, Gollihar, JD, Maranhao, AC, Ippolito, GC, Saavedra, MO, Cantu, CC, Yerramilli, P, Pruitt, L & Musser, JM 2020, , American Journal of Pathology, vol. 190, no. 8, pp. 1680-1690. https://doi.org/10.1016/j.ajpath.2020.05.014

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