Patricia Chévez-Barrios, MD

Professor of Pathology and Genomic Medicine, Institute for Academic Medicine
Full Clinical Member, Research Institute
Program Director, Ophthalmic Pathology Residency, Department of Pathology & Genomic Medicine
Houston Methodist
Weill Cornell Medical College


Research Lab


Biography

After finishing all seven of her postdoctoral training programs, Dr. Chévez-Barrios joined the faculty of the Baylor College of Medicine in 1996 as an Assistant Professor in the Department of Pathology, with a secondary appointment in the Department of Ophthalmology. She became a Clinical Assistant Professor in the Department of Ophthalmology there in 2004, and received the Fulbright & Jaworski LLP Award for Faculty Excellence in Teaching and Evaluation and became Associate Member of the Cell and Gene Therapy Center that same year. She has current appointments of adjunct professor in the Department of Pathology at The University of Texas MD Anderson Cancer Center and Department of Ophthalmology at the Baylor College of Medicine. Dr. Chévez- Barrios assumed her current positions at Methodist in 2004.

Description of Research

The main research interest of Dr. Chévez-Barrios and her laboratory is the study of retinoblastoma, including cancer stem cells, suicide gene therapy for retinoblastoma, the study of metastatic properties of retinoblastoma and preclinical models of the tumor. Other topics of interest are ocular gene therapy, cataractogenesis, vascular proliferation in hypoxic ocular diseases and corneal diseases. Dr. Chevez-Barrios’ laboratory is currently participating in the project of gene therapy for Retinoblastomas in collaboration with the Texas Children’s Cancer Center and the Center for Gene Therapy of Texas Children's Hospital, and Baylor College of Medicine. Pre-clinical studies and a phase 1 clinical trial of vitreous seed of retinoblastoma have been completed. The phase II clinical trial is in preparation. Dr. Chevez-Barrios is a committee member responsible of evaluating all enucleated eyes from the prospective multicenter study of the ARET0332 Children’s Oncology Group protocol on “A Study of Unilateral Retinoblastoma With and Without Histopathologic High-Risk Features and the Role of Adjuvant Chemotherapy. Dr. Chevez-Barrios is also interested in the biological differences between retinoblastoma cell lines that have the capability of producing metastasis, and those that behave less aggressively and remain as intraocular tumors.

Areas Of Expertise

Retinoblastoma Metastasis Gene therapy Neovascularization
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, Universidad Nacional Autonoma
Publications

Neuro-Ophthalmic Manifestations of Pituitary Carcinoma
Chang, EA, Shah, R, Smith, SV, Sadaka, A, Ortiz Gomez, J, Chevez-Barrios, P & Lee, AG 2018, Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. DOI: 10.1097/WNO.0000000000000620

Orbital Inflammatory Syndrome Secondary to Flea Bite
Prospero Ponce, CM, Malik, AI, Vickers, A, Chevez-Barrios, P & Lee, AG 2018, Plastic and Reconstructive Surgery. DOI: 10.1097/IOP.0000000000001115

Perineurial-like Cells and EMA Expression in the Suprachoroidal Region of the Human Eye
Gilbert, AR, Chévez-Barrios, P & Cykowski, MD 2018, Journal of Histochemistry and Cytochemistry. DOI: 10.1369/0022155418756308

Characterizing Anterior Segment OCT Angle Landmarks of the Trabecular Meshwork Complex
Crowell, EL, Baker, L, Chuang, AZ, Feldman, RM, Bell, NP, Chévez-Barrios, P & Blieden, LS 2018, Ophthalmology. DOI: 10.1016/j.ophtha.2018.01.018

Eye, Ocular Adnexa, and Orbit
Chévez-Barrios, P & Ortiz, JD 2018, . in D Mody, I Ramzy & R Laucirica (eds), Clinical Cytopathology: Fundamental Principles and Practice. 3rd edn, McGraw Hill Education, pp. 85-98.

Proteolytic Degradation and Inflammation Play Critical Roles in Polypoidal Choroidal Vasculopathy
Kumar, S, Nakashizuka, H, Jones, A, Lambert, A, Zhao, X, Shen, M, Parker, M, Wang, S, Berriochoa, Z, Fnu, A, VanBeuge, S, Chévez-Barrios, P, Tso, M, Rainier, J & Fu, Y 2017, American Journal of Pathology, vol 187, no. 12, pp. 2841-2857. DOI: 10.1016/j.ajpath.2017.08.025

Screening Children at Risk for Retinoblastoma. Consensus Report from the American Association of Ophthalmic Oncologists and Pathologists
Skalet, AH, Gombos, DS, Gallie, BL, Kim, JW, Shields, CL, Marr, BP, Plon, SE & Chévez-Barrios, P 2017, Ophthalmology. DOI: 10.1016/j.ophtha.2017.09.001

Rabbit model of ocular indirect photodynamic therapy using a retinoblastoma xenograft
Kim, JW, Jacobsen, B, Zolfaghari, E, Ferrario, A, Chevez-Barrios, P, Berry, JL, Lee, DK, Rico, G, Madi, I, Rao, N, Stachelek, K, Wang, LC & Gomer, C 2017, Graefes Archive for Clinical and Experimental Ophthalmology, pp. 1-11. DOI: 10.1007/s00417-017-3805-8

Perineural spread of basosquamous carcinoma to the orbit, cavernous sinus, and infratemporal fossa
Amram, AL, Hertzing, WJ, Smith, SV, Chévez-Barrios, P & Lee, AG 2017, Orbit, pp. 1-5. DOI: 10.1080/01676830.2017.1383462

Vitreous Seeds in Retinoblastoma. Clinicopathologic Classification and Correlation
Amram, AL, Rico, G, Kim, JW, Chintagumpala, M, Herzog, CE, Gombos, DS & Chévez-Barrios, P 2017, Ophthalmology. DOI: 10.1016/j.ophtha.2017.04.015

Nothing to Spit At
Hashemi, N, Billah, S, Conderman, CP, Alava, I, Supsupin, EP, Chevez-Barrios, P & Adesina, OOO 2017, Journal of Neuro-Ophthalmology. DOI: 10.1097/WNO.0000000000000504

Orbital metastasis mimicking internuclear ophthalmoplegia: A case report and review
Lin, WV, Chévez-Barrios, P, Sadaka, A & Lee, AG 2016, Canadian Journal of Ophthalmology. DOI: 10.1016/j.jcjo.2017.01.017

Histopathologic Analysis of Transvitreal Fine Needle Aspiration Biopsy Needle Tracts for Uveal Melanoma
Kim, RS, Chevez-Barrios, P, Bretana, ME, Wong, TP, Teh, BS & Schefler, AC 2017, American Journal of Ophthalmology, vol 174, pp. 9-16. DOI: 10.1016/j.ajo.2016.10.019

Early outcomes of uveal melanoma treated with intraoperative ultrasound guided brachytherapy using custom built plaques
Tann, AW, Teh, BS, Scarboro, SB, Lewis, GD, Bretana, ME, Croft, PC, Raizen, Y, Butler, EB, Kim, RS, Chevez-Barrios, P & Schefler, AC 2017, Practical Radiation Oncology. DOI: 10.1016/j.prro.2017.01.002

RecutClub.com: An Open Source, Whole Slide Image-based Pathology Education System
Christensen, PA, Lee, NE, Thrall, MJ, Powell, SZ, Chevez-Barrios, P & Long, SW 2017, Journal of Pathology Informatics, vol 8, no. 10, pp. 10. DOI: 10.4103/jpi.jpi_72_16

Microsporidial Stromal Keratitis: Successful Treatment with Topical Voriconazole and Oral Itraconazole
Coca, M, Kim, J, Shenoy, S, Chévez-Barrios, P & Kapur, M 2016, Cureus, vol 8, no. 12, pp. e934. DOI: 10.7759/cureus.934

Necrotizing Fasciitis of the Periorbital Region Complicated by Combined Central Retinal Artery Occlusion, Central Retinal Vein Occlusion, and Posterior Ciliary Occlusion
Sultan, H, Malik, A, Li, HK, Chévez-Barrios, P & Lee, AG 2016, Ophthalmic Plastic and Reconstructive Surgery. DOI: 10.1097/IOP.0000000000000770

Correlation of Insurance, Race, and Ethnicity with Pathologic Risk in a Controlled Retinoblastoma Cohort. A Children's Oncology Group Study
Green, AL, Chintagumpala, M, Krailo, M, Langholz, B, Albert, D, Eagle, R, Cockburn, M, Chevez-Barrios, P & Rodriguez-Galindo, C 2015, Ophthalmology. DOI: 10.1016/j.ophtha.2016.04.043

Acute and late toxicity of bilateral orbital irradiation in the management of primary intraocular lymphoma
Milgrom, SA, Cheah, CY, Pinnix, CC, Smith, GL, Dabaja, BS, Horace, P, Chevez-Barrios, P, Fowler, NH & Gombos, DS 2016, Leukemia and Lymphoma, pp. 1-7. DOI: 10.3109/10428194.2016.1166490

Idiopathic Orbital Inflammation Associated with Relapsing Polychondritis
Mariani, AF, Malik, AI, Chevez-Barrios, P, Smith, SV & Lee, AG 2016, Ophthalmic Plastic and Reconstructive Surgery. DOI: 10.1097/IOP.0000000000000667