Patricia Chévez-Barrios, MD

Professor of Pathology and Genomic Medicine, Academic Institute
Full Clinical Member, Research Institute
Program Director, Ophthalmic Pathology Residency, Department of Pathology & Genomic Medicine
Houston Methodist
Weill Cornell Medical College


Research Lab


Biography

After finishing all seven of her postdoctoral training programs, Dr. Chévez-Barrios joined the faculty of the Baylor College of Medicine in 1996 as an Assistant Professor in the Department of Pathology, with a secondary appointment in the Department of Ophthalmology. She became a Clinical Assistant Professor in the Department of Ophthalmology there in 2004, and received the Fulbright & Jaworski LLP Award for Faculty Excellence in Teaching and Evaluation and became Associate Member of the Cell and Gene Therapy Center that same year. She has current appointments of adjunct professor in the Department of Pathology at The University of Texas MD Anderson Cancer Center and Department of Ophthalmology at the Baylor College of Medicine. Dr. Chévez- Barrios assumed her current positions at Methodist in 2004.

Description of Research

The main research interest of Dr. Chévez-Barrios and her laboratory is the study of retinoblastoma, including cancer stem cells, suicide gene therapy for retinoblastoma, the study of metastatic properties of retinoblastoma and preclinical models of the tumor. Other topics of interest are ocular gene therapy, cataractogenesis, vascular proliferation in hypoxic ocular diseases and corneal diseases. Dr. Chevez-Barrios’ laboratory is currently participating in the project of gene therapy for Retinoblastomas in collaboration with the Texas Children’s Cancer Center and the Center for Gene Therapy of Texas Children's Hospital, and Baylor College of Medicine. Pre-clinical studies and a phase 1 clinical trial of vitreous seed of retinoblastoma have been completed. The phase II clinical trial is in preparation. Dr. Chevez-Barrios is a committee member responsible of evaluating all enucleated eyes from the prospective multicenter study of the ARET0332 Children’s Oncology Group protocol on “A Study of Unilateral Retinoblastoma With and Without Histopathologic High-Risk Features and the Role of Adjuvant Chemotherapy. Dr. Chevez-Barrios is also interested in the biological differences between retinoblastoma cell lines that have the capability of producing metastasis, and those that behave less aggressively and remain as intraocular tumors.

Areas Of Expertise

Retinoblastoma Metastasis Gene therapy Neovascularization
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, Universidad Nacional Autonoma
Publications

AUTOSOMAL DOMINANT MÜLLER CELL SHEEN DYSTROPHY: Clinical, Histopathologic, and Genetic Assessment in an Extended Family with Long Follow-Up
Dalma-Weiszhausz, J, Chacón-Camacho, O, Chevez-Barrios, P, Zenteno, JC, Franco-Cárdenas, V, García-Montaño, LA, Pérez-Bravo, J, García-Montalvo, IA, Jiménez-Sierra, JM & Dalma, A 2022, , Retina, vol. 42, no. 5, pp. 981-991. https://doi.org/10.1097/IAE.0000000000003413

Central nervous system hemorrhage due to chronic lymphocytic leukemia
Raviskanthan, S, Hall, MN, Mortensen, PW, Chévez-Barrios, P & Lee, AG 2022, , Canadian Journal of Ophthalmology, vol. 57, no. 2, pp. e56-e59. https://doi.org/10.1016/j.jcjo.2021.06.021

Three-year outcomes of uveal melanoma treated with intra-operative ultrasound-guided iodine-125 brachytherapy using custom-built eye plaques
Wong, AJ, Teh, BS, Nguyen, BT, Pino, R, Bretana, ME, Bernicker, EH, Chevez-Barrios, P, Butler, EB & Schefler, AC 2022, , Journal of Contemporary Brachytherapy, vol. 14, no. 2, pp. 130-139. https://doi.org/10.5114/jcb.2022.115379

Optic Perineuritis in Waldenström Macroglobulinemia-Related Cryoglobulinemic Vasculitis
Raviskanthan, S, Mortensen, PW, Chevez-Barrios, P, Kim, RY, Desai, MD & Lee, AG 2022, , Journal of Neuro-Ophthalmology, vol. 42, no. 1, pp. E306-E309. https://doi.org/10.1097/WNO.0000000000001406

Calciphylaxis a Giant Cell Arteritis Mimic: A Case Report and Review of the Literature
Duong, AA, Bhat, N, Bindiganavile, SH, Chevez-Barrios, P & Lee, AG 2022, , Journal of Neuro-Ophthalmology, vol. 42, no. 1, pp. E362-E366. https://doi.org/10.1097/WNO.0000000000001395

Contemporary trends in management of uveal melanoma
Chevli, N, Zuhour, RJ, Messer, JA, Haque, W, Schefler, AC, Bernicker, EH, Chevez-Barrios, P, Farach, AM, Butler, EB & Teh, BS 2022, , Journal of Contemporary Brachytherapy, vol. 14, no. 2, pp. 123-129. https://doi.org/10.5114/jcb.2022.115210

Microsporidial Stromal Keratitis: Epidemiological Features, Slit-Lamp Biomicroscopic Characteristics, and Therapy
Matoba, A, Goosey, J & Chévez-Barrios, P 2021, , Cornea, vol. 40, no. 12, pp. 1532-1540. https://doi.org/10.1097/ICO.0000000000002704

Juxtaposed Homonymous Hemianopsia Due to Neurotuberculosis
Wheelock-Gutierrez, L, Harish Bindiganavile, S, Chévez-Barrios, P, Fuller, GN, Bhat, N & Lee, AG 2021, , Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, vol. 41, no. 3, pp. e303-e306. https://doi.org/10.1097/WNO.0000000000001085

Giant cell arteritis versus Takayasu's Arteritis: Two sides of the same coin?
Mortensen, PW, Raviskanthan, S, Chévez-Barrios, P & Lee, AG 2021, , Saudi Journal of Ophthalmology, vol. 35, no. 3, pp. 198-203. https://doi.org/10.4103/SJOPT.SJOP_152_21

Establishing the clinical utility of ctdna analysis for diagnosis, prognosis, and treatment monitoring of retinoblastoma: The aqueous humor liquid biopsy
Xu, L, Kim, ME, Polski, A, Prabakar, RK, Shen, L, Peng, CC, Reid, MW, Chévez-Barrios, P, Kim, JW, Shah, R, Jubran, R, Kuhn, P, Cobrinik, D, Biegel, JA, Gai, X, Hicks, J & Berry, JL 2021, , Cancers, vol. 13, no. 6, 1282, pp. 1-15. https://doi.org/10.3390/cancers13061282

Is It Always Better to Get Faster Results in Temporal Artery Biopsies?
Chévez-Barrios, P 2021, , JAMA Ophthalmology, vol. 139, no. 4, pp. 413-414. https://doi.org/10.1001/jamaophthalmol.2020.6895

Bilateral orbital inflammation in a 6-month old with SARS-CoV-2 infection
Dermarkarian, CR, Chilakapati, M, Hussein, M, Chévez-Barrios, P & Allen, RC 2021, , Orbit (London), vol. 41, no. 5, pp. 1-4. https://doi.org/10.1080/01676830.2021.1914670

Bilateral acquired nasolacrimal duct obstruction secondary to amyloidosis in a 15-year-old
Dermarkarian, CR, Bhatt, A, Chévez-Barrios, P & Allen, RC 2021, , Journal of AAPOS, vol. 25, no. 2, pp. 126-128. https://doi.org/10.1016/j.jaapos.2020.11.011

Locally Invasive Diffuse Iris Ring Melanoma Presenting as Unilateral Severe Glaucoma: Case Report and Review of Molecular Genetics
Naguib, MM, Chévez-Barrios, P, Orengo-Nania, S & Schefler, AC 2021, , Case Reports in Oncology, vol. 14, no. 1, pp. 403-410. https://doi.org/10.1159/000512012

Defining High-risk Retinoblastoma: A Multicenter Global Survey
Kaliki, S, Shields, CL, Cassoux, N, Munier, FL, Chantada, G, Grossniklaus, HE, Yoshikawa, H, Fabian, ID, Berry, JL, McKenzie, JD, Kimani, K, Reddy, MA, Parulekar, M, Tanabe, M, Furuta, M, Grigorovski, N, Chevez-Barrios, P, Scanlan, P, Eagle, RC, Rashid, R, Coronado, RD, Sultana, S, Staffieri, S, Frenkel, S, Suzuki, S, Ushakova, TL, Ji, X & Kaliki, S 2022, , JAMA Ophthalmology, vol. 140, no. 1, pp. 30-36. https://doi.org/10.1001/jamaophthalmol.2021.4732

Infectious keratitis as the presenting sign of giant cell arteritis
Kamal, S, Al Othman, B, Kini, A, Beaver, HA, Chaudhry, I, Prospero Ponce, CM, Chévez-Barrios, P & Lee, AG 2020, , Canadian Journal of Ophthalmology, vol. 55, no. 5, pp. e182-e185. https://doi.org/10.1016/j.jcjo.2020.02.003

An Update on Endocrine Mucin-producing Sweat Gland Carcinoma: Clinicopathologic Study of 63 Cases and Comparative Analysis
Agni, M, Raven, ML, Bowen, RC, Laver, NV, Chevez-Barrios, P, Milman, T, Eberhart, CG, Couch, S, Bennett, DD, Albert, DM, Hogan, RN, Phelps, PO, Stiefel, H, Mancera, N, Hyrcza, M, Wang, A, Burris, CKH, Steele, EA, Campbell, AA, Potter, HD & Lucarelli, MJ 2020, , American Journal of Surgical Pathology, vol. 44, no. 8, pp. 1005-1016. https://doi.org/10.1097/PAS.0000000000001462

Eye plaque brachytherapy versus enucleation for ocular melanoma: an analysis from the National Cancer Database
Messer, JA, Zuhour, RJ, Haque, W, Lewis, GD, Schefler, AC, Wong, A, Bernicker, EH, Chevez-Barrios, P, Michelle Quan, E, Farach, A, Butler, EB, Hatch, SS & Teh, BS 2020, , Journal of Contemporary Brachytherapy, vol. 12, no. 4, pp. 303-310. https://doi.org/10.5114/jcb.2020.98108

Eye cancer in a young male with a vaping history
Shields, C, Kim, M, Lally, S, Chévez-Barrios, P & Shields, J 2020, , Indian Journal of Ophthalmology, vol. 68, no. 8, pp. 1699-1701. https://doi.org/10.4103/ijo.IJO_27_20

Chromosome 6p amplification in aqueous humor cell-free DNA is a prognostic biomarker for retinoblastoma ocular survival
Xu, L, Polski, A, Prabakar, RK, Reid, MW, Chevez-Barrios, P, Jubran, R, Kim, JW, Kuhn, P, Cobrinik, D, Hicks, J & Berry, JL 2020, , Molecular Cancer Research, vol. 18, no. 8, pp. 1166-1175. https://doi.org/10.1158/1541-7786.MCR-19-1262