Patricia Chévez-Barrios, MD

Professor of Pathology and Genomic Medicine, Academic Institute
Full Clinical Member, Research Institute
Program Director, Ophthalmic Pathology Residency, Department of Pathology & Genomic Medicine
Houston Methodist
Weill Cornell Medical College

Research Lab


After finishing all seven of her postdoctoral training programs, Dr. Chévez-Barrios joined the faculty of the Baylor College of Medicine in 1996 as an Assistant Professor in the Department of Pathology, with a secondary appointment in the Department of Ophthalmology. She became a Clinical Assistant Professor in the Department of Ophthalmology there in 2004, and received the Fulbright & Jaworski LLP Award for Faculty Excellence in Teaching and Evaluation and became Associate Member of the Cell and Gene Therapy Center that same year. She has current appointments of adjunct professor in the Department of Pathology at The University of Texas MD Anderson Cancer Center and Department of Ophthalmology at the Baylor College of Medicine. Dr. Chévez- Barrios assumed her current positions at Methodist in 2004.

Description of Research

The main research interest of Dr. Chévez-Barrios and her laboratory is the study of retinoblastoma, including cancer stem cells, suicide gene therapy for retinoblastoma, the study of metastatic properties of retinoblastoma and preclinical models of the tumor. Other topics of interest are ocular gene therapy, cataractogenesis, vascular proliferation in hypoxic ocular diseases and corneal diseases. Dr. Chevez-Barrios’ laboratory is currently participating in the project of gene therapy for Retinoblastomas in collaboration with the Texas Children’s Cancer Center and the Center for Gene Therapy of Texas Children's Hospital, and Baylor College of Medicine. Pre-clinical studies and a phase 1 clinical trial of vitreous seed of retinoblastoma have been completed. The phase II clinical trial is in preparation. Dr. Chevez-Barrios is a committee member responsible of evaluating all enucleated eyes from the prospective multicenter study of the ARET0332 Children’s Oncology Group protocol on “A Study of Unilateral Retinoblastoma With and Without Histopathologic High-Risk Features and the Role of Adjuvant Chemotherapy. Dr. Chevez-Barrios is also interested in the biological differences between retinoblastoma cell lines that have the capability of producing metastasis, and those that behave less aggressively and remain as intraocular tumors.

Areas Of Expertise

Retinoblastoma Metastasis Gene therapy Neovascularization
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, Universidad Nacional Autonoma

Cytomegalovirus Retinitis in an Eye with Unilateral Retinoblastoma: A Case Report
Meller, L, Jagadeesh, V, Oca, M, Wilson, K, Zuraski, C, Koretz, ZA, Chevez-Barrios, P, Liu, C, Berry, JL & Scott, NL 2024, , Case Reports in Ophthalmology, vol. 15, no. 1, pp. 476-482.

A multi-institutional feasibility study of intra-arterial chemotherapy in children with retinoblastoma. A Children's Oncology Group study (COG ARET12P1)
Chintagumpala, M, Piao, J, Gombos, D, Chévez-Barrios, P, Brock, L, Dunkel, IJ, Jubran, R, Leahey, AM, Kim, J, OBrien, J, Shields, CL & Rodriguez-Galindo, C 2024, , Pediatric Blood and Cancer, vol. 71, no. 1, e30718, pp. e30718.

Unilateral acute iris transillumination syndrome with glaucoma and iris pigment epithelium dispersion simulating iris melanoma
Gonzalez Martinez, OG, Shields, CL, Shields, JA, Chévez-Barrios, P, Walley, DR, Eagle, RC & Milman, T 2023, , American Journal of Ophthalmology Case Reports, vol. 32, 101912, pp. 101912.

Mehta, N, Scholle, T, Chevez-Barrios, P, Schefler, AC & Weng, CY 2023, , Retinal Cases and Brief Reports, vol. 17, no. 5, pp. 567-571.

Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma
Jayabal, P, Zhou, F, Ma, X, Bondra, KM, Blackman, B, Weintraub, ST, Chen, Y, Chévez-Barrios, P, Houghton, PJ, Gallie, B & Shiio, Y 2023, , Cell Reports, vol. 42, no. 2, 112103.

Retinoblastoma with MYCN Amplification Diagnosed from Cell-Free DNA in the Aqueous Humor
Joseph, S, Pike, S, Peng, CC, Brown, B, Xu, L, Berry, JL, Chévez-Barrios, P, Hubbard, GB & Grossniklaus, HE 2023, , Ocular Oncology and Pathology, vol. 10, no. 1, pp. 15-24.

Symptomatic iris varix with enlargement following argon laser
Long, GC, Chamberlain, P, Chévez-Barrios, P & Hamill, MB 2022, , Canadian Journal of Ophthalmology, vol. 57, no. 5, pp. e186-e187.

Metastatic retinoblastoma
Lin, FY, Chévez-Barrios, P & Chintagumpala, M 2022, . in Retinoblastoma: Diagnosis to Management. Nova Science Publishers, Inc. pp. 281-296.

AUTOSOMAL DOMINANT MÜLLER CELL SHEEN DYSTROPHY: Clinical, Histopathologic, and Genetic Assessment in an Extended Family with Long Follow-Up
Dalma-Weiszhausz, J, Chacón-Camacho, O, Chevez-Barrios, P, Zenteno, JC, Franco-Cárdenas, V, García-Montaño, LA, Pérez-Bravo, J, García-Montalvo, IA, Jiménez-Sierra, JM & Dalma, A 2022, , Retina, vol. 42, no. 5, pp. 981-991.

Central nervous system hemorrhage due to chronic lymphocytic leukemia
Raviskanthan, S, Hall, MN, Mortensen, PW, Chévez-Barrios, P & Lee, AG 2022, , Canadian Journal of Ophthalmology, vol. 57, no. 2, pp. e56-e59.

Contemporary trends in management of uveal melanoma
Chevli, N, Zuhour, RJ, Messer, JA, Haque, W, Schefler, AC, Bernicker, EH, Chevez-Barrios, P, Farach, AM, Butler, EB & Teh, BS 2022, , Journal of Contemporary Brachytherapy, vol. 14, no. 2, pp. 123-129.

Three-year outcomes of uveal melanoma treated with intra-operative ultrasound-guided iodine-125 brachytherapy using custom-built eye plaques
Wong, AJ, Teh, BS, Nguyen, BT, Pino, R, Bretana, ME, Bernicker, EH, Chevez-Barrios, P, Butler, EB & Schefler, AC 2022, , Journal of Contemporary Brachytherapy, vol. 14, no. 2, pp. 130-139.

Optic Perineuritis in Waldenström Macroglobulinemia-Related Cryoglobulinemic Vasculitis
Raviskanthan, S, Mortensen, PW, Chevez-Barrios, P, Kim, RY, Desai, MD & Lee, AG 2022, , Journal of Neuro-Ophthalmology, vol. 42, no. 1, pp. E306-E309.

Calciphylaxis a Giant Cell Arteritis Mimic: A Case Report and Review of the Literature
Duong, AA, Bhat, N, Bindiganavile, SH, Chevez-Barrios, P & Lee, AG 2022, , Journal of Neuro-Ophthalmology, vol. 42, no. 1, pp. E362-E366.

Malignant teratoid intraocular ciliary body medulloepithelioma in a 5-year-old male with corresponding somatic copy number alteration profile of aqueous humor cell-free DNA
Pike, S, Iyengar, R, Peng, CC, Chevez-Barrios, P, Brown, B, Shah, R, Biegel, J, Yellapantula, V, Nagiel, A, Reiser, BJ, Xu, L & Berry, JL 2022, , Ophthalmic Genetics, vol. 43, no. 6, pp. 855-861.

Pathology of the Optic Nerve and Extraocular Muscle
Chévez-Barrios, P & Cykowski, MD 2022, . in Albert and Jakobiecs Principles and Practice of Ophthalmology: Fourth Edition. Springer International Publishing, pp. 6489-6524.

Microsporidial Stromal Keratitis: Epidemiological Features, Slit-Lamp Biomicroscopic Characteristics, and Therapy
Matoba, A, Goosey, J & Chévez-Barrios, P 2021, , Cornea, vol. 40, no. 12, pp. 1532-1540.

Juxtaposed Homonymous Hemianopsia Due to Neurotuberculosis
Wheelock-Gutierrez, L, Harish Bindiganavile, S, Chévez-Barrios, P, Fuller, GN, Bhat, N & Lee, AG 2021, , Journal of Neuro-Ophthalmology, vol. 41, no. 3, pp. E303-E306.

Novel Diagnosis of the Diffuse Variant of Infantile Orbital Fibromatosis
Matharu, KS, Sweeney, AR, Chévez-Barrios, P, Edmond, JC, Marx, DP, Allen, RC & Shah, VS 2021, , Journal of Neuro-Ophthalmology, vol. 41, no. 3, pp. E316-E318.

Giant cell arteritis versus Takayasu's Arteritis: Two sides of the same coin?
Mortensen, PW, Raviskanthan, S, Chévez-Barrios, P & Lee, AG 2021, , Saudi Journal of Ophthalmology, vol. 35, no. 3, pp. 198-203.