Patricia Chévez-Barrios, MD

Professor of Pathology and Genomic Medicine, Institute for Academic Medicine
Full Clinical Member, Research Institute
Program Director, Ophthalmic Pathology Residency, Department of Pathology & Genomic Medicine
Houston Methodist
Weill Cornell Medical College


Research Lab


Biography

After finishing all seven of her postdoctoral training programs, Dr. Chévez-Barrios joined the faculty of the Baylor College of Medicine in 1996 as an Assistant Professor in the Department of Pathology, with a secondary appointment in the Department of Ophthalmology. She became a Clinical Assistant Professor in the Department of Ophthalmology there in 2004, and received the Fulbright & Jaworski LLP Award for Faculty Excellence in Teaching and Evaluation and became Associate Member of the Cell and Gene Therapy Center that same year. She has current appointments of adjunct professor in the Department of Pathology at The University of Texas MD Anderson Cancer Center and Department of Ophthalmology at the Baylor College of Medicine. Dr. Chévez- Barrios assumed her current positions at Methodist in 2004.

Description of Research

The main research interest of Dr. Chévez-Barrios and her laboratory is the study of retinoblastoma, including cancer stem cells, suicide gene therapy for retinoblastoma, the study of metastatic properties of retinoblastoma and preclinical models of the tumor. Other topics of interest are ocular gene therapy, cataractogenesis, vascular proliferation in hypoxic ocular diseases and corneal diseases. Dr. Chevez-Barrios’ laboratory is currently participating in the project of gene therapy for Retinoblastomas in collaboration with the Texas Children’s Cancer Center and the Center for Gene Therapy of Texas Children's Hospital, and Baylor College of Medicine. Pre-clinical studies and a phase 1 clinical trial of vitreous seed of retinoblastoma have been completed. The phase II clinical trial is in preparation. Dr. Chevez-Barrios is a committee member responsible of evaluating all enucleated eyes from the prospective multicenter study of the ARET0332 Children’s Oncology Group protocol on “A Study of Unilateral Retinoblastoma With and Without Histopathologic High-Risk Features and the Role of Adjuvant Chemotherapy. Dr. Chevez-Barrios is also interested in the biological differences between retinoblastoma cell lines that have the capability of producing metastasis, and those that behave less aggressively and remain as intraocular tumors.

Areas Of Expertise

Retinoblastoma Metastasis Gene therapy Neovascularization
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, Universidad Nacional Autonoma
Publications

Study of Unilateral Retinoblastoma With and Without Histopathologic High-Risk Features and the Role of Adjuvant Chemotherapy: A Children's Oncology Group Study
Chévez-Barrios, P, Eagle, RC, Krailo, M, Piao, J, Albert, DM, Gao, Y, Vemuganti, G, Ali, MJ, Khetan, V, Honavar, SG, OBrien, J, Leahey, AM, Matthay, K, Meadows, A & Chintagumpala, M 2019, Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol. 37, no. 31, pp. 2883-2891. https://doi.org/10.1200/JCO.18.01808

Chronic myelomonocytic leukemia-related vasculitis mimicking giant cell arteritis
Amin, SD, Vickers, A, Hong, BY, Ponce, CMP, Ibrahim, IF, Chévez-Barrios, P & Lee, AG 2019, Canadian Journal of Ophthalmology, vol. 54, no. 3, pp. e140-e145. https://doi.org/10.1016/j.jcjo.2018.08.017

Anterior Segment Optical Coherence Tomography of Ocular Cystinosis Confirmed by Electron Microscopy
Golla, A, Weikert, MP, Chévez-Barrios, P & Al-Mohtaseb, Z 2019, Ocular Oncology and Pathology, vol. 5, no. 2, pp. 110-113. https://doi.org/10.1159/000490389

Vestibulocochlear symptoms as the initial presentation of giant cell arteritis
Le, N, Vickers, A, Prospero Ponce, C, Chévez-Barrios, P & Lee, AG 2019, Canadian Journal of Ophthalmology, vol. 54, no. 1, pp. e1-e3. https://doi.org/10.1016/j.jcjo.2018.04.006

Technical and anatomical factors affecting intra-arterial chemotherapy fluoroscopy time and radiation dose for intraocular retinoblastoma
Area, C, Yen, CJ, Chévez-Barrios, P, Herzog, C, Kan, P, Zheng, W, Lin, F, Chintagumpala, M, Gambos, D & Chen, SR 2019, Journal of neurointerventional surgery. https://doi.org/10.1136/neurintsurg-2019-014910

Genomic cfDNA analysis of aqueous humor in retinoblastoma predicts eye salvage: The surrogate tumor biopsy for retinoblastoma
Berry, JL, Xu, L, Kooi, I, Murphree, AL, Prabakar, RK, Reid, M, Stachelek, K, Le, BHA, Welter, L, Reiser, BJ, Chévez-Barrios, P, Jubran, R, Lee, TC, Kim, JW, Kuhn, P, Cobrinik, D & Hicks, J 2018, Molecular Cancer Research, vol. 16, no. 11, pp. 1701-1712. https://doi.org/10.1158/1541-7786.MCR-18-0369

Pathologic Markers Determining Prognosis in Patients With Treated or Healing Giant Cell Arteritis
Sultan, H, Smith, SV, Lee, AG & Chévez-Barrios, P 2018, American Journal of Ophthalmology, vol. 193, pp. 45-53. https://doi.org/10.1016/j.ajo.2018.05.031

Reply
Skalet, AH, Gombos, D, Gallie, BL, Kim, JW, Shields, CL, Marr, BP, Plon, SE & Chévez-Barrios, P 2018, Ophthalmology, vol. 125, no. 9, pp. e64-e65. https://doi.org/10.1016/j.ophtha.2018.03.030

Orbital Inflammatory Syndrome Secondary to Flea Bite
Prospero Ponce, CM, Malik, AI, Vickers, A, Chevez-Barrios, P & Lee, AG 2018, Plastic and reconstructive surgery, vol. 34, no. 4, pp. e115-e118. https://doi.org/10.1097/IOP.0000000000001115

Human Papillomavirus-Driven Squamous Lesions: High-Risk Genotype Found in Conjunctival Papillomas, Dysplasia, and Carcinoma
Moyer, AB, Roberts, J, Olsen, RJ & Chévez-Barrios, P 2018, The American Journal of dermatopathology, vol. 40, no. 7, pp. 486-490. https://doi.org/10.1097/DAD.0000000000001139

Yield, techniques, and complications of transvitreal and transscleral biopsies in small uveal melanoma
Kim, RS, Chévez-Barrios, P, Divatia, MK, Bretana, ME, Teh, BS & Schefler, AC 2018, JAMA Ophthalmology, vol. 136, no. 5, pp. 482-488. https://doi.org/10.1001/jamaophthalmol.2018.0561

Clinically Significant Enhancement of Voriconazole Efficacy by Moxifloxacin and Gentamicin in Fungal Keratitis
Matoba, AY, Divatia, MK, Arguello, RA & Chévez-Barrios, P 2018, Cornea, vol. 37, no. 5, pp. 651-654. https://doi.org/10.1097/ICO.0000000000001545

Juvenile Xanthogranuloma in a Pediatric Patient with Langerhans Cell Histiocytosis
Ram, R, Marolf, MD, Chévez-Barrios, P & Herce, HH 2018, Ocular Oncology and Pathology, vol. 4, no. 3, pp. 141-144. https://doi.org/10.1159/000479524

Perineurial-like Cells and EMA Expression in the Suprachoroidal Region of the Human Eye
Gilbert, AR, Chévez-Barrios, P & Cykowski, MD 2018, Journal of Histochemistry and Cytochemistry. https://doi.org/10.1369/0022155418756308

Neuro-Ophthalmic Manifestations of Pituitary Carcinoma
Chang, EA, Shah, R, Smith, SV, Sadaka, A, Ortiz Gomez, J, Chevez-Barrios, P & Lee, AG 2018, Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. https://doi.org/10.1097/WNO.0000000000000620

Eye, Ocular Adnexa, and Orbit
Chévez-Barrios, P & Ortiz, JD 2018, . in D Mody, I Ramzy & R Laucirica (eds), Clinical Cytopathology: Fundamental Principles and Practice. 3rd edn, McGraw Hill Education, pp. 85-98.

Characterizing Anterior Segment OCT Angle Landmarks of the Trabecular Meshwork Complex
Crowell, EL, Baker, L, Chuang, AZ, Feldman, RM, Bell, NP, Chévez-Barrios, P & Blieden, LS 2018, Ophthalmology. https://doi.org/10.1016/j.ophtha.2018.01.018

DICER1 Syndrome: Characterization of the Ocular Phenotype in a Family-Based Cohort Study
Huryn, LA, Turriff, A, Harney, LA, Carr, AG, Chévez-Barrios, P, Gombos, D, Ram, R, Hufnagel, RB, Hill, DA, Zein, WM, Schultz, KAP, Bishop, R & Stewart, DR 2018, Ophthalmology. https://doi.org/10.1016/j.ophtha.2018.09.038

Proteolytic Degradation and Inflammation Play Critical Roles in Polypoidal Choroidal Vasculopathy
Kumar, S, Nakashizuka, H, Jones, A, Lambert, A, Zhao, X, Shen, M, Parker, M, Wang, S, Berriochoa, Z, Fnu, A, VanBeuge, S, Chévez-Barrios, P, Tso, M, Rainier, J & Fu, Y 2017, American Journal of Pathology, vol. 187, no. 12, pp. 2841-2857. https://doi.org/10.1016/j.ajpath.2017.08.025

Subconjunctival Silicon Oil Cysts
Ling, J, Wykoff, CC & Chévez-Barrios, P 2017, Ophthalmology Retina, vol. 1, no. 6. https://doi.org/10.1016/j.oret.2017.07.015

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