Patricia Chévez-Barrios, MD

Professor of Pathology and Genomic Medicine, Institute for Academic Medicine
Full Clinical Member, Research Institute
Program Director, Ophthalmic Pathology Residency, Department of Pathology & Genomic Medicine
Houston Methodist
Weill Cornell Medical College


Research Lab


Biography

After finishing all seven of her postdoctoral training programs, Dr. Chévez-Barrios joined the faculty of the Baylor College of Medicine in 1996 as an Assistant Professor in the Department of Pathology, with a secondary appointment in the Department of Ophthalmology. She became a Clinical Assistant Professor in the Department of Ophthalmology there in 2004, and received the Fulbright & Jaworski LLP Award for Faculty Excellence in Teaching and Evaluation and became Associate Member of the Cell and Gene Therapy Center that same year. She has current appointments of adjunct professor in the Department of Pathology at The University of Texas MD Anderson Cancer Center and Department of Ophthalmology at the Baylor College of Medicine. Dr. Chévez- Barrios assumed her current positions at Methodist in 2004.

Description of Research

The main research interest of Dr. Chévez-Barrios and her laboratory is the study of retinoblastoma, including cancer stem cells, suicide gene therapy for retinoblastoma, the study of metastatic properties of retinoblastoma and preclinical models of the tumor. Other topics of interest are ocular gene therapy, cataractogenesis, vascular proliferation in hypoxic ocular diseases and corneal diseases. Dr. Chevez-Barrios’ laboratory is currently participating in the project of gene therapy for Retinoblastomas in collaboration with the Texas Children’s Cancer Center and the Center for Gene Therapy of Texas Children's Hospital, and Baylor College of Medicine. Pre-clinical studies and a phase 1 clinical trial of vitreous seed of retinoblastoma have been completed. The phase II clinical trial is in preparation. Dr. Chevez-Barrios is a committee member responsible of evaluating all enucleated eyes from the prospective multicenter study of the ARET0332 Children’s Oncology Group protocol on “A Study of Unilateral Retinoblastoma With and Without Histopathologic High-Risk Features and the Role of Adjuvant Chemotherapy. Dr. Chevez-Barrios is also interested in the biological differences between retinoblastoma cell lines that have the capability of producing metastasis, and those that behave less aggressively and remain as intraocular tumors.

Areas Of Expertise

Retinoblastoma Metastasis Gene therapy Neovascularization
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, Universidad Nacional Autonoma
Publications

Pathologic Markers Determining Prognosis in Patients With Treated or Healing Giant Cell Arteritis
Sultan, H, Smith, SV, Lee, AG & Chévez-Barrios, P 2018, American Journal of Ophthalmology, vol. 193, pp. 45-53. DOI: 10.1016/j.ajo.2018.05.031

Reply
Skalet, AH, Gombos, DS, Gallie, BL, Kim, JW, Shields, CL, Marr, BP, Plon, SE & Chévez-Barrios, P 2018, Ophthalmology, vol. 125, no. 9, pp. e64-e65. DOI: 10.1016/j.ophtha.2018.03.030

Human Papillomavirus-Driven Squamous Lesions: High-Risk Genotype Found in Conjunctival Papillomas, Dysplasia, and Carcinoma
Moyer, AB, Roberts, J, Olsen, RJ & Chévez-Barrios, P 2018, The American Journal of dermatopathology, vol. 40, no. 7, pp. 486-490. DOI: 10.1097/DAD.0000000000001139

Yield, techniques, and complications of transvitreal and transscleral biopsies in small uveal melanoma
Kim, RS, Chevez-Barrios, P, Divatia, M, Bretana, ME, Teh, B & Schefler, AC 2018, JAMA Ophthalmology, vol. 136, no. 5, pp. 482-488. DOI: 10.1001/jamaophthalmol.2018.0561

Orbital Inflammatory Syndrome Secondary to Flea Bite
Prospero Ponce, CM, Malik, AI, Vickers, A, Chevez-Barrios, P & Lee, AG 2018, Plastic and reconstructive surgery, vol. 34, no. 4, pp. e115-e118. DOI: 10.1097/IOP.0000000000001115

Juvenile Xanthogranuloma in a Pediatric Patient with Langerhans Cell Histiocytosis
Ram, R, Marolf, MD, Chévez-Barrios, P & Herce, HH 2018, Ocular Oncology and Pathology, vol. 4, no. 3, pp. 141-144. DOI: 10.1159/000479524

Perineurial-like Cells and EMA Expression in the Suprachoroidal Region of the Human Eye
Gilbert, AR, Chévez-Barrios, P & Cykowski, MD 2018, Journal of Histochemistry and Cytochemistry. DOI: 10.1369/0022155418756308

Neuro-Ophthalmic Manifestations of Pituitary Carcinoma
Chang, EA, Shah, R, Smith, SV, Sadaka, A, Ortiz Gomez, J, Chevez-Barrios, P & Lee, AG 2018, Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. DOI: 10.1097/WNO.0000000000000620

Eye, Ocular Adnexa, and Orbit
Chévez-Barrios, P & Ortiz, JD 2018, . in D Mody, I Ramzy & R Laucirica (eds), Clinical Cytopathology: Fundamental Principles and Practice. 3rd edn, McGraw Hill Education, pp. 85-98.

Characterizing Anterior Segment OCT Angle Landmarks of the Trabecular Meshwork Complex
Crowell, EL, Baker, L, Chuang, AZ, Feldman, RM, Bell, NP, Chévez-Barrios, P & Blieden, LS 2018, Ophthalmology. DOI: 10.1016/j.ophtha.2018.01.018

Proteolytic Degradation and Inflammation Play Critical Roles in Polypoidal Choroidal Vasculopathy
Kumar, S, Nakashizuka, H, Jones, A, Lambert, A, Zhao, X, Shen, M, Parker, M, Wang, S, Berriochoa, Z, Fnu, A, VanBeuge, S, Chévez-Barrios, P, Tso, M, Rainier, J & Fu, Y 2017, American Journal of Pathology, vol. 187, no. 12, pp. 2841-2857. DOI: 10.1016/j.ajpath.2017.08.025

Perineural spread of basosquamous carcinoma to the orbit, cavernous sinus, and infratemporal fossa
Amram, AL, Hertzing, WJ, Smith, SV, Chévez-Barrios, P & Lee, AG 2017, Orbit, pp. 1-5. DOI: 10.1080/01676830.2017.1383462

Rabbit model of ocular indirect photodynamic therapy using a retinoblastoma xenograft
Kim, JW, Jacobsen, B, Zolfaghari, E, Ferrario, A, Chevez-Barrios, P, Berry, JL, Lee, DK, Rico, G, Madi, I, Rao, N, Stachelek, K, Wang, LC & Gomer, C 2017, Graefes Archive for Clinical and Experimental Ophthalmology, pp. 1-11. DOI: 10.1007/s00417-017-3805-8

Nothing to Spit At
Hashemi, N, Billah, S, Conderman, CP, Alava, I, Supsupin, EP, Chevez-Barrios, P & Adesina, OOO 2017, Journal of Neuro-Ophthalmology. DOI: 10.1097/WNO.0000000000000504

Histopathologic Analysis of Transvitreal Fine Needle Aspiration Biopsy Needle Tracts for Uveal Melanoma
Kim, RS, Chevez-Barrios, P, Bretana, ME, Wong, TP, Teh, BS & Schefler, AC 2017, American Journal of Ophthalmology, vol. 174, pp. 9-16. DOI: 10.1016/j.ajo.2016.10.019

Vitreous Seeds in Retinoblastoma. Clinicopathologic Classification and Correlation
Amram, AL, Rico, G, Kim, JW, Chintagumpala, M, Herzog, CE, Gombos, DS & Chévez-Barrios, P 2017, Ophthalmology. DOI: 10.1016/j.ophtha.2017.04.015

Early outcomes of uveal melanoma treated with intraoperative ultrasound guided brachytherapy using custom built plaques
Tann, AW, Teh, BS, Scarboro, SB, Lewis, GD, Bretana, ME, Croft, PC, Raizen, Y, Butler, EB, Kim, RS, Chevez-Barrios, P & Schefler, AC 2017, Practical radiation oncology. DOI: 10.1016/j.prro.2017.01.002

RecutClub.com: An Open Source, Whole Slide Image-based Pathology Education System
Christensen, PA, Lee, NE, Thrall, MJ, Powell, SZ, Chevez-Barrios, P & Long, SW 2017, Journal of Pathology Informatics, vol. 8, no. 10, pp. 10. DOI: 10.4103/jpi.jpi_72_16

Screening Children at Risk for Retinoblastoma. Consensus Report from the American Association of Ophthalmic Oncologists and Pathologists
Skalet, AH, Gombos, DS, Gallie, BL, Kim, JW, Shields, CL, Marr, BP, Plon, SE & Chévez-Barrios, P 2017, Ophthalmology. DOI: 10.1016/j.ophtha.2017.09.001

Atypical Retinal Pigment Epithelial Hyperplasia and Glial Proliferation Masquerading as Progressive Recurrent Retinoblastoma: A Case Report Review and Clinicopathologic Correlation
Zolfaghari, E, Kim, JW, Krishnan, S, Chévez-Barrios, P & Berry, JL 2017, Ocular Oncology and Pathology, vol. 4, no. 2, pp. 116-121. DOI: 10.1159/000479741