Patricia Chévez-Barrios, MD

Professor of Pathology and Genomic Medicine, Academic Institute
Full Clinical Member, Research Institute
Program Director, Ophthalmic Pathology Residency, Department of Pathology & Genomic Medicine
Houston Methodist
Weill Cornell Medical College


Research Lab


Biography

After finishing all seven of her postdoctoral training programs, Dr. Chévez-Barrios joined the faculty of the Baylor College of Medicine in 1996 as an Assistant Professor in the Department of Pathology, with a secondary appointment in the Department of Ophthalmology. She became a Clinical Assistant Professor in the Department of Ophthalmology there in 2004, and received the Fulbright & Jaworski LLP Award for Faculty Excellence in Teaching and Evaluation and became Associate Member of the Cell and Gene Therapy Center that same year. She has current appointments of adjunct professor in the Department of Pathology at The University of Texas MD Anderson Cancer Center and Department of Ophthalmology at the Baylor College of Medicine. Dr. Chévez- Barrios assumed her current positions at Methodist in 2004.

Description of Research

The main research interest of Dr. Chévez-Barrios and her laboratory is the study of retinoblastoma, including cancer stem cells, suicide gene therapy for retinoblastoma, the study of metastatic properties of retinoblastoma and preclinical models of the tumor. Other topics of interest are ocular gene therapy, cataractogenesis, vascular proliferation in hypoxic ocular diseases and corneal diseases. Dr. Chevez-Barrios’ laboratory is currently participating in the project of gene therapy for Retinoblastomas in collaboration with the Texas Children’s Cancer Center and the Center for Gene Therapy of Texas Children's Hospital, and Baylor College of Medicine. Pre-clinical studies and a phase 1 clinical trial of vitreous seed of retinoblastoma have been completed. The phase II clinical trial is in preparation. Dr. Chevez-Barrios is a committee member responsible of evaluating all enucleated eyes from the prospective multicenter study of the ARET0332 Children’s Oncology Group protocol on “A Study of Unilateral Retinoblastoma With and Without Histopathologic High-Risk Features and the Role of Adjuvant Chemotherapy. Dr. Chevez-Barrios is also interested in the biological differences between retinoblastoma cell lines that have the capability of producing metastasis, and those that behave less aggressively and remain as intraocular tumors.

Areas Of Expertise

Retinoblastoma Metastasis Gene therapy Neovascularization
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, Universidad Nacional Autonoma
Publications

Infectious keratitis as the presenting sign of giant cell arteritis
Kamal, S, Al Othman, B, Kini, A, Beaver, HA, Chaudhry, I, Prospero Ponce, CM, Chévez-Barrios, P & Lee, AG 2020, Canadian Journal of Ophthalmology. https://doi.org/10.1016/j.jcjo.2020.02.003

Ocular Pathology Recommendations during COVID-19 from the American Association of Ophthalmic Oncologists and Pathologists (AAOOP)
Chévez-Barrios, P, Milman, T, Grossniklaus, HE, Folberg, R, Salomão, DR & Gombos, D 2020, Ocular Oncology and Pathology, vol. 6, no. 3, pp. 223-224. https://doi.org/10.1159/000507735

An Update on Endocrine Mucin-producing Sweat Gland Carcinoma: Clinicopathologic Study of 63 Cases and Comparative Analysis
Agni, M, Raven, ML, Bowen, RC, Laver, NV, Chévez-Barrios, P, Milman, T, Eberhart, CG, Couch, S, Bennett, DD, Albert, DM, Hogan, RN, Phelps, PO, Stiefel, H, Mancera, N, Hyrcza, M, Wang, A, Steele, EA, Campbell, AA, Potter, HD & Lucarelli, MJ 2020, American Journal of Surgical Pathology. https://doi.org/10.1097/PAS.0000000000001462

Inflammatory Myofibroblastic Tumor of the Orbit in an 8-Month Old
Dermarkarian, CR, Patel, KR, Fuller, MY, Bernini, JC, Chévez-Barrios, P & Allen, RC 2020, Ophthalmic Plastic and Reconstructive Surgery, pp. E65-E68. https://doi.org/10.1097/IOP.0000000000001575

Selective pathology of intraocular tumors
Chévez-Barrios, P & Cernichiaro Espinosa, LA 2020, . in Oncological Surgical Pathology. Springer International Publishing, pp. 461-469. https://doi.org/10.1007/978-3-319-96681-6_4

Technical and anatomical factors affecting intra-arterial chemotherapy fluoroscopy time and radiation dose for intraocular retinoblastoma
Area, C, Yen, CJ, Chévez-Barrios, P, Herzog, C, Kan, P, Zheng, W, Lin, F, Chintagumpala, M, Gombos, D & Chen, SR 2019, Journal of neurointerventional surgery, vol. 11, no. 12, pp. 1273-1276. https://doi.org/10.1136/neurintsurg-2019-014910

Extraocular muscle biopsy during surgery for strabismus of unknown etiology
Assam, JH, Miller, AM, Chevez-Barrios, P & Lee, AG 2019, Journal of AAPOS, vol. 23, no. 6, pp. 356-359. https://doi.org/10.1016/j.jaapos.2019.09.010

Chronic myelomonocytic leukemia-related vasculitis mimicking giant cell arteritis
Amin, SD, Vickers, A, Hong, BY, Ponce, CMP, Ibrahim, IF, Chévez-Barrios, P & Lee, AG 2019, Canadian Journal of Ophthalmology, vol. 54, no. 3, pp. e140-e145. https://doi.org/10.1016/j.jcjo.2018.08.017

Anterior Segment Optical Coherence Tomography of Ocular Cystinosis Confirmed by Electron Microscopy
Golla, A, Weikert, MP, Chévez-Barrios, P & Al-Mohtaseb, Z 2019, Ocular Oncology and Pathology, vol. 5, no. 2, pp. 110-113. https://doi.org/10.1159/000490389

Vestibulocochlear symptoms as the initial presentation of giant cell arteritis
Le, N, Vickers, A, Prospero Ponce, C, Chévez-Barrios, P & Lee, AG 2019, Canadian Journal of Ophthalmology, vol. 54, no. 1, pp. e1-e3. https://doi.org/10.1016/j.jcjo.2018.04.006

DICER1 Syndrome: Characterization of the Ocular Phenotype in a Family-Based Cohort Study
Huryn, LA, Turriff, A, Harney, LA, Carr, AG, Chévez-Barrios, P, Gombos, D, Ram, R, Hufnagel, RB, Hill, DA, Zein, WM, Schultz, KAP, Bishop, R & Stewart, DR 2019, Ophthalmology, vol. 126, no. 2, pp. 296-304. https://doi.org/10.1016/j.ophtha.2018.09.038

Study of unilateral retinoblastoma with and without histopathologic high-risk features and the role of adjuvant chemotherapy: A children's oncology group study
Chévez-Barrios, P, Eagle, RC, Krailo, M, Piao, J, Albert, DM, Gao, Y, Vemuganti, G, Ali, MJ, Khetan, V, Honavar, SG, OBrien, J, Leahey, AM, Matthay, K, Meadows, A & Chintagumpala, M 2019, Journal of Clinical Oncology, vol. 37, no. 31, pp. 2883-2891. https://doi.org/10.1200/JCO.18.01808

Genomic cfDNA analysis of aqueous humor in retinoblastoma predicts eye salvage: The surrogate tumor biopsy for retinoblastoma
Berry, JL, Xu, L, Kooi, I, Murphree, AL, Prabakar, RK, Reid, M, Stachelek, K, Le, BHA, Welter, L, Reiser, BJ, Chévez-Barrios, P, Jubran, R, Lee, TC, Kim, JW, Kuhn, P, Cobrinik, D & Hicks, J 2018, Molecular Cancer Research, vol. 16, no. 11, pp. 1701-1712. https://doi.org/10.1158/1541-7786.MCR-18-0369

Pathologic Markers Determining Prognosis in Patients With Treated or Healing Giant Cell Arteritis
Sultan, H, Smith, SV, Lee, AG & Chévez-Barrios, P 2018, American Journal of Ophthalmology, vol. 193, pp. 45-53. https://doi.org/10.1016/j.ajo.2018.05.031

Reply
Skalet, AH, Gombos, D, Gallie, BL, Kim, JW, Shields, CL, Marr, BP, Plon, SE & Chévez-Barrios, P 2018, Ophthalmology, vol. 125, no. 9, pp. e64-e65. https://doi.org/10.1016/j.ophtha.2018.03.030

Orbital Inflammatory Syndrome Secondary to Flea Bite
Prospero Ponce, CM, Malik, AI, Vickers, A, Chevez-Barrios, P & Lee, AG 2018, Plastic and reconstructive surgery, vol. 34, no. 4, pp. e115-e118. https://doi.org/10.1097/IOP.0000000000001115

Human Papillomavirus-Driven Squamous Lesions: High-Risk Genotype Found in Conjunctival Papillomas, Dysplasia, and Carcinoma
Moyer, AB, Roberts, J, Olsen, RJ & Chévez-Barrios, P 2018, The American Journal of dermatopathology, vol. 40, no. 7, pp. 486-490. https://doi.org/10.1097/DAD.0000000000001139

Yield, techniques, and complications of transvitreal and transscleral biopsies in small uveal melanoma
Kim, RS, Chévez-Barrios, P, Divatia, MK, Bretana, ME, Teh, BS & Schefler, AC 2018, JAMA ophthalmology, vol. 136, no. 5, pp. 482-488. https://doi.org/10.1001/jamaophthalmol.2018.0561

Clinically Significant Enhancement of Voriconazole Efficacy by Moxifloxacin and Gentamicin in Fungal Keratitis
Matoba, AY, Divatia, MK, Arguello, RA & Chévez-Barrios, P 2018, Cornea, vol. 37, no. 5, pp. 651-654. https://doi.org/10.1097/ICO.0000000000001545

Juvenile Xanthogranuloma in a Pediatric Patient with Langerhans Cell Histiocytosis
Ram, R, Marolf, MD, Chévez-Barrios, P & Herce, HH 2018, Ocular Oncology and Pathology, vol. 4, no. 3, pp. 141-144. https://doi.org/10.1159/000479524

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