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Omonike Olaleye, PhD

Assistant Affiliate Member, Research Institute
Houston Methodist


A simple, sensitive and reliable LC-MS/MS method for the determination of 7-bromo-5-chloroquinolin-8-ol (CLBQ14), a potent and selective inhibitor of methionine aminopeptidases: Application to pharmacokinetic studies
Ekpenyong, O, Cooper, C, Ma, J, Liang, D, Olaleye, O & Xie, H 2018, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 1097-1098, pp. 35-43. DOI: 10.1016/j.jchromb.2018.08.027

Tuberculosis during pregnancy in the United States: Racial/ethnic disparities in pregnancy complications and in-hospital death
Dennis, EM, Hao, Y, Tamambang, M, Roshan, TN, Gatlin, KJ, Bghigh, H, Ogunyemi, OT, Diallo, F, Spooner, KK, Salemi, JL, Olaleye, OA, Khan, KZ, Aliyu, MH & Salihu, HM 2018, PLoS ONE, vol. 13, no. 3, e0194836. DOI: 10.1371/journal.pone.0194836

HIV-TB Coinfection among 57 Million Pregnant Women, Obstetric Complications, Alcohol Use, Drug Abuse, and Depression
Fernandez, D, Salami, I, Davis, J, Mbah, F, Kazeem, A, Ash, A, Babino, J, Carter, L, Salemi, JL, Spooner, KK, Olaleye, OA & Salihu, HM 2018, Journal of Pregnancy, vol. 2018, 5896901. DOI: 10.1155/2018/5896901

Severe pre-eclampsia among pregnant women with sickle cell disease and HIV
Prophet, J, Kelly, K, Domingo, J, Ayeni, H, Mekouguem, XPD, Dockery, B, Allam, F, Kaur, M, Artis, J, Spooner, KK, Salemi, JL, Olaleye, OA & Salihu, HM 2018, Pregnancy Hypertension, vol. 11, pp. 87-91. DOI: 10.1016/j.preghy.2018.01.006

Hospital length of stay and cost burden of HIV, tuberculosis, and HIV-tuberculosis coinfection among pregnant women in the United States
Falana, A, Akpojiyovwi, V, Sey, E, Akpaffiong, A, Agumbah, O, Chienye, S, Banks, J, Jones, E, Spooner, KK, Salemi, JL, Olaleye, OA, Onyiego, SD & Salihu, HM 2017, American Journal of Infection Control. DOI: 10.1016/j.ajic.2017.09.016

In vitro model of mycobacteria and HIV-1 co-infection for drug discovery
Vijayakumar, S, John, SF, Nusbaum, RJ, Ferguson, MR, Cirillo, JD, Olaleye, O & Endsley, JJ 2013, Tuberculosis, vol. 93, no. SUPPL.. DOI: 10.1016/S1472-9792(13)70013-1

Analogs of N'-hydroxy-N-(4H,5H-naphtho[1,2-d]thiazol-2-yl) methanimidamide inhibit Mycobacterium tuberculosis methionine aminopeptidases
Bhat, S, Olaleye, O, Meyer, KJ, Shi, W, Zhang, Y & Liu, JO 2012, Bioorganic and Medicinal Chemistry, vol. 20, no. 14, pp. 4507-4513. DOI: 10.1016/j.bmc.2012.05.022

Characterization of clioquinol and analogues as novel inhibitors of methionine aminopeptidases from Mycobacterium tuberculosis
Olaleye, O, Raghunand, TR, Bhat, S, Chong, C, Gu, P, Zhou, J, Zhang, Y, Bishai, WR & Liu, JO 2011, Tuberculosis, vol. 91, no. SUPPL. 1. DOI: 10.1016/

Methionine Aminopeptidases from Mycobacterium tuberculosis as Novel Antimycobacterial Targets
Olaleye, O, Raghunand, TR, Bhat, S, He, J, Tyagi, S, Lamichhane, G, Gu, P, Zhou, J, Zhang, Y, Grosset, J, Bishai, WR & Liu, JO 2010, Chemistry and Biology, vol. 17, no. 1, pp. 86-97. DOI: 10.1016/j.chembiol.2009.12.014

Targeting the role of N-terminal methionine processing enzymes in Mycobacterium tuberculosis
Olaleye, OA, Bishai, WR & Liu, JO 2009, Tuberculosis, vol. 89, no. SUPPL.1. DOI: 10.1016/S1472-9792(09)70013-7

Identification of an SH3-binding motif in a new class of methionine aminopeptidases from Mycobacterium tuberculosis suggests a mode of interaction with the ribosome
Addlagatta, A, Quillin, ML, Omotoso, O, Liu, JO & Matthews, BW 2005, Biochemistry, vol. 44, no. 19, pp. 7166-7174. DOI: 10.1021/bi0501176