Omaima Sabek

Omaima Sabek, PhD

Associate Research Professor of Surgery, Academic Institute
Associate Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

After completion of her postdoctoral training in 2005, Dr. Sabek received dual appointments as an Assistant Professor in the College of Nursing and Department of Surgery at the University of Tennessee in Memphis, Tennessee. She has collaborated on several NIH-funded research grants and published over 30 peer-reviewed papers. Dr. Sabek joined The Methodist Hospital Research Institute in 2007.

Description of Research

Dr. Sabek´s research focuses on islet cell transplantation, and specifically, the surrogate markers for prediction of long-term transplantation outcomes. She also aims to improve transplantation outcomes through the development and validation of improved techniques for islet recovery, isolation, engraftment, and post-transplant functioning/preservation. Dr. Sabek also conducts studies investigating potential biomarkers of allograft rejection.

Areas Of Expertise

Diabetes Islet cell transplantation Allograft rejection Osteocalcin Functional genomics
Education & Training

Postdoctoral Fellowship, Department of Biochemistry, University of Tennessee, Memphis, TN
PhD, University College London
Publications

Human pancreatic microenvironment promotes ß-cell differentiation via non-canonical WNT5A/JNK and BMP signaling
Chmielowiec, J, Szlachcic, WJ, Yang, D, Scavuzzo, MA, Wamble, K, Sarrion-Perdigones, A, Sabek, OM, Venken, KJT & Borowiak, M 2022, , Nature Communications, vol. 13, no. 1, 1952, pp. 1952. https://doi.org/10.1038/s41467-022-29646-1

From Mesenchymal Stromal/Stem Cells to Insulin-Producing Cells: Immunological Considerations
Refaie, AF, Elbassiouny, BL, Kloc, M, Sabek, OM, Khater, SM, Ismail, AM, Mohamed, RH & Ghoneim, MA 2021, , Frontiers in immunology, vol. 12, 690623. https://doi.org/10.3389/fimmu.2021.690623

NF-?B Blockade by NEMO Binding Domain Peptide Ameliorates Inflammation and Neurobehavioral Sequelae After Cranial Radiation Therapy in Juvenile Mice
Beamish, CA, Zawaski, JA, Inoue, T, Sarkar, P, Grosshans, DR, Sabek, OM & Gaber, MW 2021, , International Journal of Radiation Oncology Biology Physics, vol. 109, no. 5, pp. 1508-1520. https://doi.org/10.1016/j.ijrobp.2020.11.067

Cognitive and Imaging Differences After Proton and Photon Whole Brain Irradiation in a Preclinical Model
Tang, TT, Zawaski, JA, Kesler, S, Beamish, CA, Inoue, T, Perez, EC, Bronk, L, Poenisch, F, Briere, TM, Sabek, OM, Grosshans, DR & Waleed Gaber, M 2022, , International Journal of Radiation Oncology Biology Physics, vol. 112, no. 2, pp. 554-564. https://doi.org/10.1016/j.ijrobp.2021.09.005

NF-?B blockade by NBD peptide ameliorates inflammation and neurobehavioral sequelae following cranial radiotherapy in juvenile mice
Beamish, CA, Zawaski, JA, Inoue, T, Sarkar, P, Grosshans, DR, Sabek, OM & Gaber, MW 2020, , International Journal of Radiation Oncology, Biology, Physics. https://doi.org/10.1016/j.ijrobp.2020.11.067

Novel Silicon Titanium Diboride Micropatterned Substrates for Cellular Patterning
Friguglietti, J, Das, S, Le, P, Fraga, D, Quintela, M, Gazze, SA, McPhail, D, Gu, J, Sabek, O, Gaber, AO, Francis, LW, Zagozdzon-Wosik, W & Merchant, FA 2020, , Biomaterials, vol. 244, 119927. https://doi.org/10.1016/j.biomaterials.2020.119927

Tead1 reciprocally regulates adult ß-cell proliferation and function
Lee, J, Liu, R, Kim, BS, Zhang, Y, Li, F, Jagannathan, R, Yang, P, Negi, V, Perez-Garcia, EM, Saha, PK, Sabek, O, Coarfa, C, Creighton, CJ, Huising, MO, Bottino, R, Ma, K, Moulik, M & Yechoor, VK 2020, , bioRxiv. https://doi.org/10.1101/2020.03.05.979450

Serum C-peptide and osteocalcin levels in children with recently diagnosed diabetes
Sabek, OM, Redondo, MJ, Nguyen, DT, Beamish, CA, Fraga, DW, Hampe, CS, Mulukutla, SN, Graviss, EA & Gaber, AO 2020, , Endocrinology, diabetes & metabolism, vol. 3, no. 1, pp. e00104. https://doi.org/10.1002/edm2.104

Tead1 reciprocally regulates adult ß-cell proliferation and function
Sabek, O 2020, , bioRxiv preprint. https://doi.org/10.1101/2020.03.05.979450

Serum C-peptide and osteocalcin levels in children with recently diagnosed diabetes
Sabek, OM, Redondo, MJ, Nguyen, DT, Beamish, CA, Fraga, DW, Hampe, CS, Mulukutla, SN, Graviss, EA & Gaber, AO 2020, , Endocrinology, Diabetes and Metabolism, vol. 3, no. 1, e00104. https://doi.org/10.1002/edm2.104

A comprehensive preclinical assessment of late-term imaging markers of radiation-induced brain injury
Tang, TT, Zawaski, JA, Kesler, SR, Beamish, CA, Reddick, WE, Glass, JO, Carney, DH, Sabek, OM, Grosshans, DR & Gaber, MW 2019, , Neuro-Oncology Advances, vol. 1, no. 1, vdz012. https://doi.org/10.1093/noajnl/vdz012

Islet Identity in Transplantation Procedures: The Intersection of Cellular Maturity and Function
Beamish, CA & Sabek, O 2019, , OBM Transplantation , vol. 3, no. 1. https://doi.org/10.21926/obm.transplant.1901055

Cross-sectional evaluation of the relationship between Vitamin D status and supplement use across levels of kidney function in adults
Moore, LW, Suki, WN, Lunsford, KE, Sabek, OM, Knight, RJ & Gaber, AO 2019, , BMJ open, vol. 9, no. 2, e022471. https://doi.org/10.1136/bmjopen-2018-022471

Differentiation of Heterogeneous Radiation Exposure Using Hematology and Blood Chemistry
Gaber, MW, Rodgers, SP, Tang, TT, Sabek, O & Zawaski, JA 2019, , Radiation Research, vol. 193, no. 1, pp. 24-33. https://doi.org/10.1667/RR15411.1

Variability in endocrine cell identity in patients with chronic pancreatitis undergoing islet autotransplantation
Beamish, C, Gaber, AO, Afshar, S, Fraga, DW, Hamilton, DJ & Sabek, O 2018, , American Journal of Transplantation. https://doi.org/10.1111/ajt.15154

Echocardiography Differentiates Lethally Irradiated Whole-Body From Partial-Body Exposed Rats
Inoue, T, Zawaski, JA, Sheehan, V, Kanne, C, Paikari, A, Kaffes, CC, sarkar, P, Sabek, O & Waleed Gaber, M 2018, , Frontiers in cardiovascular medicine, vol. 5, 138, pp. 1-8. https://doi.org/10.3389/fcvm.2018.00138

Echocardiography Differentiates Lethally Irradiated Whole-Body From Partial-Body Exposed Rats
Inoue, T, Zawaski, JA, Sheehan, V, Kanne, C, Paikari, A, Kaffes, CC, Sarkar, P, Sabek, O & Gaber, MW 2018, Frontiers in Cardiovascular Medicine, vol. 5, 138. https://doi.org/10.3389/fcvm.2018.00138

Exercise ameliorates neurocognitive impairments in a translational model of pediatric radiotherapy
Sahnoune, I, Inoue, T, Kesler, SR, Rodgers, SP, Sabek, OM, Pedersen, SE, Zawaski, JA, Nelson, KH, Douglas Ris, M, Leigh Leasure, J & Waleed Gaber, M 2018, , Neuro-oncology, vol. 20, no. 5, pp. 695-704. https://doi.org/10.1093/neuonc/nox197

A Cross-sectional Evaluation of the Relationship Between Vitamin D Status and Supplement Use Across Levels of Kidney Function in Adults: Vitamin D Status, Supplements, and Kidney function
Moore, LW, Suki, WN, Lunsford, KE, Sabek, O, Knight, RJ & Gaber, AO 2018, , BMJ.

Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism
Mukherjee, A, Morales-Scheihing, D, Salvadores, N, Moreno-Gonzalez, I, Gonzalez, C, Taylor-Presse, K, Mendez, N, Shahnawaz, M, Gaber, AO, Sabek, OM, Fraga, DW & Soto, C 2017, , The Journal of experimental medicine. https://doi.org/10.1084/jem.20161134