Nicholas R. DiPaola, Jr.

Nicholas R. DiPaola, Jr., PhD

Assistant Professor of Clinical Pathology & Genomic Medicine, Academic Institute
Houston Methodist
Weill Cornell Medical College

Description of Research

After receiving his BA degree in Chemistry from the Hiram College, OH, Dr. DiPaola pursued medical studies for 3 years and doctoral studies in the medical sciences at the department of physiology and molecular medicine, and received his PhD from the Medical College of Ohio, Toledo, OH. Dr. DiPaola conducted postdoctoral fellowships in the Center for Anesthesiology Research and the department of cardiovascular medicine at the Cleveland Clinic Foundation in Cleveland, OH. After completing the second postdoctoral fellowship, he was appointed research scientist in the division of transplantation at The Ohio State University (2003-2006), clinical lab technologist (2006-2008), transplant technologist supervisor (2008-2010), and ASHI certified director of the histocompatibility laboratory (2010-2015) at the Wexner Medical Center at the same institution. Dr. DiPaola was appointed medical director I-STAT between 2012 and 2015, and was elected to the Board of Directors at the Lifeline of Ohio for one year (2014-2015). In 2015, he was appointed medical director of the histocompatibility and immunogenetics laboratory in the Department of Pathology and Genomics Medicine at Houston Methodist Hospital, a position that he holds until present. At this stage of his career, Dr. DiPaola has authored more than 15 peer-reviewed articles, 3 book chapters, and has presented his research at many conferences. His research interests are focused on the human leukocyte antigen (HLA) system and immunology.


Effectiveness of combined plasma cell therapy and costimulation blockade based desensitization regimen in heart transplant candidates
Fida, N, Eagar, TN, Yun, AN, Rogers, AW, Nguyen, DT, Graviss, EA, Ishaq, F, DiPaola, NR, Kim, J, Janardhana, G, Kassi, M, Yousefzai, R, Suarez, EE, Bhimaraj, A, Krisl, JC & Guha, A 2024, , Clinical Transplantation, vol. 38, no. 2, e15249, pp. e15249.

Clinical utility of C3d binding donor-specific anti-human leukocyte antigen antibody detection by single antigen beads after kidney transplantation—a retrospective study
Pelletier, RP, Balazs, I, Adams, P, Rajab, A, DiPaola, NR & Henry, ML 2018, , Transplant International, vol. 31, no. 4, pp. 424-435.

Early immunosuppression treatment correlates with later de novo donor-specific antibody development after kidney and pancreas transplantation
Pelletier, RP, Rajab, AA, Diez, A, DiPaola, Jr. NR, Bumgardner, GL, Elkhammas, EA & Henry, ML 2015, , Clinical Transplantation, vol. 29, no. 12, pp. 1119-1127.

Concordance and discordance in anti-HLA antibody testing
On behalf of the ASHI Proficiency Testing Program 2015, , Transplant Immunology, vol. 32, no. 1, pp. 1-8.

Absence of HLA-DR1 positivity in 2 familial cases of frontal fibrosing alopecia
Chan, DV, Kartono, F, Ziegler, R, Abdulwahab, N, Di Paola, N, Flynn, J & Wong, HK 2014, , Journal of the American Academy of Dermatology, vol. 71, no. 5, pp. e208-e210.

HLA-testing and laboratory medicine
DiPaola, NR, Munker, R & Atkinson, K 2013, . in The BMT Data Book: Including Cellular Therapy. Cambridge University Press, pp. 509-524.

Antibody-mediated rejection in a lung transplant recipient after acute stroke
Hayes, D, DiPaola, N, Baker, PB, Kirkby, S, Phillips, AB & Nicol, KK 2012, , Transplant Immunology, vol. 27, no. 4, pp. 171-174.

The pathogenesis of acute allograft dysfunction in desensitized renal transplant recipients
Singh, N, Sun, Q, Nadasdy, T, Adams, P, Dipaola, NR, Pesavento, T, Winters, H, Satoskar, A, Yu, Z, Henry, M, Hadley, GA & Pelletier, RP 2012, , Clinical Transplantation, vol. 26, no. 4, pp. E402-E411.

Antibodies reactive to Non-HLA antigens in transplant glomerulopathy
Dinavahi, R, George, A, Tretin, A, Akalin, E, Ames, S, Bromberg, JS, DeBoccardo, G, DiPaola, N, Lerner, SM, Mehrotra, A, Murphy, BT, Nadasdy, T, Paz-Artal, E, Salomon, DR, Schröppel, B, Sehgal, V, Sachidanandam, R & Heeger, PS 2011, , Journal of the American Society of Nephrology, vol. 22, no. 6, pp. 1168-1178.

HLA-testing and laboratory medicine
DiPaola, NR, Munker, R & Atkinson, K 2009, . in The BMT Data Book, 2nd Edition. Cambridge University Press, pp. 495-510.

An experimental model of acute humoral rejection of renal allografts associated with concomitant cellular rejection
Bickerstaff, A, Pelletier, R, Wang, JJ, Nadasdy, G, DiPaola, N, Orosz, C, Satoskar, A, Hadley, G & Nadasdy, T 2008, , American Journal of Pathology, vol. 173, no. 2, pp. 347-357.

Apparently normal mitral valves in patients with heart failure demonstrate biochemical and structural derangements: An extracellular matrix and echocardiographic study
Grande-Allen, KJ, Borowski, AG, Troughton, RW, Houghtaling, PL, Dipaola, NR, Moravec, CS, Vesely, I & Griffin, BP 2005, , Journal of the American College of Cardiology, vol. 45, no. 1, pp. 54-61.

Identification of new genes differentially expressed in coronary artery disease by expression profiling
Archacki, SR, Angheloiu, G, Tian, XL, Tan, FL, DiPaola, N, Shen, GQ, Moravec, C, Ellis, S, Topol, EJ & Wang, Q 2004, , Physiological Genomics, vol. 15, pp. 65-74.

Quantitation and distribution of ß-tubulin in human cardiac myocytes
Aquila-Pastir, LA, DiPaola, Jr. NR, Matteo, RG, Smedira, NG, McCarthy, PM & Moravec, CS 2002, , Journal of Molecular and Cellular Cardiology, vol. 34, no. 11, pp. 1513-1523.

Beta-adrenergic receptors and calcium cycling proteins in non-failing, hypertrophied and failing human hearts: Transition from hypertrophy to failure
DiPaola, NR, Sweet, WE, Stull, LB, Francis, GS & Moravec, CS 2001, , Journal of Molecular and Cellular Cardiology, vol. 33, no. 6, pp. 1283-1295.

Decreased SLIM1 expression and increased gelsolin expression in failing human hearts measured by high-density oligonucleotide arrays
Yang, J, Moravec, CS, Sussman, MA, DiPaola, NR, Fu, D, Hawthorn, L, Mitchell, CA, Young, JB, Francis, GS, McCarthy, PM & Bond, M 2000, , Circulation, vol. 102, no. 25, pp. 3046-3052.

Evaluation of the renin angiotensin system in a congenic renin Dahl salt-sensitive rat
DiPaola, Jr. NR, Rapp, JP, Brand, PH, Beierwaltes, WH, Metting, PJ & Britton, SL 1997, , FASEB Journal, vol. 11, no. 3.

Evaluation of the renin-angiotensin system in a congenic renin Dahl salt-sensitive rat.
DiPaola, NR, Rapp, JP, Brand, PH, Beierwaltes, WH, Metting, PJ & Britton, SL 1997, , Genes and function, vol. 1, no. 3, pp. 215-226.

Spontaneous pressure-flow relationships in renal circulation of conscious dogs
Skarlatos, S, DiPaola, N, Frankel, RA, Pomerantz, RW, Brand, PH, Metting, PJ & Britton, SL 1993, , American Journal of Physiology - Heart and Circulatory Physiology, vol. 264, no. 5 33-5, pp. H1517-H1527.