Neal Kleiman, MD

Lois and Carl Davis Centennial Chair II, DeBakey Heart & Vascular Center
Professor of Cardiology, Academic Institute
Full Clinical Member, Research Institute
Program Director, Interventional Cardiology Residency, Department of Cardiology
Houston Methodist
Weill Cornell Medical College

Research Lab


Dr. Neal S. Kleiman is the medical director of the cardiac catheterization laboratories at the Houston Methodist DeBakey Heart & Vascular Center at Houston Methodist Hospital and a professor at Weill Cornell Medical College. He has special interests in angioplasty, stenting, coronary artery diseases and interventional cardiology.

His research lies in the relationship between angioplasty, stenting and clotting. His laboratory, recognized nationally as a select site for platelet research, examines the effects of antiplatelet therapy, the use of medications to prevent platelets from clumping and blood from clotting in patients with coronary artery disease who undergo angioplasty procedures. Kleiman has been the principal investigator and/or collaborating investigator in more than 100 studies and multi-center trials related to arterial thrombosis, the formation of blood clots in the arteries, clotting and angioplasty, which have altered the management of patients with chest pain undergoing catheterization.

After receiving his medical degree from Columbia University in New York, Kleiman completed an internship and residency in internal medicine at Baylor College of Medicine, as well as a fellowship in cardiology.

Kleiman has published over 150 manuscripts, book chapters and abstracts. His work has appeared in such publications as the Journal of the American College of Cardiology, Annals of Thoracic Surgery, Journal of Cardiovascular Pharmacology, Circulation, The American College of Cardiology and The European Heart Journal. He is on the editorial board of The Journal of Interventional Cardiology, Circulation, The American Heart Journal and The Journal of Thrombosis and Thrombolysis.

Kleiman is a member of numerous professional organizations including The American Heart Association Council on Clinical Cardiology and Council on Thrombosis, and he is a fellow of The American College of Cardiology and the Society for Coronary Angiography and Interventions.

Description of Research

Dr. Kleiman’s research effort since joining the faculty at Baylor College of Medicine and subsequently at the Houston Methodist DeBakey Heart and Vascular Center has been focused on acute coronary syndromes and coronary interventions. The bulk of this effort has been in the design, management, and execution phases of clinical trials in these two fields, on both the single center (at Houston Methodist Hospital and Ben Taub General Hospital) and multicenter levels. As part of this effort, he has dedicated considerable time to serving on the steering committees of several dozen multicenter trials. Dr. Kleiman established the Applied Platelet Physiology Laboratory at Baylor, now at the Houston Methodist DeBakey Heart and Vascular Center. Work in that laboratory has centered on two areas: providing supporting work in a large number of clinical trials that were complemented by nested mechanistic and pathophysiologic studies, and carrying out independent physiologic studies examining such issues as aspirin dosing, platelet activation during coronary interventions, individual responses to the activity of thienopyridines, and the relation of platelet turnover and COX-2 expression to aspirin sensitivity. The laboratory has also collaborated with other laboratories in the Texas Medical Center including Rice University’s Department of Bioengineering, Baylor’s Leukocyte Biology Laboratory, and most recently, the Molecular Genetics of Cardiovascular Diseases laboratory at Baylor and the stem cell group at MD Anderson Cancer Center. These collaborations have allowed the laboratory to expand its foci to include such investigations as the effects of P2Y12 inhibition and GP IIb/IIIa ligation on leukocyte rolling, leukocyte activation following GP IIb/IIIa administration, the role of platelet P-selectin on leukocyte membrane changes, and most recently the relation circulating endothelial precursor cells and coronary collateral vessels in patients with acute coronary syndromes.

Areas Of Expertise

Acute coronary syndromes Coronary intervention
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, Columbia University College of Surgeons and Physicians

TAV-in-TAV in Failed Homograft: Redo TAVI in a Patient With 3 Previous Sternotomies
Hatab, T, Zaid, S, Wessly, P, Reardon, MJ, Atkins, MD, Faza, N, Little, SH, Kleiman, NS & Goel, S 2023, , JACC: Case Reports, vol. 22, 101973.

Now You See Me Now You Don't: Subaortic Membrane Causing a Diagnostic Dilemma
Hatab, T, Zaid, S, Toro, S, Wessly, P, Malahfji, M, Faza, N, Little, SH, Kleiman, NS, Reardon, MJ & Goel, SS 2023, , JACC: Case Reports, vol. 18, 101916, pp. 101916.

First-in-Human Multicenter Experience of the Newest Generation Supra-Annular Self-Expanding Evolut FX TAVR System
Zaid, S, Attizzani, GF, Krishnamoorthy, P, Yoon, SH, Palma Dallan, LA, Chetcuti, S, Fukuhara, S, Grossman, PM, Goel, SS, Atkins, MD, Kleiman, NS, Puri, R, Bakhtadze, B, Byrne, T, Ibrahim, AW, Grubb, KJ, Tully, A, Herrmann, HC, Faggioni, M, Ramlawi, B, Khera, S, Lerakis, S, Dangas, GD, Kini, AS, Sharma, SK, Reardon, MJ & Tang, GHL 2023, , JACC: Cardiovascular Interventions, vol. 16, no. 13, pp. 1626-1635.

When Echocardiography Is Challenging in Localizing Bioprosthetic Aortic Regurgitation: Dye Don't Lie
Hatab, T, Wessly, P, Zaid, S, Faza, N, Chang, SM, Kleiman, NS, Little, SH & Goel, SS 2023, , JACC: Case Reports, vol. 15, 101853, pp. 101853.

3-Year Outcomes After Transcatheter or Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis
Low Risk Trial Investigators 2023, , Journal of the American College of Cardiology, vol. 81, no. 17, pp. 1663-1674.

Explant vs Redo-TAVR After Transcatheter Valve Failure: Mid-Term Outcomes From the EXPLANTORREDO-TAVR International Registry
Tang, GHL, Zaid, S, Kleiman, NS, Goel, SS, Fukuhara, S, Marin-Cuartas, M, Kiefer, P, Abdel-Wahab, M, De Backer, O, Søndergaard, L, Saha, S, Hagl, C, Wyler von Ballmoos, M, Bhadra, O, Conradi, L, Grubb, KJ, Shih, E, DiMaio, JM, Szerlip, M, Vitanova, K, Ruge, H, Unbehaun, A, Kempfert, J, Pirelli, L, Kliger, CA, Van Mieghem, N, Hokken, TW, Adrichem, R, Modine, T, Corona, S, Wang, L, Petrossian, G, Robinson, N, Meier, D, Webb, JG, Cheung, A, Ramlawi, B, Herrmann, HC, Desai, ND, Andreas, M, Mach, M, Waksman, R, Schults, CC, Ahmad, H, Goldberg, JB, Geirsson, A, Forrest, JK, Denti, P, Belluschi, I, Ben-Ali, W, Asgar, AW, Taramasso, M, Rovin, JD, Di Eusanio, M, Colli, A, Kaneko, T, Nazif, TN, Leon, MB, Bapat, VN, Mack, MJ, Reardon, MJ & Sathananthan, J 2023, , JACC: Cardiovascular Interventions, vol. 16, no. 8, pp. 927-941.

Assessment of Repeat Revascularization in Percutaneous Coronary Intervention Randomized Controlled Trials as a Surrogate for Mortality: A Meta-Regression Analysis
Khan, SU, Lone, AN, Akbar, UA, Arshad, HB, Arshad, A, Arora, S, Kaluski, E, Aoun, J, Goel, SS, Shah, AR & Kleiman, NS 2023, , Current Problems in Cardiology, vol. 48, no. 4, 101555, pp. 101555.

30-Day Clinical Outcomes of a Self-Expanding Transcatheter Aortic Valve: The International PORTICO NG Study
Reardon, MJ, Chehab, B, Smith, D, Walton, AS, Worthley, SG, Manoharan, G, Sultan, I, Yong, G, Harrington, K, Mahoney, P, Kleiman, N, Makkar, RR, Fontana, G, DeLago, A, Ramana, RK, Bates, N & Søndergaard, L 2023, , JACC: Cardiovascular Interventions, vol. 16, no. 6, pp. 681-689.

Site-level variability in the processes of care and outcomes over time among patients with COVID-19 and myocardial injury: Insights from the American Heart Association's COVID-19 Cardiovascular Disease Registry
Sammour, YM, Spertus, JA, Kennedy, K, Morrow, DA, Daniels, LB, Jones, P, Alger, H, Stevens, L, Shah, A, Goel, SS, de Lemos, JA, Hayek, SS, Sutton, NR & Kleiman, NS 2023, , American Heart Journal Plus: Cardiology Research and Practice, vol. 27, 100265, pp. 100265.

Structural Valve Deterioration After Self-Expanding Transcatheter or Surgical Aortic Valve Implantation in Patients at Intermediate or High Risk
OHair, D, Yakubov, SJ, Grubb, KJ, Oh, JK, Ito, S, Deeb, GM, Van Mieghem, NM, Adams, DH, Bajwa, T, Kleiman, NS, Chetcuti, S, Søndergaard, L, Gada, H, Mumtaz, M, Heiser, J, Merhi, WM, Petrossian, G, Robinson, N, Tang, GHL, Rovin, JD, Little, SH, Jain, R, Verdoliva, S, Hanson, T, Li, S, Popma, JJ & Reardon, MJ 2023, , JAMA Cardiology, vol. 8, no. 2, pp. 111-119.

An Updated Meta-Analysis on Cerebral Embolic Protection in Patients Undergoing Transcatheter Aortic Valve Intervention Stratified by Baseline Surgical Risk and Device Type
Khan, SU, Zahid, S, Alkhouli, MA, Akbar, UA, Zaid, S, Arshad, HB, Little, SH, Reardon, MJ, Kleiman, NS & Goel, SS 2023, , Structural Heart, vol. 7, no. 4, 100178, pp. 100178.

Propensity-Matched Outcomes Comparing TAVR in Bicuspid vs Surgery in Tricuspid Aortic Valve Stenosis
Deeb, GM, Yakubov, SJ, Reardon, MJ, Ramlawi, B, Chetcuti, SJ, Kleiman, NS, Zahr, F, Song, HK, Gada, H, Mumtaz, M, Ito, S, Huang, J & Forrest, JK 2023, , Journal of the Society for Cardiovascular Angiography and Interventions, vol. 2, no. 1, 100525.

Mitral Valve-in-Valve Versus Repeat Surgical Mitral Valve Replacement in Patients With Failed Mitral Bioprostheses
Al-Abcha, A, Saleh, Y, Khan, SU, Salazar, AM, Zaid, S, Abdelkarim, O, Halboni, A, Abdelfattah, OM, Goel, SS, Kleiman, NS & Guerrero, M 2023, , Journal of the Society for Cardiovascular Angiography and Interventions, vol. 2, no. 1, 100516.

Reconstructing Interventional Cardiology Fellowships to Include Cardiac Computed Tomography Training
Janus, SE, Chami, T, Arora, S, Goessl, M, Sorajja, P, Filby, SJ, Kleiman, NS, Shishehbor, MH, Saxon, JT, Brilakis, ES & Al-Kindi, SG 2023, , Journal of the Society for Cardiovascular Angiography and Interventions.

Characteristics and Outcomes of Patients Ineligible for Transcatheter Mitral Valve Replacement
Hatab, T, Zaid, S, Wessly, P, Faza, N, Little, SH, Atkins, MD, Reardon, MJ, Kleiman, NS, Zoghbi, WA & Goel, S 2023, , Structural Heart.

Meta-analysis of Transcatheter Edge-to-Edge Repair for Atrial Functional Mitral Regurgitation
Hatab, T, Khan, SU, Arshad, HB, Zaid, S, Wessly, P, Faza, N, Little, SH, Reardon, MJ, Atkins, MD, Kleiman, NS, Zoghbi, WA & Goel, S 2023, , Journal of the Society for Cardiovascular Angiography and Interventions.

Transcatheter Treatment of Native Aortic Valve Regurgitation: The North American Experience With a Novel Device
Garcia, S, Ye, J, Webb, J, Reardon, M, Kleiman, N, Goel, S, Hatab, T, Fam, N, Peterson, M, Liauw, S, Frisoli, TM, Bashir, H, Paige, D, Rock, D, Schmidt, C, Jollis, JG & Kereiakes, DJ 2023, , JACC: Cardiovascular Interventions, vol. 16, no. 16, pp. 1953-1960.

Statin related muscle symptoms: is it time to move on
Khan, SU & Kleiman, NS 2022, , BMJ (Clinical research ed.), vol. 379, pp. o2939.

Late Transcatheter Aortic Valve Thrombosis Leading to Cardiogenic Shock
Al Abri, Q, El Nihum, LI, Hinohara, T, Chang, SM, Faza, NN, Goel, SS, Kleiman, NS, Wyler von Ballmoos, MC, Atkins, MD & Reardon, MJ 2022, , JACC: Case Reports, vol. 4, no. 22, pp. 1459-1463.

Cardiac Arrest in Young Adults With Ischemic Heart Disease in the United States, 2004-2018
Jain, V, Minhas, AMK, Kleiman, NS, Arshad, HB, Saleh, Y, Pandat, SS, Dani, SS, Goel, SS, Faza, N, Butt, SA, Blankstein, R, Cainzos-Achirica, M, Nasir, K & Khan, SU 2022, , Current Problems in Cardiology, vol. 47, no. 11, 101312, pp. 101312.