Neal Kleiman, MD

Lois and Carl Davis Centennial Chair, DeBakey Heart & Vascular Center
Professor of Cardiology, Institute for Academic Medicine
Full Clinical Member, Research Institute
Program Director, Interventional Cardiology Residency, Department of Cardiology
Houston Methodist
Weill Cornell Medical College


Research Lab


Biography

Dr. Neal S. Kleiman is the medical director of the cardiac catheterization laboratories at the Houston Methodist DeBakey Heart & Vascular Center at Houston Methodist Hospital and a professor at Weill Cornell Medical College. He has special interests in angioplasty, stenting, coronary artery diseases and interventional cardiology.

His research lies in the relationship between angioplasty, stenting and clotting. His laboratory, recognized nationally as a select site for platelet research, examines the effects of antiplatelet therapy, the use of medications to prevent platelets from clumping and blood from clotting in patients with coronary artery disease who undergo angioplasty procedures. Kleiman has been the principal investigator and/or collaborating investigator in more than 100 studies and multi-center trials related to arterial thrombosis, the formation of blood clots in the arteries, clotting and angioplasty, which have altered the management of patients with chest pain undergoing catheterization.

After receiving his medical degree from Columbia University in New York, Kleiman completed an internship and residency in internal medicine at Baylor College of Medicine, as well as a fellowship in cardiology.

Kleiman has published over 150 manuscripts, book chapters and abstracts. His work has appeared in such publications as the Journal of the American College of Cardiology, Annals of Thoracic Surgery, Journal of Cardiovascular Pharmacology, Circulation, The American College of Cardiology and The European Heart Journal. He is on the editorial board of The Journal of Interventional Cardiology, Circulation, The American Heart Journal and The Journal of Thrombosis and Thrombolysis.

Kleiman is a member of numerous professional organizations including The American Heart Association Council on Clinical Cardiology and Council on Thrombosis, and he is a fellow of The American College of Cardiology and the Society for Coronary Angiography and Interventions.

Description of Research

Dr. Kleiman’s research effort since joining the faculty at Baylor College of Medicine and subsequently at the Houston Methodist DeBakey Heart and Vascular Center has been focused on acute coronary syndromes and coronary interventions. The bulk of this effort has been in the design, management, and execution phases of clinical trials in these two fields, on both the single center (at Houston Methodist Hospital and Ben Taub General Hospital) and multicenter levels. As part of this effort, he has dedicated considerable time to serving on the steering committees of several dozen multicenter trials. Dr. Kleiman established the Applied Platelet Physiology Laboratory at Baylor, now at the Houston Methodist DeBakey Heart and Vascular Center. Work in that laboratory has centered on two areas: providing supporting work in a large number of clinical trials that were complemented by nested mechanistic and pathophysiologic studies, and carrying out independent physiologic studies examining such issues as aspirin dosing, platelet activation during coronary interventions, individual responses to the activity of thienopyridines, and the relation of platelet turnover and COX-2 expression to aspirin sensitivity. The laboratory has also collaborated with other laboratories in the Texas Medical Center including Rice University’s Department of Bioengineering, Baylor’s Leukocyte Biology Laboratory, and most recently, the Molecular Genetics of Cardiovascular Diseases laboratory at Baylor and the stem cell group at MD Anderson Cancer Center. These collaborations have allowed the laboratory to expand its foci to include such investigations as the effects of P2Y12 inhibition and GP IIb/IIIa ligation on leukocyte rolling, leukocyte activation following GP IIb/IIIa administration, the role of platelet P-selectin on leukocyte membrane changes, and most recently the relation circulating endothelial precursor cells and coronary collateral vessels in patients with acute coronary syndromes.

Areas Of Expertise

Acute coronary syndromes Coronary intervention
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, Columbia University College of Surgeons and Physicians
Active Clinical Trials

COAPT

NCT01626079


CoreValve™ Evolut™

NCT02207569


The MARE Study

NCT02153307


REPRISE III

NCT02202434


Corevalve Continued Access Study Extreme Risk Patients

NCT01531374


View All
Publications

Impact of Periprocedural Myocardial Biomarker Elevation on Mortality Following Elective Percutaneous Coronary Intervention
Garcia-Garcia, HM, McFadden, EP, von Birgelen, C, Rademaker-Havinga, T, Spitzer, E, Kleiman, N, Cohen, DJ, Kennedy, KF, Camenzind, E, Mauri, L, Steg, PG, Wijns, W, Silber, S, van Es, GA, Serruys, PW, Windecker, S, Cutlip, D & Vranckx, P 2019, JACC: Cardiovascular Interventions, vol. 12, no. 19, pp. 1954-1962. https://doi.org/10.1016/j.jcin.2019.07.014

The Value of Left Ventricular Support in Patients With Reduced Left Ventricular Function Undergoing Extensive Revascularization: An Analysis From the PROTECT-II Randomized Trial
Burke, DA, Kundi, H, Almonacid, A, ONeill, W, Moses, J, Kleiman, N, Dixon, S, Palacios, I, Guzman, LA, Ohman, EM, Popma, JJ & Pinto, DS 2019, JACC: Cardiovascular Interventions, vol. 12, no. 19, pp. 1985-1987. https://doi.org/10.1016/j.jcin.2019.07.050

Durability and Clinical Outcomes of Transcatheter Aortic Valve Replacement for Failed Surgical Bioprostheses
Dauerman, HL, Deeb, GM, OHair, DP, Waksman, R, Yakubov, SJ, Kleiman, N, Chetcuti, SJ, Hermiller, JB, Bajwa, T, Khabbaz, K, de Marchena, E, Salerno, T, Dries-Devlin, JL, Li, S, Popma, JJ & Reardon, MJ 2019, Circulation. Cardiovascular interventions, vol. 12, no. 10, pp. e008155. https://doi.org/10.1161/CIRCINTERVENTIONS.119.008155

Incidence and Outcomes of Surgical Bailout During TAVR: Insights From the STS/ACC TVT Registry
Pineda, AM, Harrison, JK, Kleiman, N, Rihal, CS, Kodali, SK, Kirtane, AJ, Leon, MB, Sherwood, MW, Manandhar, P, Vemulapalli, S & Beohar, N 2019, JACC: Cardiovascular Interventions, vol. 12, no. 18, pp. 1751-1764. https://doi.org/10.1016/j.jcin.2019.04.026

Temporal Trends and Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement for Bicuspid Aortic Valve Stenosis
Elbadawi, A, Saad, M, Elgendy, IY, Barssoum, K, Omer, MA, Soliman, A, Almahmoud, MF, Ogunbayo, GO, Mentias, A, Gilani, S, Jneid, H, Aronow, HD, Kleiman, N & Abbott, JD 2019, JACC: Cardiovascular Interventions, vol. 12, no. 18, pp. 1811-1822. https://doi.org/10.1016/j.jcin.2019.06.037

Vein of Marshall ethanol infusion for persistent atrial fibrillation: VENUS and MARS clinical trial design
Valderrábano, M, Peterson, LE, Bunge, R, Prystash, M, Dave, A, Nagueh, S & Kleiman, N 2019, American Heart Journal, vol. 215, pp. 52-61. https://doi.org/10.1016/j.ahj.2019.04.022

Comparison of Outcomes after Transcatheter vs Surgical Aortic Valve Replacement among Patients at Intermediate Operative Risk with a History of Coronary Artery Bypass Graft Surgery: A Post Hoc Analysis of the SURTAVI Randomized Clinical Trial
Reardon, MJ, Heijmen, RH, Van Mieghem, NM, Williams, MR, Yakubov, SJ, Watson, D, Kleiman, N, Conte, J, Chawla, A, Hockmuth, D, Petrossian, G, Robinson, N, Kappetein, AP, Li, S & Popma, JJ 2019, JAMA Cardiology. https://doi.org/10.1001/jamacardio.2019.1856

Association between Transcatheter Aortic Valve Replacement and Early Postprocedural Stroke
Huded, CP, Tuzcu, EM, Krishnaswamy, A, Mick, SL, Kleiman, N, Svensson, LG, Carroll, J, Thourani, VH, Kirtane, AJ, Manandhar, P, Kosinski, AS, Vemulapalli, S & Kapadia, SR 2019, JAMA - Journal of the American Medical Association, vol. 321, no. 23, pp. 2306-2315. https://doi.org/10.1001/jama.2019.7525

Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients
Popma, JJ, Deeb, GM, Yakubov, SJ, Mumtaz, M, Gada, H, O’Hair, D, Bajwa, T, Heiser, JC, Merhi, W, Kleiman, NS, Askew, J, Sorajja, P, Rovin, J, Chetcuti, SJ, Adams, DH, Teirstein, PS, Zorn, GL, Forrest, JK, Tchétché, D, Resar, J, Walton, A, Piazza, N, Ramlawi, B, Robinson, N, Petrossian, G, Gleason, TG, Oh, JK, Boulware, MJ, Qiao, H, Mugglin, AS & Reardon, MJ 2019, New England Journal of Medicine, vol. 380, no. 18, pp. 1706-1715. https://doi.org/10.1056/NEJMoa1816885

Simultaneous Transfemoral Mitral and Tricuspid Valve in Ring Implantation: First Case Report with Edwards Sapien 3 Valve
Beg, F, Dadu, RT, Reardon, MJ, Little, SH, Kleiman, N & Barker, CM 2019, Methodist DeBakey cardiovascular journal, vol. 15, no. 2, pp. 149-151. https://doi.org/10.14797/mdcj-15-2-149

The Implications of Acute Clinical Care Responsibilities on the Contemporary Practice of Interventional Cardiology
Workgroup on Acute Care Cardiology and the Interventional Section Leadership Council & American College of Cardiology 2019, JACC: Cardiovascular Interventions, vol. 12, no. 6, pp. 595-599. https://doi.org/10.1016/j.jcin.2018.12.030

Frailty and clinical outcomes in chronic obstructive pulmonary disease
NETT Research Group 2019, Annals of the American Thoracic Society, vol. 16, no. 2, pp. 217-224. https://doi.org/10.1513/AnnalsATS.201803-175OC

Surgical bailout for left ventricular outflow tract obstruction following a complicated mitral valve-in-valve procedure
Wyler von Ballmoos, MC, Barker, CM, Kothapalli, PR, Kleiman, N & Reardon, MJ 2019, Cardiovascular Revascularization Medicine. https://doi.org/10.1016/j.carrev.2019.07.027

Effect of increasing age on percutaneous coronary intervention vs coronary artery bypass grafting in older adults with unprotected left main coronary artery disease: A meta-analysis and meta-regression
Khan, MR, Kayani, WT, Ahmad, W, Manan, M, Hira, RS, Hamzeh, I, Jneid, H, Virani, SS, Kleiman, N, Lakkis, N & Alam, M 2019, Clinical Cardiology. https://doi.org/10.1002/clc.23253

Prescription Patterns of Clopidogrel, Prasugrel, and Ticagrelor After Percutaneous Coronary Intervention With Stent Implantation (from the NCDR PINNACLE Registry)
Khalid, U, Bandeali, S, Jones, PG, Virani, SS, Hira, R, Hamzeh, I, Chan, PS, Kleiman, N, Lakkis, N & Alam, M 2019, American Journal of Cardiology. https://doi.org/10.1016/j.amjcard.2019.09.003

Balloon Predilation in Transcatheter Aortic Valve Replacement with Self-expanding Valves
Rehman, H, Kalra, A, Cochran, JM, Peterson, L, Khera, S, Puri, R, Kolte, D, Gupta, T, Attizzani, GF, Bhatt, DL, Barker, CM, Reardon, MJ & Kleiman, NS 2018, Structural Heart, pp. 1-7. https://doi.org/10.1080/24748706.2018.1549763

5-Year Outcomes of Self-Expanding Transcatheter Versus Surgical Aortic Valve Replacement in High-Risk Patients
CoreValve U.S. Pivotal High Risk Trial Clinical Investigators 2018, Journal of the American College of Cardiology, vol. 72, no. 22, pp. 2687-2696. https://doi.org/10.1016/j.jacc.2018.08.2146

Long-Term Outcomes of Drug-Eluting Stents Versus Bare-Metal Stents in End-Stage Renal Disease Patients on Dialysis: A Systematic Review and Meta-Analysis
Khera, S, Villablanca, PA, Kolte, D, Gupta, T, Hasan Khan, M, Velagapudi, P, Kalra, A, Kleiman, N, Aronow, HD, Abbott, JD, Rosenfield, K, Drachman, DE, Bangalore, S, Bhatt, DL & Naidu, SS 2018, Cardiology in review, vol. 26, no. 6, pp. 277-286. https://doi.org/10.1097/CRD.0000000000000192

Neurological Complications After Transcatheter Versus Surgical Aortic Valve Replacement in Intermediate-Risk Patients
Durko, AP, Reardon, MJ, Kleiman, N, Popma, JJ, Van Mieghem, NM, Gleason, TG, Bajwa, T, OHair, D, Brown, DL, Ryan, WH, Chang, Y, De Leon, SD & Kappetein, AP 2018, Journal of the American College of Cardiology, vol. 72, no. 18, pp. 2109-2119. https://doi.org/10.1016/j.jacc.2018.07.093

One-year outcomes of patients with severe aortic stenosis and an STS PROM of less than three percent in the SURTAVI trial
Serruys, PW, Modolo, R, Reardon, MJ, Miyazaki, Y, Windecker, S, Popma, J, Chang, Y, Kleiman, N, Lilly, S, Amrane, H, Boonstra, PW, Kappetein, AP, Onuma, Y, Søndergaard, L & Van Mieghem, N 2018, EuroIntervention, vol. 14, no. 8, pp. 877-883. https://doi.org/10.4244/EIJ-D-18-00460

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