Neal Kleiman, MD

Lois and Carl Davis Centennial Chair II, DeBakey Heart & Vascular Center
Professor of Cardiology, Academic Institute
Full Clinical Member, Research Institute
Program Director, Interventional Cardiology Residency, Department of Cardiology
Houston Methodist
Weill Cornell Medical College


Research Lab


Biography

Dr. Neal S. Kleiman is the medical director of the cardiac catheterization laboratories at the Houston Methodist DeBakey Heart & Vascular Center at Houston Methodist Hospital and a professor at Weill Cornell Medical College. He has special interests in angioplasty, stenting, coronary artery diseases and interventional cardiology.

His research lies in the relationship between angioplasty, stenting and clotting. His laboratory, recognized nationally as a select site for platelet research, examines the effects of antiplatelet therapy, the use of medications to prevent platelets from clumping and blood from clotting in patients with coronary artery disease who undergo angioplasty procedures. Kleiman has been the principal investigator and/or collaborating investigator in more than 100 studies and multi-center trials related to arterial thrombosis, the formation of blood clots in the arteries, clotting and angioplasty, which have altered the management of patients with chest pain undergoing catheterization.

After receiving his medical degree from Columbia University in New York, Kleiman completed an internship and residency in internal medicine at Baylor College of Medicine, as well as a fellowship in cardiology.

Kleiman has published over 150 manuscripts, book chapters and abstracts. His work has appeared in such publications as the Journal of the American College of Cardiology, Annals of Thoracic Surgery, Journal of Cardiovascular Pharmacology, Circulation, The American College of Cardiology and The European Heart Journal. He is on the editorial board of The Journal of Interventional Cardiology, Circulation, The American Heart Journal and The Journal of Thrombosis and Thrombolysis.

Kleiman is a member of numerous professional organizations including The American Heart Association Council on Clinical Cardiology and Council on Thrombosis, and he is a fellow of The American College of Cardiology and the Society for Coronary Angiography and Interventions.

Description of Research

Dr. Kleiman’s research effort since joining the faculty at Baylor College of Medicine and subsequently at the Houston Methodist DeBakey Heart and Vascular Center has been focused on acute coronary syndromes and coronary interventions. The bulk of this effort has been in the design, management, and execution phases of clinical trials in these two fields, on both the single center (at Houston Methodist Hospital and Ben Taub General Hospital) and multicenter levels. As part of this effort, he has dedicated considerable time to serving on the steering committees of several dozen multicenter trials. Dr. Kleiman established the Applied Platelet Physiology Laboratory at Baylor, now at the Houston Methodist DeBakey Heart and Vascular Center. Work in that laboratory has centered on two areas: providing supporting work in a large number of clinical trials that were complemented by nested mechanistic and pathophysiologic studies, and carrying out independent physiologic studies examining such issues as aspirin dosing, platelet activation during coronary interventions, individual responses to the activity of thienopyridines, and the relation of platelet turnover and COX-2 expression to aspirin sensitivity. The laboratory has also collaborated with other laboratories in the Texas Medical Center including Rice University’s Department of Bioengineering, Baylor’s Leukocyte Biology Laboratory, and most recently, the Molecular Genetics of Cardiovascular Diseases laboratory at Baylor and the stem cell group at MD Anderson Cancer Center. These collaborations have allowed the laboratory to expand its foci to include such investigations as the effects of P2Y12 inhibition and GP IIb/IIIa ligation on leukocyte rolling, leukocyte activation following GP IIb/IIIa administration, the role of platelet P-selectin on leukocyte membrane changes, and most recently the relation circulating endothelial precursor cells and coronary collateral vessels in patients with acute coronary syndromes.

Areas Of Expertise

Acute coronary syndromes Coronary intervention
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, Columbia University College of Surgeons and Physicians
Active Clinical Trials

The MARE Study

NCT02153307


SURTAVI

NCT01586910


CoreValve® Expanded

NCT01675440


COAPT

NCT01626079

Publications

Cardiac Arrest in Young Adults With Ischemic Heart Disease in the United States, 2004-2018
Jain, V, Minhas, AMK, Kleiman, NS, Arshad, HB, Saleh, Y, Pandat, SS, Dani, SS, Goel, SS, Faza, N, Butt, SA, Blankstein, R, Cainzos-Achirica, M, Nasir, K & Khan, SU 2022, , Current Problems in Cardiology, vol. 47, no. 11, 101312. https://doi.org/10.1016/j.cpcardiol.2022.101312

The Complexities of Redo TAVR
Kleiman, NS & Carroll, JD 2022, , JACC: Cardiovascular Interventions, vol. 15, no. 15, pp. 1555-1557. https://doi.org/10.1016/j.jcin.2022.05.046

Upping the Transcatheter Edge-to-Edge Repair Game: Patient Selection Based on Newly Described Echocardiographic Measurements
Kleiman, NS & Goel, S 2022, , Circulation: Cardiovascular Interventions, vol. 15, no. 7, pp. E012174. https://doi.org/10.1161/CIRCINTERVENTIONS.122.012174

Trends in Outcomes of Hospitalized Adults Undergoing Percutaneous Balloon Mitral Valvuloplasty in the United States
Minhas, AMK, Ahmed, T, Arshad, HB, Sagheer, S, Ullah, W, Kleiman, NS, Kapadia, SR & Goel, S 2022, , Cardiovascular Revascularization Medicine, vol. 39, pp. 117-120. https://doi.org/10.1016/j.carrev.2021.10.005

Trends in 30-Day and 90-Day Readmission Rates After Transcatheter Aortic Valve Implantation
Gupta, T, Tripathi, B, Kalra, A, Khera, S, Sawant, A, Nazif, TM, Kleiman, NS, Kirtane, AJ, Goel, SS, Bhatt, DL, Pershad, A & Kodali, SK 2022, , American Journal of Cardiology, vol. 167, pp. 167-170. https://doi.org/10.1016/j.amjcard.2021.12.049

Propensity-Matched 1-Year Outcomes Following Transcatheter Aortic Valve Replacement in Low-Risk Bicuspid and Tricuspid Patients
Deeb, GM, Reardon, MJ, Ramlawi, B, Yakubov, SJ, Chetcuti, SJ, Kleiman, NS, Mangi, AA, Zahr, F, Song, HK, Gada, H, Mumtaz, M, Heiser, J, Merhi, W, Murrah, CP, Noel, T, Kirshner, M, Byrne, T, Ito, S, Huang, J & Forrest, JK 2022, , JACC: Cardiovascular Interventions, vol. 15, no. 5, pp. 511-522. https://doi.org/10.1016/j.jcin.2021.10.027

2-Year Outcomes After Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients
Forrest, JK, Deeb, GM, Yakubov, SJ, Rovin, JD, Mumtaz, M, Gada, H, OHair, D, Bajwa, T, Sorajja, P, Heiser, JC, Merhi, W, Mangi, A, Spriggs, DJ, Kleiman, NS, Chetcuti, SJ, Teirstein, PS, Zorn, GL, Tadros, P, Tchétché, D, Resar, JR, Walton, A, Gleason, TG, Ramlawi, B, Iskander, A, Caputo, R, Oh, JK, Huang, J & Reardon, MJ 2022, , Journal of the American College of Cardiology, vol. 79, no. 9, pp. 882-896. https://doi.org/10.1016/j.jacc.2021.11.062

Comparative Outcomes of Transcatheter Aortic Valve Implantation and Mitral Transcatheter Edge-to-Edge Repair: Same Versus Different Hospitalization
Sagheer, S, Minhas, AMK, Arshad, HB, Nazir, S, Ijaz, SH, Ullah, W, Khan, SU, Kleiman, NS, Kapadia, SR & Goel, SS 2022, , American Journal of Cardiology, vol. 164, pp. 133-135. https://doi.org/10.1016/j.amjcard.2021.10.011

Meta-Analysis Investigating the Role of Optical Coherence Tomography Versus Intravascular Ultrasound in Low-Risk Percutaneous Coronary Intervention
Saleh, Y, Al-abcha, A, Abdelkarim, O, Abdelfattah, OM, Abela, GS, Hashim, H, Goel, SS & Kleiman, NS 2022, , American Journal of Cardiology, vol. 164, pp. 136-138. https://doi.org/10.1016/j.amjcard.2021.10.016

Prognostic Value of Computed Tomography-Derived Fractional Flow Reserve Comparison With Myocardial Perfusion Imaging
Ahmed, AI, Han, Y, Al Rifai, M, Alnabelsi, T, Nabi, F, Chang, SM, Cocker, M, Schwemmer, C, Ramirez-Giraldo, JC, Kleiman, NS, Zoghbi, WA, Mahmarian, JJ & Al-Mallah, MH 2022, , JACC: Cardiovascular Imaging, vol. 15, no. 2, pp. 284-295. https://doi.org/10.1016/j.jcmg.2021.09.007

Dethroning Contrast Angiography: A Place for Electroanatomic Mapping?
Kleiman, NS 2022, , JACC: Basic to Translational Science, vol. 7, no. 2, pp. 143-145. https://doi.org/10.1016/j.jacbts.2021.11.011

Mechanisms of Death in Low-Risk Patients After Transcatheter or Surgical Aortic Valve Replacement
Ramlawi, B, Deeb, GM, Yakubov, SJ, Markowitz, AH, Hughes, GC, Kiaii, RB, Huang, J, Kleiman, NS & Reardon, MJ 2022, , Cardiovascular Revascularization Medicine, vol. 42, pp. 1-5. https://doi.org/10.1016/j.carrev.2022.03.027

Clinical Impact of Tricuspid Regurgitation on Transcatheter Edge-to-Edge Mitral Valve Repair for Mitral Regurgitation
Chitturi, KR, Bhardwaj, B, Murtaza, G, Karuparthi, PR, Faza, NN, Goel, SS, Reardon, MJ, Kleiman, NS & Aggarwal, K 2022, , Cardiovascular Revascularization Medicine, vol. 41, pp. 1-9. https://doi.org/10.1016/j.carrev.2022.01.027

Getting it Right: Aortic Valve Replacement and the SYNTAX Score
Kleiman, NS 2021, , JACC: Cardiovascular Interventions, vol. 14, no. 22, pp. 2500-2502. https://doi.org/10.1016/j.jcin.2021.09.030

Mitral Valve Surgery After Transcatheter Edge-to-Edge Repair: Mid-Term Outcomes From the CUTTING-EDGE International Registry
CUTTING-EDGE Investigators 2021, , JACC: Cardiovascular Interventions, vol. 14, no. 18, pp. 2010-2021. https://doi.org/10.1016/j.jcin.2021.07.029

Surgical Explantation After TAVR Failure: Mid-Term Outcomes From the EXPLANT-TAVR International Registry
EXPLANT-TAVR Investigators 2021, , JACC: Cardiovascular Interventions, vol. 14, no. 18, pp. 1978-1991. https://doi.org/10.1016/j.jcin.2021.07.015

Transcatheter aortic valve replacement with self-expandable supra-annular valves for degenerated surgical bioprostheses: Insights from transcatheter valve therapy registry
Dallan, LAP, Forrest, JK, Reardon, MJ, Szeto, WY, George, I, Kodali, S, Kleiman, NS, Yakubov, SJ, Grubb, KJ, Liu, F, Baeza, C & Attizzani, GF 2021, , Journal of the American Heart Association, vol. 10, no. 18, e021871. https://doi.org/10.1161/JAHA.121.021871

Association of Peri-Procedural Major Bleeding With Outcomes in Patients Undergoing Transcatheter Mitral Edge-To-Edge Repair
Nazir, S, Gupta, T, Ahuja, KR, Minhas, AMK, Ariss, RW, Gupta, R, Goel, SS & Kleiman, NS 2021, , American Journal of Cardiology, vol. 152, pp. 172-174. https://doi.org/10.1016/j.amjcard.2021.04.025

Monster Under the Bed? Coronary Access After TAVR
Kleiman, NS 2021, , JACC: Cardiovascular Interventions, vol. 14, no. 14, pp. 1591-1593. https://doi.org/10.1016/j.jcin.2021.06.001

Combined Transcatheter Aortic and Mitral Valve Interventions: Insights From a National Database
Elbadawi, A, Elgendy, IY, Afify, H, Eid, M, Hamed, M, Abowali, HA, Kleiman, NS, Reardon, MJ, Kapadia, SR & Goel, SS 2021, , JACC: Cardiovascular Interventions, vol. 14, no. 13, pp. 1505-1507. https://doi.org/10.1016/j.jcin.2021.03.047