Neal Kleiman, MD

Lois and Carl Davis Centennial Chair, DeBakey Heart & Vascular Center
Professor of Cardiology, Academic Institute
Full Clinical Member, Research Institute
Program Director, Interventional Cardiology Residency, Department of Cardiology
Houston Methodist
Weill Cornell Medical College


Research Lab


Biography

Dr. Neal S. Kleiman is the medical director of the cardiac catheterization laboratories at the Houston Methodist DeBakey Heart & Vascular Center at Houston Methodist Hospital and a professor at Weill Cornell Medical College. He has special interests in angioplasty, stenting, coronary artery diseases and interventional cardiology.

His research lies in the relationship between angioplasty, stenting and clotting. His laboratory, recognized nationally as a select site for platelet research, examines the effects of antiplatelet therapy, the use of medications to prevent platelets from clumping and blood from clotting in patients with coronary artery disease who undergo angioplasty procedures. Kleiman has been the principal investigator and/or collaborating investigator in more than 100 studies and multi-center trials related to arterial thrombosis, the formation of blood clots in the arteries, clotting and angioplasty, which have altered the management of patients with chest pain undergoing catheterization.

After receiving his medical degree from Columbia University in New York, Kleiman completed an internship and residency in internal medicine at Baylor College of Medicine, as well as a fellowship in cardiology.

Kleiman has published over 150 manuscripts, book chapters and abstracts. His work has appeared in such publications as the Journal of the American College of Cardiology, Annals of Thoracic Surgery, Journal of Cardiovascular Pharmacology, Circulation, The American College of Cardiology and The European Heart Journal. He is on the editorial board of The Journal of Interventional Cardiology, Circulation, The American Heart Journal and The Journal of Thrombosis and Thrombolysis.

Kleiman is a member of numerous professional organizations including The American Heart Association Council on Clinical Cardiology and Council on Thrombosis, and he is a fellow of The American College of Cardiology and the Society for Coronary Angiography and Interventions.

Description of Research

Dr. Kleiman’s research effort since joining the faculty at Baylor College of Medicine and subsequently at the Houston Methodist DeBakey Heart and Vascular Center has been focused on acute coronary syndromes and coronary interventions. The bulk of this effort has been in the design, management, and execution phases of clinical trials in these two fields, on both the single center (at Houston Methodist Hospital and Ben Taub General Hospital) and multicenter levels. As part of this effort, he has dedicated considerable time to serving on the steering committees of several dozen multicenter trials. Dr. Kleiman established the Applied Platelet Physiology Laboratory at Baylor, now at the Houston Methodist DeBakey Heart and Vascular Center. Work in that laboratory has centered on two areas: providing supporting work in a large number of clinical trials that were complemented by nested mechanistic and pathophysiologic studies, and carrying out independent physiologic studies examining such issues as aspirin dosing, platelet activation during coronary interventions, individual responses to the activity of thienopyridines, and the relation of platelet turnover and COX-2 expression to aspirin sensitivity. The laboratory has also collaborated with other laboratories in the Texas Medical Center including Rice University’s Department of Bioengineering, Baylor’s Leukocyte Biology Laboratory, and most recently, the Molecular Genetics of Cardiovascular Diseases laboratory at Baylor and the stem cell group at MD Anderson Cancer Center. These collaborations have allowed the laboratory to expand its foci to include such investigations as the effects of P2Y12 inhibition and GP IIb/IIIa ligation on leukocyte rolling, leukocyte activation following GP IIb/IIIa administration, the role of platelet P-selectin on leukocyte membrane changes, and most recently the relation circulating endothelial precursor cells and coronary collateral vessels in patients with acute coronary syndromes.

Areas Of Expertise

Acute coronary syndromes Coronary intervention
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, Columbia University College of Surgeons and Physicians
Active Clinical Trials

COAPT

NCT01626079


The MARE Study

NCT02153307


REPRISE III

NCT02202434


CoreValve® Expanded

NCT01675440


SURTAVI

NCT01586910

Publications

Tip-to-Base LAMPOON for Transcatheter Mitral Valve Replacement With a Protected Mitral Annulus
Lisko, JC, Babaliaros, VC, Khan, JM, Kamioka, N, Gleason, PT, Paone, G, Byku, I, Tiwana, J, McCabe, JM, Cherukuri, K, Khalil, R, Lasorda, D, Goel, SS, Kleiman, NS, Reardon, MJ, Daniels, DV, Spies, C, Mahoney, P, Case, BC, Whisenant, BK, Yadav, PK, Condado, JF, Koch, R, Grubb, KJ, Bruce, CG, Rogers, T, Lederman, RJ & Greenbaum, AB 2021, , JACC: Cardiovascular Interventions, vol. 14, no. 5, pp. 541-550. https://doi.org/10.1016/j.jcin.2020.11.034

Is This a Good Time to Revisit the Tropics? Platelet Function Testing in Patients With Acute Coronary Syndromes
Kleiman, NS 2021, , JACC: Cardiovascular Interventions, vol. 14, no. 4, pp. 428-430. https://doi.org/10.1016/j.jcin.2020.12.041

First in Man Pilot Feasibility Study in Extracranial Carotid Robotic-Assisted Endovascular Intervention
Desai, VR, Lee, JJ, Sample, T, Kleiman, NS, Lumsden, A & Britz, GW 2021, , Neurosurgery, vol. 88, no. 3, pp. 506-514. https://doi.org/10.1093/neuros/nyaa461

Arrhythmic burden in patients with new-onset persistent left bundle branch block after transcatheter aortic valve replacement: 2-year results of the MARE study
Muntané-Carol, G, Urena, M, Nombela-Franco, L, Amat-Santos, I, Kleiman, N, Munoz-Garcia, A, Atienza, F, Serra, V, Deyell, MW, Veiga-Fernandez, G, Masson, JB, Canadas-Godoy, V, Himbert, D, Castrodeza, J, Elizaga, J, Francisco Pascual, J, Webb, JG, de la Torre Hernandez, JM, Asmarats, L, Pelletier-Beaumont, E, Philippon, F & Rodés-Cabau, J 2021, , Europace, vol. 23, no. 2, pp. 254-263. https://doi.org/10.1093/europace/euaa213

Should Interventional Cardiologists Super-Subspecialize? Moving From Patient Selection to Operator Selection
Interventional Section Leadership Council, American College of Cardiology 2021, , JACC: Cardiovascular Interventions, vol. 14, no. 1, pp. 97-100. https://doi.org/10.1016/j.jcin.2020.10.029

Impact of Myocardial Scar on Prognostic Implication of Secondary Mitral Regurgitation in Heart Failure
Tayal, B, Debs, D, Nabi, F, Malahfji, M, Little, SH, Reardon, M, Zoghbi, W, Kleiman, N & Shah, DJ 2021, , JACC: Cardiovascular Imaging, vol. 14, no. 4, pp. 812-822. https://doi.org/10.1016/j.jcmg.2020.11.004

Predicting and measuring mortality risk after transcatheter aortic valve replacement
Gupta, T, Joseph, DT, Goel, SS & Kleiman, NS 2021, , Expert Review of Cardiovascular Therapy. https://doi.org/10.1080/14779072.2021.1888715

Transcatheter Edge-to-Edge Repair With MitraClip in Systolic Heart Failure With Ischemic Versus Nonischemic Cardiomyopathy
Elbadawi, A, Elgendy, IY, Lee, B, Saleh, M, Khalife, WI, Bhimaraj, A, Kapadia, SR, Kleiman, NS & Goel, SS 2020, , JACC: Cardiovascular Interventions, vol. 13, no. 23, pp. 2818-2819. https://doi.org/10.1016/j.jcin.2020.09.027

Mechanical Prosthetic Aortic Valve Thrombosis Complicated by an Acute Coronary Syndrome During Fibrinolysis
Aoun, J, Assaker, JP, Faza, N, Kleiman, NS, Zacca, N & Little, SH 2020, , JACC: Case Reports, vol. 2, no. 14, pp. 2186-2190. https://doi.org/10.1016/j.jaccas.2020.08.029

Surgical Bailout for Left Ventricular Outflow Tract Obstruction Following a Complicated Mitral Valve-in-Valve Procedure
Wyler von Ballmoos, MC, Barker, CM, Kothapalli, PR, Kleiman, NS & Reardon, MJ 2020, , Cardiovascular Revascularization Medicine, vol. 21, no. 11, pp. 1343-1347. https://doi.org/10.1016/j.carrev.2019.07.027

Aortic Valve Replacement in Bioprosthetic Failure: Insights From The Society of Thoracic Surgeons National Database
Kalra, A, Raza, S, Hussain, M, Shorbaji, K, Delozier, S, Deo, SV, Khera, S, Kleiman, NS, Reardon, MJ, Kolte, D, Gupta, T, Mustafa, R, Bhatt, DL & Sabik, JF 2020, , Annals of Thoracic Surgery, vol. 110, no. 5, pp. 1637-1642. https://doi.org/10.1016/j.athoracsur.2019.08.023

Effect of Catheter Ablation with Vein of Marshall Ethanol Infusion vs Catheter Ablation Alone on Persistent Atrial Fibrillation: The VENUS Randomized Clinical Trial
Valderrábano, M, Peterson, LE, Swarup, V, Schurmann, PA, Makkar, A, Doshi, RN, Delurgio, D, Athill, CA, Ellenbogen, KA, Natale, A, Koneru, J, Dave, AS, Giorgberidze, I, Afshar, H, Guthrie, ML, Bunge, R, Morillo, CA & Kleiman, NS 2020, , JAMA - Journal of the American Medical Association, vol. 324, no. 16, pp. 1620-1628. https://doi.org/10.1001/jama.2020.16195

Propensity-Matched Comparison of Evolut-R Transcatheter Aortic Valve Implantation With Surgery in Intermediate-Risk Patients (from the SURTAVI Trial)
Yakubov, SJ, Van Mieghem, NM, Reardon, MJ, Serruys, PW, Gada, H, Mumtaz, M, Deeb, GM, Kodali, S, George, I, Windecker, S, Kleiman, N, Chetcuti, SJ, Sanchez, C, Dauerman, HL, Li, S & Popma, JJ 2020, , American Journal of Cardiology, vol. 131, pp. 82-90. https://doi.org/10.1016/j.amjcard.2020.06.051

Natural History of Functional Tricuspid Regurgitation Quantified by Cardiovascular Magnetic Resonance
Zhan, Y, Debs, D, Khan, MA, Nguyen, DT, Graviss, EA, Khalaf, S, Little, SH, Reardon, MJ, Nagueh, S, Quiñones, MA, Kleiman, N, Zoghbi, WA & Shah, DJ 2020, , Journal of the American College of Cardiology, vol. 76, no. 11, pp. 1291-1301. https://doi.org/10.1016/j.jacc.2020.07.036

Renin-Angiotensin System Blockade in Aortic Stenosis: Implications Before and After Aortic Valve Replacement
Goel, SS, Kleiman, NS, Zoghbi, WA, Reardon, MJ & Kapadia, SR 2020, , Journal of the American Heart Association, vol. 9, no. 18, pp. e016911. https://doi.org/10.1161/JAHA.120.016911

Triage considerations for patients referred for structural heart disease intervention during the COVID-19 pandemic: An ACC/SCAI position statement
Shah, PB, Welt, FGP, Mahmud, E, Phillips, A, Kleiman, NS, Young, MN, Sherwood, M, Batchelor, W, Wang, DD, Davidson, L, Wyman, J, Kadavath, S, Szerlip, M, Hermiller, J, Fullerton, D & Anwaruddin, S 2020, , Catheterization and Cardiovascular Interventions, vol. 96, no. 3, pp. 659-663. https://doi.org/10.1002/ccd.28910

Clinical Implications of Physical Function and Resilience in Patients Undergoing Transcatheter Aortic Valve Replacement
Goel, K, OLeary, JM, Barker, CM, Levack, M, Rajagopal, V, Makkar, RR, Bajwa, T, Kleiman, N, Linke, A, Kereiakes, DJ, Waksman, R, Allocco, DJ, Rizik, DG, Reardon, MJ & Lindman, BR 2020, , Journal of the American Heart Association, vol. 9, no. 17, pp. e017075. https://doi.org/10.1161/JAHA.120.017075

Role of Teleproctoring in Challenging and Innovative Structural Interventions Amid the COVID-19 Pandemic and Beyond
Goel, SS, Greenbaum, AB, Patel, A, Little, SH, Parikh, R, Wyler von Ballmoos, MC, Lumsden, AB, Reardon, MJ & Kleiman, NS 2020, , JACC: Cardiovascular Interventions, vol. 13, no. 16, pp. 1945-1948. https://doi.org/10.1016/j.jcin.2020.04.013

Transcatheter Mitral Valve Repair with MitraClip for Severe Mitral Regurgitation and Cardiogenic Shock During the COVID-19 Pandemic
Chitturi, KR, Faza, NN, Little, SH, Kleiman, NS, Reardon, MJ & Goel, SS 2020, , Cardiovascular Revascularization Medicine, vol. 21, no. 8, pp. 950-953. https://doi.org/10.1016/j.carrev.2020.05.030

Triage Considerations for Patients Referred for Structural Heart Disease Intervention During the COVID-19 Pandemic: An ACC/SCAI Position Statement
American College of Cardiology and the Society for Cardiovascular Angiography and Interventions 2020, , JACC: Cardiovascular Interventions, vol. 13, no. 12, pp. 1484-1488. https://doi.org/10.1016/j.jcin.2020.04.001