Neal Kleiman, MD

Lois and Carl Davis Centennial Chair II, DeBakey Heart & Vascular Center
Professor of Cardiology, Academic Institute
Full Clinical Member, Research Institute
Program Director, Interventional Cardiology Residency, Department of Cardiology
Houston Methodist
Weill Cornell Medical College


Research Lab


Biography

Dr. Neal S. Kleiman is the medical director of the cardiac catheterization laboratories at the Houston Methodist DeBakey Heart & Vascular Center at Houston Methodist Hospital and a professor at Weill Cornell Medical College. He has special interests in angioplasty, stenting, coronary artery diseases and interventional cardiology.

His research lies in the relationship between angioplasty, stenting and clotting. His laboratory, recognized nationally as a select site for platelet research, examines the effects of antiplatelet therapy, the use of medications to prevent platelets from clumping and blood from clotting in patients with coronary artery disease who undergo angioplasty procedures. Kleiman has been the principal investigator and/or collaborating investigator in more than 100 studies and multi-center trials related to arterial thrombosis, the formation of blood clots in the arteries, clotting and angioplasty, which have altered the management of patients with chest pain undergoing catheterization.

After receiving his medical degree from Columbia University in New York, Kleiman completed an internship and residency in internal medicine at Baylor College of Medicine, as well as a fellowship in cardiology.

Kleiman has published over 150 manuscripts, book chapters and abstracts. His work has appeared in such publications as the Journal of the American College of Cardiology, Annals of Thoracic Surgery, Journal of Cardiovascular Pharmacology, Circulation, The American College of Cardiology and The European Heart Journal. He is on the editorial board of The Journal of Interventional Cardiology, Circulation, The American Heart Journal and The Journal of Thrombosis and Thrombolysis.

Kleiman is a member of numerous professional organizations including The American Heart Association Council on Clinical Cardiology and Council on Thrombosis, and he is a fellow of The American College of Cardiology and the Society for Coronary Angiography and Interventions.

Description of Research

Dr. Kleiman’s research effort since joining the faculty at Baylor College of Medicine and subsequently at the Houston Methodist DeBakey Heart and Vascular Center has been focused on acute coronary syndromes and coronary interventions. The bulk of this effort has been in the design, management, and execution phases of clinical trials in these two fields, on both the single center (at Houston Methodist Hospital and Ben Taub General Hospital) and multicenter levels. As part of this effort, he has dedicated considerable time to serving on the steering committees of several dozen multicenter trials. Dr. Kleiman established the Applied Platelet Physiology Laboratory at Baylor, now at the Houston Methodist DeBakey Heart and Vascular Center. Work in that laboratory has centered on two areas: providing supporting work in a large number of clinical trials that were complemented by nested mechanistic and pathophysiologic studies, and carrying out independent physiologic studies examining such issues as aspirin dosing, platelet activation during coronary interventions, individual responses to the activity of thienopyridines, and the relation of platelet turnover and COX-2 expression to aspirin sensitivity. The laboratory has also collaborated with other laboratories in the Texas Medical Center including Rice University’s Department of Bioengineering, Baylor’s Leukocyte Biology Laboratory, and most recently, the Molecular Genetics of Cardiovascular Diseases laboratory at Baylor and the stem cell group at MD Anderson Cancer Center. These collaborations have allowed the laboratory to expand its foci to include such investigations as the effects of P2Y12 inhibition and GP IIb/IIIa ligation on leukocyte rolling, leukocyte activation following GP IIb/IIIa administration, the role of platelet P-selectin on leukocyte membrane changes, and most recently the relation circulating endothelial precursor cells and coronary collateral vessels in patients with acute coronary syndromes.

Areas Of Expertise

Acute coronary syndromes Coronary intervention
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, Columbia University College of Surgeons and Physicians
Publications

Quality of Life 5 Years Following Transfemoral TAVR or SAVR in Intermediate Risk Patients
Kleiman, NS, Van Mieghem, NM, Reardon, MJ, Gada, H, Mumtaz, M, Olsen, PS, Heiser, J, Merhi, W, Chetcuti, S, Deeb, GM, Chawla, A, Kiaii, B, Teefy, P, Chu, MWA, Yakubov, SJ, Windecker, S, Althouse, AD & Baron, SJ 2024, , JACC: Cardiovascular Interventions, vol. 17, no. 8, pp. 979-988. https://doi.org/10.1016/j.jcin.2024.02.014

Reinterventions After CoreValve/Evolut Transcatheter or Surgical Aortic Valve Replacement for Treatment of Severe Aortic Stenosis
Grubb, KJ, Lisko, JC, OHair, D, Merhi, W, Forrest, JK, Mahoney, P, Van Mieghem, NM, Windecker, S, Yakubov, SJ, Williams, MR, Chetcuti, SJ, Deeb, GM, Kleiman, NS, Althouse, AD & Reardon, MJ 2024, , JACC: Cardiovascular Interventions, vol. 17, no. 8, pp. 1007-1016. https://doi.org/10.1016/j.jcin.2024.01.292

Prognostic Value of Right Ventricular Afterload in Patients Undergoing Mitral Transcatheter Edge-to-Edge Repair
Bou Chaaya, RG, Hatab, T, Samimi, S, Qamar, F, Kharsa, C, Aoun, J, Faza, N, Little, SH, Atkins, MD, Reardon, MJ, Kleiman, N, Nagueh, SF, Zoghbi, WA, Guha, A, Zaid, S & Goel, S 2024, , Journal of the American Heart Association, vol. 13, no. 8, e033510. https://doi.org/10.1161/JAHA.123.033510

Intraprocedural Doppler and Invasive Hemodynamic Profiling Predict Clinical Outcomes After Mitral TEER
Zaid, S, Wessly, P, Hatab, T, Faza, N, Little, SH, Atkins, MD, Reardon, MJ, Kleiman, NS, Zoghbi, WA & Goel, SS 2024, , JACC: Cardiovascular Imaging, vol. 17, no. 4, pp. 454-456. https://doi.org/10.1016/j.jcmg.2023.10.013

Optimizing Dual Antiplatelet Therapy After Percutaneous Coronary Intervention in Older Adults
Khan, SU & Kleiman, NS 2024, , JAMA Network Open, vol. 7, no. 3, pp. E246951. https://doi.org/10.1001/jamanetworkopen.2024.6951

Echocardiographic Profiling Predicts Clinical Outcomes After Mitral Transcatheter Edge-to-Edge Repair
Hatab, T, Samimi, S, Chaaya, RGB, Qamar, F, Kharsa, C, Wessly, P, Faza, N, Little, SH, Atkins, MD, Reardon, MJ, Kleiman, NS, Zoghbi, WA, Nagueh, SF, Zaid, S & Goel, SS 2024, , Journal of the American Heart Association, vol. 13, no. 5, e032784, pp. e032784. https://doi.org/10.1161/JAHA.123.032784

The Shape of Things to Come? Is a Trial of Combined Interventional Procedures Necessary in Today's World?
Kleiman, N & Goel, SS 2024, , Circulation, vol. 149, no. 10, pp. 744-746. https://doi.org/10.1161/CIRCULATIONAHA.123.067744

Five-Year Follow-Up from the CoreValve Expanded Use Transcatheter Aortic Valve-in-Surgical Aortic Valve Study
Bajwa, TK, Laham, RJ, Khabbaz, K, Dauerman, HL, Waksman, R, Weiss, E, Allaqaband, S, Badr, S, Caskey, M, Byrne, T, Applegate, RJ, Kon, ND, Li, S, Kleiman, N, Reardon, MJ, Chetcuti, SJ & Deeb, GM 2024, , American Journal of Cardiology, vol. 214, pp. 1-7. https://doi.org/10.1016/j.amjcard.2023.11.071

Characteristics and Outcomes of Patients Ineligible for Tricuspid Transcatheter Edge-to-Edge Repair
Hatab, T, Bou Chaaya, RG, Samimi, S, Qamar, F, Faza, N, Little, SH, Reardon, MJ, Kleiman, NS, Zoghbi, WA, Guha, A, Zaid, S & Goel, SS 2024, , Structural Heart, vol. 8, no. 2, 100235, pp. 100235. https://doi.org/10.1016/j.shj.2023.100235

Edge to Edge Mitral Valve Repair After Transcatheter Valve Implantation: Jumping the Gun or Doing What Needs to Be Done?
Kleiman, NS 2024, , American Journal of Cardiology, vol. 210, pp. 288-289. https://doi.org/10.1016/j.amjcard.2023.10.022

Impact of transcatheter heart valve type on outcomes of surgical explantation after failed transcatheter aortic valve replacement: the EXPLANT-TAVR international registry
the EXPLANT-TAVR registry investigators 2024, , EuroIntervention, vol. 20, no. 2, pp. E146-E157. https://doi.org/10.4244/EIJ-D-23-00722

Percutaneous coronary intervention before transcatheter aortic valve implantation: A propensity score matched analysis
Khan, SU, Dani, SS, Ganatra, S, Ahmed, T, Agalan, A, Khadke, S, Agarwal, S, Zaid, S, Arshad, HB, Zahid, S, Shah, AR, Goel, SS & Kleiman, N 2024, , Cardiovascular Revascularization Medicine. https://doi.org/10.1016/j.carrev.2024.03.011

Do We Still Need Aspirin in Coronary Artery Disease?
Maqsood, MH, Levine, GN, Kleiman, ND, Hasdai, D, Uretsky, BF & Birnbaum, Y 2023, , Journal of Clinical Medicine, vol. 12, no. 24, 7534. https://doi.org/10.3390/jcm12247534

Outcomes With Intravascular Ultrasound and Optical Coherence Tomography Guidance in Percutaneous Coronary Intervention
Arora, S, Jaswaney, R, Khawaja, T, Jain, A, Khan, SU, Gidwani, UK, Osman, MN, Goel, S, Shah, AR & Kleiman, NS 2023, , American Journal of Cardiology, vol. 207, pp. 470-478. https://doi.org/10.1016/j.amjcard.2023.08.065

Surgical Explantation of Failed Transcatheter Aortic Valve Replacement
EXPLANT-TAVR Investigators 2023, , Annals of Thoracic Surgery, vol. 116, no. 5, pp. 933-942. https://doi.org/10.1016/j.athoracsur.2023.05.036

Feasibility and Outcomes of Mitral Transcatheter Edge-To-Edge Repair in Patients With Variable Degrees of Mitral Annular Calcification
Hatab, T, Bou Chaaya, RG, Zaid, S, Wessly, P, Satish, P, Villanueva, V, Faza, N, Little, SH, Atkins, MD, Reardon, MJ, Kleiman, NS, Zoghbi, WA & Goel, SS 2023, , Journal of the American Heart Association, vol. 12, no. 19, e031118, pp. e031118. https://doi.org/10.1161/JAHA.123.031118

TAV-in-TAV in Failed Homograft: Redo TAVI in a Patient With 3 Previous Sternotomies
Hatab, T, Zaid, S, Wessly, P, Reardon, MJ, Atkins, MD, Faza, N, Little, SH, Kleiman, NS & Goel, SS 2023, , JACC: Case Reports, vol. 22, 101973, pp. 101973. https://doi.org/10.1016/j.jaccas.2023.101973

Now You See Me Now You Don't: Subaortic Membrane Causing a Diagnostic Dilemma
Hatab, T, Zaid, S, Toro, S, Wessly, P, Malahfji, M, Faza, N, Little, SH, Kleiman, NS, Reardon, MJ & Goel, SS 2023, , JACC: Case Reports, vol. 18, 101916, pp. 101916. https://doi.org/10.1016/j.jaccas.2023.101916

First-in-Human Multicenter Experience of the Newest Generation Supra-Annular Self-Expanding Evolut FX TAVR System
Zaid, S, Attizzani, GF, Krishnamoorthy, P, Yoon, SH, Palma Dallan, LA, Chetcuti, S, Fukuhara, S, Grossman, PM, Goel, SS, Atkins, MD, Kleiman, NS, Puri, R, Bakhtadze, B, Byrne, T, Ibrahim, AW, Grubb, KJ, Tully, A, Herrmann, HC, Faggioni, M, Ramlawi, B, Khera, S, Lerakis, S, Dangas, GD, Kini, AS, Sharma, SK, Reardon, MJ & Tang, GHL 2023, , JACC: Cardiovascular Interventions, vol. 16, no. 13, pp. 1626-1635. https://doi.org/10.1016/j.jcin.2023.05.004

When Echocardiography Is Challenging in Localizing Bioprosthetic Aortic Regurgitation: Dye Don't Lie
Hatab, T, Wessly, P, Zaid, S, Faza, N, Chang, SM, Kleiman, NS, Little, SH & Goel, SS 2023, , JACC: Case Reports, vol. 15, 101853, pp. 101853. https://doi.org/10.1016/j.jaccas.2023.101853