Neal Kleiman, MD

Professor of Cardiology, Institute for Academic Medicine
Full Clinical Member, Research Institute
Program Director, Interventional Cardiology Residency, Department of Cardiology
Houston Methodist
Weill Cornell Medical College


Research Lab


Biography

Dr. Neal S. Kleiman is the medical director of the cardiac catheterization laboratories at the Houston Methodist DeBakey Heart & Vascular Center at Houston Methodist Hospital and a professor at Weill Cornell Medical College. He has special interests in angioplasty, stenting, coronary artery diseases and interventional cardiology.

His research lies in the relationship between angioplasty, stenting and clotting. His laboratory, recognized nationally as a select site for platelet research, examines the effects of antiplatelet therapy, the use of medications to prevent platelets from clumping and blood from clotting in patients with coronary artery disease who undergo angioplasty procedures. Kleiman has been the principal investigator and/or collaborating investigator in more than 100 studies and multi-center trials related to arterial thrombosis, the formation of blood clots in the arteries, clotting and angioplasty, which have altered the management of patients with chest pain undergoing catheterization.

After receiving his medical degree from Columbia University in New York, Kleiman completed an internship and residency in internal medicine at Baylor College of Medicine, as well as a fellowship in cardiology.

Kleiman has published over 150 manuscripts, book chapters and abstracts. His work has appeared in such publications as the Journal of the American College of Cardiology, Annals of Thoracic Surgery, Journal of Cardiovascular Pharmacology, Circulation, The American College of Cardiology and The European Heart Journal. He is on the editorial board of The Journal of Interventional Cardiology, Circulation, The American Heart Journal and The Journal of Thrombosis and Thrombolysis.

Kleiman is a member of numerous professional organizations including The American Heart Association Council on Clinical Cardiology and Council on Thrombosis, and he is a fellow of The American College of Cardiology and the Society for Coronary Angiography and Interventions.

Description of Research

Dr. Kleiman’s research effort since joining the faculty at Baylor College of Medicine and subsequently at the Houston Methodist DeBakey Heart and Vascular Center has been focused on acute coronary syndromes and coronary interventions. The bulk of this effort has been in the design, management, and execution phases of clinical trials in these two fields, on both the single center (at Houston Methodist Hospital and Ben Taub General Hospital) and multicenter levels. As part of this effort, he has dedicated considerable time to serving on the steering committees of several dozen multicenter trials. Dr. Kleiman established the Applied Platelet Physiology Laboratory at Baylor, now at the Houston Methodist DeBakey Heart and Vascular Center. Work in that laboratory has centered on two areas: providing supporting work in a large number of clinical trials that were complemented by nested mechanistic and pathophysiologic studies, and carrying out independent physiologic studies examining such issues as aspirin dosing, platelet activation during coronary interventions, individual responses to the activity of thienopyridines, and the relation of platelet turnover and COX-2 expression to aspirin sensitivity. The laboratory has also collaborated with other laboratories in the Texas Medical Center including Rice University’s Department of Bioengineering, Baylor’s Leukocyte Biology Laboratory, and most recently, the Molecular Genetics of Cardiovascular Diseases laboratory at Baylor and the stem cell group at MD Anderson Cancer Center. These collaborations have allowed the laboratory to expand its foci to include such investigations as the effects of P2Y12 inhibition and GP IIb/IIIa ligation on leukocyte rolling, leukocyte activation following GP IIb/IIIa administration, the role of platelet P-selectin on leukocyte membrane changes, and most recently the relation circulating endothelial precursor cells and coronary collateral vessels in patients with acute coronary syndromes.

Areas Of Expertise

Acute coronary syndromes Coronary intervention
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, Columbia University College of Surgeons and Physicians
Publications

Delayed Coronary Obstruction After TAVR: A Call for Vigilance *
Kleiman, NS 2018, Journal of the American College of Cardiology, vol 71, no. 14, pp. 1525-1527. DOI: 10.1016/j.jacc.2018.01.067

Very Late Migration of Balloon-Expandable Transcatheter Aortic Valve
Kalra, A, Avenatti, E, Chinnadurai, P, Reardon, MJ, Kleiman, NS, Little, SH & Barker, CM 2018, Journal of Invasive Cardiology, vol 30, no. 4, pp. E28-E30.

Very Late Migration of Balloon-Expandable Transcatheter Aortic Valve
Kalra, A, Avenatti, E, Chinnadurai, P, Reardon, MJ, Kleiman, NS, Little, SH & Barker, CM 2018, The Journal of invasive cardiology, vol 30, no. 4, pp. E28-E30.

When to SAVR in the age of TAVR? A perspective on surgical aortic valve replacement in 2018
Wyler von Ballmoos, MC, Barker, CM, Reul, RM, Dadu, R, Ramchandani, M, Kleiman, NS & Reardon, MJ 2018, Cardiovascular Revascularization Medicine, vol 19, no. 2, pp. 139-141. DOI: 10.1016/j.carrev.2018.03.014

Transcatheter aortic valve replacement in patients with severe mitral or tricuspid regurgitation at extreme risk for surgery
Little, SH, Popma, JJ, Kleiman, NS, Deeb, GM, Gleason, TG, Yakubov, SJ, Checuti, S, OHair, D, Bajwa, T, Mumtaz, M, Maini, B, Hartman, A, Katz, S, Robinson, N, Petrossian, G, Heiser, J, Merhi, W, Moore, BJ, Li, S, Adams, DH & Reardon, MJ 2018, Journal of Thoracic and Cardiovascular Surgery. DOI: 10.1016/j.jtcvs.2017.11.108

Transcatheter and Doppler waveform correlation in transcatheter aortic valve replacement
Kalra, A, Makkar, RR, Bhatt, DL, Khera, S, Kleiman, NS, Reardon, MJ & Kern, MJ 2018, Open Heart, vol 5, no. 1, e000728. DOI: 10.1136/openhrt-2017-000728

The Impact of Annular Size on Outcomes After Surgical or Transcatheter Aortic Valve Replacement
Deeb, GM, Chetcuti, SJ, Yakubov, SJ, Patel, HJ, Grossman, PM, Kleiman, NS, Heiser, J, Merhi, W, Zorn, GL, Tadros, PN, Petrossian, G, Robinson, N, Mumtaz, M, Gleason, TG, Huang, J, Conte, JV, Popma, JJ & Reardon, MJ 2018, Annals of Thoracic Surgery. DOI: 10.1016/j.athoracsur.2017.08.059

Early Outcomes With the Evolut PRO Repositionable Self-Expanding Transcatheter Aortic Valve With Pericardial Wrap
Forrest, JK, Mangi, AA, Popma, JJ, Khabbaz, K, Reardon, MJ, Kleiman, NS, Yakubov, SJ, Watson, D, Kodali, S, George, I, Tadros, P, Zorn, GL, Brown, J, Kipperman, R, Saul, S, Qiao, H, Oh, JK & Williams, MR 2018, JACC: Cardiovascular Interventions, vol 11, no. 2, pp. 160-168. DOI: 10.1016/j.jcin.2017.10.014

Effect of mechanically expanded vs self-expanding transcatheter aortic valve replacement on mortality and major adverse clinical events in high-risk patients with aortic stenosis the REPRISE III randomized clinical trial
Feldman, TE, Reardon, MJ, Rajagopal, V, Makkar, RR, Bajwa, TK, Kleiman, NS, Linke, A, Kereiakes, DJ, Waksman, R, Thourani, VH, Stoler, RC, Mishkel, GJ, Rizik, DG, Iyer, VS, Gleason, TG, Tchétché, D, Rovin, JD, Buchbinder, M, Meredith, IT, Götberg, M, Bjursten, H, Meduri, C, Salinger, MH, Allocco, DJ & Dawkins, KD 2018, JAMA - Journal of the American Medical Association, vol 319, no. 1, pp. 27-37. DOI: 10.1001/jama.2017.19132

Early Experience With New Transcatheter Mitral Valve Replacement
Bapat, V, Rajagopal, V, Meduri, C, Farivar, RS, Walton, A, Duffy, SJ, Gooley, R, Almeida, A, Reardon, MJ, Kleiman, NS, Spargias, K, Pattakos, S, Ng, MK, Wilson, M, Adams, DH, Leon, M, Mack, MJ, Chenoweth, S, Sorajja, P & Intrepid Global Pilot Study Investigators 2018, Journal of the American College of Cardiology, vol 71, no. 1, pp. 12-21. DOI: 10.1016/j.jacc.2017.10.061

Direct Aortic Access for Transcatheter Aortic Valve Replacement Using a Self-Expanding Device
OHair, DP, Bajwa, TK, Popma, JJ, Watson, DR, Yakubov, SJ, Adams, DH, Sharma, S, Robinson, N, Petrossian, G, Caskey, M, Byrne, T, Kleiman, NS, Zhang, A & Reardon, MJ 2017, Annals of Thoracic Surgery. DOI: 10.1016/j.athoracsur.2017.07.051

Long-Term Outcomes With Transcatheter Aortic Valve Replacement in Women Compared With Men. Evidence From a Meta-Analysis
Saad, M, Nairooz, R, Pothineni, NVK, Almomani, A, Kovelamudi, S, Sardar, P, Katz, M, Abdel-Wahab, M, Bangalore, S, Kleiman, NS, Block, PC & Abbott, JD 2017, JACC: Cardiovascular Interventions. DOI: 10.1016/j.jcin.2017.08.015

Regional Variation in Utilization, In-hospital Mortality, and Health-Care Resource Use of Transcatheter Aortic Valve Implantation in the United States
Gupta, T, Kalra, A, Kolte, D, Khera, S, Villablanca, PA, Goel, K, Bortnick, AE, Aronow, WS, Panza, JA, Kleiman, NS, Abbott, JD, Slovut, DP, Taub, CC, Fonarow, GC, Reardon, MJ, Rihal, CS, Garcia, MJ & Bhatt, DL 2017, American Journal of Cardiology. DOI: 10.1016/j.amjcard.2017.07.102

In Touch But Out of Time: Aggressive hospital discharge and readmissions after transcatheter aortic valve replacement
Kleiman, NS 2017, Journal of the American Heart Association, vol 6, no. 8, e007086. DOI: 10.1161/JAHA.117.007086

Trends and outcomes of off-label use of transcatheter aortic valve replacement: Insights from the NCDR STS/ACC TVT registry
Hira, RS, Vemulapalli, S, Li, Z, McCabe, JM, Rumsfeld, JS, Kapadia, SR, Alam, M, Jneid, H, Don, C, Reisman, M, Virani, SS & Kleiman, NS 2017, JAMA Cardiology, vol 2, no. 8, pp. 846-854. DOI: 10.1001/jamacardio.2017.1685

Platelet pathophysiology, pharmacology, and function in coronary artery disease
Ibrahim, H & Kleiman, NS 2017, Coronary Artery Disease. DOI: 10.1097/MCA.0000000000000519

Early Trifecta valve failure: Report of a cluster of cases from a tertiary care referral center
Kalra, A, Rehman, H, Ramchandani, M, Barker, CM, Lawrie, GM, Reul, RM, Reardon, MJ & Kleiman, NS 2017, Journal of Thoracic and Cardiovascular Surgery. DOI: 10.1016/j.jtcvs.2017.05.044

Association between hospital volume and 30-day readmissions following transcatheter aortic valve replacement
Khera, S, Kolte, D, Gupta, T, Goldsweig, A, Velagapudi, P, Kalra, A, Tang, GHL, Aronow, WS, Fonarow, GC, Bhatt, DL, Aronow, HD, Kleiman, NS, Reardon, M, Gordon, PC, Sharaf, B & Abbott, JD 2017, JAMA Cardiology, vol 2, no. 7, pp. 732-741. DOI: 10.1001/jamacardio.2017.1630

Transcatheter Aortic Valve Replacement for Perceval Sutureless Aortic Valve Failure
Kalra, A, Reyes, M, Yang, EY, Little, SH, Nabi, F, Barker, CM, Ramchandani, M, Reul, RM, Reardon, MJ & Kleiman, NS 2017, Journal of Invasive Cardiology, vol 29, no. 6, pp. E65-E66.

At Arm's Length: Radiation Safety During Radial Percutaneous Coronary Intervention
Kleiman, NS & Kleiman, NJ 2017, Journal of the American College of Cardiology, vol 69, no. 20, pp. 2538-2541. DOI: 10.1016/j.jacc.2017.03.016