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Nancy A. Jenkins, PhD

Emeritus Professor of Oncology, Institute for Academic Medicine
Full Emeritus Member, Research Institute
Houston Methodist


Biography

Dr. Nancy Jenkins received her Ph.D. in molecular and cellular biology from Indiana University. Following postdoctoral studies at Harvard Medical School she joined the staff of The Jackson Laboratory and then the National Cancer Institute-Frederick, where she was a Senior Investigator and Head of the Molecular Genetics of Development Section for 22 years. She moved to the Institute of Molecular and Cell Biology in Singapore in 2006, where she served as Deputy Director for most of her stay. In 2011 she returned to the United States to serve as Co-Director of Houston Methodist Cancer Biology Program at Houston Methodist Research Institute. For more than 30 years she has co-headed a laboratory with Neal Copeland; the focus of their current research is cancer genetics. They have co-authored more than 800 papers and are among the most cited biomedical research scientists in the world today. Both have served on numerous scientific advisory and editorial boards and they have consulted for several biotechnology and pharmaceutical companies. Dr. Jenkins and Dr. Copeland are also members of the U.S. National Academy of Sciences.

Description of Research

Jenkins and Copeland have modeled many different types of human disease in the mouse, but the focus of their current research is exclusively cancer. They are using the Sleeping Beauty transposable element system to tag and clone genes involved in the initiation, progression and metastasis of cancer. It is hoped that a better understanding of the genetics of cancer will lead to the development of additional targeted therapies for the treatment of various forms of the disease.

Areas Of Expertise

Mouse models of cancer Insertional mutagenesis Forward genetic screens High throughput sequencing Candidate cancer gene detection
Education & Training

PhD, Indiana University, Bloomington, IN
MA, Indiana University, Bloomington, IN
Postdoctoral Fellowship, The Jackson Laboratory
Postdoctoral Fellowship, Dana-Farber Cancer Institute
Publications

Stability and function of hippocampal mossy fiber synapses depend on Bcl11b/Ctip2
De Bruyckere, E, Simon, R, Nestel, S, Heimrich, B, Kätzel, D, Egorov, AV, Liu, P, Jenkins, NA, Copeland, NG, Schwegler, H, Draguhn, A & Britsch, S 2018, Frontiers in Molecular Neuroscience, vol. 11, 103. DOI: 10.3389/fnmol.2018.00103

SBCDDB: Sleeping Beauty Cancer Driver Database for gene discovery in mouse models of human cancers
Newberg, JY, Mann, KM, Mann, MB, Jenkins, NA & Copeland, NG 2018, Nucleic acids research, vol. 46, no. D1, pp. D1011-D1017. DOI: 10.1093/nar/gkx956

p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia
Short, SP, Kondo, J, Smalley-Freed, WG, Takeda, H, Dohn, MR, Powell, AE, Carnahan, RH, Washington, MK, Tripathi, M, Payne, DM, Jenkins, NA, Copeland, NG, Coffey, RJ & Reynolds, AB 2017, Journal of Clinical Investigation, vol. 127, no. 12, pp. 4462-4476. DOI: 10.1172/JCI77217

In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epithelial ovarian cancer
Kodama, M, Kodama, T, Newberg, JY, Katayama, H, Kobayashi, M, Hanash, SM, Yoshihara, K, Wei, Z, Tien, JC, Rangel, R, Hashimoto, K, Mabuchi, S, Sawada, K, Kimura, T, Copeland, NG & Jenkins, NA 2017, Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 35, pp. E7301-E7310. DOI: 10.1073/pnas.1705441114

Identification of new tumor suppressor genes in triple-negative breast cancer
Rangel, R, Guzman-Rojas, L, Kodama, T, Kodama, M, Newberg, JY, Copeland, NG & Jenkins, NA 2017, Cancer Research, vol. 77, no. 15, pp. 4089-4101. DOI: 10.1158/0008-5472.CAN-17-0785

Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for stratification
Chen, L, Jenjaroenpun, P, Pillai, AMC, Ivshina, AV, Ow, ZS, Efthimios, M, Zhiqun, T, Tan, TZ, Lee, SC, Rogers, K, Ward, JM, Mori, S, Adams, DJ, Jenkins, NA, Copeland, NG, Ban, KHK, Kuznetsov, VA & Thiery, JP 2017, Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 11, pp. E2215-E2224. DOI: 10.1073/pnas.1701512114

Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression
Rangel, R, Lee, SC, Ban, KHK, Guzman-Rojas, L, Mann, MB, Newberg, JY, Kodama, T, McNoe, LA, Selvanesan, L, Ward, JM, Rust, AG, Chin, KY, Black, MA, Jenkins, NA & Copeland, NG 2016, Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 48, pp. E7749-E7758. DOI: 10.1073/pnas.1613859113

Analyzing tumor heterogeneity and driver genes in single myeloid leukemia cells with SBCapSeq
Mann, KM, Newberg, JY, Black, MA, Jones, DJ, Amaya-Manzanares, F, Guzman-Rojas, L, Kodama, T, Ward, JM, Rust, AG, Van Der Weyden, L, Yew, CCK, Waters, JL, Leung, ML, Rogers, K, Rogers, SM, Mcnoe, LA, Selvanesan, L, Navin, N, Jenkins, NA, Copeland, NG & Mann, MB 2016, Nature Biotechnology, vol. 34, no. 9, pp. 962-972. DOI: 10.1038/nbt.3637

A recellularized human colon model identifies cancer driver genes
Chen, HJ, Wei, Z, Sun, J, Bhattacharya, A, Savage, DJ, Serda, R, Mackeyev, Y, Curley, SA, Bu, P, Wang, L, Chen, S, Cohen-Gould, L, Huang, E, Shen, X, Lipkin, SM, Copeland, NG, Jenkins, NA & Shuler, ML 2016, Nature Biotechnology, vol. 34, no. 8, pp. 845-851. DOI: 10.1038/nbt.3586

Transposon mutagenesis identifies genes and cellular processes driving epithelial-mesenchymal transition in hepatocellular carcinoma
Kodama, T, Newberg, JY, Kodama, M, Rangel, R, Yoshihara, K, Tien, JC, Parsons, PH, Wu, H, Finegold, MJ, Copeland, N & Jenkins, NA 2016, Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 24, pp. E3384-E3393. DOI: 10.1073/pnas.1606876113

Sleeping Beauty transposon mutagenesis identifies genes that cooperate with mutant Smad4 in gastric cancer development
Takeda, H, Rust, AG, Ward, JM, Yew, CCK, Jenkins, NA & Copeland, N 2016, Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 14, pp. E2057-E2065. DOI: 10.1073/pnas.1603223113

Structure-function integrity of the adult hippocampus depends on the transcription factor Bcl11b/Ctip2
Simon, R, Baumann, L, Fischer, J, Seigfried, FA, De Bruyckere, E, Liu, P, Jenkins, NA, Copeland, NG, Schwegler, H & Britsch, S 2016, Genes, Brain and Behavior, vol. 15, no. 4, pp. 405-419. DOI: 10.1111/gbb.12287

Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death
Bouilloux, F, Thireau, J, Ventéo, S, Farah, C, Karam, S, Dauvilliers, Y, Valmier, J, Copeland, NG, Jenkins, NA, Richard, S & Marmigère, F 2016, eLife, vol. 5, no. FEBRUARY2016, e11627. DOI: 10.7554/eLife.11627

KRAS-related proteins in pancreatic cancer
Mann, KM, Ying, H, Juan, J, Jenkins, NA & Copeland, NG 2016, Pharmacology and Therapeutics. DOI: 10.1016/j.pharmthera.2016.09.003

Two-Step Forward Genetic Screen in Mice Identifies Ral GTPase-Activating Proteins as Suppressors of Hepatocellular Carcinoma
Kodama, T, Bard-Chapeau, EA, Newberg, JY, Kodama, M, Rangel, R, Yoshihara, K, Ward, JM, Jenkins, NA & Copeland, NG 2015, Gastroenterology. DOI: 10.1053/j.gastro.2016.04.040

Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis
Basheer, WA, Harris, BS, Mentrup, HL, Abreha, M, Thames, EL, Lea, JB, Swing, DA, Copeland, NG, Jenkins, NA, Price, RL & Matesic, LE 2015, Journal of Molecular and Cellular Cardiology, vol. 88, 8184, pp. 1-13. DOI: 10.1016/j.yjmcc.2015.09.004

Bcl11a (Ctip1) Controls Migration of Cortical Projection Neurons through Regulation of Sema3c
Wiegreffe, C, Simon, R, Peschkes, K, Kling, C, Strehle, M, Cheng, J, Srivatsa, S, Liu, P, Jenkins, NA, Copeland, NG, Tarabykin, V & Britsch, S 2015, Neuron, vol. 87, no. 2, pp. 311-326. DOI: 10.1016/j.neuron.2015.06.023

The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development
Yu, Y, Wang, C, Clare, S, Wang, J, Lee, SC, Brandt, C, Burke, S, Lu, L, He, D, Jenkins, NA, Copeland, NG, Dougan, G & Liu, P 2015, The Journal of experimental medicine, vol. 212, no. 6, pp. 865-74. DOI: 10.1084/jem.20142318

Transposon mutagenesis identifies genetic drivers of Braf V600E melanoma
Mann, MB, Black, MA, Jones, DJ, Ward, JM, Yew, CCK, Newberg, JY, Dupuy, AJ, Rust, AG, Bosenberg, MW, Mcmahon, M, Print, CG, Copeland, NG & Jenkins, NA 2015, Nature genetics, vol. 47, no. 5, pp. 486-495. DOI: 10.1038/ng.3275

BCL11A is a Triple-negative breast cancer gene with critical functions in stem and progenitor cells
Khaled, WT, Lee, SC, Stingl, J, Chen, X, Ali, HR, Rueda, OM, Hadi, F, Wang, J, Yu, Y, Chin, SF, Stratton, M, Futreal, A, Jenkins, NA, Aparicio, S, Copeland, NG, Watson, CJ, Caldas, C & Liu, P 2015, Nature communications, vol. 6, 6987, pp. 5987. DOI: 10.1038/ncomms6987