Nakul Gupta VIEW CLINICAL PROFILE

Nakul Gupta, MD

Assistant Professor of Clinical Radiology, Academic Institute
Program Director, Abdominal Imaging Fellowship, Department of Radiology
Vice-Chair of Translational Imaging, Department of Radiology
Houston Methodist
Weill Cornell Medical College


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Biography

Dr. Gupta graduated from Rice University summa cum laude with a B.A. in Biochemistry, and subsequently earned his M.D. from the University of Texas Southwestern in 2008. After completing his internship in Internal Medicine at the Mount Sinai Hospital in New York City, he began residency in Radiology at SUNY Downstate in Brooklyn, which he subsequently completed at the University of Texas Health Science Center in Houston, TX, where has also completed a fellowship in Abdominal Imaging. As Director of MRI and Vice-Chair of Translational Imaging at Houston Methodist Hospital, he oversees departmental MRI policies and protocols while incorporating next-gen diagnostic and interventional imaging technologies into clinical practice. He is an active member of the Society of Advanced Body Imaging as well as the Society of Abdominal Radiology, among others. He is a regular reviewer for the Journal of Computer Assisted Tomography and Abdominal Imaging and has reviewed for several additional journals as well.

Description of Research

Perhaps more than any other technology, imaging (such as CT, MRI, and ultrasound) has transformed modern medicine over the past 50 years. Dr. Gupta believes in the power of next-gen imaging tools to drive further transformative improvements in how we approach preventative health, non-invasive diagnosis, as well as minimally invasive therapies in the future. A few specific areas of interest are:

 

  1. ‘Whole-Body’ MRI – WB-MRI has recently become an accepted modality for periodic screening in patients with certain cancer predisposition syndromes, such as Li-Fraumeni Syndrome. While WB-MRI is currently focused on cancer detection, Dr. Gupta is exploring the potential of WB-MRI as a preventative health tool in the early detection of a host of additional common diseases.
  2. Quantum CT – Next-gen photon counting detectors are poised to revolutionize the way we use CT scans to diagnose disease by allowing material decomposition, increased resolution and reduced radiation dose. Dr. Gupta aim’s to be at the forefront of this revolution by leading clinical adoption and evidence generation.
  3. Ablative therapies – Imaging has the power to not only diagnose non-invasively, but also to guide minimally invasive treatments. Dr. Gupta has a keen interest in minimally invasive ablative therapies, particularly in the treatment of liver tumors.

Publications

Shear wave elastography of the ulnar collateral ligament in division IA pitchers across a competitive collegiate season
Gupta, N, Taylor, RE, Lambert, B, Dong, D, Phillips, P, Jack, RA, Goble, HM, Labis, JS, Trakhtenbroit, MA & McCulloch, PC 2023, , JSES International, vol. 7, no. 4, pp. 703-708. https://doi.org/10.1016/j.jseint.2023.03.014

Shear wave elastography of the ulnar collateral ligament in Division IA pitchers across a competitive collegiate season
Gupta, N, Taylor, RE, Lambert, B, Dong, D, Phillips, P, Jack, RA, Goble, HM, Labis, JS, Trakhtenbroit, MA & McCulloch, PC 2023, , JSES International, vol. 7, no. 4, pp. 703-708. https://doi.org/10.1016/j.jseint.2023.03.014

A Phase 2 Trial of Enhancing Immune Checkpoint Blockade by Stereotactic Radiation and In Situ Virus Gene Therapy in Metastatic Triple-Negative Breast Cancer
Sun, K, Xu, Y, Zhang, L, Niravath, P, Darcourt, J, Patel, T, Teh, BS, Farach, AM, Guerrero, C, Mathur, S, Sultenfuss, MA, Gupta, N, Schwartz, MR, Haley, SL, Nair, S, Li, X, Nguyen, TTA, Butner, JD, Ensor, J, Mejia, JA, Mei, Z, Butler, EB, Chen, SH, Bernicker, EH & Chang, JC 2022, , Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 28, no. 20, pp. 4392-4401. https://doi.org/10.1158/1078-0432.CCR-22-0622, https://doi.org/10.1158/1078-0432.CCR-22-0622

Quantitative high-resolution 7T MRI to assess longitudinal changes in articular cartilage after anterior cruciate ligament injury in a rabbit model of post-traumatic osteoarthritis
Terracciano, R, Carcamo-Bahena, Y, Royal, ALR, Demarchi, D, Labis, JS, Harris, JD, Weiner, BK, Gupta, N & Filgueira, CS 2022, , Osteoarthritis and Cartilage Open, vol. 4, no. 2, 100259. https://doi.org/10.1016/j.ocarto.2022.100259

A phase 1/2 clinical trial of the nitric oxide synthase inhibitor L-NMMA and taxane for treating chemoresistant triple-negative breast cancer
Chung, AW, Anand, K, Anselme, AC, Chan, AA, Gupta, N, Venta, LA, Schwartz, MR, Qian, W, Xu, Y, Zhang, L, Kuhn, J, Patel, T, Rodriguez, AA, Belcheva, A, Darcourt, J, Ensor, J, Bernicker, E, Pan, PY, Chen, SH, Lee, DJ, Niravath, PA & Chang, JC 2021, , Science translational medicine, vol. 13, no. 624, abj5070. https://doi.org/10.1126/scitranslmed.abj5070

Machine learning automatically detects COVID-19 using chest CTs in a large multicenter cohort
Mortani Barbosa, EJ, Georgescu, B, Chaganti, S, Aleman, GB, Cabrero, JB, Chabin, G, Flohr, T, Grenier, P, Grbic, S, Gupta, N, Mellot, F, Nicolaou, S, Re, T, Sanelli, P, Sauter, AW, Yoo, Y, Ziebandt, V & Comaniciu, D 2021, , European Radiology, vol. 31, no. 11, pp. 8775-8785. https://doi.org/10.1007/s00330-021-07937-3

Machine learning automatically detects COVID-19 using chest CTs in a large multicenter cohort
Mortani Barbosa, EJ, Georgescu, B, Chaganti, S, Aleman, GB, Cabrero, JB, Chabin, G, Flohr, T, Grenier, P, Grbic, S, Gupta, N, Mellot, F, Nicolaou, S, Re, T, Sanelli, P, Sauter, AW, Yoo, Y, Ziebandt, V & Comaniciu, D 2021, , European Radiology, vol. 31, no. 11, pp. 8775-8785. https://doi.org/10.1007/s00330-021-07937-3

Shear-wave elastography of the ulnar collateral ligament of the elbow in healthy volunteers: a pilot study
Gupta, N, Labis, JS, Harris, JD, Trakhtenbroit, MA, Peterson, LE, Jack, RA & McCulloch, P 2019, , Skeletal Radiology, vol. 48, no. 8, pp. 1241-1249. https://doi.org/10.1007/s00256-019-3162-2

Iodine quantification and detectability thresholds among major dual-energy CT platforms
Taylor, RE, Mager, P, Yu, NC, Katz, DP, Brady, JR & Gupta, N 2019, , British Journal of Radiology, vol. 92, no. 1104, 20190530. https://doi.org/10.1259/bjr.20190530

Computed tomography criteria for the use of advanced localization techniques in minimally invasive thoracoscopic lung resection
Kim, MP, Nguyen, DT, Chan, EY, Meisenbach, LM, Kopas, LM, Graviss, EA, Lumsden, AB & Gupta, N 2018, , Journal of Thoracic Disease, vol. 10, no. 6. <http://jtd.amegroups.com/article/view/21534>

Liver transplantation for locally advanced intrahepatic cholangiocarcinoma treated with neoadjuvant therapy: a prospective case-series
Lunsford, KE, Javle, M, Heyne, K, Shroff, RT, Abdel-Wahab, R, Gupta, N, Mobley, CM, Saharia, A, Victor, DW, Nguyen, DT, Graviss, EA, Kaseb, AO, McFadden, RS, Aloia, TA, Conrad, C, Li, XC, Monsour, HP, Gaber, AO, Vauthey, J-N, Ghobrial, RM & Methodist–MD Anderson Joint Cholangiocarcinoma Collaborative Committee (MMAJCCC) 2018, , The Lancet Gastroenterology and Hepatology, vol. 3, no. 5, pp. 337-348. https://doi.org/10.1016/S2468-1253(18)30045-1

Management of the solitary pulmonary nodule
Chan, EY, Gaur, P, Ge, Y, Kopas, L, Santacruz, JF, Gupta, N, Munden, RF, Cagle, PT & Kim, MP 2017, , Archives of Pathology and Laboratory Medicine, vol. 141, no. 7, pp. 927-931. https://doi.org/10.5858/arpa.2016-0307-RA

Multiple Renal Artery Pseudoaneurysms in Patients Undergoing Renal Artery Embolization Following Partial Nephrectomy: Correlation with RENAL Nephrometry Scores
Gupta, N, Patel, A, Ensor, J, Ahrar, K, Ahrar, J, Tam, A, Odisio, B, Huang, S, Murthy, R, Mahvash, A, Avritscher, R, McRae, S, Sabir, S, Wallace, M, Matin, S & Gupta, S 2016, , CardioVascular and Interventional Radiology, vol. 40, no. 2, pp. 202-209. https://doi.org/10.1007/s00270-016-1473-4

Management of the Solitary Pulmonary Nodule
Chan, EY, Gaur, P, Ge, Y, Kopas, L, Santacruz, JF, Gupta, N, Munden, RF, Cagle, PT & Kim, MP 2016, , Archives of Pathology and Laboratory Medicine. https://doi.org/10.5858/arpa.2016-0307-RA

CT findings in temporal bone osteoradionecrosis
Ahmed, S, Gupta, N, Hamilton, JD, Garden, AS, Gidley, PW & Ginsberg, LE 2014, , Journal of Computer Assisted Tomography, vol. 38, no. 5, pp. 662-666. https://doi.org/10.1097/RCT.0000000000000096

Thoracic Imaging
Gupta, N, Oldham, SAA & Matta, EJ 2014, . in K Elsayes (ed.), Introduction to Diagnostic Radiology. McGraw Hill Education, pp. 135-248.

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