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Ming You, MD, PhD

Daniel E. Lehane, MD Distinguished Chair in Cancer Excellence, Dr. Mary and Ron Neal Cancer Center
Professor of Cancer Biology in Medicine, Academic Institute
Full Member, Research Institute
Director, Center for Cancer Prevention, Dr. Mary and Ron Neal Cancer Center
Houston Methodist
Weill Cornell Medical College


You Lab


Publications

Combining PEGylated mito-atovaquone with MCT and Krebs cycle redox inhibitors as a potential strategy to abrogate tumor cell proliferation
Cheng, G, Hardy, M, You, M & Kalyanaraman, B 2022, , Scientific Reports, vol. 12, no. 1, 5143. https://doi.org/10.1038/s41598-022-08984-6

Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer
Byun, J, Han, Y, Li, Y, Xia, J, Long, E, Choi, J, Xiao, X, Zhu, M, Zhou, W, Sun, R, Bossé, Y, Song, Z, Schwartz, A, Lusk, C, Rafnar, T, Stefansson, K, Zhang, T, Zhao, W, Pettit, RW, Liu, Y, Li, X, Zhou, H, Walsh, KM, Gorlov, I, Gorlova, O, Zhu, D, Rosenberg, SM, Pinney, S, Bailey-Wilson, JE, Mandal, D, de Andrade, M, Gaba, C, Willey, JC, You, M, Anderson, M, Wiencke, JK, Albanes, D, Lam, S, Tardon, A, Chen, C, Goodman, G, Bojeson, S, Brenner, H, Landi, MT, Chanock, SJ, Johansson, M, Muley, T, Risch, A, Wichmann, HE, Bickeböller, H, Christiani, DC, Rennert, G, Arnold, S, Field, JK, Shete, S, Le Marchand, L, Melander, O, Brunnstrom, H, Liu, G, Andrew, AS, Kiemeney, LA, Shen, H, Zienolddiny, S, Grankvist, K, Johansson, M, Caporaso, N, Cox, A, Hong, YC, Yuan, JM, Lazarus, P, Schabath, MB, Aldrich, MC, Patel, A, Lan, Q, Rothman, N, Taylor, F, Kachuri, L, Witte, JS, Sakoda, LC, Spitz, M, Brennan, P, Lin, X, McKay, J, Hung, RJ & Amos, CI 2022, , Nature Genetics, vol. 54, no. 8, pp. 1167-1177. https://doi.org/10.1038/s41588-022-01115-x

Chemoprevention of Lung Cancer with a Combination of Mitochondria-Targeted Compounds
Zhang, Q, Xiong, D, Pan, J, Wang, Y, Hardy, M, Kalyanaraman, B & You, M 2022, , Cancers, vol. 14, no. 10, 2538. https://doi.org/10.3390/cancers14102538

Prevention of Tumor Growth and Dissemination by In Situ Vaccination with Mitochondria-Targeted Atovaquone
Huang, M, Xiong, D, Pan, J, Zhang, Q, Wang, Y, Myers, CR, Johnson, BD, Hardy, M, Kalyanaraman, B & You, M 2022, , Advanced Science, vol. 9, no. 12, 2101267. https://doi.org/10.1002/advs.202101267

Targeting Glutamine Metabolism to Enhance Immunoprevention of EGFR-Driven Lung Cancer
Huang, M, Xiong, D, Pan, J, Zhang, Q, Sei, S, Shoemaker, RH, Lubet, RA, Montuenga, LM, Wang, Y, Slusher, BS & You, M 2022, , Advanced Science. https://doi.org/10.1002/advs.202105885

Reply to: “Inconsistent prediction capability of ImmuneCells.Sig across different RNA-seq datasets”
Xiong, D, Wang, Y & You, M 2021, , Nature Communications, vol. 12, no. 1, 4168. https://doi.org/10.1038/s41467-021-24304-4

Inhibition of lung tumorigenesis by a small molecule CA170 targeting the immune checkpoint protein VISTA
Pan, J, Chen, Y, Zhang, Q, Khatun, A, Palen, K, Xin, G, Wang, L, Yang, C, Johnson, BD, Myers, CR, Sei, S, Shoemaker, RH, Lubet, RA, Wang, Y, Cui, W & You, M 2021, , Communications Biology, vol. 4, no. 1, 906. https://doi.org/10.1038/s42003-021-02381-x

Rare deleterious germline variants and risk of lung cancer
Liu, Y, Xia, J, McKay, J, Tsavachidis, S, Xiao, X, Spitz, MR, Cheng, C, Byun, J, Hong, W, Li, Y, Zhu, D, Song, Z, Rosenberg, SM, Scheurer, ME, Kheradmand, F, Pikielny, CW, Lusk, CM, Schwartz, AG, Wistuba, II, Cho, MH, Silverman, EK, Bailey-Wilson, J, Pinney, SM, Anderson, M, Kupert, E, Gaba, C, Mandal, D, You, M, de Andrade, M, Yang, P, Liloglou, T, Davies, MPA, Lissowska, J, Swiatkowska, B, Zaridze, D, Mukeria, A, Janout, V, Holcatova, I, Mates, D, Stojsic, J, Scelo, G, Brennan, P, Liu, G, Field, JK, Hung, RJ, Christiani, DC & Amos, CI 2021, , npj Precision Oncology, vol. 5, no. 1, 12. https://doi.org/10.1038/s41698-021-00146-7

Genetic variation and recurrent haplotypes on chromosome 6q23-25 risk locus in familial lung cancer
Musolf, AM, Simpson, CL, Moiz, BA, Pikielny, CW, Middlebrooks, CD, Mandal, D, De Andrade, M, Cole, MD, Gaba, C, Yang, P, You, M, Li, Y, Kupert, EY, Anderson, MW, Schwartz, AG, Pinney, SM, Amos, CI & Bailey-Wilson, JE 2021, , Cancer research, vol. 81, no. 12, pp. 3162-3173. https://doi.org/10.1158/0008-5472.CAN-20-3196

Mitochondria as a novel target for cancer chemoprevention: Emergence of mitochondrial-targeting agents
Huang, M, Myers, CR, Wang, Y & You, M 2021, , Cancer Prevention Research, vol. 14, no. 3, pp. 285-306. https://doi.org/10.1158/1940-6207.CAPR-20-0425

Pulmonary Aerosol Delivery of Let-7b microRNA Confers a Striking Inhibitory Effect on Lung Carcinogenesis through Targeting the Tumor Immune Microenvironment
Zhang, Q, Pan, J, Xiong, D, Wang, Y, Miller, MS, Sei, S, Shoemaker, RH, Izzotti, A & You, M 2021, , Advanced Science, vol. 8, no. 17, 2100629. https://doi.org/10.1002/advs.202100629

Efficacy of EGFR Inhibitors and NSAIDs against Basal Bladder Cancers in a Rat Model: Daily vs. Weekly Dosing, Combining EGFR Inhibitors with Naproxen, and Effects on RNA Expression
Lubet, RA, Kumar, A, Fox, JT, You, M, Mohammed, A, Juliana, MM & Grubbs, CJ 2021, , Bladder Cancer, vol. 7, no. 3, pp. 335-345. https://doi.org/10.3233/BLC-200423

Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer
Bui, D, Yin, T, Duan, S, Wei, B, Yang, P, Wong, SJ, You, M, Singh, R & Hu, M 2021, , Journal of Natural Products, vol. 84, no. 9, pp. 2486-2495. https://doi.org/10.1021/acs.jnatprod.1c00501

A gene expression signature of TREM2hi macrophages and ?d T cells predicts immunotherapy response
Xiong, D, Wang, Y & You, M 2020, , Nature Communications, vol. 11, no. 1, 5084. https://doi.org/10.1038/s41467-020-18546-x

Uncoupling Therapeutic Efficacy from Immune-Related Adverse Events in Immune Checkpoint Blockade
Hu, W, Wang, G, Wang, Y, Riese, MJ & You, M 2020, , iScience, vol. 23, no. 10, 101580. https://doi.org/10.1016/j.isci.2020.101580

Pharmacokinetic and Metabolic Profiling of Key Active Components of Dietary Supplement Magnolia officinalis Extract for Prevention against Oral Carcinoma
Bui, D, Li, L, Yin, T, Wang, X, Wang, X, Gao, S, You, M, Singh, R & Hu, M 2020, , Journal of Agricultural and Food Chemistry, vol. 68, no. 24, pp. 6576-6587. https://doi.org/10.1021/acs.jafc.0c01475

Anticancer effect of physical activity is mediated by modulation of extracellular microRNA in blood
Pulliero, A, You, M, Chaluvally-Raghavan, P, Marengo, B, Domenicotti, C, Banelli, B, Degan, P, Molfetta, L, Gianiorio, F & Izzotti, A 2020, , Oncotarget, vol. 11, no. 22, pp. 2106-2119. https://doi.org/10.18632/oncotarget.27609

Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex i
Zhang, Q, Cheng, G, Pan, J, Zielonka, J, Xiong, D, Myers, CR, Feng, L, Shin, SS, Kim, YH, Bui, D, Hu, M, Bennett, B, Schmainda, K, Wang, Y, Kalyanaraman, B & You, M 2020, , Cell Communication and Signaling, vol. 18, no. 1, 58. https://doi.org/10.1186/s12964-020-0524-2

Increased formation of reactive oxygen species during tumor growth: Ex vivo low-temperature EPR and in vivo bioluminescence analyses
Cheng, G, Pan, J, Podsiadly, R, Zielonka, J, Garces, AM, Dias Duarte Machado, LG, Bennett, B, McAllister, D, Dwinell, MB, You, M & Kalyanaraman, B 2020, , Free Radical Biology and Medicine, vol. 147, pp. 167-174. https://doi.org/10.1016/j.freeradbiomed.2019.12.020

Whole exome sequencing of highly aggregated lung cancer families reveals linked loci for increased cancer risk on chromosomes 12q, 7p, and 4q
Musolf, AM, Moiz, BA, Sun, H, Pikielny, CW, Bosse, Y, Mandal, D, De Andrade, M, Gaba, C, Yang, P, Li, Y, You, M, Govindan, R, Wilson, RK, Kupert, EY, Anderson, MW, Schwartz, AG, Pinney, SM, Amos, CI & Bailey-Wilson, JE 2020, , Cancer Epidemiology Biomarkers and Prevention, vol. 29, no. 2, pp. 434-442. https://doi.org/10.1158/1055-9965.EPI-19-0887

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