Ming You, MD, PhD

Daniel E. Lehane, MD Distinguished Chair in Cancer Excellence, Dr. Mary and Ron Neal Cancer Center
Professor of Cancer Biology in Medicine, Academic Institute
Full Member, Research Institute
Director, Center for Cancer Prevention, Dr. Mary and Ron Neal Cancer Center
Houston Methodist
Weill Cornell Medical College

You Lab


Striking efficacy of a vaccine targeting TOP2A for triple-negative breast cancer immunoprevention
Lee, SB, Pan, J, Xiong, D, Palen, K, Johnson, B, Lubet, RA, Shoemaker, RH, Green, JE, Fernando, RI, Sei, S, You, M & Wang, Y 2023, , npj Precision Oncology, vol. 7, no. 1, 108. https://doi.org/10.1038/s41698-023-00461-1

Primary Prevention and Interception Studies in RAS-Mutated Tumor Models Employing Small Molecules or Vaccines
Dragnev, KH, Lubet, RA, Miller, MS, Sei, S, Fox, JT & You, M 2023, , Cancer Prevention Research, vol. 16, no. 10, pp. 549-560. https://doi.org/10.1158/1940-6207.CAPR-23-0027

The preventive role of the red gingeng ginsenoside Rg3 in the treatment of lung tumorigenesis induced by benzo(a)pyrene
Xiong, J, Yuan, H, Fei, S, Yang, S, You, M & Liu, L 2023, , Scientific Reports, vol. 13, no. 1, 4528, pp. 4528. https://doi.org/10.1038/s41598-023-31710-9

Precision immunointerception of EGFR-driven tumorigenesis for lung cancer prevention
Pan, J, Xiong, D, Zhang, Q, Palen, K, Shoemaker, RH, Johnson, B, Sei, S, Wang, Y & You, M 2023, , Frontiers in immunology, vol. 14, 1036563, pp. 1036563. https://doi.org/10.3389/fimmu.2023.1036563

Mitochondria-targeted atovaquone promotes anti-lung cancer immunity by reshaping tumor microenvironment and enhancing energy metabolism of anti-tumor immune cells
Xiong, D, Yin, Z, Huang, M, Wang, Y, Hardy, M, Kalyanaraman, B, Wong, ST & You, M 2023, , Cancer communications (London, England). https://doi.org/10.1002/cac2.12500

Aerosolized miR-138-5p and miR-200c targets PD-L1 for lung cancer prevention
Zhang, Q, Pan, J, Xiong, D, Zheng, J, McPherson, KN, Lee, S, Huang, M, Xu, Y, Chen, S-H, Wang, Y, Hildebrandt Ruiz, L & You, M 2023, , Frontiers in immunology, vol. 14, 1166951, pp. 1166951. https://doi.org/10.3389/fimmu.2023.1166951

Mitochondria-targeted atovaquone promotes anti-lung cancer immunity by reshaping tumor microenvironment and enhancing energy metabolism of anti-tumor immune cells
Xiong, D, Yin, Z, Huang, M, Wang, Y, Hardy, M, Kalyanaraman, B, Wong, ST & You, M 2023, , Cancer Communications. https://doi.org/10.1002/cac2.12500

OXPHOS-targeting drugs in oncology: new perspectives
Kalyanaraman, B, Cheng, G, Hardy, M & You, M 2023, , Expert Opinion on Therapeutic Targets, vol. 27, no. 10, pp. 939-952. https://doi.org/10.1080/14728222.2023.2261631

Cancer chemoprevention with PV-1, a novel Prunella vulgaris-containing herbal mixture that remodels the tumor immune microenvironment in mice
Zhang, Q, Chen, X, Palen, K, Johnson, B, Bui, D, Xiong, D, Pan, J, Hu, M, Wang, Y & You, M 2023, , Frontiers in immunology, vol. 14, 1196434. https://doi.org/10.3389/fimmu.2023.1196434

Pharmacokinetic Basis for Using Saliva Matrine Concentrations as a Clinical Compliance Monitoring in Antitumor B Chemoprevention Trials in Humans
Bui, D, McWilliams, LA, Wu, L, Zhou, H, Wong, SJ, You, M, Chow, DSL, Singh, R & Hu, M 2022, , Cancers, vol. 15, no. 1, 89. https://doi.org/10.3390/cancers15010089

Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer
Byun, J, Han, Y, Li, Y, Xia, J, Long, E, Choi, J, Xiao, X, Zhu, M, Zhou, W, Sun, R, Bossé, Y, Song, Z, Schwartz, A, Lusk, C, Rafnar, T, Stefansson, K, Zhang, T, Zhao, W, Pettit, RW, Liu, Y, Li, X, Zhou, H, Walsh, KM, Gorlov, I, Gorlova, O, Zhu, D, Rosenberg, SM, Pinney, S, Bailey-Wilson, JE, Mandal, D, de Andrade, M, Gaba, C, Willey, JC, You, M, Anderson, M, Wiencke, JK, Albanes, D, Lam, S, Tardon, A, Chen, C, Goodman, G, Bojeson, S, Brenner, H, Landi, MT, Chanock, SJ, Johansson, M, Muley, T, Risch, A, Wichmann, HE, Bickeböller, H, Christiani, DC, Rennert, G, Arnold, S, Field, JK, Shete, S, Le Marchand, L, Melander, O, Brunnstrom, H, Liu, G, Andrew, AS, Kiemeney, LA, Shen, H, Zienolddiny, S, Grankvist, K, Johansson, M, Caporaso, N, Cox, A, Hong, YC, Yuan, JM, Lazarus, P, Schabath, MB, Aldrich, MC, Patel, A, Lan, Q, Rothman, N, Taylor, F, Kachuri, L, Witte, JS, Sakoda, LC, Spitz, M, Brennan, P, Lin, X, McKay, J, Hung, RJ & Amos, CI 2022, , Nature Genetics, vol. 54, no. 8, pp. 1167-1177. https://doi.org/10.1038/s41588-022-01115-x

Chemoprevention of Lung Cancer with a Combination of Mitochondria-Targeted Compounds
Zhang, Q, Xiong, D, Pan, J, Wang, Y, Hardy, M, Kalyanaraman, B & You, M 2022, , Cancers, vol. 14, no. 10, 2538. https://doi.org/10.3390/cancers14102538

Prevention of Tumor Growth and Dissemination by In Situ Vaccination with Mitochondria-Targeted Atovaquone
Huang, M, Xiong, D, Pan, J, Zhang, Q, Wang, Y, Myers, CR, Johnson, BD, Hardy, M, Kalyanaraman, B & You, M 2022, , Advanced Science, vol. 9, no. 12, 2101267, pp. e2101267. https://doi.org/10.1002/advs.202101267

Combining PEGylated mito-atovaquone with MCT and Krebs cycle redox inhibitors as a potential strategy to abrogate tumor cell proliferation
Cheng, G, Hardy, M, You, M & Kalyanaraman, B 2022, , Scientific Reports, vol. 12, no. 1, 5143, pp. 5143. https://doi.org/10.1038/s41598-022-08984-6

Targeting Glutamine Metabolism to Enhance Immunoprevention of EGFR-Driven Lung Cancer
Huang, M, Xiong, D, Pan, J, Zhang, Q, Sei, S, Shoemaker, RH, Lubet, RA, Montuenga, LM, Wang, Y, Slusher, BS & You, M 2022, , Advanced Science, vol. 9, no. 26, pp. e2105885. https://doi.org/10.1002/advs.202105885

Reply to: “Inconsistent prediction capability of ImmuneCells.Sig across different RNA-seq datasets”
Xiong, D, Wang, Y & You, M 2021, , Nature Communications, vol. 12, no. 1, 4168. https://doi.org/10.1038/s41467-021-24304-4

Rare deleterious germline variants and risk of lung cancer
Liu, Y, Xia, J, McKay, J, Tsavachidis, S, Xiao, X, Spitz, MR, Cheng, C, Byun, J, Hong, W, Li, Y, Zhu, D, Song, Z, Rosenberg, SM, Scheurer, ME, Kheradmand, F, Pikielny, CW, Lusk, CM, Schwartz, AG, Wistuba, II, Cho, MH, Silverman, EK, Bailey-Wilson, J, Pinney, SM, Anderson, M, Kupert, E, Gaba, C, Mandal, D, You, M, de Andrade, M, Yang, P, Liloglou, T, Davies, MPA, Lissowska, J, Swiatkowska, B, Zaridze, D, Mukeria, A, Janout, V, Holcatova, I, Mates, D, Stojsic, J, Scelo, G, Brennan, P, Liu, G, Field, JK, Hung, RJ, Christiani, DC & Amos, CI 2021, , npj Precision Oncology, vol. 5, no. 1, 12. https://doi.org/10.1038/s41698-021-00146-7

Inhibition of lung tumorigenesis by a small molecule CA170 targeting the immune checkpoint protein VISTA
Pan, J, Chen, Y, Zhang, Q, Khatun, A, Palen, K, Xin, G, Wang, L, Yang, C, Johnson, BD, Myers, CR, Sei, S, Shoemaker, RH, Lubet, RA, Wang, Y, Cui, W & You, M 2021, , Communications Biology, vol. 4, no. 1, 906, pp. 906. https://doi.org/10.1038/s42003-021-02381-x

Genetic variation and recurrent haplotypes on chromosome 6q23-25 risk locus in familial lung cancer
Musolf, AM, Simpson, CL, Moiz, BA, Pikielny, CW, Middlebrooks, CD, Mandal, D, De Andrade, M, Cole, MD, Gaba, C, Yang, P, You, M, Li, Y, Kupert, EY, Anderson, MW, Schwartz, AG, Pinney, SM, Amos, CI & Bailey-Wilson, JE 2021, , Cancer research, vol. 81, no. 12, pp. 3162-3173. https://doi.org/10.1158/0008-5472.CAN-20-3196

Mitochondria as a novel target for cancer chemoprevention: Emergence of mitochondrial-targeting agents
Huang, M, Myers, CR, Wang, Y & You, M 2021, , Cancer Prevention Research, vol. 14, no. 3, pp. 285-306. https://doi.org/10.1158/1940-6207.CAPR-20-0425