Ming You, MD, PhD

Professor of Oncology, Academic Institute
Full Member, Research Institute
Director, Center for Cancer Prevention, Dr. Mary and Ron Neal Cancer Center
Houston Methodist

You Lab


Combining PEGylated mito-atovaquone with MCT and Krebs cycle redox inhibitors as a potential strategy to abrogate tumor cell proliferation
Cheng, G, Hardy, M, You, M & Kalyanaraman, B 2022, , Scientific Reports, vol. 12, no. 1, 5143. https://doi.org/10.1038/s41598-022-08984-6

Prevention of Tumor Growth and Dissemination by In Situ Vaccination with Mitochondria-Targeted Atovaquone
Huang, M, Xiong, D, Pan, J, Zhang, Q, Wang, Y, Myers, CR, Johnson, BD, Hardy, M, Kalyanaraman, B & You, M 2022, , Advanced Science, vol. 9, no. 12, 2101267. https://doi.org/10.1002/advs.202101267

Reply to: “Inconsistent prediction capability of ImmuneCells.Sig across different RNA-seq datasets”
Xiong, D, Wang, Y & You, M 2021, , Nature Communications, vol. 12, no. 1, 4168. https://doi.org/10.1038/s41467-021-24304-4

Inhibition of lung tumorigenesis by a small molecule CA170 targeting the immune checkpoint protein VISTA
Pan, J, Chen, Y, Zhang, Q, Khatun, A, Palen, K, Xin, G, Wang, L, Yang, C, Johnson, BD, Myers, CR, Sei, S, Shoemaker, RH, Lubet, RA, Wang, Y, Cui, W & You, M 2021, , Communications Biology, vol. 4, no. 1, 906. https://doi.org/10.1038/s42003-021-02381-x

Rare deleterious germline variants and risk of lung cancer
Liu, Y, Xia, J, McKay, J, Tsavachidis, S, Xiao, X, Spitz, MR, Cheng, C, Byun, J, Hong, W, Li, Y, Zhu, D, Song, Z, Rosenberg, SM, Scheurer, ME, Kheradmand, F, Pikielny, CW, Lusk, CM, Schwartz, AG, Wistuba, II, Cho, MH, Silverman, EK, Bailey-Wilson, J, Pinney, SM, Anderson, M, Kupert, E, Gaba, C, Mandal, D, You, M, de Andrade, M, Yang, P, Liloglou, T, Davies, MPA, Lissowska, J, Swiatkowska, B, Zaridze, D, Mukeria, A, Janout, V, Holcatova, I, Mates, D, Stojsic, J, Scelo, G, Brennan, P, Liu, G, Field, JK, Hung, RJ, Christiani, DC & Amos, CI 2021, , npj Precision Oncology, vol. 5, no. 1, 12. https://doi.org/10.1038/s41698-021-00146-7

Genetic variation and recurrent haplotypes on chromosome 6q23-25 risk locus in familial lung cancer
Musolf, AM, Simpson, CL, Moiz, BA, Pikielny, CW, Middlebrooks, CD, Mandal, D, De Andrade, M, Cole, MD, Gaba, C, Yang, P, You, M, Li, Y, Kupert, EY, Anderson, MW, Schwartz, AG, Pinney, SM, Amos, CI & Bailey-Wilson, JE 2021, , Cancer research, vol. 81, no. 12, pp. 3162-3173. https://doi.org/10.1158/0008-5472.CAN-20-3196

Mitochondria as a novel target for cancer chemoprevention: Emergence of mitochondrial-targeting agents
Huang, M, Myers, CR, Wang, Y & You, M 2021, , Cancer Prevention Research, vol. 14, no. 3, pp. 285-306. https://doi.org/10.1158/1940-6207.CAPR-20-0425

Pulmonary Aerosol Delivery of Let-7b microRNA Confers a Striking Inhibitory Effect on Lung Carcinogenesis through Targeting the Tumor Immune Microenvironment
Zhang, Q, Pan, J, Xiong, D, Wang, Y, Miller, MS, Sei, S, Shoemaker, RH, Izzotti, A & You, M 2021, , Advanced Science, vol. 8, no. 17, 2100629. https://doi.org/10.1002/advs.202100629

Efficacy of EGFR Inhibitors and NSAIDs against Basal Bladder Cancers in a Rat Model: Daily vs. Weekly Dosing, Combining EGFR Inhibitors with Naproxen, and Effects on RNA Expression
Lubet, RA, Kumar, A, Fox, JT, You, M, Mohammed, A, Juliana, MM & Grubbs, CJ 2021, , Bladder Cancer, vol. 7, no. 3, pp. 335-345. https://doi.org/10.3233/BLC-200423

Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer
Bui, D, Yin, T, Duan, S, Wei, B, Yang, P, Wong, SJ, You, M, Singh, R & Hu, M 2021, , Journal of Natural Products, vol. 84, no. 9, pp. 2486-2495. https://doi.org/10.1021/acs.jnatprod.1c00501

A gene expression signature of TREM2hi macrophages and ?d T cells predicts immunotherapy response
Xiong, D, Wang, Y & You, M 2020, , Nature Communications, vol. 11, no. 1, 5084. https://doi.org/10.1038/s41467-020-18546-x

Uncoupling Therapeutic Efficacy from Immune-Related Adverse Events in Immune Checkpoint Blockade
Hu, W, Wang, G, Wang, Y, Riese, MJ & You, M 2020, , iScience, vol. 23, no. 10, 101580. https://doi.org/10.1016/j.isci.2020.101580

Pharmacokinetic and Metabolic Profiling of Key Active Components of Dietary Supplement Magnolia officinalis Extract for Prevention against Oral Carcinoma
Bui, D, Li, L, Yin, T, Wang, X, Wang, X, Gao, S, You, M, Singh, R & Hu, M 2020, , Journal of Agricultural and Food Chemistry, vol. 68, no. 24, pp. 6576-6587. https://doi.org/10.1021/acs.jafc.0c01475

Anticancer effect of physical activity is mediated by modulation of extracellular microRNA in blood
Pulliero, A, You, M, Chaluvally-Raghavan, P, Marengo, B, Domenicotti, C, Banelli, B, Degan, P, Molfetta, L, Gianiorio, F & Izzotti, A 2020, , Oncotarget, vol. 11, no. 22, pp. 2106-2119. https://doi.org/10.18632/oncotarget.27609

Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex i
Zhang, Q, Cheng, G, Pan, J, Zielonka, J, Xiong, D, Myers, CR, Feng, L, Shin, SS, Kim, YH, Bui, D, Hu, M, Bennett, B, Schmainda, K, Wang, Y, Kalyanaraman, B & You, M 2020, , Cell Communication and Signaling, vol. 18, no. 1, 58. https://doi.org/10.1186/s12964-020-0524-2

Increased formation of reactive oxygen species during tumor growth: Ex vivo low-temperature EPR and in vivo bioluminescence analyses
Cheng, G, Pan, J, Podsiadly, R, Zielonka, J, Garces, AM, Dias Duarte Machado, LG, Bennett, B, McAllister, D, Dwinell, MB, You, M & Kalyanaraman, B 2020, , Free Radical Biology and Medicine, vol. 147, pp. 167-174. https://doi.org/10.1016/j.freeradbiomed.2019.12.020

Whole exome sequencing of highly aggregated lung cancer families reveals linked loci for increased cancer risk on chromosomes 12q, 7p, and 4q
Musolf, AM, Moiz, BA, Sun, H, Pikielny, CW, Bosse, Y, Mandal, D, De Andrade, M, Gaba, C, Yang, P, Li, Y, You, M, Govindan, R, Wilson, RK, Kupert, EY, Anderson, MW, Schwartz, AG, Pinney, SM, Amos, CI & Bailey-Wilson, JE 2020, , Cancer Epidemiology Biomarkers and Prevention, vol. 29, no. 2, pp. 434-442. https://doi.org/10.1158/1055-9965.EPI-19-0887

miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer
Parashar, D, Geethadevi, A, Aure, MR, Mishra, J, George, J, Chen, C, Mishra, MK, Tahiri, A, Zhao, W, Nair, B, Lu, Y, Mangala, LS, Rodriguez-Aguayo, C, Lopez-Berestein, G, Camara, AKS, Liang, M, Rader, JS, Ramchandran, R, You, M, Sood, AK, Kristensen, VN, Mills, GB, Pradeep, S & Chaluvally-Raghavan, P 2019, , Cell Reports, vol. 29, no. 13, pp. 4389-4406.e10. https://doi.org/10.1016/j.celrep.2019.11.085

Tumor intrinsic immunity related proteins may be novel tumor suppressors in some types of cancer
Xiong, D, Wang, Y & You, M 2019, , Scientific Reports, vol. 9, no. 1, 10918. https://doi.org/10.1038/s41598-019-47382-3

Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis
Cheng, G, Zhang, Q, Pan, J, Lee, Y, Ouari, O, Hardy, M, Zielonka, M, Myers, CR, Zielonka, J, Weh, K, Chang, AC, Chen, G, Kresty, L, Kalyanaraman, B & You, M 2019, , Nature Communications, vol. 10, no. 1, 2205. https://doi.org/10.1038/s41467-019-10042-1