Milos Kojic

Milos Kojic, PhD

Professor of Nanomedicine, Academic Institute
Full Member, Research Institute
Houston Methodist


Biography

Dr. Kojic was a Professor of Mechanics at the University of Kragujevac in Serbia and is a senior research scientist in the Physiology Program a the Harvard School of Public Health. He was also a visiting scholar at MIT in Boston; a research engineer at ADINA R&D software company in Watertown, MA; a research professor at the University of Texas Medical Center at Houston; a senior researcher at Zastava Automobili in Kragujevac, Serbia; and director of the R&D Center for Bioengineering in Kragujevac. Dr. Kojic is a member of several academic organizations, including the Serbian Academy of Sciences and Arts.

The focus of Dr. Kojic's research includes computational methods and software development. He has conducted pioneering work in modern numerical methods and engineering software development in Serbia, while mentoring a significant number of Ph.D. students and researchers. The result of this effort is a general-purpose finite element program PAK for solids, fluids, mass and heat transfer, biomechanics, and coupled problems; and a large group of researchers who are part of a "Serbian School" in computational mechanics.

Dr. Kojic is the first president of the Serbian Society for Computational Mechanics, Editor of the Journal of the Serbian Society for Computational Mechanics, and the founder of the R&D Center for Bioengineering, Kragujevac. His initial work in computer modeling primarily focused on solid mechanics and is summarized in the textbook: M. Kojic and K. J. Bathe: Inelastic Analysis of Solids and Structures, Springer, 2005. His more recent research has focused on modeling of bioengineering problems, and the results are summarized in the textbook: M. Kojic, N. Filipovic, B. Stojanovic, N. Kojic: Computer Modeling in Bioengineering- Theoretical Background, Examples and Software, J. Wiley and Sons, 2008.

Description of Research

Dr. Kojic's research focuses on modeling of biological and drug delivery transport phenomena, and multiscale modeling. This includes transport of molecules and bio-mechanical interactions of micro-nano particles.

Areas Of Expertise

Computational methods Coupling imaging Computer simulations
Education & Training

PhD, Rice University
MS, University of Belgrade
Publications

Huxley muscle model surrogates for high-speed multi-scale simulations of cardiac contraction
Milicevic, B, Ivanovic, M, Stojanovic, B, Miloševic, M, Kojic, M & Filipovic, N 2022, , Computers in Biology and Medicine, vol. 149, 105963. https://doi.org/10.1016/j.compbiomed.2022.105963

In Silico Clinical Trials for Cardiovascular Disease
Filipovic, N, Saveljic, I, Sustersic, T, Milosevic, M, Milicevic, B, Simic, V, Ivanovic, M & Kojic, M 2022, , Journal of Visualized Experiments, no. 183, e63573. https://doi.org/10.3791/63573

InSilc Computational Tool for in Silico Optimization of Drug-Eluting Bioresorbable Vascular Scaffolds
Milosevic, M, Anic, M, Nikolic, D, Milicevic, B, Kojic, M & Filipovic, N 2022, , Computational and Mathematical Methods in Medicine, vol. 2022, 5311208. https://doi.org/10.1155/2022/5311208

Author Correction: Preparation and modeling of three-layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release (Scientific Reports, (2020), 10, 1, (11126), 10.1038/s41598-020-68117-9)
Milosevic, M, Stojanovic, DB, Simic, V, Grkovic, M, Bjelovic, M, Uskokovic, PS & Kojic, M 2021, , Scientific Reports, vol. 11, no. 1, 16028. https://doi.org/10.1038/s41598-021-95377-w

Attenuated microcirculation in small metastatic tumors in murine liver
Ziemys, A, Simic, V, Milosevic, M, Kojic, M, Liu, YT & Yokoi, K 2021, , Pharmaceutics, vol. 13, no. 5, 703. https://doi.org/10.3390/pharmaceutics13050703

In vitro and in silico testing of partially and fully bioresorbable vascular scaffold
Filipovic, N, Nikolic, D, Isailovic, V, Milosevic, M, Geroski, V, Karanasiou, G, Fawdry, M, Flanagan, A, Fotiadis, D & Kojic, M 2021, , Journal of Biomechanics, vol. 115, 110158. https://doi.org/10.1016/j.jbiomech.2020.110158

Computational model for simulation of left ventricle behaviour during heart beat
Milosevic, M, Milicevic, B, Simic, V, Geroski, V, Filipovic, N & Kojic, M 2021, . in BIBE 2021 - 21st IEEE International Conference on BioInformatics and BioEngineering, Proceedings. BIBE 2021 - 21st IEEE International Conference on BioInformatics and BioEngineering, Proceedings, Institute of Electrical and Electronics Engineers Inc. 21st IEEE International Conference on BioInformatics and BioEngineering, BIBE 2021, Kragujevac, Serbia, 10/25/21. https://doi.org/10.1109/BIBE52308.2021.9635417

3D reconstruction and computational modeling of solid-fluid interaction in realistic heart model
Simic, V, Milosevic, M, Saveljic, I, Milicevic, B, Filipovic, N & Kojic, M 2021, . in BIBE 2021 - 21st IEEE International Conference on BioInformatics and BioEngineering, Proceedings. BIBE 2021 - 21st IEEE International Conference on BioInformatics and BioEngineering, Proceedings, Institute of Electrical and Electronics Engineers Inc. 21st IEEE International Conference on BioInformatics and BioEngineering, BIBE 2021, Kragujevac, Serbia, 10/25/21. https://doi.org/10.1109/BIBE52308.2021.9635284

Semi-Automatic Left Ventricle Model Generation
Milicevic, B, Milosevic, M, Simic, V, Trifunovic, D, Filipovic, N & Kojic, M 2021, . in BIBE 2021 - 21st IEEE International Conference on BioInformatics and BioEngineering, Proceedings. BIBE 2021 - 21st IEEE International Conference on BioInformatics and BioEngineering, Proceedings, Institute of Electrical and Electronics Engineers Inc. 21st IEEE International Conference on BioInformatics and BioEngineering, BIBE 2021, Kragujevac, Serbia, 10/25/21. https://doi.org/10.1109/BIBE52308.2021.9635408

COMPUTATIONAL MODEL FOR HEART TISSUE WITH DIRECT USE OF EXPERIMENTAL CONSTITUTIVE RELATIONSHIPS
Kojic, M, Miloševic, M, Milicevic, B, Geroski, V, Simic, V, Trifunovic, D, Stankovic, G & Filipovic, N 2021, , Journal of the Serbian Society for Computational Mechanics, vol. 15, no. 1, pp. 1-23. https://doi.org/10.24874/jsscm.2021.15.01.01

Preparation and modeling of three-layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release
Milosevic, M, Stojanovic, DB, Simic, V, Grkovic, M, Bjelovic, M, Uskokovic, PS & Kojic, M 2020, , Scientific Reports, vol. 10, no. 1, 11126. https://doi.org/10.1038/s41598-020-68117-9

MULTISCALE COMPOSITE 3D FINITE ELEMENT FOR LUNG MECHANICS
Kojic, M 2020, , Journal of the Serbian Society for Computational Mechanics, vol. 14, no. 1, pp. 1-11. https://doi.org/10.24874/jsscm.2020.14.01.01

Smeared Multiscale Finite Element Models for Mass Transport and Electrophysiology Coupled to Muscle Mechanics
Kojic, M, Milosevic, M, Simic, V, Milicevic, B, Geroski, V, Nizzero, S, Ziemys, A, Filipovic, N & Ferrari, M 2019, , Frontiers in Bioengineering and Biotechnology, vol. 7, 381. https://doi.org/10.3389/fbioe.2019.00381

Smeared finite element model of heart wall: Electrophysiology coupled with muscle mechanics
Kojic, M, Milosevic, M, Simic, V, Milicevic, B, Geroski, V & Filipovic, N 2019, . in Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019., 8941983, Institute of Electrical and Electronics Engineers Inc. pp. 458-461, 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019, Athens, Greece, 10/28/19. https://doi.org/10.1109/BIBE.2019.00089

Tumor Site-Dependent Transport Properties Determine Nanotherapeutics Delivery and Its Efficacy
Kai, M, Ziemys, A, Liu, YT, Kojic, M, Ferrari, M & Yokoi, K 2019, , Translational Oncology, vol. 12, no. 9, pp. 1196-1205. https://doi.org/10.1016/j.tranon.2019.05.011

Coupling tumor growth and bio distribution models
Santagiuliana, R, Milosevic, M, Milicevic, B, Sciumè, G, Simic, V, Ziemys, A, Kojic, M & Schrefler, BA 2019, , Biomedical Microdevices, vol. 21, no. 2, 33. https://doi.org/10.1007/s10544-019-0368-y

Smeared multiscale finite element model for electrophysiology and ionic transport in biological tissue
Kojic, M, Milosevic, M, Simic, V, Geroski, V, Ziemys, A, Filipovic, N & Ferrari, M 2019, , Computers in Biology and Medicine, vol. 108, pp. 288-304. https://doi.org/10.1016/j.compbiomed.2019.03.023

Progression-dependent transport heterogeneity of breast cancer liver metastases as a factor in therapeutic resistance
Ziemys, A, Yokoi, K, Kai, M, Liu, YT, Kojic, M, Simic, V, Milosevic, M, Holder, AM & Ferrari, M 2018, , Journal of Controlled Release, vol. 291, pp. 99-105. https://doi.org/10.1016/j.jconrel.2018.10.014

A computational model for drug release from PLGA implant
Milosevic, M, Stojanovic, D, Simic, V, Milicevic, B, Radisavljevic, A, Uskokovic, P & Kojic, M 2018, , Materials, vol. 11, no. 12, 2416. https://doi.org/10.3390/ma11122416

Correction function for accuracy improvement of the Composite Smeared Finite Element for diffusive transport in biological tissue systems
Milosevic, M, Simic, V, Milicevic, B, Koay, EJ, Ferrari, M, Ziemys, A & Kojic, M 2018, , Computer Methods in Applied Mechanics and Engineering, vol. 338, pp. 97-116. https://doi.org/10.1016/j.cma.2018.04.012