Not found

Milos Kojic, PhD

Professor of Nanomedicine, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist


Biography

Dr. Kojic's research focuses on modeling of biological and drug delivery transport phenomena, and multiscale modeling. This includes transport of molecules and bio-mechanical interactions of micro-nano particles.

Description of Research

Dr. Kojic was a Professor of Mechanics at the University of Kragujevac in Serbia and is a senior research scientist in the Physiology Program a the Harvard School of Public Health. He was also a visiting scholar at MIT in Boston; a research engineer at ADINA R&D software company in Watertown, MA; a research professor at the University of Texas Medical Center at Houston; a senior researcher at Zastava Automobili in Kragujevac, Serbia; and director of the R&D Center for Bioengineering in Kragujevac. Dr. Kojic is a member of several academic organizations, including the Serbian Academy of Sciences and Arts.

The focus of Dr. Kojic's research includes computational methods and software development. He has conducted pioneering work in modern numerical methods and engineering software development in Serbia, while mentoring a significant number of Ph.D. students and researchers. The result of this effort is a general-purpose finite element program PAK for solids, fluids, mass and heat transfer, biomechanics, and coupled problems; and a large group of researchers who are part of a "Serbian School" in computational mechanics.

Dr. Kojic is the first president of the Serbian Society for Computational Mechanics, Editor of the Journal of the Serbian Society for Computational Mechanics, and the founder of the R&D Center for Bioengineering, Kragujevac. His initial work in computer modeling primarily focused on solid mechanics and is summarized in the textbook: M. Kojic and K. J. Bathe: Inelastic Analysis of Solids and Structures, Springer, 2005. His more recent research has focused on modeling of bioengineering problems, and the results are summarized in the textbook: M. Kojic, N. Filipovic, B. Stojanovic, N. Kojic: Computer Modeling in Bioengineering- Theoretical Background, Examples and Software, J. Wiley and Sons, 2008.

Areas Of Expertise

Computational methods Coupling imaging Computer simulations
Education & Training

PhD, Rice University
MS, University of Belgrade
Publications

Correction function for accuracy improvement of the Composite Smeared Finite Element for diffusive transport in biological tissue systems
Milosevic, M, Simic, V, Milicevic, B, Koay, EJ, Ferrari, M, Ziemys, A & Kojic, M 2018, Computer Methods in Applied Mechanics and Engineering, vol 338, pp. 97-116. DOI: 10.1016/j.cma.2018.04.012

Multiscale smeared finite element model for mass transport in biological tissue: From blood vessels to cells and cellular organelles
Kojic, M, Milosevic, M, Simic, V, Koay, EJ, Kojic, N, Ziemys, A & Ferrari, M 2018, Computers in Biology and Medicine, vol 99, pp. 7-23. DOI: 10.1016/j.compbiomed.2018.05.022

Mass release curves as the constitutive curves for modeling diffusive transport within biological tissue
Kojic, M, Milosevic, M, Kojic, N, Koay, EJ, Fleming, JB, Ferrari, M & Ziemys, A 2018, Computers in Biology and Medicine, vol 92, pp. 156-167. DOI: 10.1016/j.compbiomed.2016.06.026

Numerical modeling of drug delivery in organs: From CT scans to FE model
Milosevic, M, Simic, V & Kojic, M 2018, . in Pervasive Computing Paradigms for Mental Health - Selected Papers from MindCare 2016, Fabulous 2016, and IIoT 2015. vol. 207, Lecture Notes of the Institute for Computer Sciences, Social-Informatics and Telecommunications Engineering, LNICST, vol. 207, Springer Verlag, pp. 87-92, International Symposium on Pervasive Computing Paradigms for Mental Health - MindCare,2016, Barcelona, Spain, 11/28/16. DOI: 10.1007/978-3-319-74935-8_12

Tumor progression effects on drug vector access to tumor-associated capillary bed
Kiseliovas, V, Milosevic, M, Kojic, M, Mazutis, L, Kai, M, Liu, YT, Yokoi, K, Ferrari, M & Ziemys, A 2017, Journal of Controlled Release, vol 261, pp. 216-222. DOI: 10.1016/j.jconrel.2017.05.031

A composite smeared finite element for mass transport in capillary systems and biological tissue
Kojic, M, Milosevic, M, Simic, V, Koay, EJ, Fleming, JB, Nizzero, S, Kojic, N, Ziemys, A & Ferrari, M 2017, Computer Methods in Applied Mechanics and Engineering, vol 324, pp. 413-437. DOI: 10.1016/j.cma.2017.06.019

A radial 1D finite element for drug release from drug loaded nanofibers
Kojic, M, Milosevic, M, Simic, V, Stojanovic, D & Uskokovic, P 2017, Journal of the Serbian Society for Computational Mechanics, vol 11, no. 1, pp. 82-93. DOI: 10.24874/jsscm.2017.11.01.08

Incremental finite element formulation for large strains based on the nodal force increments
Kojic, M, Simic, V & Milosevic, M 2017, Journal of the Serbian Society for Computational Mechanics, vol 11, no. 1, pp. 97-109. DOI: 10.24874/jsscm.2017.11.01.10

Extension of the composite smeared finite element (CSFE) to include lymphatic system in modeling mass transport in capillary systems and biological tissue
Kojic, M, Milosevic, M, Simic, V, Koay, EJ, Kojic, N, Ziemys, A & Ferrari, M 2017, Journal of the Serbian Society for Computational Mechanics, vol 11, no. 2, pp. 108-119. DOI: 10.24874/JSSCM.2017.11.02.09

Computational analysis of drug transport in tumor microenvironment as a critical compartment for nanotherapeutic pharmacokinetics
Ziemys, A, Klemm, S, Milosevic, M, Yokoi, K, Ferrari, M & Kojic, M 2016, Drug Delivery, vol 23, no. 7, pp. 2524-2531. DOI: 10.3109/10717544.2015.1022837

A MODEL FOR DRUG TRANSPORT IN TUMOR
Kojic, M, Simic, V, Ferrari, M, Koay, EJ & Ziemys, A 2016, . in ECCOMAS Congress 2016, Crete Island, Greece, 5-10 June.

A review of models in bioengineering developed by the group led by Miloš Kojic in the period 2006-2016
Kojic, M 2016, Journal of the Serbian Society for Computational Mechanics, vol 10, no. 1, pp. 5-19.

Hybrid SPECT/MSCT 3D computational preoperative simulation in breast cancer surgery
Nikolic, D, Matovic, M, Jeremic, M, Cvetkovic, A, Ninkovic, S, Kojic, M & Filipovic, N 2015, . in 2015 IEEE 15th International Conference on Bioinformatics and Bioengineering, BIBE 2015., 7367670, IEEE, 15th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2015, Belgrade, Serbia, 11/2/15. DOI: 10.1109/BIBE.2015.7367670

Computational models for convective and diffusive drug transport in capillaries and tissue
Kojic, M, Milosevic, M, Isailovic, V, Simic, V, Ferrari, M & Ziemys, A 2015, . in 2015 IEEE 15th International Conference on Bioinformatics and Bioengineering, BIBE 2015., 7367633, IEEE, 15th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2015, Belgrade, Serbia, 11/2/15. DOI: 10.1109/BIBE.2015.7367633

Liposomal doxorubicin extravasation controlled by phenotype-specific transport properties of tumor microenvironment and vascular barrier
Yokoi, K, Chan, D, Kojic, M, Milosevic, M, Engler, D, Matsunami, R, Tanei, T, Saito, Y, Ferrari, M & Ziemys, A 2015, Journal of Controlled Release, vol 217, pp. 293-299. DOI: 10.1016/j.jconrel.2015.09.044

Capillary collagen as the physical transport barrier in drug delivery to tumor microenvironment
Ziemys, A, Yokoi, K & Kojic, M 2015, Tissue barriers, vol 3, no. 3, pp. e1037418. DOI: 10.1080/21688370.2015.1037418

Physicochemical properties affect the synthesis, controlled delivery, degradation and pharmacokinetics of inorganic nanoporous materials
Yazdi, IK, Ziemys, A, Evangelopoulos, M, Martinez, JO, Kojic, M & Tasciotti, E 2015, Nanomedicine, vol 10, no. 19, pp. 3057-3075. DOI: 10.2217/nnm.15.133

A multi-scale FE model for convective-diffusive drug transport within tumor and large vascular networks
Kojic, M, Milosevic, M, Kojic, N, Starosolski, Z, Ghaghada, K, Serda, R, Annapragada, A, Ferrari, M & Ziemys, A 2015, Computer Methods in Applied Mechanics and Engineering, vol 294, pp. 100-122. DOI: 10.1016/j.cma.2015.06.002

Mass partitioning effects in diffusion transport
Kojic, M, Milosevic, M, Wu, S, Blanco, E, Ferrari, M & Ziemys, A 2015, Physical Chemistry Chemical Physics, vol 17, no. 32, pp. 20630-20635. DOI: 10.1039/c5cp02720a

A computational study of circulating large tumor cells traversing microvessels
Kojic, N, Miloševic, M, Petrovic, D, Isailovic, V, Sarioglu, AF, Haber, DA, Kojic, M & Toner, M 2015, Computers in Biology and Medicine, vol 63, pp. 187-195. DOI: 10.1016/j.compbiomed.2015.05.024