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Michael W. Lieberman, MD, PhD

Emeritus Professor of Pathology and Laboratory Medicine, Institute for Academic Medicine
Full Emeritus Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Michael W. Lieberman is an Emeritus Member of Houston Methodist Research Institute. He formerly held the positions of CEO and Director of Research Institute as the Ernest Cockrell, Jr. Distinguished Endowed Chair. He was also chair of the Department of Pathology at Houston Methodist Hospital, Professor of Pathology at Weill Cornell Medical College of Cornell University, and Professor of Biology and Biochemistry at the University of Houston.

A native of Pittsburgh, Pennsylvania, he is a graduate of Yale University and received his M.D. and Ph.D. degrees from the University of Pittsburgh School of Medicine. Dr. Lieberman’s research has focused on cancer including the repair of DNA damage by carcinogens, gene expression in cancer and the role of glutathione in the protection of cells from carcinogens and environmental agents.

He was a fellow at the Fels Research Institute (Temple University), the Chester Beatty Institute for Cancer Research (UK), and the National Cancer Institute. He served as head of the somatic cell genetics section of the National Institute of Environmental Health Sciences, professor of pathology and biological chemistry at Washington University (St. Louis), chair of the department of pathology at The Fox Chase Cancer Center and adjunct professor of pathology at the University of Pennsylvania. He came to Houston in 1988 as the W.L. Moody, Jr., professor and chair of the department of pathology and professor in the department of molecular and cellular biology at Baylor College of Medicine. He is the founding director of the Baylor Cancer Center and has led the pathology service at The Methodist Hospital since 1988.

Dr. Lieberman has served on and/or chaired study sections for the National Institutes of Health and the American Cancer Society and is a former member of the National Institute of Environmental Health Sciences National Advisory Board (“Council”). He is past president of the American Society for Investigative Pathology and the Association of University Pathologists. He has been honored with the Gold Headed Cane, a life time achievement award, from the American Society for Investigative Pathology.

Education & Training

Clinical Fellowship, University of Pittsburgh
Residency, University of Pittsburgh
MD, University of Pittsburgh
Publications

Glutathione is essential for early embryogenesis - Analysis of a glutathione synthetase knockout mouse
Winkler, A, Njålsson, R, Carlsson, K, Elgadi, A, Rozell, B, Abraham, L, Ercal, N, Shi, ZZ, Lieberman, MW, Larsson, A & Norgren, S 2011, Biochemical and Biophysical Research Communications, vol. 412, no. 1, pp. 121-126. DOI: 10.1016/j.bbrc.2011.07.056

System xc- and thioredoxin reductase 1 cooperatively rescue glutathione deficiency
Mandal, PK, Seiler, A, Perisic, T, Kölle, P, Canak, AB, Förster, H, Weiss, N, Kremmer, E, Lieberman, MW, Bannai, S, Kuhlencordt, P, Sato, H, Bornkamm, GW & Conrad, M 2010, Journal of Biological Chemistry, vol. 285, no. 29, pp. 22244-22253. DOI: 10.1074/jbc.M110.121327

OLA1, an Obg-like ATPase, suppresses antioxidant response via nontranscriptional mechanisms
Zhang, J, Rubio, V, Lieberman, MW & Shi, ZZ 2009, Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 36, pp. 15356-15361. DOI: 10.1073/pnas.0907213106

Glutathione protects cells against arsenite-induced toxicity
Habib, GM, Shi, ZZ & Lieberman, MW 2007, Free Radical Biology and Medicine, vol. 42, no. 2, pp. 191-201. DOI: 10.1016/j.freeradbiomed.2006.10.036

Interactions between leukotriene C4 and interleukin 13 signaling pathways in a mouse model of airway disease
Chavez, J, Young, HWJ, Corry, DB & Lieberman, MW 2006, Archives of Pathology and Laboratory Medicine, vol. 130, no. 4, pp. 440-446.

Survival and cell death in cells constitutively unable to synthesize glutathione
Valverde, M, Rojas, E, Kala, SV, Kala, G & Lieberman, MW 2006, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, vol. 594, no. 1-2, pp. 172-180. DOI: 10.1016/j.mrfmmm.2005.08.004

Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway
Zhang, DD, Lo, SC, Sun, Z, Habib, GM, Lieberman, MW & Hannink, M 2005, Journal of Biological Chemistry, vol. 280, no. 34, pp. 30091-30099. DOI: 10.1074/jbc.M501279200

Elimination of the differential chemoresistance between the murine B-cell lymphoma LY-ar and LY-as cell lines after arsenic (As2O3) exposure via the overexpression of gsto1 (p28)
Giri, U, Terry, NHA, Kala, SV, Lieberman, MW & Story, MD 2005, Cancer Chemotherapy and Pharmacology, vol. 55, no. 6, pp. 511-521. DOI: 10.1007/s00280-004-0920-0

Arsenic inhibition of the JAK-STAT pathway
Cheng, HY, Li, P, David, M, Smithgall, TE, Feng, L & Lieberman, MW 2004, Oncogene, vol. 23, no. 20, pp. 3603-3612. DOI: 10.1038/sj.onc.1207466

Formation and Urinary Excretion of Arsenic Triglutathione and Methylarsenic Diglutathione
Kala, SV, Kala, G, Prater, CI, Sartorelli, AC & Lieberman, MW 2004, Chemical Research in Toxicology, vol. 17, no. 2, pp. 243-249. DOI: 10.1021/tx0342060

Cell survival and changes in gene expression in cells unable to synthesize glutathione
Rojas, E, Shi, ZZ, Valverde, M, Paules, RS, Habib, GM & Lieberman, MW 2003, BioFactors, vol. 17, no. 1-4, pp. 13-19.

Identification of two additional members of the membrane-bound dipeptidase family.
Habib, GM, Shi, ZZ, Cuevas, AA & Lieberman, MW 2003, The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 17, no. 10, pp. 1313-1315.

Reversible skeletal abnormalities in ?-glutamyl transpeptidase-deficient mice
Levasseur, R, Barrios, R, Elefteriou, F, Glass, DA, Lieberman, MW & Karsenty, G 2003, Endocrinology, vol. 144, no. 7, pp. 2761-2764. DOI: 10.1210/en.2002-0071

Bleomycin-induced pulmonary fibrosis is attenuated in ?-glutamyl transpeptidase-deficient mice
Pardo, A, Ruiz, V, Arreola, JL, Ramírez, R, Cisneros-Lira, J, Gaxiola, M, Barrios, R, Kala, SV, Lieberman, MW & Selman, M 2003, American Journal of Respiratory and Critical Care Medicine, vol. 167, no. 6, pp. 925-932. DOI: 10.1164/rccm.200209-1007OC

?-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D4 formation in vivo
Han, B, Luo, G, Shi, ZZ, Barrios, R, Atwood, D, Liu, W, Habib, GM, Sifers, RN, Corry, DB & Lieberman, MW 2002, American Journal of Pathology, vol. 161, no. 2, pp. 481-490.

Physiology: The ventilatory response to hypoxia
Gozal, D, Gaston, BM, Lipton, AJ, Johnson, MA, Macdonald, T & Lieberman, MW 2002, Nature, vol. 419, no. 6908.

Oxygen-induced pulmonary injury in ?-glutamyl transpeptidase-deficient mice
Barrios, R, Shi, ZZ, Kala, SV, Wiseman, AL, Welty, SE, Kala, G, Bahler, AA, Ou, CN & Lieberman, MW 2001, Lung, vol. 179, no. 5, pp. 319-330. DOI: 10.1007/s004080000071

?-glutamyl transpeptidase-deficient mice are resistant to the nephrotoxic effects of cisplatin
Hanigan, MH, Lykissa, ED, Townsend, DM, Ou, CN, Barrios, R & Lieberman, MW 2001, American Journal of Pathology, vol. 159, no. 5, pp. 1889-1894.

S-Nitrosothiols signal the ventilatory response to hypoxia
Lipton, AJ, Johnson, MA, Macdonald, T, Lieberman, MW, Gozal, D & Gaston, B 2001, Nature, vol. 413, no. 6852, pp. 171-174. DOI: 10.1038/35093117

Disruption of ?-glutamyl leukotrienase results in disruption of leukotriene D4 synthesis in vivo and attenuation of the acute inflammatory response
Shi, ZZ, Han, B, Habib, GM, Matzuk, MM & Lieberman, MW 2001, Molecular and Cellular Biology, vol. 21, no. 16, pp. 5389-5395. DOI: 10.1128/MCB.21.16.5389-5395.2001