Mahinur Mattohti

Mahinur Mattohti, MD, PhD

Assistant Professor of Surgery, Academic Institute
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Description of Research

I am interested in understanding how epigenetic changes contribute to tumorigenesis, disease progression and the development of therapy resistance, and how we can exploit these aberrations to engineer novel therapeutic approaches. In the lab, we utilize experimental, computational, and high-throughput technologies to study and modulate the epigenetic changes in cancer with the goal of (1) identifying the epigenetic drivers of cancer development and progression (2) identifying epigenetic alterations and the mechanisms underlying targeted and immuno-therapy resistance (3) exploit novel epigenetic targets and develop therapeutic strategies.  

Areas Of Expertise

Immunotherapy Transcriptional regulation Epigenomics therapy resistance
Publications

The androgen receptor is a therapeutic target in desmoplastic small round cell sarcoma
Lamhamedi-Cherradi, SE, Maitituoheti, M, Menegaz, BA, Krishnan, S, Vetter, AM, Camacho, P, Wu, CC, Beird, HC, Porter, RW, Ingram, DR, Ramamoorthy, V, Mohiuddin, S, McCall, D, Truong, DD, Cuglievan, B, Futreal, PA, Velasco, AR, Anvar, NE, Utama, B, Titus, M, Lazar, AJ, Wang, WL, Rodriguez-Aguayo, C, Ratan, R, Livingston, JA, Rai, K, MacLeod, AR, Daw, NC, Hayes-Jordan, A & Ludwig, JA 2022, , Nature Communications, vol. 13, no. 1, 3057. https://doi.org/10.1038/s41467-022-30710-z

Chromatin state dynamics confers specific therapeutic strategies in enhancer subtypes of colorectal cancer
Orouji, E, Raman, AT, Singh, AK, Sorokin, A, Arslan, E, Ghosh, AK, Schulz, J, Terranova, C, Jiang, S, Tang, M, Maitituoheti, M, Callahan, SC, Barrodia, P, Tomczak, K, Jiang, Y, Jiang, Z, Davis, JS, Ghosh, S, Lee, HM, Reyes-Uribe, L, Chang, K, Liu, Y, Chen, H, Azhdarinia, A, Morris, J, Vilar, E, Carmon, KS, Kopetz, SE & Rai, K 2022, , Gut, vol. 71, no. 5, pp. 938-949. https://doi.org/10.1136/gutjnl-2020-322835

Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy
Terranova, CJ, Tang, M, Maitituoheti, M, Raman, AT, Ghosh, AK, Schulz, J, Amin, SB, Orouji, E, Tomczak, K, Sarkar, S, Oba, J, Creasy, C, Wu, CJ, Khan, S, Lazcano, R, Wani, K, Singh, A, Barrodia, P, Zhao, D, Chen, K, Haydu, LE, Wang, WL, Lazar, AJ, Woodman, SE, Bernatchez, C & Rai, K 2021, , Cell Reports, vol. 36, no. 3, 109410. https://doi.org/10.1016/j.celrep.2021.109410

KMT2D deficiency confers a therapeutic vulnerability to glycolytic and IGFR inhibitors in melanoma
Murugesan, N & Maitituoheti, M 2021, , Molecular and Cellular Oncology, vol. 8, no. 5, 1984827. https://doi.org/10.1080/23723556.2021.1984827

Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma
Maitituoheti, M, Keung, EZ, Tang, M, Yan, L, Alam, H, Han, G, Singh, AK, Raman, AT, Terranova, C, Sarkar, S, Orouji, E, Amin, SB, Sharma, S, Williams, M, Samant, NS, Dhamdhere, M, Zheng, N, Shah, T, Shah, A, Axelrad, JB, Anvar, NE, Lin, YH, Jiang, S, Chang, EQ, Ingram, DR, Wang, WL, Lazar, A, Lee, MG, Muller, F, Wang, L, Ying, H & Rai, K 2020, , Cell Reports, vol. 33, no. 3, 108293. https://doi.org/10.1016/j.celrep.2020.108293

KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer
Alam, H, Tang, M, Maitituoheti, M, Dhar, SS, Kumar, M, Han, CY, Ambati, CR, Amin, SB, Gu, B, Chen, TY, Lin, YH, Chen, J, Muller, FL, Putluri, N, Flores, ER, DeMayo, FJ, Baseler, L, Rai, K & Lee, MG 2020, , Cancer Cell, vol. 37, no. 4, pp. 599-617.e7. https://doi.org/10.1016/j.ccell.2020.03.005

Erratum: Soluble B and T lymphocyte attenuator possesses antitumor effects and facilitates heat shock protein 70 vaccine-triggered antitumor immunity against a murine TC-1 cervical cancer model in vivo (Journal of Immunology (2009) 183 (7842-7850) DOI: 10.4049/jimmunol.0804379)
Han, L, Wang, W, Fang, Y, Feng, Z, Liao, S, Li, W, Li, Y, Li, C, Maitituoheti, M, Dong, H, Lai, Z, Gao, Q, Xi, L, Wu, M, Wang, D, Zhou, J, Meng, L, Wang, S & Ma, D 2020, , Journal of Immunology, vol. 204, no. 4, pp. 1069-1070. https://doi.org/10.4049/jimmunol.1901449

Atypical plant homeodomain of UBR7 functions as an H2BK120Ub ligase and breast tumor suppressor
Adhikary, S, Chakravarti, D, Terranova, C, Sengupta, I, Maitituoheti, M, Dasgupta, A, Srivastava, DK, Ma, J, Raman, AT, Tarco, E, Sahin, AA, Bassett, R, Yang, F, Tapia, C, Roy, S, Rai, K & Das, C 2019, , Nature Communications, vol. 10, no. 1, 1398. https://doi.org/10.1038/s41467-019-08986-5

An integrated platform for genome-wide mapping of chromatin states using high-throughput chip-sequencing in tumor tissues
Terranova, C, Tang, M, Orouji, E, Maitituoheti, M, Raman, A, Amin, S, Liu, Z & Rai, K 2018, , Journal of Visualized Experiments, vol. 2018, no. 134, e56972. https://doi.org/10.3791/56972

Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression
Fiziev, P, Akdemir, KC, Miller, JP, Keung, EZ, Samant, NS, Sharma, S, Natale, CA, Terranova, CJ, Maitituoheti, M, Amin, SB, Martinez-Ledesma, E, Dhamdhere, M, Axelrad, JB, Shah, A, Cheng, CS, Mahadeshwar, H, Seth, S, Barton, MC, Protopopov, A, Tsai, KY, Davies, MA, Garcia, BA, Amit, I, Chin, L, Ernst, J & Rai, K 2017, , Cell Reports, vol. 19, no. 4, pp. 875-889. https://doi.org/10.1016/j.celrep.2017.03.078

EMDomics: A robust and powerful method for the identification of genes differentially expressed between heterogeneous classes
Nabavi, S, Schmolze, D, Maitituoheti, M, Malladi, S & Beck, AH 2016, , Bioinformatics, vol. 32, no. 4, pp. 533-541. https://doi.org/10.1093/bioinformatics/btv634

Application of statistical machine learning in identifying candidate biomarkers of resistant to anti-cancer drugs in ovarian cancer
Nabavi, S, Maitituoheti, M, Yamada, M & Tonellato, P 2014, . in Proceedings - 2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014., 6972886, Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, vol. 2014-December, Institute of Electrical and Electronics Engineers Inc. 2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014, Boston, United States, 4/25/14. https://doi.org/10.1109/NEBEC.2014.6972886

Twist2 contributes to cisplatin-resistance of ovarian cancer through the AKT/GSK-3ß signaling pathway
Wang, T, Li, Y, Tuerhanjiang, A, Wang, W, Wu, Z, Yuan, M, Maitituoheti, M & Wang, S 2014, , Oncology Letters, vol. 7, no. 4, pp. 1102-1108. https://doi.org/10.3892/ol.2014.1816

Association of an oestrogen receptor gene polymorphism in Chinese Han women with endometriosis and endometriosis-related infertility
Wang, W, Li, Y, Maitituoheti, M, Yang, R, Wu, Z, Wang, T, Ma, D & Wang, S 2013, , Reproductive BioMedicine Online, vol. 26, no. 1, pp. 93-98. https://doi.org/10.1016/j.rbmo.2012.09.007

Erratum: Soluble B and T lymphocyte attenuator possesses antitumor effects and facilitates heat shock protein 70 vaccine-triggered antitumor immunity against a murine TC-1 cervical cancer model in vivo (Journal of Immunology (2009) 183 (7842-7850))
Han, L, Wang, W, Fang, Y, Feng, Z, Liao, S, Li, W, Li, Y, Li, C, Maitituoheti, M, Dong, H, Lai, Z, Gao, Q, Xi, L, Wu, M, Wang, D, Zhou, J, Meng, L, Wang, S & Ma, D 2012, , Journal of Immunology, vol. 188, no. 9, pp. 4709. https://doi.org/10.4049/jimmunol.1290013

Smoking and risk of endometriosis: A Meta-analysis of case control studies
Yang, RF, Mayinuer, M, Wu, ZY, Wang, T, Wang, WW, Li, Y & Wang, SX 2012, , Chinese Journal of Evidence-Based Medicine, vol. 12, no. 1, pp. 68-73.

Adeno-associated virus-mediated local delivery of LIGHT suppresses tumorigenesis in a murine cervical cancer model
Maitituoheti, M, Li, Y, Wang, W, Wang, W, Han, L, Yang, R, Wang, T, Wu, Z, Ma, D & Wang, S 2011, , Journal of Immunotherapy, vol. 34, no. 8, pp. 581-587. https://doi.org/10.1097/CJI.0b013e31822b9fe0

Peroxiredoxin 2 inhibits granulosa cell apoptosis during follicle atresia through the NFKB pathway in mice
Yang, S, Luo, A, Hao, X, Lai, Z, Ding, T, Ma, X, Mayinuer, M, Shen, W, Wang, X, Lu, Y, Ma, D & Wang, S 2011, , Biology of Reproduction, vol. 84, no. 6, pp. 1182-1189. https://doi.org/10.1095/biolreprod.110.087569

Soluble B and T lymphocyte attenuator possesses antitumor effects and facilitates heat shock protein 70 vaccine-triggered antitumor immunity against a murine TC-1 cervical cancer model in vivo
Han, L, Wang, W, Fang, Y, Feng, Z, Liao, S, Li, W, Li, Y, Li, C, Maitituoheti, M, Dong, H, Lai, Z, Gao, Q, Xi, L, Wu, M, Wang, D, Zhou, J, Meng, L, Wang, S & Ma, D 2009, , Journal of Immunology, vol. 183, no. 12, pp. 7842-7850. https://doi.org/10.4049/jimmunol.0804379

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