Max W. Adelman, MD, MSc

Assistant Professor of Medicine, Academic Institute
Assistant Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

I am a clinician-scientist with clinical training in Infectious Diseases and Critical Care Medicine. I actively practice both of these specialties at Houston Methodist, where I also teach residents, fellows, and Texas A&M EnMed medical students as the Critical Care Clerkship Director. I additionally conduct clinical and translational research on issues relevant to critically ill patients with or at risk of severe infections, including the impact of multi-drug resistant bacteria and yeasts. 

Description of Research

I am clinically trained in both Infectious Diseases and Critical Care Medicine and my research interests sit at the intersection of these fields. My current clinical and translational research focuses on the clinical and immune impact of gut colonization with multi-drug resistant bacteria and yeasts, including the emerging multi-drug resistant fungus Candida auris. I have received funding from Houston Methodist Research Institute to examine these issues in patients at high risk for adverse outcomes, including critically ill patients and patients after solid organ transplatation. Additionally, I collaborate with experts in Candida biology and immunology from around the Texas Medical Center. I have extensive prior experience in COVID-19 outcomes and clinical trials research, as well as in other topics relevant to both Infectious Diseases and Critical Care including C. difficile infection and sepsis.

Areas Of Expertise

Critical care Critical care medicine Antibiotic resistance Critical care and intensive care medicine Sepsis Antimicrobial resistance
Publications

Single-center Outcomes After Liver Transplantation With SARS-CoV-2–Positive Donors: An Argument for Increased Utilization
Connor, AA, Adelman, MW, Mobley, CM, Moaddab, M, Erhardt, AJ, Hsu, DE, Brombosz, EW, Sanghvi, M, Lee Cheah, Y, Simon, CJ, Hobeika, MJ, Saharia, AS, Victor, DW, Kodali, S, Basra, T, Graviss, EA, Nguyen, DT, Elsaiey, A, Moore, LW, Nigo, M, Drews, AL, Grimes, KA, Arias, CA, Li, XC, Gaber, AO & Ghobrial, RM 2024, , Transplantation Direct, vol. 10, no. 4, pp. E1590. https://doi.org/10.1097/TXD.0000000000001590

Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial
for the I-SPY COVID Consortium 2024, , Critical Care, vol. 28, no. 1, 56. https://doi.org/10.1186/s13054-024-04819-0

Bloodstream infections after solid organ transplantation: clinical epidemiology and antimicrobial resistance (2016–21)
Adelman, MW, Connor, AA, Hsu, E, Saharia, A, Mobley, CM, Victor, DW, Hobeika, MJ, Lin, J, Grimes, KA, Ramos, E, Pedroza, C, Brombosz, EW, Ghobrial, RM & Arias, CA 2024, , JAC-Antimicrobial Resistance, vol. 6, no. 1, 158, pp. dlad158. https://doi.org/10.1093/jacamr/dlad158

The accuracy of infection diagnoses among patients meeting Sepsis-3 criteria in the emergency department
Adelman, MW, Septimus, EJ & Arias, CA 2023, , Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 77, no. 2, pp. 327. https://doi.org/10.1093/cid/ciad240

Report of the first seven agents in the I-SPY COVID trial: a phase 2, open label, adaptive platform randomised controlled trial
The I-SPY COVID Consortium 2023, , EClinicalMedicine, vol. 58, 101889, pp. 101889. https://doi.org/10.1016/j.eclinm.2023.101889

SARS-CoV-2 Evolution and Immune Escape in Immunocompromised Patients
Scherer, EM, Babiker, A, Adelman, MW, Allman, B, Key, A, Kleinhenz, JM, Langsjoen, RM, Nguyen, PV, Onyechi, I, Sherman, JD, Simon, TW, Soloff, H, Tarabay, J, Varkey, J, Webster, AS, Weiskopf, D, Weissman, DB, Xu, Y, Waggoner, JJ, Koelle, K, Rouphael, N, Pouch, SM & Piantadosi, A 2022, , New England Journal of Medicine, vol. 386, no. 25, pp. 2436-2438. https://doi.org/10.1056/NEJMc2202861

I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations
ISPY COVID Adaptive Platform Trial Network 2022, , BMJ open, vol. 12, no. 6, pp. e060664. https://doi.org/10.1136/bmjopen-2021-060664

Trends in ICU Mortality From Coronavirus Disease 2019: A Tale of Three Surges
Emory COVID-19 Quality and Clinical Research Collaborative 2022, , Critical Care Medicine, vol. 50, no. 2, pp. 245-255. https://doi.org/10.1097/CCM.0000000000005185

Distinctive Features of Ertapenem-Mono-Resistant Carbapenem-Resistant Enterobacterales in the United States: A Cohort Study
Adelman, MW, Bower, CW, Grass, JE, Ansari, UA, Soda, EA, See, I, Lutgring, JD & Jacob, JT 2022, , Open Forum Infectious Diseases, vol. 9, no. 1, ofab643. https://doi.org/10.1093/ofid/ofab643

Clinical trial design during and beyond the pandemic: the I-SPY COVID trial
The I-SPY COVID Consortium 2022, , Nature Medicine, vol. 28, no. 1, pp. 9-11. https://doi.org/10.1038/s41591-021-01617-x

Secondary Bacterial Pneumonias and Bloodstream Infections in Patients Hospitalized with COVID-19
Adelman, MW, Bhamidipati, DR, Hernandez-Romieu, AC, Babiker, A, Woodworth, MH, Robichaux, C, Murphy, DJ, Auld, SC, Kraft, CS & Jacob, JT 2021, , Annals of the American Thoracic Society, vol. 18, no. 9, pp. 1584-1587. https://doi.org/10.1513/AnnalsATS.202009-1093RL

Changes in treatment of community-onset Clostridioides difficile infection after release of updated guidelines, Atlanta, Georgia, 2018
Adelman, MW, Goodenough, D, Sefton, S, Mackey, C, Thomas, S, Fridkin, SK & Woodworth, MH 2021, , Anaerobe, vol. 70, 102364. https://doi.org/10.1016/j.anaerobe.2021.102364

Current capabilities of gut microbiome-based diagnostics and the promise of clinical application
Damhorst, GL, Adelman, MW, Woodworth, MH & Kraft, CS 2021, , Journal of Infectious Diseases, vol. 223, pp. S270-S275. https://doi.org/10.1093/infdis/jiaa689

Validation of High-Sensitivity Severe Acute Respiratory Syndrome Coronavirus 2 Testing for Stool - Toward the New Normal for Fecal Microbiota Transplantation
Babiker, A, Ingersoll, JM, Adelman, MW, Webster, AS, Broder, KJ, Stittleburg, V, Waggoner, JJ, Kraft, CS & Woodworth, MH 2021, , Clinical and translational gastroenterology, vol. 12, no. 6, pp. E00363. https://doi.org/10.14309/ctg.0000000000000363

Infection- and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variant
Edara, VV, Norwood, C, Floyd, K, Lai, L, Davis-Gardner, ME, Hudson, WH, Mantus, G, Nyhoff, LE, Adelman, MW, Fineman, R, Patel, S, Byram, R, Gomes, DN, Michael, G, Abdullahi, H, Beydoun, N, Panganiban, B, McNair, N, Hellmeister, K, Pitts, J, Winters, J, Kleinhenz, J, Usher, J, OKeefe, JB, Piantadosi, A, Waggoner, JJ, Babiker, A, Stephens, DS, Anderson, EJ, Edupuganti, S, Rouphael, N, Ahmed, R, Wrammert, J & Suthar, MS 2021, , Cell Host and Microbe, vol. 29, no. 4, pp. 516-521.e3. https://doi.org/10.1016/j.chom.2021.03.009

Incidence and severity of COVID-19 in HIV-positive persons receiving antiretroviral therapy
Titanji, B, Hernandez-Romieu, AC & Adelman, MW 2021, , Annals of Internal Medicine, vol. 174, no. 4, pp. 580-581. https://doi.org/10.7326/L20-1398

Neuromyelitis Optica Presenting as Infectious Meningoencephalitis: Case Report and Literature Review
Tfaily, MAH, Titanji, B, Schniederjan, MJ, Goodman, A, Lava, NS, Pouch, SM, Collins, MH & Adelman, MW 2021, , American Journal of the Medical Sciences, vol. 361, no. 4, pp. 534-541. https://doi.org/10.1016/j.amjms.2020.12.011

Retinopathy and Systemic Disease Morbidity in Severe COVID-19
Emory COVID-19 Quality and Clinical Research Collaborative 2021, , Ocular Immunology and Inflammation, vol. 29, no. 4, pp. 743-750. https://doi.org/10.1080/09273948.2021.1952278

Timing of Intubation and Mortality Among Critically Ill Coronavirus Disease 2019 Patients: A Single-Center Cohort Study
Hernandez-Romieu, AC, Adelman, MW, Hockstein, MA, Robichaux, CJ, Edwards, JA, Fazio, JC, Blum, JM, Jabaley, CS, Caridi-Scheible, M, Martin, GS, Murphy, DJ & Auld, SC 2020, , Critical Care Medicine, vol. 48, no. 11, pp. E1045-E1053. https://doi.org/10.1097/CCM.0000000000004600

A brain abscess and pulmonary nodules in a heart/kidney transplant recipient
Adelman, MW, Dean, CL & Friedman-Moraco, RJ 2020, , Clinical Infectious Diseases, vol. 71, no. 7, pp. 1795-1797. https://doi.org/10.1093/cid/ciaa106