Matthew D. Cykowski VIEW CLINICAL PROFILE

Matthew D. Cykowski, MD

Associate Professor of Pathology and Genomic Medicine, Academic Institute
Jerold B. Katz Investigator, Academic Institute
Houston Methodist
Weill Cornell Medical College


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Publications

Limbic-predominant age-related TDP-43 encephalopathy (LATE-NC): Co-pathologies and genetic risk factors provide clues about pathogenesis
Nelson, PT, Fardo, DW, Wu, X, Aung, KZ, Cykowski, MD & Katsumata, Y 2024, , Journal of Neuropathology and Experimental Neurology, vol. 83, no. 6, pp. 396-415. https://doi.org/10.1093/jnen/nlae032

Anterior insula is more vulnerable than posterior insula to TDP-43 pathology in common dementias and ALS
Lochner, RH, Arumanayagam, AS, Powell, SZ, Masdeu, JC, Pascual, B & Cykowski, MD 2024, , Journal of Neuropathology and Experimental Neurology, vol. 83, no. 5, pp. 307-317. https://doi.org/10.1093/jnen/nlae027

MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study
Picks disease International Consortium 2024, , The Lancet Neurology, vol. 23, no. 5, pp. 487-499. https://doi.org/10.1016/S1474-4422(24)00083-8

Letter to the Editor Response: LETTERS TO THE EDITOR RESPONSE
Stuebe, CM, Jenson, AV, Lines, TW, Holloman, AM, Cykowski, MD, Fung, SH, Fisher, RE, McClain, KL & Baskin, DS 2024, , Journal of Neurosurgery: Case Lessons, vol. 7, no. 9, CASE23667. https://doi.org/10.3171/CASE23667

Recurrent petit mal seizures in Erdheim-Chester disease mimicking an intra-axial brain tumor: illustrative case
Stuebe, CM, Jenson, AV, Lines, TW, Holloman, AM, Cykowski, MD, Fung, SH, Fisher, RE, McClain, KL & Baskin, DS 2023, , Journal of Neurosurgery: Case Lessons, vol. 6, no. 16, CASE23248. https://doi.org/10.3171/CASE23248

LATE-NC staging in routine neuropathologic diagnosis: an update
Nelson, PT, Lee, EB, Cykowski, MD, Alafuzoff, I, Arfanakis, K, Attems, J, Brayne, C, Corrada, MM, Dugger, BN, Flanagan, ME, Ghetti, B, Grinberg, LT, Grossman, M, Grothe, MJ, Halliday, GM, Hasegawa, M, Hokkanen, SRK, Hunter, S, Jellinger, K, Kawas, CH, Keene, CD, Kouri, N, Kovacs, GG, Leverenz, JB, Latimer, CS, Mackenzie, IR, Mao, Q, McAleese, KE, Merrick, R, Montine, TJ, Murray, ME, Myllykangas, L, Nag, S, Neltner, JH, Newell, KL, Rissman, RA, Saito, Y, Sajjadi, SA, Schwetye, KE, Teich, AF, Thal, DR, Tomé, SO, Troncoso, JC, Wang, SHJ, White, CL, Wisniewski, T, Yang, HS, Schneider, JA, Dickson, DW & Neumann, M 2023, , Acta Neuropathologica, vol. 145, no. 2, pp. 159-173. https://doi.org/10.1007/s00401-022-02524-2

Genetics and Pathogenesis of Parkinson's Syndrome
Ye, H, Robak, LA, Yu, M, Cykowski, M & Shulman, JM 2023, , Annual Review of Pathology: Mechanisms of Disease, vol. 18, pp. 95-121. https://doi.org/10.1146/annurev-pathmechdis-031521-034145

Urinary Incontinence in a Community-Based Autopsy Cohort Is Associated with Limbic Predominant Age-Related TDP-43 Encephalopathy Neuropathologic Changes
Di, J, Nelson, RS, Jicha, GA, Moga, DC, Barber, JM, Cykowski, MD, Fardo, DW, Abner, EL & Nelson, PT 2023, , Journal of Alzheimers Disease, vol. 94, no. 1, pp. 333-346. https://doi.org/10.3233/JAD-230425

Primary visual cortex pathology in ALS patients with C9ORF72 expansion
Cykowski, MD, Arumanayagam, AS, Powell, SZ & Appel, SH 2024, , Brain Pathology, vol. 34, no. 5, e13229. https://doi.org/10.1111/bpa.13229

Author Correction: REST overexpression in mice causes deficits in spontaneous locomotion
Lu, L, Marisetty, A, Liu, B, Kamal, MM, Gumin, J, Veo, B, Cai, YQ, Kassem, DH, Weng, C, Maynard, ME, Hood, KN, Fuller, GN, Pan, ZZ, Cykowski, MD, Dash, PK & Majumder, S 2022, , Scientific Reports, vol. 12, no. 1, 21759, pp. 21759. https://doi.org/10.1038/s41598-022-25607-2

Frequency of LATE neuropathologic change across the spectrum of Alzheimer’s disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts
Nelson, PT, Brayne, C, Flanagan, ME, Abner, EL, Agrawal, S, Attems, J, Castellani, RJ, Corrada, MM, Cykowski, MD, Di, J, Dickson, DW, Dugger, BN, Ervin, JF, Fleming, J, Graff-Radford, J, Grinberg, LT, Hokkanen, SRK, Hunter, S, Kapasi, A, Kawas, CH, Keage, HAD, Keene, CD, Kero, M, Knopman, DS, Kouri, N, Kovacs, GG, Labuzan, SA, Larson, EB, Latimer, CS, Leite, REP, Matchett, BJ, Matthews, FE, Merrick, R, Montine, TJ, Murray, ME, Myllykangas, L, Nag, S, Nelson, RS, Neltner, JH, Nguyen, AT, Petersen, RC, Polvikoski, T, Reichard, RR, Rodriguez, RD, Suemoto, CK, Wang, SHJ, Wharton, SB, White, L & Schneider, JA 2022, , Acta Neuropathologica, vol. 144, no. 1, pp. 27-44. https://doi.org/10.1007/s00401-022-02444-1

Limbic-Predominant Age-Related TDP-43 Encephalopathy: Medical and Pathologic Factors Associated With Comorbid Hippocampal Sclerosis
Gauthreaux, KM, Teylan, MA, Katsumata, Y, Mock, C, Culhane, JE, Chen, YC, Chan, KCG, Fardo, DW, Dugan, AJ, Cykowski, MD, Jicha, GA, Kukull, WA & Nelson, PT 2022, , Neurology, vol. 98, no. 14, pp. E1422-E1433. https://doi.org/10.1212/WNL.0000000000200001

Translocator Protein 18 kDa PET Imaging Highlights Asymptomatic Isolated Cerebellar Dysplasia
Pascual, B, Hodics, T, Funk, Q, Cykowski, MD, Nakawah, MO & Masdeu, JC 2022, , Neurology, vol. 98, no. 13, pp. 538-539. https://doi.org/10.1212/WNL.0000000000200221

Apolipoprotein E Proteinopathy Is a Major Dementia-Associated Pathologic Biomarker in Individuals with or without the APOE Epsilon 4 Allele
Gal, J, Katsumata, Y, Zhu, H, Srinivasan, S, Chen, J, Johnson, LA, Wang, WX, Golden, LR, Wilcock, DM, Jicha, GA, Cykowski, MD & Nelson, PT 2022, , American Journal of Pathology, vol. 192, no. 3, pp. 564-578. https://doi.org/10.1016/j.ajpath.2021.11.013

Patterns of amygdala region pathology in LATE-NC: subtypes that differ with regard to TDP-43 histopathology, genetic risk factors, and comorbid pathologies
Cykowski, MD, Arumanayagam, AS, Powell, SZ, Rivera, AL, Abner, EL, Roman, GC, Masdeu, JC & Nelson, PT 2022, , Acta Neuropathologica, vol. 143, no. 5, pp. 531-545. https://doi.org/10.1007/s00401-022-02416-5

A 57-year-old woman with falls, slurred speech, and abnormal MRI signal in the pons, middle cerebellar peduncles, and cerebellum
Holloman, A, Panchal, S, Mistry, E, Monroig-Bosque, P, Christensen, P, Lai, E & Cykowski, M 2022, , Brain Pathology, vol. 32, no. 4, e13072, pp. e13072. https://doi.org/10.1111/bpa.13072

Pathology of the Optic Nerve and Extraocular Muscle
Chévez-Barrios, P & Cykowski, MD 2022, . in Albert and Jakobiecs Principles and Practice of Ophthalmology: Fourth Edition. Springer International Publishing, pp. 6489-6524. https://doi.org/10.1007/978-3-030-42634-7_136

Paraneoplastic Lower Motor Neuron Disease
Kleinschmidt-Demasters, BK, Marshall, CB & Cykowski, MD 2021, , Journal of Neuropathology and Experimental Neurology, vol. 80, no. 12, pp. 1125-1127. https://doi.org/10.1093/jnen/nlab078

Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study
Alzheimer’s Disease Genetics Consortium 2021, , Acta Neuropathologica Communications, vol. 9, no. 1, 152, pp. 152. https://doi.org/10.1186/s40478-021-01250-2

Fast progression in amyotrophic lateral sclerosis is associated with greater tdp-43 burden in spinal cord
Cathcart, SJ, Appel, SH, Peterson, LE, Greene, EP, Powell, SZ, Arumanayagam, AS, Rivera, AL & Cykowski, MD 2021, , Journal of Neuropathology and Experimental Neurology, vol. 80, no. 8, pp. 754-763. https://doi.org/10.1093/jnen/nlab061

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