Matthew D. Cykowski, MD

Assistant Professor of Pathology and Genomic Medicine, Academic Institute
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Publications

Neuroinflammation is highest in areas of disease progression in semantic dementia
Pascual, B, Funk, Q, Zanotti Fregonara, P, Cykowski, MD, Veronese, M, Rockers, E, Bradbury, K, Yu, M, Nakawah, MO, Román, GC, Schulz, PE, Arumanayagam, AS, Beers, D, Faridar, A, Fujita, M, Appel, SH & Masdeu, JC 2021, , Brain, vol. 144, no. 5, pp. 1565-1575. https://doi.org/10.1093/brain/awab057

Neuroinflammation is highest in areas of disease progression in semantic dementia
Pascual, B, Funk, Q, Zanotti-Fregonara, P, Cykowski, MD, Veronese, M, Rockers, E, Bradbury, K, Yu, M, Nakawah, MO, Román, GC, Schulz, PE, Arumanayagam, AS, Beers, D, Faridar, A, Fujita, M, Appel, SH & Masdeu, JC 2021, , Brain, vol. 144, no. 5, pp. 1565-1575. https://doi.org/10.1093/brain/awab057

Spinal cord and motor neuron TDP-43 pathology in a sporadic inclusion body myositis patient
Cathcart, SJ, Greene, EP, Powell, SZ, Arumanayagam, AS, Rivera, AL, Tawil, R, Appel, SH & Cykowski, MD 2021, , Journal of Neuropathology and Experimental Neurology, vol. 79, no. 10, pp. 1130-1133. https://doi.org/10.1093/JNEN/NLAA066

Brain arteriolosclerosis
Blevins, BL, Vinters, HV, Love, S, Wilcock, DM, Grinberg, LT, Schneider, JA, Kalaria, RN, Katsumata, Y, Gold, BT, Wang, DJJ, Ma, SJ, Shade, LMP, Fardo, DW, Hartz, AMS, Jicha, GA, Nelson, KB, Magaki, SD, Schmitt, FA, Teylan, MA, Ighodaro, ET, Phe, P, Abner, EL, Cykowski, MD, Van Eldik, LJ & Nelson, PT 2021, , Acta Neuropathologica, vol. 141, no. 1. https://doi.org/10.1007/s00401-020-02235-6

Distinct clinicopathologic clusters of persons with TDP-43 proteinopathy
Katsumata, Y, Abner, EL, Karanth, S, Teylan, MA, Mock, CN, Cykowski, MD, Lee, EB, Boehme, KL, Mukherjee, S, Kauwe, JSK, Kryscio, RJ, Schmitt, FA, Fardo, DW & Nelson, PT 2020, , Acta Neuropathologica, vol. 140, no. 5, pp. 659-674. https://doi.org/10.1007/s00401-020-02211-0

Pathology Trainee Redeployment and Education During the COVID-19 Pandemic: An Institutional Experience
Monroig-Bosque, PDC, Hsu, JW, Lin, MS, Shehabeldin, AN, Rogers, JT, Kim, CF, Kalsekar, AG, Jin, Z, Cara, LR, Barbieri, AN, El-Zaatari, Z, Eskandari, G, Sheu, TG, Tomsula, JA, Long, SW, Zieske, AW, Leveque, CM, Salazar, E, Mody, DR, Schwartz, MR, Cykowski, MD, Yi, X, Powell, SZ & Thomas, JS 2020, , Academic Pathology, vol. 7. https://doi.org/10.1177/2374289520953548

Fourth Nerve Palsy Due to Neurocysticercosis
Hong, BYB, Bean, A, Vickers, A, Cykowski, M & Lee, AG 2020, , Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, vol. 40, no. 3, pp. 414-416. https://doi.org/10.1097/WNO.0000000000000785

A 70-Year Old Man with Dystonic and Choreiform Movements
Perez, A, Roman, GC, Powell, SZ-E, Fisher, R, Rivera, AL, Masdeu, JC & Cykowski, MD 2020, , Brain Pathology, vol. 30, no. 2, pp. 415-416. https://doi.org/10.1111/bpa.12819

OCIAD1 contributes to neurodegeneration in Alzheimer’s disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages
Li, X, Wang, L, Cykowski, MD, He, T, Liu, T, Chakranarayan, J, Rivera, A, Zhao, H, Powell, SZ-E, Xia, W & Wong, ST 2020, , EBioMedicine, vol. 51, 102569. https://doi.org/10.1016/j.ebiom.2019.11.030

Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults
Karanth, S, Nelson, PT, Katsumata, Y, Kryscio, RJ, Schmitt, FA, Fardo, DW, Cykowski, MD, Jicha, GA, Van Eldik, LJ & Abner, EL 2020, , JAMA Neurology, vol. 77, no. 10, pp. 1299-1307. https://doi.org/10.1001/jamaneurol.2020.1741

Biopsy proven metastatic meningioma: A case report and review of the literature
Vakil, H, Tran, L, Lewis, GD, Cykowski, MD, Butler, EB & Teh, BS 2019, , Reports of Practical Oncology and Radiotherapy, vol. 24, no. 6, pp. 528-532. https://doi.org/10.1016/j.rpor.2019.08.002

Dipeptide repeat (DPR) pathology in the skeletal muscle of ALS patients with C9ORF72 repeat expansion
Cykowski, MD, Dickson, DW, Powell, SZ, Arumanayagam, AS, Rivera, AL & Appel, SH 2019, , Acta Neuropathologica, vol. 138, no. 4, pp. 667-670. https://doi.org/10.1007/s00401-019-02050-8

REST overexpression in mice causes deficits in spontaneous locomotion
Lu, L, Marisetty, A, Liu, B, Kamal, MM, Gumin, J, Veo, B, Cai, YQ, Kassem, DH, Weng, C, Maynard, ME, Hood, KN, Fuller, GN, Pan, ZZ, Cykowski, MD, Dash, PK & Majumder, S 2018, , Scientific Reports, vol. 8, no. 1, 12083. https://doi.org/10.1038/s41598-018-29441-3

Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis
Cykowski, MD, Powell, SZ, Appel, JW, Arumanayagam, AS, Rivera, AL & Appel, SH 2018, , Acta Neuropathologica Communications, vol. 6, no. 1, pp. 28. https://doi.org/10.1186/s40478-018-0528-y

Creutzfeldt astrocytes may be seen in IDH-wildtype glioblastoma and retain expression of DNA repair and chromatin binding proteins
Ballester, LY, Boghani, Z, Baskin, DS, Britz, GW, Olsen, R, Fuller, GN, Powell, SZ & Cykowski, MD 2018, , Brain Pathology, vol. 28, no. 6, pp. 1012-1019. https://doi.org/10.1111/bpa.12604

Tumor-to-tumor metastasis: Lung adenocarcinoma into a clinically non-functioning gonadotroph pituitary adenoma: A rare case
Sav, A, Altinöz, MA, Rotondo, F, Cykowski, M, Özer, AF & Kovacs, K 2018, , Neurological Sciences and Neurophysiology, vol. 35, no. 1, pp. 53-59. https://doi.org/10.24165/jns.9865.16

Perineurial-like Cells and EMA Expression in the Suprachoroidal Region of the Human Eye
Gilbert, AR, Chévez-Barrios, P & Cykowski, MD 2018, , Journal of Histochemistry and Cytochemistry, vol. 66, no. 5, pp. 367-375. https://doi.org/10.1369/0022155418756308

The amygdala as a locus of pathologic misfolding in neurodegenerative diseases
Nelson, PT, Abner, EL, Patel, E, Anderson, S, Wilcock, DM, Kryscio, RJ, Van Eldik, LJ, Jicha, GA, Gal, Z, Nelson, RS, Nelson, BG, Gal, J, Azam, MT, Fardo, DW & Cykowski, MD 2018, , Journal of Neuropathology and Experimental Neurology, vol. 77, no. 1, pp. 2-20. https://doi.org/10.1093/jnen/nlx099

Creutzfeldt Cell Rich Glioblastoma: A Diagnostic Dilemma
Boghani, Z, Steele, WJ, Cykowski, MD, Ballester, LY & Britz, G 2017, Cureus, vol. 9, no. 10, pp. e1749. https://doi.org/10.7759/cureus.1749

Hippocampal sclerosis in older patients practical examples and guidance with a focus on cerebral age-related TDP-43 with sclerosis
Cykowski, MD, Powell, SZ, Schulz, PE, Takei, H, Rivera, AL, Jackson, RE, Roman, G, Jicha, GA & Nelson, PT 2017, , Archives of Pathology and Laboratory Medicine, vol. 141, no. 8, pp. 1113-1126. https://doi.org/10.5858/arpa.2016-0469-SA