Matthew D. Cykowski, MD

Assistant Professor of Pathology and Genomic Medicine, Academic Institute
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Publications

Genetics and Pathogenesis of Parkinson's Syndrome
Ye, H, Robak, LA, Yu, M, Cykowski, M & Shulman, JM 2023, , Annual Review of Pathology: Mechanisms of Disease, vol. 18, pp. 95-121. https://doi.org/10.1146/annurev-pathmechdis-031521-034145

Author Correction: REST overexpression in mice causes deficits in spontaneous locomotion (Scientific Reports, (2018), 8, 1, (12083), 10.1038/s41598-018-29441-3)
Lu, L, Marisetty, A, Liu, B, Kamal, MM, Gumin, J, Veo, B, Cai, YQ, Kassem, DH, Weng, C, Maynard, ME, Hood, KN, Fuller, GN, Pan, ZZ, Cykowski, MD, Dash, PK & Majumder, S 2022, , Scientific Reports, vol. 12, no. 1, 21759. https://doi.org/10.1038/s41598-022-25607-2

Frequency of LATE neuropathologic change across the spectrum of Alzheimer’s disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts
Nelson, PT, Brayne, C, Flanagan, ME, Abner, EL, Agrawal, S, Attems, J, Castellani, RJ, Corrada, MM, Cykowski, MD, Di, J, Dickson, DW, Dugger, BN, Ervin, JF, Fleming, J, Graff-Radford, J, Grinberg, LT, Hokkanen, SRK, Hunter, S, Kapasi, A, Kawas, CH, Keage, HAD, Keene, CD, Kero, M, Knopman, DS, Kouri, N, Kovacs, GG, Labuzan, SA, Larson, EB, Latimer, CS, Leite, REP, Matchett, BJ, Matthews, FE, Merrick, R, Montine, TJ, Murray, ME, Myllykangas, L, Nag, S, Nelson, RS, Neltner, JH, Nguyen, AT, Petersen, RC, Polvikoski, T, Reichard, RR, Rodriguez, RD, Suemoto, CK, Wang, SHJ, Wharton, SB, White, L & Schneider, JA 2022, , Acta Neuropathologica, vol. 144, no. 1, pp. 27-44. https://doi.org/10.1007/s00401-022-02444-1

Limbic-Predominant Age-Related TDP-43 Encephalopathy: Medical and Pathologic Factors Associated With Comorbid Hippocampal Sclerosis
Gauthreaux, KM, Teylan, MA, Katsumata, Y, Mock, C, Culhane, JE, Chen, YC, Chan, KCG, Fardo, DW, Dugan, AJ, Cykowski, MD, Jicha, GA, Kukull, WA & Nelson, PT 2022, , Neurology, vol. 98, no. 14, pp. E1422-E1433. https://doi.org/10.1212/WNL.0000000000200001

Translocator Protein 18 kDa PET Imaging Highlights Asymptomatic Isolated Cerebellar Dysplasia
Pascual, B, Hodics, T, Funk, Q, Cykowski, MD, Nakawah, MO & Masdeu, JC 2022, , Neurology, vol. 98, no. 13, pp. 538-539. https://doi.org/10.1212/WNL.0000000000200221

Apolipoprotein E Proteinopathy Is a Major Dementia-Associated Pathologic Biomarker in Individuals with or without the APOE Epsilon 4 Allele
Gal, J, Katsumata, Y, Zhu, H, Srinivasan, S, Chen, J, Johnson, LA, Wang, WX, Golden, LR, Wilcock, DM, Jicha, GA, Cykowski, MD & Nelson, PT 2022, , American Journal of Pathology, vol. 192, no. 3, pp. 564-578. https://doi.org/10.1016/j.ajpath.2021.11.013

Patterns of amygdala region pathology in LATE-NC: subtypes that differ with regard to TDP-43 histopathology, genetic risk factors, and comorbid pathologies
Cykowski, MD, Arumanayagam, AS, Powell, SZ, Rivera, AL, Abner, EL, Roman, GC, Masdeu, JC & Nelson, PT 2022, , Acta Neuropathologica, vol. 143, no. 5, pp. 531-545. https://doi.org/10.1007/s00401-022-02416-5

A 57-year-old woman with falls, slurred speech, and abnormal MRI signal in the pons, middle cerebellar peduncles, and cerebellum
Holloman, A, Panchal, S, Mistry, E, Monroig-Bosque, P, Christensen, P, Lai, E & Cykowski, M 2022, , Brain Pathology, vol. 32, no. 4, e13072, pp. e13072. https://doi.org/10.1111/bpa.13072

Paraneoplastic Lower Motor Neuron Disease
Kleinschmidt-Demasters, BK, Marshall, CB & Cykowski, MD 2021, , Journal of Neuropathology and Experimental Neurology, vol. 80, no. 12, pp. 1125-1127. https://doi.org/10.1093/jnen/nlab078

Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study
Alzheimer’s Disease Genetics Consortium 2021, , Acta Neuropathologica Communications, vol. 9, no. 1, 152, pp. 152. https://doi.org/10.1186/s40478-021-01250-2

Fast progression in amyotrophic lateral sclerosis is associated with greater tdp-43 burden in spinal cord
Cathcart, SJ, Appel, SH, Peterson, LE, Greene, EP, Powell, SZ, Arumanayagam, AS, Rivera, AL & Cykowski, MD 2021, , Journal of Neuropathology and Experimental Neurology, vol. 80, no. 8, pp. 754-763. https://doi.org/10.1093/jnen/nlab061

Ankyrin-r regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K+ channels
Stevens, SR, Longley, CM, Ogawa, Y, Teliska, LH, Arumanayagam, AS, Nair, S, Oses-Prieto, JA, Burlingame, AL, Cykowski, MD, Xue, M & Rasband, MN 2021, , eLife, vol. 10, e66491. https://doi.org/10.7554/eLife.66491

Neuroinflammation is highest in areas of disease progression in semantic dementia
Pascual, B, Funk, Q, Zanotti Fregonara, P, Cykowski, MD, Veronese, M, Rockers, E, Bradbury, K, Yu, M, Nakawah, MO, Román, GC, Schulz, PE, Arumanayagam, AS, Beers, D, Faridar, A, Fujita, M, Appel, SH & Masdeu, JC 2021, , Brain, vol. 144, no. 5, pp. 1565-1575. https://doi.org/10.1093/brain/awab057

Neuroinflammation is highest in areas of disease progression in semantic dementia
Pascual, B, Funk, Q, Zanotti-Fregonara, P, Cykowski, MD, Veronese, M, Rockers, E, Bradbury, K, Yu, M, Nakawah, MO, Román, GC, Schulz, PE, Arumanayagam, AS, Beers, D, Faridar, A, Fujita, M, Appel, SH & Masdeu, JC 2021, , Brain, vol. 144, no. 5, pp. 1565-1575. https://doi.org/10.1093/brain/awab057

Spinal cord and motor neuron TDP-43 pathology in a sporadic inclusion body myositis patient
Cathcart, SJ, Greene, EP, Powell, SZ, Arumanayagam, AS, Rivera, AL, Tawil, R, Appel, SH & Cykowski, MD 2021, , Journal of Neuropathology and Experimental Neurology, vol. 79, no. 10, pp. 1130-1133. https://doi.org/10.1093/JNEN/NLAA066

Brain arteriolosclerosis
Blevins, BL, Vinters, HV, Love, S, Wilcock, DM, Grinberg, LT, Schneider, JA, Kalaria, RN, Katsumata, Y, Gold, BT, Wang, DJJ, Ma, SJ, Shade, LMP, Fardo, DW, Hartz, AMS, Jicha, GA, Nelson, KB, Magaki, SD, Schmitt, FA, Teylan, MA, Ighodaro, ET, Phe, P, Abner, EL, Cykowski, MD, Van Eldik, LJ & Nelson, PT 2021, , Acta Neuropathologica, vol. 141, no. 1. https://doi.org/10.1007/s00401-020-02235-6

Distinct clinicopathologic clusters of persons with TDP-43 proteinopathy
Katsumata, Y, Abner, EL, Karanth, S, Teylan, MA, Mock, CN, Cykowski, MD, Lee, EB, Boehme, KL, Mukherjee, S, Kauwe, JSK, Kryscio, RJ, Schmitt, FA, Fardo, DW & Nelson, PT 2020, , Acta Neuropathologica, vol. 140, no. 5, pp. 659-674. https://doi.org/10.1007/s00401-020-02211-0

Pathology Trainee Redeployment and Education During the COVID-19 Pandemic: An Institutional Experience
Monroig-Bosque, PDC, Hsu, JW, Lin, MS, Shehabeldin, AN, Rogers, JT, Kim, CF, Kalsekar, AG, Jin, Z, Cara, LR, Barbieri, AN, El-Zaatari, Z, Eskandari, G, Sheu, TG, Tomsula, JA, Long, SW, Zieske, AW, Leveque, CM, Salazar, E, Mody, DR, Schwartz, MR, Cykowski, MD, Yi, X, Powell, SZ & Thomas, JS 2020, , Academic Pathology, vol. 7. https://doi.org/10.1177/2374289520953548

Fourth Nerve Palsy Due to Neurocysticercosis
Hong, BYB, Bean, A, Vickers, A, Cykowski, M & Lee, AG 2020, , Journal of Neuro-Ophthalmology, vol. 40, no. 3, pp. 414-416. https://doi.org/10.1097/WNO.0000000000000785

A 70-Year Old Man with Dystonic and Choreiform Movements
Perez, A, Roman, GC, Powell, SZ-E, Fisher, R, Rivera, AL, Masdeu, JC & Cykowski, MD 2020, , Brain Pathology, vol. 30, no. 2, pp. 415-416. https://doi.org/10.1111/bpa.12819