R. Mark Ghobrial, MD, PhD

Sherrie and Alan Conover Chair for Excellence in Liver Transplantation, Sherrie and Alan Conover Center for Liver Disease & Transplantation
Director, J.C. Walter Jr. Transplant Center
Professor of Surgery, Academic Institute
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Sherrie and Alan Conover Center for Liver Disease and Transplantation


Biography

After receiving his Bachelor of Medicine and Bachelor of Surgery degrees from Cairo University Medical School in Cairo, Egypt, Dr. Ghobrial completed several surgical residencies in the United Kingdom and the United States. While a surgery resident at University of Texas Health Science Center in Houston, Texas, he completed a PhD in Immunology at the UT Graduate School of Biomedical Sciences in 1994. After residency, he accepted a position as clinical instructor in the Department of Surgery at the David Geffen School of Medicine at University of California, Los Angeles (UCLA) and was awarded a Dumont-UCLA Transplant Fellowship. He received his full professorship in 2005 and served as Director of the Pancreas Transplant Program and Living Donor Liver Transplantation, and Service Director for Liver, Pancreas, and Small Bowel Transplantation. He was recruited to the Houston Methodist Hospital in 2008.

Description of Research

One of the primary goals of Dr. Ghobrial´s research is to increase donor tolerance to organ transplants and allografts. Dr. Ghobrial has shown in preclinical studies that tolerizing the host to dominant donor epitopes induces tolerance in the recipient. By engineering chimeric proteins, or proteins that contain sequences from both donor and recipient, and exposing the recipient to these proteins prior to tissue graft, peripheral, long-term tolerance is induced. Dr. Ghobrial also has a long-standing interest in the effects of Hepatitis (B and C) on transplantation patients.

Areas Of Expertise

Liver resection Transplantation Hepatocellular carcinoma Liver transplant Liver disease
Education & Training

Clinical Fellowship, Dumont-UCLA Transplant Center
MD, University of Cairo Medical School
Residency, University of Texas Health Science Center at Houston
PhD, University of Texas Health Science Center at Houston
Publications

Effects of vitamin D on macrophages and myeloid-derived suppressor cells (MDSCs) hyperinflammatory response in the lungs of COVID-19 patients
Kloc, M, Ghobrial, RM, Lipinska-Opalka, A, Wawrzyniak, A, Zdanowski, R, Kalicki, B & Kubiak, JZ 2021, , Cellular Immunology, vol. 360, 104259. https://doi.org/10.1016/j.cellimm.2020.104259

Role of macrophages and rhoa pathway in atherosclerosis
Kloc, M, Uosef, A, Kubiak, JZ & Ghobrial, RM 2021, , International journal of molecular sciences, vol. 22, no. 1, 216, pp. 1-13. https://doi.org/10.3390/ijms22010216

Macrophage proinflammatory responses to microorganisms and transplanted organs
Kloc, M, Uosef, A, Kubiak, JZ & Ghobrial, RM 2020, , International journal of molecular sciences, vol. 21, no. 24, 9669, pp. 1-14. https://doi.org/10.3390/ijms21249669

The Rise of the Machines: Will They Fulfill the Restoration Promise?
Nolte Fong, JV, Saharia, A, Hobeika, M, Podder, H & Ghobrial, RM 2020, , Liver Transplantation, vol. 26, no. 12, pp. 1568-1570. https://doi.org/10.1002/lt.25912

The multiple sclerosis (MS) drugs as a potential treatment of ARDS in COVID-19 patients
Kloc, M & Ghobrial, RM 2020, , Multiple Sclerosis and Related Disorders, vol. 45, 102437. https://doi.org/10.1016/j.msard.2020.102437

Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics
Chen, S, Zhang, L, Ying, Y, Wang, Y, Arnold, PR, Wang, G, Li, J, Ghobrial, RM, Chen, W, Xiao, X & Li, XC 2020, , American Journal of Transplantation, vol. 20, no. 9, pp. 2366-2379. https://doi.org/10.1111/ajt.15845

How nicotine can inhibit cytokine storm in the lungs and prevent or lessen the severity of COVID-19 infection?
Kloc, M, Ghobrial, RM & Kubiak, JZ 2020, , Immunology Letters, vol. 224, pp. 28-29. https://doi.org/10.1016/j.imlet.2020.06.002

Development of child immunity in the context of COVID-19 pandemic
Kloc, M, Ghobrial, RM, Kuchar, E, Lewicki, S & Kubiak, JZ 2020, , Clinical Immunology, vol. 217, 108510, pp. 108510. https://doi.org/10.1016/j.clim.2020.108510

Delayed implantation of pumped kidneys decreases renal allograft futility in combined liver-kidney transplantation
Lunsford, KE, Agopian, VG, Yi, S, Nguyen, DTM, Graviss, EA, Harlander-Locke, MP, Saharia, A, Kaldas, FM, Mobley, CM, Zarrinpar, A, Hobeika, MJ, Veale, JL, Podder, H, Farmer, DG, Knight, RJ, Danovitch, GM, Gritsch, HA, Li, XC, Ghobrial, RM, Busuttil, RW & Gaber, AO 2020, , Transplantation, vol. 104, no. 8, pp. 1591-1603. https://doi.org/10.1097/TP.0000000000003040

The Role of Genetic Sex and Mitochondria in Response to COVID-19 Infection
Kloc, M, Ghobrial, RM & Kubiak, JZ 2020, , International Archives of Allergy and Immunology, vol. 181, no. 8, pp. 629-634. https://doi.org/10.1159/000508560

Siponimod (Mayzent) Downregulates RhoA and Cell Surface Expression of the S1P1 and CX3CR1 Receptors in Mouse RAW 264.7 Macrophages
Uosef, A, Vaughn, N, Chu, X, Elshawwaf, M, Abdelshafy, AAA, Elsaid, KMK, Ghobrial, RM & Kloc, M 2020, , Archivum Immunologiae et Therapiae Experimentalis, vol. 68, no. 3, 19. https://doi.org/10.1007/s00005-020-00584-4

Pathologic Response to Pretransplant Locoregional Therapy is Predictive of Patient Outcome after Liver Transplantation for Hepatocellular Carcinoma: Analysis from the US Multicenter HCC Transplant Consortium
Dinorcia, J, Florman, SS, Haydel, B, Tabrizian, P, Ruiz, RM, Klintmalm, GB, Senguttuvan, S, Lee, DD, Taner, CB, Verna, EC, Halazun, KJ, Hoteit, M, Levine, MH, Chapman, WC, Vachharajani, N, Aucejo, F, Nguyen, MH, Melcher, ML, Tevar, AD, Humar, A, Mobley, C, Ghobrial, M, Nydam, TL, Amundsen, B, Markmann, JF, Berumen, J, Hemming, AW, Langnas, AN, Carney, CA, Sudan, DL, Hong, JC, Kim, J, Zimmerman, MA, Rana, A, Kueht, ML, Jones, CM, Fishbein, TM, Markovic, D, Busuttil, RW & Agopian, VG 2020, , Annals of surgery, vol. 271, no. 4, pp. 616-624. https://doi.org/10.1097/SLA.0000000000003253

Liver Transplantation for Colorectal and Neuroendocrine Liver Metastases and Hepatoblastoma. Working Group Report from the ILTS Transplant Oncology Consensus Conference
Hibi, T, Rela, M, Eason, JD, Line, PD, Fung, J, Sakamoto, S, Selzner, N, Man, K, Ghobrial, RM & Sapisochin, G 2020, , Transplantation, pp. 1131-1135. https://doi.org/10.1097/TP.0000000000003118

Posttransplant Management of Recipients Undergoing Liver Transplantation for Hepatocellular Carcinoma. Working Group Report from the ILTS Transplant Oncology Consensus Conference
Berenguer, M, Burra, P, Ghobrial, M, Hibi, T, Metselaar, H, Sapisochin, G, Bhoori, S, Kwan Man, N, Mas, V, Ohira, M, Sangro, B & Van Der Laan, LJW 2020, , Transplantation, pp. 1143-1149. https://doi.org/10.1097/TP.0000000000003196

Liver Transplantation for Cholangiocarcinoma and Mixed Hepatocellular Cholangiocarcinoma: Working Group Report from the ILTS Transplant Oncology Consensus Conference
Sapisochin, G, Javle, M, Lerut, J, Ohtsuka, M, Ghobrial, M, Hibi, T, Kwan, NM & Heimbach, J 2020, , Transplantation, pp. 1125-1130. https://doi.org/10.1097/TP.0000000000003212

Liver Transplantation for Hepatocellular Carcinoma. Working Group Report from the ILTS Transplant Oncology Consensus Conference
Mehta, N, Bhangui, P, Yao, FY, Mazzaferro, V, Toso, C, Akamatsu, N, Durand, F, Ijzermans, J, Polak, W, Zheng, S, Roberts, JP, Sapisochin, G, Hibi, T, Kwan, NM, Ghobrial, M & Soin, A 2020, , Transplantation, pp. 1136-1142. https://doi.org/10.1097/TP.0000000000003174

The ILTS Consensus Conference on Transplant Oncology: Setting the Stage
Sapisochin, G, Hibi, T, Ghobrial, M & Man, K 2020, , Transplantation, pp. 1119-1120. https://doi.org/10.1097/TP.0000000000003175

Podwójna twarz komórek macierzystych w pediatrii: Zastosowania terapeutyczne mezenchymalnych komórek macierzystych i zagrozenia rakowymi komórkami macierzystymi
Uosef, A, Ghobrial, RM, Jederka, K, Pulawska-Czub, A, Lewicki, S, Kubiak, JZ & Kloc, M 2020, , Pediatria i Medycyna Rodzinna, vol. 16, no. 2, pp. 171-174. https://doi.org/10.15557/PiMR.2020.0032

Skutki uboczne kontrastów do MRI zawierajacych gadolin
Uosef, A, Villagran, M, Kubiak, JZ, Wosik, J, Ghobrial, RM & Kloc, M 2020, , Pediatria i Medycyna Rodzinna, vol. 16, no. 1, pp. 49-52. https://doi.org/10.15557/PiMR.2020.0008

Macrophages in diabetes mellitus (DM) and COVID-19: do they trigger DM?
Kloc, M, Ghobrial, RM, Lewicki, S & Kubiak, JZ 2020, , Journal of Diabetes and Metabolic Disorders, pp. 1-4. https://doi.org/10.1007/s40200-020-00665-3