R. Mark Ghobrial, MD, PhD

Sherrie and Alan Conover Chair for Excellence in Liver Transplantation, Sherrie and Alan Conover Center for Liver Disease & Transplantation
Professor of Surgery, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Sherrie and Alan Conover Center for Liver Disease and Transplantation


Biography

After receiving his Bachelor of Medicine and Bachelor of Surgery degrees from Cairo University Medical School in Cairo, Egypt, Dr. Ghobrial completed several surgical residencies in the United Kingdom and the United States. While a surgery resident at University of Texas Health Science Center in Houston, Texas, he completed a PhD in Immunology at the UT Graduate School of Biomedical Sciences in 1994. After residency, he accepted a position as clinical instructor in the Department of Surgery at the David Geffen School of Medicine at University of California, Los Angeles (UCLA) and was awarded a Dumont-UCLA Transplant Fellowship. He received his full professorship in 2005 and served as Director of the Pancreas Transplant Program and Living Donor Liver Transplantation, and Service Director for Liver, Pancreas, and Small Bowel Transplantation. He was recruited to the Houston Methodist Hospital in 2008.

Description of Research

One of the primary goals of Dr. Ghobrial´s research is to increase donor tolerance to organ transplants and allografts. Dr. Ghobrial has shown in preclinical studies that tolerizing the host to dominant donor epitopes induces tolerance in the recipient. By engineering chimeric proteins, or proteins that contain sequences from both donor and recipient, and exposing the recipient to these proteins prior to tissue graft, peripheral, long-term tolerance is induced. Dr. Ghobrial also has a long-standing interest in the effects of Hepatitis (B and C) on transplantation patients.

Areas Of Expertise

Liver resection Transplantation Hepatocellular carcinoma Liver transplant Liver disease
Education & Training

Residency, The University of Texas Health Science Center at Houston
Clinical Fellowship, Dumont-UCLA Transplant Center
MD, University of Cairo Medical School
PhD, The University of Texas Health Science Center
Active Clinical Trials

Sorafenib Therapy in High Risk OLT Recipients with HCC

NCT01624285

Publications

Liver transplantation for locally advanced intrahepatic cholangiocarcinoma – Authors' reply
Lunsford, KE, Javle, M, Gaber, AO, Vauthey, JN & Ghobrial, RM 2018, The Lancet Gastroenterology and Hepatology, vol 3, no. 8, pp. 529-530. DOI: 10.1016/S2468-1253(18)30167-5

Outcomes of Early Liver Transplantation for Patients With Severe Alcoholic Hepatitis
Lee, BP, Mehta, N, Platt, L, Gurakar, A, Rice, JP, Lucey, MR, Im, GY, Therapondos, G, Han, H, Victor, DW, Fix, OK, Dinges, L, Dronamraju, D, Hsu, C, Voigt, MD, Rinella, ME, Maddur, H, Eswaran, S, Hause, J, Foley, D, Ghobrial, RM, Dodge, JL, Li, Z & Terrault, NA 2018, Gastroenterology, vol 155, no. 2, pp. 422-430.e1. DOI: 10.1053/j.gastro.2018.04.009

Magnetic Field Changes Macrophage Phenotype
Wosik, J, Chen, W, Qin, K, Ghobrial, RM, Kubiak, JZ & Kloc, M 2018, Biophysical Journal, vol 114, no. 8, pp. 2001-2013. DOI: 10.1016/j.bpj.2018.03.002

Liver transplantation for locally advanced intrahepatic cholangiocarcinoma treated with neoadjuvant therapy: a prospective case-series
Lunsford, KE, Javle, M, Heyne, K, Shroff, RT, Abdel-Wahab, R, Gupta, N, Mobley, CM, Saharia, A, Victor, DW, Nguyen, DT, Graviss, EA, Kaseb, AO, McFadden, RS, Aloia, TA, Conrad, C, Li, XC, Monsour, HP, Gaber, AO, Vauthey, J-N, Ghobrial, RM & Methodist–MD Anderson Joint Cholangiocarcinoma Collaborative Committee (MMAJCCC) 2018, The lancet. Gastroenterology & hepatology. DOI: 10.1016/S2468-1253(18)30045-1

Conquering combined thoracic organ and liver transplantation: Indications and outcomes for heart-liver and lung-liver transplantation
Yi, SG, Lunsford, KE, Bruce, C & Ghobrial, RM 2018, Current Opinion in Organ Transplantation, vol 23, no. 2, pp. 180-186. DOI: 10.1097/MOT.0000000000000509

Screening RhoA/ROCK inhibitors for the ability to prevent chronic rejection of mouse cardiac allografts
Chen, W, Chen, S, Chen, W, Li, XC, Ghobrial, RM & Kloc, M 2018, Transplant Immunology. DOI: 10.1016/j.trim.2018.06.002

Inhibition of RhoA and mTORC2/Rictor by Fingolimod (FTY720) induces p21-activated kinase 1, PAK-1 and amplifies podosomes in mouse peritoneal macrophages
Chen, W, Ghobrial, RM, Li, XC & Kloc, M 2018, Immunobiology. DOI: 10.1016/j.imbio.2018.07.009

Rho-specific Guanine nucleotide exchange factors (Rho-GEFs) inhibition affects macrophage phenotype and disrupts Golgi complex
Chen, W, Zhao, Y, Li, XC, Kubiak, JZ, Ghobrial, RM & Kloc, M 2017, International Journal of Biochemistry and Cell Biology, vol 93, pp. 12-24. DOI: 10.1016/j.biocel.2017.10.009

Treatment of Refractory Gastrointestinal Bleeding in Patients With Portal Hypertension: A Case Series and Treatment Algorithm
Balogh, J, Gordon-Burroughs, S, Schwarz, P, Galati, J, McFadden, RA, Cusick, M, Snyder, MJ, Bailey, HR, Weiner, M, Wong, A, Ochoa, RA, Saharia, A, Gaber, AO & Ghobrial, RM 2017, Transplantation Proceedings, vol 49, no. 8, pp. 1864-1869. DOI: 10.1016/j.transproceed.2017.06.022

Impact of Pretransplant Bridging Locoregional Therapy for Patients with Hepatocellular Carcinoma Within Milan Criteria Undergoing Liver Transplantation: Analysis of 3601 Patients from the US Multicenter HCC Transplant Consortium
Agopian, VG, Harlander-Locke, MP, Ruiz, RM, Klintmalm, GB, Senguttuvan, S, Florman, SS, Haydel, B, Hoteit, M, Levine, MH, Lee, DD, Taner, CB, Verna, EC, Halazun, KJ, Abdelmessih, R, Tevar, AD, Humar, A, Aucejo, F, Chapman, WC, Vachharajani, N, Nguyen, MH, Melcher, ML, Nydam, TL, Mobley, C, Ghobrial, RM, Amundsen, B, Markmann, JF, Langnas, AN, Carney, CA, Berumen, J, Hemming, AW, Sudan, DL, Hong, JC, Kim, J, Zimmerman, MA, Rana, A, Kueht, ML, Jones, CM, Fishbein, TM & Busuttil, RW 2017, Annals of Surgery, vol 266, no. 3, pp. 525-535. DOI: 10.1097/SLA.0000000000002381

The phenotype of peritoneal mouse macrophages depends on the mitochondria and ATP/ADP homeostasis
Chen, W, Sandoval, H, Kubiak, JZ, Li, XC, Ghobrial, RM & Kloc, M 2017, Cellular Immunology. DOI: 10.1016/j.cellimm.2017.11.003

Strongyloides stercoralis in solid organ transplantation: early diagnosis gets the worm
Mobley, CM, Dhala, A & Ghobrial, RM 2017, Current Opinion in Organ Transplantation. DOI: 10.1097/MOT.0000000000000428

Risk Analysis of Patients with Proven Coronary Artery Disease Undergoing Liver Transplant
Balogh, J, Lunsford, KE, Nguyen, DTM, Graviss, EA, Cercio, O, Mobley, CM, Saharia, A, Burroughs, SG, Gaber, AO & Ghobrial, RM 2017, American Journal of Transplantation, vol 17, no. suppl 3.

Optimizing Survival Outcomes for Advanced Age Patients Undergoing Liver Transplant
Balogh, J, Lunsford, KE, Nguyen, DTM, Graviss, EA, Saharia, A, Mobley, CM, Burroughs, SG, Cercio, O, Victor, JD, Monsour, Jr. HP, Gaber, AO & Ghobrial, RM 2017, 2017 American Transplant Congress, 4/30/17, .

Macrophages and RhoA Pathway in Transplanted Organs
Liu, Y, Kubiak, JZ, Li, XC, Ghobrial, RM & Kloc, M 2017, . in Results and Problems in Cell Differentiation. vol. 62, Results and Problems in Cell Differentiation, vol. 62, Springer-Verlag, pp. 365-376. DOI: 10.1007/978-3-319-54090-0_15

TNF superfamily receptor OX40 triggers invariant NKT cell pyroptosis and liver injury
Lan, P, Fan, Y, Zhao, Y, Lou, X, Monsour, HP, Zhang, X, Choi, Y, Dou, Y, Ishii, N, Ghobrial, RM, Xiao, X & Li, XC 2017, The Journal of clinical investigation. DOI: 10.1172/JCI91075

Longitudinal assessment of T cell inhibitory receptors in liver transplant recipients and their association with posttransplant infections
Mysore, KR, Ghobrial, RM, Kannanganat, S, Minze, LJ, Graviss, EA, Nguyen, DT, Perez, KK & Li, XC 2017, American Journal of Transplantation. DOI: 10.1111/ajt.14546

Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction
Wu, J, Zhang, H, Shi, X, Xiao, X, Fan, Y, Minze, LJ, Wang, J, Ghobrial, RM, Xia, J, Sciammas, R, Li, XC & Chen, W 2017, Immunity. DOI: 10.1016/j.immuni.2017.11.003

Dissonant response of M0/M2 and M1 bone-marrow-derived macrophages to RhoA pathway interference
Liu, Y, Chen, W, Minze, LJ, Kubiak, JZ, Li, XC, Ghobrial, RM & Kloc, M 2016, Cell and Tissue Research, pp. 1-14. DOI: 10.1007/s00441-016-2491-x

Graft-Infiltrating Macrophages Adopt an M2 Phenotype and Are Inhibited by Purinergic Receptor P2X7 Antagonist in Chronic Rejection
Wu, C, Zhao, Y, Xiao, X, Fan, Y, Kloc, M, Liu, W, Ghobrial, RM, Lan, P, He, X & Li, XC 2016, American Journal of Transplantation, vol 16, no. 9, pp. 2563-2573. DOI: 10.1111/ajt.13808