R. Mark Ghobrial, MD, PhD

J.C. Walter Jr. Presidential Distinguished Chair, Director, J.C. Walter Jr. Transplant Center
Professor of Surgery, Academic Institute
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Sherrie and Alan Conover Center for Liver Disease and Transplantation


Biography

After receiving his Bachelor of Medicine and Bachelor of Surgery degrees from Cairo University Medical School in Cairo, Egypt, Dr. Ghobrial completed several surgical residencies in the United Kingdom and the United States. While a surgery resident at University of Texas Health Science Center in Houston, Texas, he completed a PhD in Immunology at the UT Graduate School of Biomedical Sciences in 1994. After residency, he accepted a position as clinical instructor in the Department of Surgery at the David Geffen School of Medicine at University of California, Los Angeles (UCLA) and was awarded a Dumont-UCLA Transplant Fellowship. He received his full professorship in 2005 and served as Director of the Pancreas Transplant Program and Living Donor Liver Transplantation, and Service Director for Liver, Pancreas, and Small Bowel Transplantation. He was recruited to the Houston Methodist Hospital in 2008.

Description of Research

One of the primary goals of Dr. Ghobrial´s research is to increase donor tolerance to organ transplants and allografts. Dr. Ghobrial has shown in preclinical studies that tolerizing the host to dominant donor epitopes induces tolerance in the recipient. By engineering chimeric proteins, or proteins that contain sequences from both donor and recipient, and exposing the recipient to these proteins prior to tissue graft, peripheral, long-term tolerance is induced. Dr. Ghobrial also has a long-standing interest in the effects of Hepatitis (B and C) on transplantation patients.

Areas Of Expertise

Liver resection Transplantation Hepatocellular carcinoma Liver transplant Liver disease
Education & Training

Clinical Fellowship, Dumont-UCLA Transplant Center
MD, University of Cairo Medical School
Residency, University of Texas Health Science Center at Houston
PhD, University of Texas Health Science Center at Houston
Publications

An imageomics and multi-network based deep learning model for risk assessment of liver transplantation for hepatocellular cancer
He, T, Fong, JN, Moore, LW, Ezeana, CF, Victor, D, Divatia, M, Vasquez, M, Ghobrial, RM & Wong, STC 2021, , Computerized Medical Imaging and Graphics, vol. 89, 101894. https://doi.org/10.1016/j.compmedimag.2021.101894

Donation After Circulatory Death Liver Transplantation: An in Depth Analysis and Propensity-Score Matched Comparison
Hobeika, MJ, Saharia, A, Mobley, CM, Menser, T, Nguyen, DT, Graviss, EA, McMillan, RR, Podder, H, Nolte Fong, JV, Jones, SL, Yi, SG, Elshawwaf, M, Osama Gaber, A & Ghobrial, RM 2021, , Clinical Transplantation, pp. e14304. https://doi.org/10.1111/ctr.14304

New insights into cellular functions of nuclear actin
Kloc, M, Chanana, P, Vaughn, N, Uosef, A, Kubiak, JZ & Ghobrial, RM 2021, , Biology, vol. 10, no. 4, 304. https://doi.org/10.3390/biology10040304

Exaptation of retroviral syncytin for development of syncytialized placenta, its limited homology to the sars-cov-2 spike protein and arguments against disturbing narrative in the context of covid-19 vaccination
Kloc, M, Uosef, A, Kubiak, JZ & Ghobrial, RM 2021, , Biology, vol. 10, no. 3, 238. https://doi.org/10.3390/biology10030238

Effects of vitamin D on macrophages and myeloid-derived suppressor cells (MDSCs) hyperinflammatory response in the lungs of COVID-19 patients
Kloc, M, Ghobrial, RM, Lipinska-Opalka, A, Wawrzyniak, A, Zdanowski, R, Kalicki, B & Kubiak, JZ 2021, , Cellular Immunology, vol. 360, 104259, pp. 104259. https://doi.org/10.1016/j.cellimm.2020.104259

RhoA-and actin-dependent functions of macrophages from the rodent cardiac transplantation model perspective-timing is the essence
Kloc, M, Uosef, A, Villagran, M, Zdanowski, R, Kubiak, JZ, Wosik, J & Ghobrial, RM 2021, , Biology, vol. 10, no. 2, 70, pp. 1-16. https://doi.org/10.3390/biology10020070

Role of macrophages and rhoa pathway in atherosclerosis
Kloc, M, Uosef, A, Kubiak, JZ & Ghobrial, RM 2021, , International journal of molecular sciences, vol. 22, no. 1, 216, pp. 1-13. https://doi.org/10.3390/ijms22010216

New Breakthroughs for Liver Transplantation of Cholangiocarcinoma
McMillan, RR, Saharia, A, Abdelrahim, M & Ghobrial, RM 2021, , Current Transplantation Reports, vol. 8, no. 1, pp. 21-27. https://doi.org/10.1007/s40472-021-00313-6

In silico deceased donor intervention research: A potential accelerant for progress
Hobeika, MJ, Casarin, S, Saharia, A, Mobley, C, Yi, S, McMillan, R, Mark Ghobrial, R & Gaber, AO 2021, , American Journal of Transplantation. https://doi.org/10.1111/ajt.16482

Donation after circulatory death liver transplantation: An in-depth analysis and propensity score–matched comparison
Hobeika, MJ, Saharia, A, Mobley, CM, Menser, T, Nguyen, DT, Graviss, EA, McMillan, RR, Podder, H, Nolte Fong, JV, Jones, SL, Yi, SG, Elshawwaf, M, Gaber, AO & Ghobrial, RM 2021, , Clinical Transplantation. https://doi.org/10.1111/ctr.14304

Patterns of Alcohol Use After Early Liver Transplantation for Alcoholic Hepatitis
Lee, BP, Im, GY, Rice, JP, Lazar, A, Weinberg, E, Han, H, Maddur, H, Ghobrial, RM, Therapondos, G, Hsu, C, Fix, OK, Eswaran, S, Shetty, K, Chhatwal, J, Dalgic, OO, Jakhete, N, Mobley, C, Victor, DW, Mehta, N, Dinges, L, Rinella, M, Schiano, TD, Lucey, MR & Terrault, N 2020, , Clinical Gastroenterology and Hepatology. https://doi.org/10.1016/j.cgh.2020.11.024

Macrophage proinflammatory responses to microorganisms and transplanted organs
Kloc, M, Uosef, A, Kubiak, JZ & Ghobrial, RM 2020, , International journal of molecular sciences, vol. 21, no. 24, 9669, pp. 1-14. https://doi.org/10.3390/ijms21249669

The Rise of the Machines: Will They Fulfill the Restoration Promise?
Nolte Fong, JV, Saharia, A, Hobeika, M, Podder, H & Ghobrial, RM 2020, , Liver Transplantation, vol. 26, no. 12, pp. 1568-1570. https://doi.org/10.1002/lt.25912

Liver Transplantation Outcomes in a U.S. Multicenter Cohort of 789 Patients With Hepatocellular Carcinoma Presenting Beyond Milan Criteria
Kardashian, A, Florman, SS, Haydel, B, Ruiz, RM, Klintmalm, GB, Lee, DD, Taner, CB, Aucejo, F, Tevar, AD, Humar, A, Verna, EC, Halazun, KJ, Chapman, WC, Vachharajani, N, Hoteit, M, Levine, MH, Nguyen, MH, Melcher, ML, Langnas, AN, Carney, CA, Mobley, C, Ghobrial, M, Amundsen, B, Markmann, JF, Sudan, DL, Jones, CM, Berumen, J, Hemming, AW, Hong, JC, Kim, J, Zimmerman, MA, Nydam, TL, Rana, A, Kueht, ML, Fishbein, TM, Markovic, D, Busuttil, RW & Agopian, VG 2020, , Hepatology, vol. 72, no. 6, pp. 2014-2028. https://doi.org/10.1002/hep.31210

The multiple sclerosis (MS) drugs as a potential treatment of ARDS in COVID-19 patients
Kloc, M & Ghobrial, RM 2020, , Multiple Sclerosis and Related Disorders, vol. 45, 102437. https://doi.org/10.1016/j.msard.2020.102437

Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics
Chen, S, Zhang, L, Ying, Y, Wang, Y, Arnold, PR, Wang, G, Li, J, Ghobrial, RM, Chen, W, Xiao, X & Li, XC 2020, , American Journal of Transplantation, vol. 20, no. 9, pp. 2366-2379. https://doi.org/10.1111/ajt.15845

How nicotine can inhibit cytokine storm in the lungs and prevent or lessen the severity of COVID-19 infection?
Kloc, M, Ghobrial, RM & Kubiak, JZ 2020, , Immunology Letters, vol. 224, pp. 28-29. https://doi.org/10.1016/j.imlet.2020.06.002

Development of child immunity in the context of COVID-19 pandemic
Kloc, M, Ghobrial, RM, Kuchar, E, Lewicki, S & Kubiak, JZ 2020, , Clinical Immunology, vol. 217, 108510, pp. 108510. https://doi.org/10.1016/j.clim.2020.108510

Delayed implantation of pumped kidneys decreases renal allograft futility in combined liver-kidney transplantation
Lunsford, KE, Agopian, VG, Yi, S, Nguyen, DTM, Graviss, EA, Harlander-Locke, MP, Saharia, A, Kaldas, FM, Mobley, CM, Zarrinpar, A, Hobeika, MJ, Veale, JL, Podder, H, Farmer, DG, Knight, RJ, Danovitch, GM, Gritsch, HA, Li, XC, Ghobrial, RM, Busuttil, RW & Gaber, AO 2020, , Transplantation, vol. 104, no. 8, pp. 1591-1603. https://doi.org/10.1097/TP.0000000000003040

The Role of Genetic Sex and Mitochondria in Response to COVID-19 Infection
Kloc, M, Ghobrial, RM & Kubiak, JZ 2020, , International Archives of Allergy and Immunology, vol. 181, no. 8, pp. 629-634. https://doi.org/10.1159/000508560