R. Mark Ghobrial, MD, PhD

Sherrie and Alan Conover Chair for Excellence in Liver Transplantation, Sherrie and Alan Conover Center for Liver Disease & Transplantation
Professor of Surgery, Academic Institute
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Sherrie and Alan Conover Center for Liver Disease and Transplantation


Biography

After receiving his Bachelor of Medicine and Bachelor of Surgery degrees from Cairo University Medical School in Cairo, Egypt, Dr. Ghobrial completed several surgical residencies in the United Kingdom and the United States. While a surgery resident at University of Texas Health Science Center in Houston, Texas, he completed a PhD in Immunology at the UT Graduate School of Biomedical Sciences in 1994. After residency, he accepted a position as clinical instructor in the Department of Surgery at the David Geffen School of Medicine at University of California, Los Angeles (UCLA) and was awarded a Dumont-UCLA Transplant Fellowship. He received his full professorship in 2005 and served as Director of the Pancreas Transplant Program and Living Donor Liver Transplantation, and Service Director for Liver, Pancreas, and Small Bowel Transplantation. He was recruited to the Houston Methodist Hospital in 2008.

Description of Research

One of the primary goals of Dr. Ghobrial´s research is to increase donor tolerance to organ transplants and allografts. Dr. Ghobrial has shown in preclinical studies that tolerizing the host to dominant donor epitopes induces tolerance in the recipient. By engineering chimeric proteins, or proteins that contain sequences from both donor and recipient, and exposing the recipient to these proteins prior to tissue graft, peripheral, long-term tolerance is induced. Dr. Ghobrial also has a long-standing interest in the effects of Hepatitis (B and C) on transplantation patients.

Areas Of Expertise

Liver resection Transplantation Hepatocellular carcinoma Liver transplant Liver disease
Education & Training

Residency, The University of Texas Health Science Center at Houston
Clinical Fellowship, Dumont-UCLA Transplant Center
MD, University of Cairo Medical School
PhD, The University of Texas Health Science Center
Active Clinical Trials

Sorafenib Therapy in High Risk OLT Recipients with HCC

NCT01624285

Publications

Outcomes of Liver Transplantation for Hepatocellular Carcinoma beyond the University of California San Francisco Criteria: A Single-center Experience
Victor, III, DW, Monsour, HP, Boktour, M, Lunsford, K, Balogh, J, Graviss, EA, Nguyen, DT, McFadden, RS, Divatia, MK, Heyne, K, Ankoma-Sey, V, Egwim, C, Galati, J, Duchini, A, Saharia, A, Mobley, CM, Gaber, AO & Ghobrial, RM 2020, Transplantation, pp. 113-121. https://doi.org/10.1097/TP.0000000000002835

Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics
Chen, S, Zhang, L, Ying, Y, Wang, Y, Arnold, PR, Wang, G, Li, J, Ghobrial, RM, Chen, W, Xiao, X & Li, XC 2020, American Journal of Transplantation. https://doi.org/10.1111/ajt.15845

Is Surgery-first Still a Reasonable Option in the Era of Neoadjuvant Chemotherapy for Resectable Pancreatic Cancer?
Saharia, A, Potter, LM, Baio, F, Elaileh, A, Mobley, C, Ghobrial, RM, Abdelrahim, M & Heyne, K 2019, American journal of clinical oncology. https://doi.org/10.1097/COC.0000000000000661

Delayed Implantation of Pumped Kidneys Decreases Renal Allograft Futility in Combined Liver-Kidney Transplantation
Lunsford, KE, Agopian, VG, Yi, SG, Nguyen, DTM, Graviss, EA, Harlander-Locke, MP, Saharia, A, Kaldas, FM, Mobley, CM, Zarrinpar, A, Hobeika, M, Veale, JL, Podder, H, Farmer, DG, Knight, RJ, Danovitch, GM, Gritsch, HA, Li, XC, Ghobrial, RM, Busuttil, RW & Gaber, AO 2019, Transplantation. https://doi.org/10.1097/TP.0000000000003040

Macrophage phenotype bioengineered by magnetic, genetic, or pharmacologic interference
Wosik, J, Suarez-Villagran, M, Miller, JH, Ghobrial, RM & Kloc, M 2019, Immunologic Research, vol. 67, no. 1, pp. 1-11. https://doi.org/10.1007/s12026-019-9066-3

Macrophage functions in wound healing
Kloc, M, Ghobrial, RM, Wosik, J, Lewicka, A, Lewicki, S & Kubiak, JZ 2019, Journal of Tissue Engineering and Regenerative Medicine, vol. 13, no. 1, pp. 99-109. https://doi.org/10.1002/term.2772

International Liver Transplantation Consensus Statement on End-stage Liver Disease Due to Nonalcoholic Steatohepatitis and Liver Transplantation
Tsochatzis, E, Coilly, A, Nadalin, S, Levistky, J, Tokat, Y, Ghobrial, RM, Klinck, J & Berenguer, M 2019, Transplantation, vol. 103, no. 1, pp. 45-56. https://doi.org/10.1097/TP.0000000000002433

RhoA pathway and actin regulation of the golgi/centriole complex
Kloc, M, Uosef, A, Wosik, J, Kubiak, JZ & Ghobrial, RM 2019, . in Results and Problems in Cell Differentiation. Results and Problems in Cell Differentiation, vol. 67, Springer-Verlag, pp. 81-93. https://doi.org/10.1007/978-3-030-23173-6_5

Effects of magnetic fields and field gradients on living cells
Wosik, J, Villagran, M, Uosef, A, Ghobrial, RM, Miller, JH & Kloc, M 2019, eMagRes, vol. 8, no. 4, pp. 371-386. https://doi.org/10.1002/9780470034590.emrstm1609

Coinhibition of mTORC1/mTORC2 and RhoA /ROCK pathways prevents chronic rejection of rat cardiac allografts
Chen, W, Chen, W, Li, XC, Ghobrial, RM & Kloc, M 2018, Transplantation Reports, vol. 3, no. 4, pp. 21-28. https://doi.org/10.1016/j.tpr.2018.09.002

Transplantation for Hepatocellular carcinoma is there a tumor size limit?
Ahmed, D, Larry, T, Mark, GR, Edward, G, Sherif, M, Amany, S, Mostafa, E-S & Osama, GA 2018, Transplantation Proceedings, vol. 50, no. 10, pp. 3577-3581. https://doi.org/10.1016/j.transproceed.2018.04.038

Screening RhoA/ROCK inhibitors for the ability to prevent chronic rejection of mouse cardiac allografts
Chen, W, Chen, S, Chen, W, Li, XC, Ghobrial, RM & Kloc, M 2018, Transplant Immunology, vol. 50, pp. 15-25. https://doi.org/10.1016/j.trim.2018.06.002

Liver transplantation for locally advanced intrahepatic cholangiocarcinoma – Authors' reply
Lunsford, KE, Javle, M, Gaber, AO, Vauthey, JN & Ghobrial, RM 2018, The Lancet Gastroenterology and Hepatology, vol. 3, no. 8, pp. 529-530. https://doi.org/10.1016/S2468-1253(18)30167-5

Outcomes of Early Liver Transplantation for Patients With Severe Alcoholic Hepatitis
Lee, BP, Mehta, N, Platt, L, Gurakar, A, Rice, JP, Lucey, MR, Im, GY, Therapondos, G, Han, H, Victor, III, DW, Fix, OK, Dinges, L, Dronamraju, D, Hsu, C, Voigt, MD, Rinella, ME, Maddur, H, Eswaran, S, Hause, J, Foley, D, Ghobrial, RM, Dodge, JL, Li, Z & Terrault, NA 2018, Gastroenterology, vol. 155, no. 2, pp. 422-430.e1. https://doi.org/10.1053/j.gastro.2018.04.009

Liver transplantation for locally advanced intrahepatic cholangiocarcinoma treated with neoadjuvant therapy: a prospective case-series
Lunsford, KE, Javle, M, Heyne, K, Shroff, RT, Abdel-Wahab, R, Gupta, N, Mobley, CM, Saharia, A, Victor, DW, Nguyen, DT, Graviss, EA, Kaseb, AO, McFadden, RS, Aloia, TA, Conrad, C, Li, XC, Monsour, HP, Gaber, AO, Vauthey, J-N, Ghobrial, RM & Methodist–MD Anderson Joint Cholangiocarcinoma Collaborative Committee (MMAJCCC) 2018, The Lancet Gastroenterology and Hepatology, vol. 3, no. 5, pp. 337-348. https://doi.org/10.1016/S2468-1253(18)30045-1

Magnetic Field Changes Macrophage Phenotype
Wosik, J, Chen, W, Qin, K, Ghobrial, RM, Kubiak, JZ & Kloc, M 2018, Biophysical Journal, vol. 114, no. 8, pp. 2001-2013. https://doi.org/10.1016/j.bpj.2018.03.002

Editorial
Ghobrial, RM 2018, Current opinion in organ transplantation, vol. 23, no. 2, pp. 143-144. https://doi.org/10.1097/MOT.0000000000000519

The phenotype of peritoneal mouse macrophages depends on the mitochondria and ATP/ADP homeostasis
Chen, W, Sandoval, H, Kubiak, JZ, Li, XC, Ghobrial, RM & Kloc, M 2018, Cellular Immunology, vol. 324, pp. 1-7. https://doi.org/10.1016/j.cellimm.2017.11.003

Conquering combined thoracic organ and liver transplantation: Indications and outcomes for heart-liver and lung-liver transplantation
Yi, S, Lunsford, KE, Bruce, C & Ghobrial, RM 2018, Current opinion in organ transplantation, vol. 23, no. 2, pp. 180-186. https://doi.org/10.1097/MOT.0000000000000509

Inhibition of RhoA and mTORC2/Rictor by Fingolimod (FTY720) induces p21-activated kinase 1, PAK-1 and amplifies podosomes in mouse peritoneal macrophages
Chen, W, Ghobrial, RM, Li, XC & Kloc, M 2018, Immunobiology. https://doi.org/10.1016/j.imbio.2018.07.009

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