R. Mark Ghobrial, MD, PhD

J.C. Walter Jr. Presidential Distinguished Chair, Director, J.C. Walter Jr. Transplant Center
Professor of Surgery, Academic Institute
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Sherrie and Alan Conover Center for Liver Disease and Transplantation


Biography

After receiving his Bachelor of Medicine and Bachelor of Surgery degrees from Cairo University Medical School in Cairo, Egypt, Dr. Ghobrial completed several surgical residencies in the United Kingdom and the United States. While a surgery resident at University of Texas Health Science Center in Houston, Texas, he completed a PhD in Immunology at the UT Graduate School of Biomedical Sciences in 1994. After residency, he accepted a position as clinical instructor in the Department of Surgery at the David Geffen School of Medicine at University of California, Los Angeles (UCLA) and was awarded a Dumont-UCLA Transplant Fellowship. He received his full professorship in 2005 and served as Director of the Pancreas Transplant Program and Living Donor Liver Transplantation, and Service Director for Liver, Pancreas, and Small Bowel Transplantation. He was recruited to the Houston Methodist Hospital in 2008.

Description of Research

One of the primary goals of Dr. Ghobrial´s research is to increase donor tolerance to organ transplants and allografts. Dr. Ghobrial has shown in preclinical studies that tolerizing the host to dominant donor epitopes induces tolerance in the recipient. By engineering chimeric proteins, or proteins that contain sequences from both donor and recipient, and exposing the recipient to these proteins prior to tissue graft, peripheral, long-term tolerance is induced. Dr. Ghobrial also has a long-standing interest in the effects of Hepatitis (B and C) on transplantation patients.

Areas Of Expertise

Liver resection Transplantation Hepatocellular carcinoma Liver transplant Liver disease
Education & Training

Clinical Fellowship, Dumont-UCLA Transplant Center
MD, University of Cairo Medical School
Residency, University of Texas Health Science Center at Houston
PhD, University of Texas Health Science Center at Houston
Publications

Natural genetic engineering: A programmed chromosome/DNA elimination
Kloc, M, Kubiak, JZ & Ghobrial, RM 2022, , Developmental Biology, vol. 486, pp. 15-25. https://doi.org/10.1016/j.ydbio.2022.03.008

Utilization of Immunotherapy for the Treatment of Hepatocellular Carcinoma in the Peri-Transplant Setting: Transplant Oncology View
Abdelrahim, M, Esmail, A, Saharia, A, Abudayyeh, A, Abdel-Wahab, N, Diab, A, Murakami, N, Kaseb, AO, Chang, JC, Gaber, AO & Ghobrial, RM 2022, , Cancers, vol. 14, no. 7, 1760. https://doi.org/10.3390/cancers14071760

The Effect of Magnetic Field Gradient and Gadolinium-Based MRI Contrast Agent Dotarem on Mouse Macrophages
Chanana, P, Uosef, A, Vaughn, N, Suarez-Villagran, M, Ghobrial, RM, Kloc, M & Wosik, J 2022, , Cells, vol. 11, no. 5, 757. https://doi.org/10.3390/cells11050757

Transarterial Chemoembolization (TACE) Plus Sorafenib Compared to TACE Alone in Transplant Recipients with Hepatocellular Carcinoma: An Institution Experience
Abdelrahim, M, Victor, D, Esmail, A, Kodali, S, Graviss, EA, Nguyen, DT, Moore, LW, Saharia, A, McMillan, R, Fong, JN, Uosef, A, Elshawwaf, M, Heyne, K & Ghobrial, RM 2022, , Cancers, vol. 14, no. 3, 650. https://doi.org/10.3390/cancers14030650

Utility of Cell-Free DNA Detection in Transplant Oncology
Reddy, T, Esmail, A, Chang, JC, Ghobrial, RM & Abdelrahim, M 2022, , Cancers, vol. 14, no. 3, 743. https://doi.org/10.3390/cancers14030743

Early humoral immune response to two doses of severe acute respiratory syndrome coronavirus 2 vaccine in a diverse group of solid organ transplant candidates and recipients
Huang, HJ, Yi, SG, Mobley, CM, Saharia, A, Bhimaraj, A, Moore, LW, Kloc, M, Adrogue, HE, Graviss, EA, Nguyen, DT, Eagar, TN, Jones, SL, Ankoma-Sey, V, MacGillivray, TE, Knight, RJ, Gaber, AO & Ghobrial, RM 2022, , Clinical Transplantation, pp. e14600. https://doi.org/10.1111/ctr.14600

Impact of Portable Normothermic Blood-Based Machine Perfusion on Outcomes of Liver Transplant: The OCS Liver PROTECT Randomized Clinical Trial
Markmann, JF, Abouljoud, MS, Ghobrial, RM, Bhati, CS, Pelletier, SJ, Lu, AD, Ottmann, S, Klair, T, Eymard, C, Roll, GR, Magliocca, J, Pruett, TL, Reyes, J, Black, SM, Marsh, CL, Schnickel, G, Kinkhabwala, M, Florman, SS, Merani, S, Demetris, AJ, Kimura, S, Rizzari, M, Saharia, A, Levy, M, Agarwal, A, Cigarroa, FG, Eason, JD, Syed, S, Washburn, WK, Parekh, J, Moon, J, Maskin, A, Yeh, H, Vagefi, PA & Macconmara, MP 2022, , JAMA Surgery, vol. 157, no. 3, pp. 189-198. https://doi.org/10.1001/jamasurg.2021.6781

Virus interactions with the actin cytoskeleton—what we know and do not know about SARS-CoV-2
Kloc, M, Uosef, A, Wosik, J, Kubiak, JZ & Ghobrial, RM 2022, , Archives of Virology, vol. 167, no. 3, pp. 737-749. https://doi.org/10.1007/s00705-022-05366-1

Early humoral immune response to two doses of severe acute respiratory syndrome coronavirus 2 vaccine in a diverse group of solid organ transplant candidates and recipients
Huang, HJ, Yi, SG, Mobley, CM, Saharia, A, Bhimaraj, A, Moore, LW, Kloc, M, Adrogue, HE, Graviss, EA, Nguyen, DT, Eagar, TN, Jones, SL, Ankoma-Sey, V, MacGillivray, TE, Knight, RJ, Gaber, AO & Ghobrial, RM 2022, , Clinical Transplantation, vol. 36, no. 5, e14600. https://doi.org/10.1111/ctr.14600

The RNA helicase DHX15 is a critical regulator of natural killer-cell homeostasis and functions
Wang, G, Xiao, X, Wang, Y, Chu, X, Dou, Y, Minze, LJ, Ghobrial, RM, Zhang, Z & Li, XC 2022, , Cellular and Molecular Immunology, vol. 19, no. 6, pp. 687-701. https://doi.org/10.1038/s41423-022-00852-7

Artificial intelligence to identify harmful alcohol use after early liver transplant for alcohol-associated hepatitis
Lee, BP, Roth, N, Rao, P, Im, GY, Vogel, AS, Hasbun, J, Roth, Y, Shenoy, A, Arvelakis, A, Ford, L, Dawe, I, Schiano, TD, Davis, JP, Rice, JP, Eswaran, S, Weinberg, E, Han, H, Hsu, C, Fix, OK, Maddur, H, Ghobrial, RM, Therapondos, G, Dilkina, B & Terrault, NA 2022, , American Journal of Transplantation. https://doi.org/10.1111/ajt.17059

Risk Factors Associated with an Impaired Antibody Response in Kidney Transplant Recipients following 2 Doses of the SARS-CoV-2 mRNA Vaccine
Yi, SG, Moore, LW, Eagar, T, Graviss, EA, Nguyen, DT, Ibrahim, H, Huang, HJ, Hobeika, M, McMillan, R, Saharia, A, Mobley, C, Podder, H, Drews, A, Ghobrial, RM, Gaber, AO & Knight, RJ 2021, , Transplantation Direct, vol. 8, no. 1, e1257. https://doi.org/10.1097/TXD.0000000000001257

Transplant oncology: An evolving field in cancer care
Abdelrahim, M, Esmail, A, Abudayyeh, A, Murakami, N, Saharia, A, McMillan, R, Victor, D, Kodali, S, Shetty, A, Fong, JVN, Moore, LW, Heyne, K, Gaber, AO & Ghobrial, RM 2021, , Cancers, vol. 13, no. 19, 4911. https://doi.org/10.3390/cancers13194911

Pre-transplant T-cell Clonality: An Observational Study of a Biomarker for Prediction of Sepsis in Liver Transplant Recipients
Jones, SL, Moore, LW, Li, XC, Mobley, CM, Fields, PA, Graviss, EA, Nguyen, DT, Nolte Fong, J, Saharia, A, Hobeika, MJ, McMillan, RR, Victor, DW, Minze, LJ, Gaber, AO & Ghobrial, RM 2021, , Annals of surgery, vol. 274, no. 3, pp. 411-418. https://doi.org/10.1097/SLA.0000000000004998

Kidney Transplant Recipients Rarely Show an Early Antibody Response Following the First COVID-19 Vaccine Administration
Yi, SG, Knight, RJ, Graviss, EA, Moore, LW, Nguyen, DT, Ghobrial, RM, Gaber, AO & Huang, HJ 2021, , Transplantation, vol. 105, no. 7, pp. e72-e73. https://doi.org/10.1097/TP.0000000000003764

Management of intrahepatic cholangiocarcinoma
Kodali, S, Shetty, A, Shekhar, S, Victor, DW & Ghobrial, RM 2021, , Journal of Clinical Medicine, vol. 10, no. 11, 2368. https://doi.org/10.3390/jcm10112368

An imageomics and multi-network based deep learning model for risk assessment of liver transplantation for hepatocellular cancer
He, T, Fong, JN, Moore, LW, Ezeana, CF, Victor, D, Divatia, M, Vasquez, M, Ghobrial, RM & Wong, STC 2021, , Computerized Medical Imaging and Graphics, vol. 89, 101894. https://doi.org/10.1016/j.compmedimag.2021.101894

New insights into cellular functions of nuclear actin
Kloc, M, Chanana, P, Vaughn, N, Uosef, A, Kubiak, JZ & Ghobrial, RM 2021, , Biology, vol. 10, no. 4, 304. https://doi.org/10.3390/biology10040304

Exaptation of retroviral syncytin for development of syncytialized placenta, its limited homology to the sars-cov-2 spike protein and arguments against disturbing narrative in the context of covid-19 vaccination
Kloc, M, Uosef, A, Kubiak, JZ & Ghobrial, RM 2021, , Biology, vol. 10, no. 3, 238. https://doi.org/10.3390/biology10030238

Effects of vitamin D on macrophages and myeloid-derived suppressor cells (MDSCs) hyperinflammatory response in the lungs of COVID-19 patients
Kloc, M, Ghobrial, RM, Lipinska-Opalka, A, Wawrzyniak, A, Zdanowski, R, Kalicki, B & Kubiak, JZ 2021, , Cellular Immunology, vol. 360, 104259, pp. 104259. https://doi.org/10.1016/j.cellimm.2020.104259