R. Mark Ghobrial, MD, PhD

J.C. Walter Jr. Presidential Distinguished Chair, Director, J.C. Walter Jr. Transplant Center
Professor of Surgery, Academic Institute
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Sherrie and Alan Conover Center for Liver Disease and Transplantation


Biography

After receiving his Bachelor of Medicine and Bachelor of Surgery degrees from Cairo University Medical School in Cairo, Egypt, Dr. Ghobrial completed several surgical residencies in the United Kingdom and the United States. While a surgery resident at University of Texas Health Science Center in Houston, Texas, he completed a PhD in Immunology at the UT Graduate School of Biomedical Sciences in 1994. After residency, he accepted a position as clinical instructor in the Department of Surgery at the David Geffen School of Medicine at University of California, Los Angeles (UCLA) and was awarded a Dumont-UCLA Transplant Fellowship. He received his full professorship in 2005 and served as Director of the Pancreas Transplant Program and Living Donor Liver Transplantation, and Service Director for Liver, Pancreas, and Small Bowel Transplantation. He was recruited to the Houston Methodist Hospital in 2008.

Description of Research

One of the primary goals of Dr. Ghobrial´s research is to increase donor tolerance to organ transplants and allografts. Dr. Ghobrial has shown in preclinical studies that tolerizing the host to dominant donor epitopes induces tolerance in the recipient. By engineering chimeric proteins, or proteins that contain sequences from both donor and recipient, and exposing the recipient to these proteins prior to tissue graft, peripheral, long-term tolerance is induced. Dr. Ghobrial also has a long-standing interest in the effects of Hepatitis (B and C) on transplantation patients.

Areas Of Expertise

Liver resection Transplantation Hepatocellular carcinoma Liver transplant Liver disease
Education & Training

Clinical Fellowship, Dumont-UCLA Transplant Center
MD, University of Cairo Medical School
Residency, University of Texas Health Science Center at Houston
PhD, University of Texas Health Science Center at Houston
Publications

Novel Benchmark Values for Redo Liver Transplantation: Does the Outcome Justify the Effort?
Abbassi, F, Gero, D, Muller, X, Bueno, A, Figiel, W, Robin, F, Laroche, S, Picard, B, Shankar, S, Ivanics, T, van Reeven, M, van Leeuwen, OB, Braun, HJ, Monbaliu, D, Breton, A, Vachharajani, N, Bonaccorsi Riani, E, Nowak, G, McMillan, RR, Abu-Gazala, S, Nair, A, Bruballa, R, Paterno, F, Weppler Sears, D, Pinna, AD, Guarrera, JV, de Santibañes, E, de Santibañes, M, Hernandez-Alejandro, R, Olthoff, K, Ghobrial, RM, Ericzon, BG, Ciccarelli, O, Chapman, WC, Mabrut, JY, Pirenne, J, Müllhaupt, B, Ascher, NL, Porte, RJ, de Meijer, VE, Polak, WG, Sapisochin, G, Attia, M, Soubrane, O, Weiss, E, Adam, RA, Cherqui, D, Boudjema, K, Zieniewicz, K, Jassem, W, Dutkowski, P & Clavien, PA 2022, , Annals of surgery, vol. 276, no. 5, pp. 860-867. https://doi.org/10.1097/SLA.0000000000005634

Predicting a Positive Antibody Response after 2 SARS-CoV-2 mRNA Vaccines in Transplant Recipients: A Machine Learning Approach with External Validation
Alejo, JL, Mitchell, J, Chiang, TPY, Chang, A, Abedon, AT, Werbel, WA, Boyarsky, BJ, Zeiser, LB, Avery, RK, Tobian, AAR, Levan, ML, Warren, DS, Massie, AB, Moore, LW, Guha, A, Huang, HJ, Knight, RJ, Gaber, AO, Ghobrial, RM, Garonzik-Wang, JM, Segev, DL & Bae, S 2022, , Transplantation, vol. 106, no. 10, pp. E452-E460. https://doi.org/10.1097/TP.0000000000004259

Combined liver transplant and sleeve gastrectomy: report of a brief-interval staged approach
Tariq, N, Saharia, A, Nwokedi, U, Hobeika, MJ, Mobley, CM, Hsu, D, Potter, LM, Moore, LW, Elaileh, A, Sherman, V & Ghobrial, RM 2022, , Liver Transplantation. https://doi.org/10.1002/lt.26560

Giant Multinucleated Cells in Aging and Senescence—An Abridgement
Kloc, M, Uosef, A, Subuddhi, A, Kubiak, JZ, Piprek, RP & Ghobrial, RM 2022, , Biology, vol. 11, no. 8, 1121. https://doi.org/10.3390/biology11081121

Liver transplantation and intrahepatic cholangiocarcinoma: time to go forward again?
Kodali, S, Saharia, A & Ghobrial, RM 2022, , Current opinion in organ transplantation, vol. 27, no. 4, pp. 320-328. https://doi.org/10.1097/MOT.0000000000000983

Liver transplantation and intrahepatic cholangiocarcinoma: time to go forward again?
Kodali, S, Saharia, A & Ghobrial, RM 2022, , Current opinion in organ transplantation, vol. 27, no. 4, pp. 320-328. https://doi.org/10.1097/MOT.0000000000000983

Graft and Patient Survival after Liver Transplantation
Yi, S, Mobley, CM & Ghobrial, RM 2022, . in P Burra (ed.), Textbook of Liver Transplantation. Springer, pp. 433-448.

Gemcitabine Plus Cisplatin Versus Non-Gemcitabine and Cisplatin Regimens as Neoadjuvant Treatment for Cholangiocarcinoma Patients Prior to Liver Transplantation: An Institution Experience
Abdelrahim, M, Esmail, A, Xu, J, Umoru, G, Al-Rawi, H, Saharia, A, Abudayyeh, A, Victor, D, McMillan, R, Kodali, S & Ghobrial, RM 2022, , Frontiers in Oncology, vol. 12, 908687. https://doi.org/10.3389/fonc.2022.908687

Natural genetic engineering: A programmed chromosome/DNA elimination
Kloc, M, Kubiak, JZ & Ghobrial, RM 2022, , Developmental Biology, vol. 486, pp. 15-25. https://doi.org/10.1016/j.ydbio.2022.03.008

Monocyte–Macrophage Lineage Cell Fusion
Kloc, M, Subuddhi, A, Uosef, A, Kubiak, JZ & Ghobrial, RM 2022, , International journal of molecular sciences, vol. 23, no. 12, 6553. https://doi.org/10.3390/ijms23126553

Immunotherapy as a Neoadjuvant Therapy for a Patient with Hepatocellular Carcinoma in the Pretransplant Setting: A Case Report
Abdelrahim, M, Esmail, A, Umoru, G, Westhart, K, Abudayyeh, A, Saharia, A & Ghobrial, RM 2022, , Current Oncology, vol. 29, no. 6, 4267. https://doi.org/10.3390/curroncol29060341

Gemcitabine and Cisplatin as Neo-Adjuvant for Cholangiocarcinoma Patients Prior to Liver Transplantation: Case-Series
Abdelrahim, M, Al-Rawi, H, Esmail, A, Xu, J, Umoru, G, Ibnshamsah, F, Abudayyeh, A, Victor, D, Saharia, A, McMillan, R, Al Najjar, E, Bugazia, D, Al-Rawi, M & Ghobrial, RM 2022, , Current Oncology, vol. 29, no. 5, pp. 3585-3594. https://doi.org/10.3390/curroncol29050290

Utilization of Immunotherapy for the Treatment of Hepatocellular Carcinoma in the Peri-Transplant Setting: Transplant Oncology View
Abdelrahim, M, Esmail, A, Saharia, A, Abudayyeh, A, Abdel-Wahab, N, Diab, A, Murakami, N, Kaseb, AO, Chang, JC, Gaber, AO & Ghobrial, RM 2022, , Cancers, vol. 14, no. 7, 1760. https://doi.org/10.3390/cancers14071760

The Effect of Magnetic Field Gradient and Gadolinium-Based MRI Contrast Agent Dotarem on Mouse Macrophages
Chanana, P, Uosef, A, Vaughn, N, Suarez-Villagran, M, Ghobrial, RM, Kloc, M & Wosik, J 2022, , Cells, vol. 11, no. 5, 757. https://doi.org/10.3390/cells11050757

Transarterial Chemoembolization (TACE) Plus Sorafenib Compared to TACE Alone in Transplant Recipients with Hepatocellular Carcinoma: An Institution Experience
Abdelrahim, M, Victor, D, Esmail, A, Kodali, S, Graviss, EA, Nguyen, DT, Moore, LW, Saharia, A, McMillan, R, Fong, JN, Uosef, A, Elshawwaf, M, Heyne, K & Ghobrial, RM 2022, , Cancers, vol. 14, no. 3, 650. https://doi.org/10.3390/cancers14030650

Utility of Cell-Free DNA Detection in Transplant Oncology
Reddy, T, Esmail, A, Chang, JC, Ghobrial, RM & Abdelrahim, M 2022, , Cancers, vol. 14, no. 3, 743. https://doi.org/10.3390/cancers14030743

Early humoral immune response to two doses of severe acute respiratory syndrome coronavirus 2 vaccine in a diverse group of solid organ transplant candidates and recipients
Huang, HJ, Yi, SG, Mobley, CM, Saharia, A, Bhimaraj, A, Moore, LW, Kloc, M, Adrogue, HE, Graviss, EA, Nguyen, DT, Eagar, TN, Jones, SL, Ankoma-Sey, V, MacGillivray, TE, Knight, RJ, Gaber, AO & Ghobrial, RM 2022, , Clinical Transplantation, vol. 36, no. 5, e14600. https://doi.org/10.1111/ctr.14600, https://doi.org/10.1111/ctr.14600

Impact of Portable Normothermic Blood-Based Machine Perfusion on Outcomes of Liver Transplant: The OCS Liver PROTECT Randomized Clinical Trial
Markmann, JF, Abouljoud, MS, Ghobrial, RM, Bhati, CS, Pelletier, SJ, Lu, AD, Ottmann, S, Klair, T, Eymard, C, Roll, GR, Magliocca, J, Pruett, TL, Reyes, J, Black, SM, Marsh, CL, Schnickel, G, Kinkhabwala, M, Florman, SS, Merani, S, Demetris, AJ, Kimura, S, Rizzari, M, Saharia, A, Levy, M, Agarwal, A, Cigarroa, FG, Eason, JD, Syed, S, Washburn, WK, Parekh, J, Moon, J, Maskin, A, Yeh, H, Vagefi, PA & Macconmara, MP 2022, , JAMA Surgery, vol. 157, no. 3, pp. 189-198. https://doi.org/10.1001/jamasurg.2021.6781

Virus interactions with the actin cytoskeleton—what we know and do not know about SARS-CoV-2
Kloc, M, Uosef, A, Wosik, J, Kubiak, JZ & Ghobrial, RM 2022, , Archives of Virology, vol. 167, no. 3, pp. 737-749. https://doi.org/10.1007/s00705-022-05366-1

Early humoral immune response to two doses of severe acute respiratory syndrome coronavirus 2 vaccine in a diverse group of solid organ transplant candidates and recipients
Huang, HJ, Yi, SG, Mobley, CM, Saharia, A, Bhimaraj, A, Moore, LW, Kloc, M, Adrogue, HE, Graviss, EA, Nguyen, DT, Eagar, TN, Jones, SL, Ankoma-Sey, V, MacGillivray, TE, Knight, RJ, Gaber, AO & Ghobrial, RM 2022, , Clinical Transplantation, vol. 36, no. 5, e14600. https://doi.org/10.1111/ctr.14600