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Malgorzata Kloc, PhD

Research Professor of Surgery, Academic Institute
Associate Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Prior to completing her postdoctoral training in Canada, Dr. Kloc-Stepkowska was a tenured Associate Professor in the Department of Zoology at the University of Warsaw, Poland. She also served as a Research Associate in the Department of Biology at Carleton University in Ottawa, Canada. While completing her postdoctoral training, Dr. Kloc-Stepkowska earned the AHFMR Research Award from the University of Calgary and the MRC Biotechnology Training Award from Dalhousie University. She joined the University of Texas M.D. Anderson Cancer Center as a Research Scientist in the Department of Molecular Genetics in 1987, and became an Associate Professor in the Department of Biochemistry and Molecular Biology there in 2006. Dr. Kloc-Stepkowska joined the Houston Methodist Research Institute in 2008.

Description of Research

Dr. Kloc-Stepkowska’s research focuses on investigations into the role of structural RNA in the organization of cellular cytoskeleton. She has numerous publications in the medical literature and her current studies are funded by the National Science Foundation. Dr. Kloc-Stepkowska also works closely with Dr. R. Mark Ghobrial on transplant immunomodulation studies using allochimeric molecules to improve transplant acceptance.

Areas Of Expertise

Immunology Transplant biology Structural RNA Cytoskeleton
Education & Training

Postdoctoral Fellowship, Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia
Postdoctoral Fellowship, Department of Biology, University of Calgary, Calgary, Alberta
Postdoctoral Fellowship, Department of Chemistry, Saint Mary's University, Halifax, Nova Scotia
PhD, University of Warsaw
MS, University of Warsaw
Publications

Neovascularized implantable cell homing encapsulation platform with tunable local immunosuppressant delivery for allogeneic cell transplantation
Paez-Mayorga, J, Capuani, S, Hernandez, N, Farina, M, Chua, YX, Blanchard, R, Sizovs, A, Liu, HC, Fraga, DW, Niles, JA, Salazar, HF, Corradetti, B, Sikora, AG, Kloc, M, Li, XC, Gaber, AO, Nichols, J & Grattoni, A 2020, , Biomaterials, vol. 257, 120232. https://doi.org/10.1016/j.biomaterials.2020.120232

How nicotine can inhibit cytokine storm in the lungs and prevent or lessen the severity of COVID-19 infection?
Kloc, M, Ghobrial, RM & Kubiak, JZ 2020, , Immunology Letters, vol. 224, pp. 28-29. https://doi.org/10.1016/j.imlet.2020.06.002

Development of child immunity in the context of COVID-19 pandemic
Kloc, M, Ghobrial, RM, Kuchar, E, Lewicki, S & Kubiak, JZ 2020, , Clinical Immunology, vol. 217, 108510. https://doi.org/10.1016/j.clim.2020.108510

Siponimod (Mayzent) Downregulates RhoA and Cell Surface Expression of the S1P1 and CX3CR1 Receptors in Mouse RAW 264.7 Macrophages
Uosef, A, Vaughn, N, Chu, X, Elshawwaf, M, Abdelshafy, AAA, Elsaid, KMK, Ghobrial, RM & Kloc, M 2020, Archivum Immunologiae et Therapiae Experimentalis, vol. 68, no. 3, 19. https://doi.org/10.1007/s00005-020-00584-4

Podwójna twarz komórek macierzystych w pediatrii: Zastosowania terapeutyczne mezenchymalnych komórek macierzystych i zagrozenia rakowymi komórkami macierzystymi
Uosef, A, Ghobrial, RM, Jederka, K, Pulawska-Czub, A, Lewicki, S, Kubiak, JZ & Kloc, M 2020, , Pediatria i Medycyna Rodzinna, vol. 16, no. 2, pp. 171-174. https://doi.org/10.15557/PiMR.2020.0032

Skutki uboczne kontrastów do MRI zawierajacych gadolin
Uosef, A, Villagran, M, Kubiak, JZ, Wosik, J, Ghobrial, RM & Kloc, M 2020, , Pediatria i Medycyna Rodzinna, vol. 16, no. 1, pp. 49-52. https://doi.org/10.15557/PiMR.2020.0008

N-Cadherin Is Critical for the Survival of Germ Cells, the Formation of Steroidogenic Cells, and the Architecture of Developing Mouse Gonads
Piprek, RP, Kolasa, M, Podkowa, D, Kloc, M & Kubiak, JZ 2019, Cells, vol. 8, no. 12. https://doi.org/10.3390/cells8121610

Divergent roles of the Wnt/PCP Formin Daam1 in renal ciliogenesis
Corkins, ME, Krneta-Stankic, V, Kloc, M, McCrea, PD, Gladden, AB & Miller, RK 2019, , PLoS ONE, vol. 14, no. 8, e0221698. https://doi.org/10.1371/journal.pone.0221698

Transcriptome profiling reveals male- and female-specific gene expression pattern and novel gene candidates for the control of sex determination and gonad development in Xenopus laevis
Piprek, RP, Damulewicz, M, Tassan, JP, Kloc, M & Kubiak, JZ 2019, Development Genes and Evolution, vol. 229, no. 2-3, pp. 53-72. https://doi.org/10.1007/s00427-019-00630-y

Characterisation of white and yellow eye colour mutant strains of house cricket, Acheta domesticus
Francikowski, J, Krzyzowski, M, Kochanska, B, Potrzebska, M, Baran, B, Chajec, L, Urbisz, A, Malota, K, Lozowski, B, Kloc, M & Kubiak, J 2019, , PLoS ONE, vol. 14, no. 5, e0216281. https://doi.org/10.1371/JOURNAL.PONE.0216281

Matrix metalloproteinase-dependent regulation of extracellular matrix shapes the structure of sexually differentiating mouse gonads
Piprek, RP, Kloc, M & Kubiak, JZ 2019, Differentiation, vol. 106, pp. 23-34. https://doi.org/10.1016/j.diff.2019.01.006

Macrophage phenotype bioengineered by magnetic, genetic, or pharmacologic interference
Wosik, J, Suarez-Villagran, M, Miller, JH, Ghobrial, RM & Kloc, M 2019, , Immunologic Research, vol. 67, no. 1, pp. 1-11. https://doi.org/10.1007/s12026-019-9066-3

RhoA pathway and actin regulation of the golgi/centriole complex
Kloc, M, Uosef, A, Wosik, J, Kubiak, JZ & Ghobrial, RM 2019, . in Results and Problems in Cell Differentiation. Results and Problems in Cell Differentiation, vol. 67, Springer-Verlag, pp. 81-93. https://doi.org/10.1007/978-3-030-23173-6_5

Tissue-specific knockout of E-cadherin (Cdh1) in developing mouse gonads causes germ cells loss
Piprek, RP, Kolasa, M, Podkowa, D, Kloc, M & Kubiak, JZ 2019, , Reproduction, vol. 158, no. 2, pp. 147-157. https://doi.org/10.1530/REP-18-0621

The Rove Beetle Creophilus maxillosus as a Model System to Study Asymmetric Division, Oocyte Specification, and the Germ-Somatic Cell Signaling
Kloc, M 2019, . in Results and Problems in Cell Differentiation. Results and Problems in Cell Differentiation, vol. 68, Springer-Verlag, pp. 217-230. https://doi.org/10.1007/978-3-030-23459-1_9

Preface
Kloc, M 2019, Results and Problems in Cell Differentiation, vol. 67, pp. v.

Effects of magnetic fields and field gradients on living cells
Wosik, J, Villagran, M, Uosef, A, Ghobrial, RM, Miller, JH & Kloc, M 2019, , eMagRes, vol. 8, no. 4, pp. 371-386. https://doi.org/10.1002/9780470034590.emrstm1609

Expression of primary cilia-related genes in developing mouse gonads
Piprek, RP, Podkowa, D, Kloc, M & Kubiak, JZ 2019, , International Journal of Developmental Biology, vol. 63, no. 11-12, pp. 615-621. https://doi.org/10.1387/ijdb.190049rp

Coinhibition of mTORC1/mTORC2 and RhoA /ROCK pathways prevents chronic rejection of rat cardiac allografts
Chen, W, Chen, W, Li, XC, Ghobrial, RM & Kloc, M 2018, , Transplantation Reports, vol. 3, no. 4, pp. 21-28. https://doi.org/10.1016/j.tpr.2018.09.002

Effects of genistein on insulin pathway related genes in mouse differentiated myoblast C2C12 cell line: evidences for two independent modes of action
Lewicki, S, Lewicka, A, Kalicki, B, Sobolewska-Ruta, A, Debski, B, Zdanowski, R, Syrylo, T, Kloc, M & Kubiak, JZ 2018, Folia Histochemica et Cytobiologica, vol. 56, no. 3, pp. 123-132. https://doi.org/10.5603/FHC.a2018.0014