Malgorzata Kloc

Malgorzata Kloc, PhD

Research Professor of Surgery, Academic Institute
Associate Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Prior to completing her postdoctoral training in Canada, Dr. Kloc-Stepkowska was a tenured Associate Professor in the Department of Zoology at the University of Warsaw, Poland. She also served as a Research Associate in the Department of Biology at Carleton University in Ottawa, Canada. While completing her postdoctoral training, Dr. Kloc-Stepkowska earned the AHFMR Research Award from the University of Calgary and the MRC Biotechnology Training Award from Dalhousie University. She joined the University of Texas M.D. Anderson Cancer Center as a Research Scientist in the Department of Molecular Genetics in 1987, and became an Associate Professor in the Department of Biochemistry and Molecular Biology there in 2006. Dr. Kloc-Stepkowska joined the Houston Methodist Research Institute in 2008.

Description of Research

Dr. Kloc-Stepkowska’s research focuses on investigations into the role of structural RNA in the organization of cellular cytoskeleton. She has numerous publications in the medical literature and her current studies are funded by the National Science Foundation. Dr. Kloc-Stepkowska also works closely with Dr. R. Mark Ghobrial on transplant immunomodulation studies using allochimeric molecules to improve transplant acceptance.

Areas Of Expertise

Immunology Transplant biology Structural RNA Cytoskeleton
Education & Training

Postdoctoral Fellowship, Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia
Postdoctoral Fellowship, Department of Biology, University of Calgary, Calgary, Alberta
Postdoctoral Fellowship, Department of Chemistry, Saint Mary's University, Halifax, Nova Scotia
PhD, University of Warsaw
MS, University of Warsaw
Publications

Transplantation of insulin-producing cells derived from human mesenchymal stromal/stem cells into diabetic humanized mice
Ghoneim, MA, Gabr, MM, Refaie, AF, El-Halawani, SM, Al-issawi, MM, Elbassiouny, BL, Kader, MAAE, Ismail, AM, Zidan, MF, Karras, MS, Magar, RW, Khater, SM, Ashamallah, SA, Zakaria, MM & Kloc, M 2022, , Stem Cell Research and Therapy, vol. 13, no. 1, 350. https://doi.org/10.1186/s13287-022-03048-y

Dissecting Physiopathology of COVID-19
Kubiak, JZ & Kloc, M 2022, , International journal of molecular sciences, vol. 23, no. 17. https://doi.org/10.3390/ijms23179602

Giant Multinucleated Cells in Aging and Senescence—An Abridgement
Kloc, M, Uosef, A, Subuddhi, A, Kubiak, JZ, Piprek, RP & Ghobrial, RM 2022, , Biology, vol. 11, no. 8, 1121. https://doi.org/10.3390/biology11081121

Natural genetic engineering: A programmed chromosome/DNA elimination
Kloc, M, Kubiak, JZ & Ghobrial, RM 2022, , Developmental Biology, vol. 486, pp. 15-25. https://doi.org/10.1016/j.ydbio.2022.03.008

Monocyte–Macrophage Lineage Cell Fusion
Kloc, M, Subuddhi, A, Uosef, A, Kubiak, JZ & Ghobrial, RM 2022, , International journal of molecular sciences, vol. 23, no. 12, 6553. https://doi.org/10.3390/ijms23126553

Remembering prof. Zygmunt Kraczkiewicz (1900–1971) and his pioneering research
Kloc, M 2022, , Kosmos, vol. 71, no. 1, pp. 1-4. https://doi.org/10.36921/kos.2022_2846

Remembering Professor Bohdan Matuszewski
Kloc, M 2022, , Developmental Biology, vol. 487, pp. 21-23. https://doi.org/10.1016/j.ydbio.2022.04.002

The Effect of Magnetic Field Gradient and Gadolinium-Based MRI Contrast Agent Dotarem on Mouse Macrophages
Chanana, P, Uosef, A, Vaughn, N, Suarez-Villagran, M, Ghobrial, RM, Kloc, M & Wosik, J 2022, , Cells, vol. 11, no. 5, 757. https://doi.org/10.3390/cells11050757

A 10-Year-old Girl with Late Acute Lymphoblastic Leukemia Recurrence Diagnosed with COVID-19 and Treated with Remdesivir
Gadzinska, J, Kuchar, E, Matysiak, M, Wanke-Rytt, M, Kloc, M & Kubiak, JZ 2022, , Journal of pediatric hematology/oncology, vol. 44, no. 2, pp. E537-E538. https://doi.org/10.1097/MPH.0000000000002166

Desmoplakin (Dsp) conditional knockout in NR5A1+ somatic cells affects germ cell survival in developing mouse gonads
Piprek, RP, Rams-Pociecha, I, Zdanowski, R, Kloc, M & Kubiak, JZ 2022, , Reproduction, vol. 163, no. 4, pp. 199-207. https://doi.org/10.1530/REP-21-0295

The Role of Vitamin D in COVID-19 and the Impact of Pandemic Restrictions on Vitamin D Blood Content
Tomaszewska, A, Rustecka, A, Lipinska-Opalka, A, Piprek, RP, Kloc, M, Kalicki, B & Kubiak, JZ 2022, , Frontiers in Pharmacology, vol. 13, 836738. https://doi.org/10.3389/fphar.2022.836738

Early humoral immune response to two doses of severe acute respiratory syndrome coronavirus 2 vaccine in a diverse group of solid organ transplant candidates and recipients
Huang, HJ, Yi, SG, Mobley, CM, Saharia, A, Bhimaraj, A, Moore, LW, Kloc, M, Adrogue, HE, Graviss, EA, Nguyen, DT, Eagar, TN, Jones, SL, Ankoma-Sey, V, MacGillivray, TE, Knight, RJ, Gaber, AO & Ghobrial, RM 2022, , Clinical Transplantation, vol. 36, no. 5, e14600. https://doi.org/10.1111/ctr.14600, https://doi.org/10.1111/ctr.14600

Virus interactions with the actin cytoskeleton—what we know and do not know about SARS-CoV-2
Kloc, M, Uosef, A, Wosik, J, Kubiak, JZ & Ghobrial, RM 2022, , Archives of Virology, vol. 167, no. 3, pp. 737-749. https://doi.org/10.1007/s00705-022-05366-1

Early humoral immune response to two doses of severe acute respiratory syndrome coronavirus 2 vaccine in a diverse group of solid organ transplant candidates and recipients
Huang, HJ, Yi, SG, Mobley, CM, Saharia, A, Bhimaraj, A, Moore, LW, Kloc, M, Adrogue, HE, Graviss, EA, Nguyen, DT, Eagar, TN, Jones, SL, Ankoma-Sey, V, MacGillivray, TE, Knight, RJ, Gaber, AO & Ghobrial, RM 2022, , Clinical Transplantation, vol. 36, no. 5, e14600. https://doi.org/10.1111/ctr.14600

The Wnt/PCP formin Daam1 drives cell-cell adhesion during nephron development
Krneta-Stankic, V, Corkins, ME, Paulucci-Holthauzen, A, Kloc, M, Gladden, AB & Miller, RK 2021, , Cell Reports, vol. 36, no. 1, 109340. https://doi.org/10.1016/j.celrep.2021.109340

From Mesenchymal Stromal/Stem Cells to Insulin-Producing Cells: Immunological Considerations
Refaie, AF, Elbassiouny, BL, Kloc, M, Sabek, OM, Khater, SM, Ismail, AM, Mohamed, RH & Ghoneim, MA 2021, , Frontiers in immunology, vol. 12, 690623. https://doi.org/10.3389/fimmu.2021.690623

The role of monocytes and macrophages in homeostasis and disease and novel avenues for putative treatments
Kloc, M & Kubiak, JZ 2021, , International journal of molecular sciences, vol. 22, no. 9, 4927. https://doi.org/10.3390/ijms22094927

New insights into cellular functions of nuclear actin
Kloc, M, Chanana, P, Vaughn, N, Uosef, A, Kubiak, JZ & Ghobrial, RM 2021, , Biology, vol. 10, no. 4, 304. https://doi.org/10.3390/biology10040304

Exaptation of retroviral syncytin for development of syncytialized placenta, its limited homology to the sars-cov-2 spike protein and arguments against disturbing narrative in the context of covid-19 vaccination
Kloc, M, Uosef, A, Kubiak, JZ & Ghobrial, RM 2021, , Biology, vol. 10, no. 3, 238. https://doi.org/10.3390/biology10030238

Children were less frequently infected with SARS-CoV-2 than adults during 2020 COVID-19 pandemic in Warsaw, Poland
Kuchar, E, Zaleski, A, Wronowski, M, Krankowska, D, Podsiadly, E, Brodaczewska, K, Lewicka, A, Lewicki, S, Kieda, C, Horban, A, Kloc, M & Kubiak, JZ 2021, , European Journal of Clinical Microbiology and Infectious Diseases, vol. 40, no. 3, pp. 541-547. https://doi.org/10.1007/s10096-020-04038-9