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Malgorzata Kloc, PhD

Research Professor of Surgery, Institute for Academic Medicine
Associate Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Prior to completing her postdoctoral training in Canada, Dr. Kloc-Stepkowska was a tenured Associate Professor in the Department of Zoology at the University of Warsaw, Poland. She also served as a Research Associate in the Department of Biology at Carleton University in Ottawa, Canada. While completing her postdoctoral training, Dr. Kloc-Stepkowska earned the AHFMR Research Award from the University of Calgary and the MRC Biotechnology Training Award from Dalhousie University. She joined the University of Texas M.D. Anderson Cancer Center as a Research Scientist in the Department of Molecular Genetics in 1987, and became an Associate Professor in the Department of Biochemistry and Molecular Biology there in 2006. Dr. Kloc-Stepkowska joined the Houston Methodist Research Institute in 2008.

Description of Research

Dr. Kloc-Stepkowska’s research focuses on investigations into the role of structural RNA in the organization of cellular cytoskeleton. She has numerous publications in the medical literature and her current studies are funded by the National Science Foundation. Dr. Kloc-Stepkowska also works closely with Dr. R. Mark Ghobrial on transplant immunomodulation studies using allochimeric molecules to improve transplant acceptance.

Areas Of Expertise

Immunology Transplant biology Structural RNA Cytoskeleton
Education & Training

Postdoctoral Fellowship, Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia
Postdoctoral Fellowship, Department of Biology, University of Calgary, Calgary, Alberta
PhD, University of Warsaw
MS, University of Warsaw
Postdoctoral Fellowship, Department of Chemistry, Saint Mary's University, Halifax, Nova Scotia
Publications

Transcriptome profiling reveals male- and female-specific gene expression pattern and novel gene candidates for the control of sex determination and gonad development in Xenopus laevis
Piprek, RP, Damulewicz, M, Tassan, JP, Kloc, M & Kubiak, JZ 2019, Development Genes and Evolution, vol. 229, no. 2-3, pp. 53-72. https://doi.org/10.1007/s00427-019-00630-y

Matrix metalloproteinase-dependent regulation of extracellular matrix shapes the structure of sexually differentiating mouse gonads
Piprek, RP, Kloc, M & Kubiak, JZ 2019, Differentiation, vol. 106, pp. 23-34. https://doi.org/10.1016/j.diff.2019.01.006

Macrophage phenotype bioengineered by magnetic, genetic, or pharmacologic interference
Wosik, J, Suarez-Villagran, M, Miller, JH, Ghobrial, RM & Kloc, M 2019, Immunologic Research, vol. 67, no. 1, pp. 1-11. https://doi.org/10.1007/s12026-019-9066-3

Characterisation of white and yellow eye colour mutant strains of house cricket, Acheta domesticus
Francikowski, J, Krzyzowski, M, Kochanska, B, Potrzebska, M, Baran, B, Chajec, L, Urbisz, A, Malota, K, Lozowski, B, Kloc, M & Kubiak, J 2019, PloS one, vol. 14, no. 5, pp. e0216281. https://doi.org/10.1371/journal.pone.0216281

RhoA pathway and actin regulation of the golgi/centriole complex
Kloc, M, Uosef, A, Wosik, J, Kubiak, JZ & Ghobrial, RM 2019, . in Results and Problems in Cell Differentiation. Results and Problems in Cell Differentiation, vol. 67, Springer-Verlag, pp. 81-93. https://doi.org/10.1007/978-3-030-23173-6_5

Coinhibition of mTORC1/mTORC2 and RhoA /ROCK pathways prevents chronic rejection of rat cardiac allografts
Chen, W, Chen, W, Li, XC, Ghobrial, RM & Kloc, M 2018, Transplantation Reports, vol. 3, no. 4, pp. 21-28. https://doi.org/10.1016/j.tpr.2018.09.002

Effects of genistein on insulin pathway related genes in mouse differentiated myoblast C2C12 cell line: evidences for two independent modes of action
Lewicki, S, Lewicka, A, Kalicki, B, Sobolewska-Ruta, A, Debski, B, Zdanowski, R, Syrylo, T, Kloc, M & Kubiak, JZ 2018, Folia Histochemica et Cytobiologica, vol. 56, no. 3, pp. 123-132. https://doi.org/10.5603/FHC.a2018.0014

Magnetic Field Changes Macrophage Phenotype
Wosik, J, Chen, W, Qin, K, Ghobrial, RM, Kubiak, JZ & Kloc, M 2018, Biophysical Journal, vol. 114, no. 8, pp. 2001-2013. https://doi.org/10.1016/j.bpj.2018.03.002

Effects of Hexachlorophene, a Chemical Accumulating in Adipose Tissue, on Mouse and Human Mesenchymal Stem Cells
Lesniak, M, Zdanowski, R, Suska, M, Brewczynska, A, Stankiewicz, W, Kloc, M, Kubiak, JZ & Lewicki, S 2018, Tissue Engineering and Regenerative Medicine, vol. 15, no. 2, pp. 211-222. https://doi.org/10.1007/s13770-017-0103-9

Transcriptome analysis identifies genes involved in sex determination and development of Xenopus laevis gonads
Piprek, RP, Damulewicz, M, Kloc, M & Kubiak, JZ 2018, Differentiation, vol. 100, pp. 46-56. https://doi.org/10.1016/j.diff.2018.02.004

Transcriptional profiling validates involvement of extracellular matrix and proteinases genes in mouse gonad development
Piprek, RP, Kolasa, M, Podkowa, D, Kloc, M & Kubiak, JZ 2018, Mechanisms of Development, vol. 149, pp. 9-19. https://doi.org/10.1016/j.mod.2017.11.001

Screening RhoA/ROCK inhibitors for the ability to prevent chronic rejection of mouse cardiac allografts
Chen, W, Chen, S, Chen, W, Li, XC, Ghobrial, RM & Kloc, M 2018, Transplant Immunology. https://doi.org/10.1016/j.trim.2018.06.002

Macrophage functions in wound healing
Kloc, M, Ghobrial, RM, Wosik, J, Lewicka, A, Lewicki, S & Kubiak, JZ 2019, Journal of Tissue Engineering and Regenerative Medicine. https://doi.org/10.1002/term.2772

Inhibition of RhoA and mTORC2/Rictor by Fingolimod (FTY720) induces p21-activated kinase 1, PAK-1 and amplifies podosomes in mouse peritoneal macrophages
Chen, W, Ghobrial, RM, Li, XC & Kloc, M 2018, Immunobiology. https://doi.org/10.1016/j.imbio.2018.07.009

Development of Xenopus laevis bipotential gonads into testis or ovary is driven by sex-specific cell-cell interactions, proliferation rate, cell migration and deposition of extracellular matrix
Piprek, RP, Kloc, M, Tassan, JP & Kubiak, JZ 2017, Developmental Biology, vol. 432, no. 2, pp. 298-310. https://doi.org/10.1016/j.ydbio.2017.10.020

Rho-specific Guanine nucleotide exchange factors (Rho-GEFs) inhibition affects macrophage phenotype and disrupts Golgi complex
Chen, W, Zhao, Y, Li, XC, Kubiak, JZ, Ghobrial, RM & Kloc, M 2017, International Journal of Biochemistry and Cell Biology, vol. 93, pp. 12-24. https://doi.org/10.1016/j.biocel.2017.10.009

Selection of mitochondria in female germline cells: is Balbiani body implicated in this process?
Bilinski, SM, Kloc, M & Tworzydlo, W 2017, Journal of Assisted Reproduction and Genetics, vol. 34, no. 11, pp. 1405-1412. https://doi.org/10.1007/s10815-017-1006-3

Cell adhesion molecules expression pattern indicates that somatic cells arbitrate gonadal sex of differentiating bipotential fetal mouse gonad
Piprek, RP, Kolasa, M, Podkowa, D, Kloc, M & Kubiak, JZ 2017, Mechanisms of Development, vol. 147, pp. 17-27. https://doi.org/10.1016/j.mod.2017.07.001

The phenotype of peritoneal mouse macrophages depends on the mitochondria and ATP/ADP homeostasis
Chen, W, Sandoval, H, Kubiak, JZ, Li, XC, Ghobrial, RM & Kloc, M 2017, Cellular Immunology. https://doi.org/10.1016/j.cellimm.2017.11.003

Macrophages and RhoA Pathway in Transplanted Organs
Liu, Y, Kubiak, JZ, Li, XC, Ghobrial, RM & Kloc, M 2017, . in Results and Problems in Cell Differentiation. vol. 62, Results and Problems in Cell Differentiation, vol. 62, Springer-Verlag, pp. 365-376. https://doi.org/10.1007/978-3-319-54090-0_15

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