Malgorzata Kloc

Malgorzata Kloc, PhD

Research Professor of Surgery, Academic Institute
Associate Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Prior to completing her postdoctoral training in Canada, Dr. Kloc-Stepkowska was a tenured Associate Professor in the Department of Zoology at the University of Warsaw, Poland. She also served as a Research Associate in the Department of Biology at Carleton University in Ottawa, Canada. While completing her postdoctoral training, Dr. Kloc-Stepkowska earned the AHFMR Research Award from the University of Calgary and the MRC Biotechnology Training Award from Dalhousie University. She joined the University of Texas M.D. Anderson Cancer Center as a Research Scientist in the Department of Molecular Genetics in 1987, and became an Associate Professor in the Department of Biochemistry and Molecular Biology there in 2006. Dr. Kloc-Stepkowska joined the Houston Methodist Research Institute in 2008.

Description of Research

Dr. Kloc-Stepkowska’s research focuses on investigations into the role of structural RNA in the organization of cellular cytoskeleton. She has numerous publications in the medical literature and her current studies are funded by the National Science Foundation. Dr. Kloc-Stepkowska also works closely with Dr. R. Mark Ghobrial on transplant immunomodulation studies using allochimeric molecules to improve transplant acceptance.

Areas Of Expertise

Immunology Transplant biology Structural RNA Cytoskeleton
Education & Training

Postdoctoral Fellowship, Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia
Postdoctoral Fellowship, Department of Biology, University of Calgary, Calgary, Alberta
Postdoctoral Fellowship, Department of Chemistry, Saint Mary's University, Halifax, Nova Scotia
PhD, University of Warsaw
MS, University of Warsaw
Publications

Natural genetic engineering: A programmed chromosome/DNA elimination
Kloc, M, Kubiak, JZ & Ghobrial, RM 2022, , Developmental Biology, vol. 486, pp. 15-25. https://doi.org/10.1016/j.ydbio.2022.03.008

The Effect of Magnetic Field Gradient and Gadolinium-Based MRI Contrast Agent Dotarem on Mouse Macrophages
Chanana, P, Uosef, A, Vaughn, N, Suarez-Villagran, M, Ghobrial, RM, Kloc, M & Wosik, J 2022, , Cells, vol. 11, no. 5, 757. https://doi.org/10.3390/cells11050757

A 10-Year-old Girl with Late Acute Lymphoblastic Leukemia Recurrence Diagnosed with COVID-19 and Treated with Remdesivir
Gadzinska, J, Kuchar, E, Matysiak, M, Wanke-Rytt, M, Kloc, M & Kubiak, JZ 2022, , Journal of pediatric hematology/oncology, vol. 44, no. 2, pp. E537-E538. https://doi.org/10.1097/MPH.0000000000002166

Desmoplakin (Dsp) conditional knockout in NR5A1+ somatic cells affects germ cell survival in developing mouse gonads
Piprek, RP, Rams-Pociecha, I, Zdanowski, R, Kloc, M & Kubiak, JZ 2022, , Reproduction, vol. 163, no. 4, pp. 199-207. https://doi.org/10.1530/REP-21-0295

The Role of Vitamin D in COVID-19 and the Impact of Pandemic Restrictions on Vitamin D Blood Content
Tomaszewska, A, Rustecka, A, Lipinska-Opalka, A, Piprek, RP, Kloc, M, Kalicki, B & Kubiak, JZ 2022, , Frontiers in Pharmacology, vol. 13, 836738. https://doi.org/10.3389/fphar.2022.836738

Early humoral immune response to two doses of severe acute respiratory syndrome coronavirus 2 vaccine in a diverse group of solid organ transplant candidates and recipients
Huang, HJ, Yi, SG, Mobley, CM, Saharia, A, Bhimaraj, A, Moore, LW, Kloc, M, Adrogue, HE, Graviss, EA, Nguyen, DT, Eagar, TN, Jones, SL, Ankoma-Sey, V, MacGillivray, TE, Knight, RJ, Gaber, AO & Ghobrial, RM 2022, , Clinical Transplantation, pp. e14600. https://doi.org/10.1111/ctr.14600

Virus interactions with the actin cytoskeleton—what we know and do not know about SARS-CoV-2
Kloc, M, Uosef, A, Wosik, J, Kubiak, JZ & Ghobrial, RM 2022, , Archives of Virology, vol. 167, no. 3, pp. 737-749. https://doi.org/10.1007/s00705-022-05366-1

Early humoral immune response to two doses of severe acute respiratory syndrome coronavirus 2 vaccine in a diverse group of solid organ transplant candidates and recipients
Huang, HJ, Yi, SG, Mobley, CM, Saharia, A, Bhimaraj, A, Moore, LW, Kloc, M, Adrogue, HE, Graviss, EA, Nguyen, DT, Eagar, TN, Jones, SL, Ankoma-Sey, V, MacGillivray, TE, Knight, RJ, Gaber, AO & Ghobrial, RM 2022, , Clinical Transplantation, vol. 36, no. 5, e14600. https://doi.org/10.1111/ctr.14600

The Wnt/PCP formin Daam1 drives cell-cell adhesion during nephron development
Krneta-Stankic, V, Corkins, ME, Paulucci-Holthauzen, A, Kloc, M, Gladden, AB & Miller, RK 2021, , Cell Reports, vol. 36, no. 1, 109340. https://doi.org/10.1016/j.celrep.2021.109340

From Mesenchymal Stromal/Stem Cells to Insulin-Producing Cells: Immunological Considerations
Refaie, AF, Elbassiouny, BL, Kloc, M, Sabek, OM, Khater, SM, Ismail, AM, Mohamed, RH & Ghoneim, MA 2021, , Frontiers in immunology, vol. 12, 690623. https://doi.org/10.3389/fimmu.2021.690623

The role of monocytes and macrophages in homeostasis and disease and novel avenues for putative treatments
Kloc, M & Kubiak, JZ 2021, , International journal of molecular sciences, vol. 22, no. 9, 4927. https://doi.org/10.3390/ijms22094927

New insights into cellular functions of nuclear actin
Kloc, M, Chanana, P, Vaughn, N, Uosef, A, Kubiak, JZ & Ghobrial, RM 2021, , Biology, vol. 10, no. 4, 304. https://doi.org/10.3390/biology10040304

Exaptation of retroviral syncytin for development of syncytialized placenta, its limited homology to the sars-cov-2 spike protein and arguments against disturbing narrative in the context of covid-19 vaccination
Kloc, M, Uosef, A, Kubiak, JZ & Ghobrial, RM 2021, , Biology, vol. 10, no. 3, 238. https://doi.org/10.3390/biology10030238

Children were less frequently infected with SARS-CoV-2 than adults during 2020 COVID-19 pandemic in Warsaw, Poland
Kuchar, E, Zaleski, A, Wronowski, M, Krankowska, D, Podsiadly, E, Brodaczewska, K, Lewicka, A, Lewicki, S, Kieda, C, Horban, A, Kloc, M & Kubiak, JZ 2021, , European Journal of Clinical Microbiology and Infectious Diseases, vol. 40, no. 3, pp. 541-547. https://doi.org/10.1007/s10096-020-04038-9

Effects of vitamin D on macrophages and myeloid-derived suppressor cells (MDSCs) hyperinflammatory response in the lungs of COVID-19 patients
Kloc, M, Ghobrial, RM, Lipinska-Opalka, A, Wawrzyniak, A, Zdanowski, R, Kalicki, B & Kubiak, JZ 2021, , Cellular Immunology, vol. 360, 104259, pp. 104259. https://doi.org/10.1016/j.cellimm.2020.104259

Aquatic models of human ciliary diseases
Corkins, ME, Krneta-Stankic, V, Kloc, M & Miller, RK 2021, , Genesis, vol. 59, no. 1-2, e23410. https://doi.org/10.1002/dvg.23410

RhoA-and actin-dependent functions of macrophages from the rodent cardiac transplantation model perspective-timing is the essence
Kloc, M, Uosef, A, Villagran, M, Zdanowski, R, Kubiak, JZ, Wosik, J & Ghobrial, RM 2021, , Biology, vol. 10, no. 2, 70, pp. 1-16. https://doi.org/10.3390/biology10020070

Role of macrophages and rhoa pathway in atherosclerosis
Kloc, M, Uosef, A, Kubiak, JZ & Ghobrial, RM 2021, , International journal of molecular sciences, vol. 22, no. 1, 216, pp. 1-13. https://doi.org/10.3390/ijms22010216

The Assessment of the Usefulness of Selected Markers in the Diagnosis of Chronic Kidney Disease in Children
Bedzichowska, A, Jobs, K, Kloc, M, Bujnowska, A & Kalicki, B 2021, , Biomarker Insights, vol. 16. https://doi.org/10.1177/11772719211011173

Mitotic timing is differentially controlled by A- And B-type cyclins and by CDC6 associated with a bona fide CDK inhibitor Xic1 in Xenopus laevis cell-free extract
EL DIKA, MOHAMMED, WECHSELBERGER, LISA, DJEGHOUT, BILAL, BENOUARETH, DJAMELEDDINE, JEDERKA, KRYSTYNA, LEWICKI, SLAWOMIR, ZDANOWSKI, ROBERT, PRIGENT, CLAUDE, KLOC, MALGORZATA & KUBIAK, JACEKZ 2021, , International Journal of Developmental Biology, vol. 65, no. 7-9, pp. 487-496. https://doi.org/10.1387/IJDB.200313JK