Malcolm Brenner, MD, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Biography

Dr. Brenner completed his postdoctoral training in 1981 and joined the Clinical Research Centre of Northwick Park Hospital in London, England as a MRC Clinical Scientist and Honorary Senior Registrar. He also began lecturing in Haematology at the Royal Free Hospital and Hospital for Sick Children, also in London.

Dr. Brenner joined the faculty at the University of Tennessee in Memphis as a Professor in the Departments of Pediatrics and Medicine in 1990. He also became the Director of the Bone Marrow Transplant Division of the St. Jude Children's Research Hospital that same year. He later directed the Cell and Gene Therapy Program at St. Jude's from 1994 until 1997, when he assumed his current positions at the Baylor College of Medicine.

Description of Research

Dr. Brenner's research focuses on gene transfer to stem cells and to effector cells of the immune system. His research group was one of the first to use gene transfer in human subjects, establishing the feasibility of tracking human stem cells and their progeny in subjects with cancer. Dr. Brenner also develops tumor vaccines for pediatric and hematological malignancies, using genetic modification with retroviral and adenoviral vectors.

Areas Of Expertise

Stem cells Gene therapy Cell therapy Vectors
Education & Training

PhD, Cambridge University
Publications

Allogeneic hematopoietic stem cell transplant for relapsed and refractory non-Hodgkin lymphoma in pediatric patients
Naik, S, Martinez, CA, Omer, B, Sasa, G, Yassine, K, Allen, CE, Kamdar, K, Orth, R, Wu, M, Leung, K, Gottschalk, S, Brenner, MK, Heslop, H & Krance, RA 2019, Blood Advances, vol. 3, no. 18, pp. 2689-2695. https://doi.org/10.1182/bloodadvances.2018026203

Erratum: Tandem CAR T cells targeting HER2 and IL13Ra2 mitigate tumor antigen escape Trivalent CAR T cells overcome interpatient antigenic variability in glioblastoma (Journal of Clinical Investigation (2019) 129:8 (3464) DOI:10.1172/JCI131246)
Hegde, M, Mukherjee, M, Grada, Z, Pignata, A, Landi, D, Navai, SA, Wakefield, A, Fousek, K, Bielamowicz, K, Chow, KKH, Brawley, VS, Byrd, TT, Krebs, S, Gottschalk, S, Wels, WS, Baker, ML, Dotti, G, Mamonkin, M, Brenner, M, Orange, JS & Ahmed, N 2019, Journal of Clinical Investigation, vol. 129, no. 8. https://doi.org/10.1172/JCI131245

Adoptive Cell Therapy for Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia
Lulla, PD, Mamonkin, M & Brenner, M 2019, Cancer Journal (United States), vol. 25, no. 3, pp. 199-207. https://doi.org/10.1097/PPO.0000000000000376

Adoptive Cell Therapy: ACT-Up or ACT-Out?
Brenner, M 2019, Molecular Therapy. https://doi.org/10.1016/j.ymthe.2019.02.017

Chimeric antigen receptors for T-cell malignancies
Scherer, LD, Brenner, M & Mamonkin, M 2019, Frontiers in Oncology, vol. 9, no. MAR, 126. https://doi.org/10.3389/fonc.2019.00126

A phase I/IIa trial using CD19-targeted third-generation CAR T cells for lymphoma and leukemia
Enblad, G, Karlsson, H, Gammelgård, G, Wenthe, J, Lövgren, T, Amini, RM, Wikstrom, KI, Essand, M, Savoldo, B, Hallböök, H, Höglund, M, Dotti, G, Brenner, M, Hagberg, H & Loskog, A 2018, Clinical Cancer Research, vol. 24, no. 24, pp. 6185-6194. https://doi.org/10.1158/1078-0432.CCR-18-0426

EBV/LMP-specific T cells maintain remissions of T- and B-cell EBV lymphomas after allogeneic bone marrow transplantation
McLaughlin, LP, Rouce, R, Gottschalk, S, Torrano, V, Carrum, G, Wu, MF, Hoq, F, Grilley, B, Marcogliese, AM, Hanley, PJ, Gee, AP, Brenner, M, Rooney, CM, Heslop, H & Bollard, CM 2018, Blood, vol. 132, no. 22, pp. 2351-2361. https://doi.org/10.1182/blood-2018-07-863654

Enhancing the potency and specificity of engineered T cells for cancer treatment
Sukumaran, S, Watanabe, N, Bajgain, P, Raja, K, Mohammed, S, Fisher, WE, Brenner, M, Leen, AM & Vera, JF 2018, Cancer Discovery, vol. 8, no. 8, pp. 972-987. https://doi.org/10.1158/2159-8290.CD-17-1298

CAR T cell therapy for breast cancer: Harnessing the tumor milieu to drive T cell activation
Bajgain, P, Tawinwung, S, DElia, L, Sukumaran, S, Watanabe, N, Hoyos, V, Lulla, P, Brenner, M, Leen, AM & Vera, JF 2018, Journal for ImmunoTherapy of Cancer, vol. 6, no. 1, 34. https://doi.org/10.1186/s40425-018-0347-5

Tumor-specific t-cells engineered to overcome tumor immune evasion induce clinical responses in patients with relapsed hodgkin lymphoma
Bollard, CM, Tripic, T, Cruz, CR, Dotti, G, Gottschalk, S, Torrano, V, Dakhova, O, Carrum, G, Ramos, CA, Liu, H, Wu, MF, Marcogliese, AN, Barese, C, Zu, Y, Lee, DY, O’Connor, O, Gee, AP, Brenner, M, Heslop, H & Rooney, CM 2018, Journal of Clinical Oncology, vol. 36, no. 11, pp. 1128-1139. https://doi.org/10.1200/JCO.2017.74.3179

Onward and upward for immuno-oncology
Brenner, M 2018, Chinese Clinical Oncology, vol. 7, no. 2, 18. https://doi.org/10.21037/cco.2018.01.04

Seek and You Will Not Find: Ending the Hunt for Replication-Competent Retroviruses during Human Gene Therapy
Heslop, H & Brenner, M 2018, Molecular Therapy, vol. 26, no. 1, pp. 1-2. https://doi.org/10.1016/j.ymthe.2017.12.004

Outcomes after Allogeneic Transplant in Patients with Wiskott-Aldrich Syndrome
Ngwube, A, Hanson, IC, Orange, J, Rider, NL, Seeborg, F, Shearer, W, Noroski, L, Nicholas, S, Forbes, L, Leung, K, Sasa, G, Naik, S, Hegde, M, Omer, B, Ahmed, N, Allen, C, Gottschalk, S, Wu, MF, Liu, H, Brenner, M, Heslop, H, Krance, R & Martinez, C 2018, Biology of Blood and Marrow Transplantation. https://doi.org/10.1016/j.bbmt.2017.11.019

Reversible transgene expression reduces fratricide and permits 4-1BB Costimulation of CAR T cells directed to T-cell malignancies
Mamonkin, M, Mukherjee, M, Srinivasan, M, Sharma, S, Gomes-Silva, D, Mo, F, Krenciute, G, Orange, JS & Brenner, M 2018, Cancer Immunology Research, vol. 6, no. 1, pp. 47-58. https://doi.org/10.1158/2326-6066.CIR-17-0126

In Vivo Fate and Activity of Second- versus Third-Generation CD19-Specific CAR-T Cells in B Cell Non-Hodgkin's Lymphomas
Ramos, CA, Rouce, R, Robertson, CS, Reyna, A, Narala, N, Vyas, G, Mehta, B, Zhang, H, Dakhova, O, Carrum, G, Kamble, RT, Gee, AP, Mei, Z, Wu, MF, Liu, H, Grilley, B, Rooney, CM, Heslop, H, Brenner, M, Savoldo, B & Dotti, G 2018, Molecular Therapy. https://doi.org/10.1016/j.ymthe.2018.09.009

Current Allogeneic Hematopoietic Stem Cell Transplantation for Pediatric Acute Lymphocytic Leukemia: Success, Failure and Future Perspectives—A Single-Center Experience, 2008 to 2016
Yanir, AD, Martinez, CA, Sasa, G, Leung, K, Gottschalk, S, Omer, B, Ahmed, N, Hegde, M, Eunji, J, Liu, H, Heslop, H, Brenner, M, Krance, RA & Naik, S 2018, Biology of Blood and Marrow Transplantation. https://doi.org/10.1016/j.bbmt.2018.03.001

High Incidence of Autoimmune Disease after Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease
Yanir, AD, Hanson, IC, Shearer, WT, Noroski, LM, Forbes, LR, Seeborg, FO, Nicholas, S, Chinn, I, Orange, JS, Rider, NL, Leung, KS, Naik, S, Carrum, G, Sasa, G, Hegde, M, Omer, BA, Ahmed, N, Allen, CE, Khaled, Y, Wu, MF, Liu, H, Gottschalk, SM, Heslop, H, Brenner, M, Krance, RA & Martinez, CA 2018, Biology of Blood and Marrow Transplantation. https://doi.org/10.1016/j.bbmt.2018.03.029

Current gene marking and gene therapy protocols for human bone marrow transplantation
Brenner, M 2018, . in Somatic Gene Therapy. CRC Press, pp. 225-242. https://doi.org/10.1201/9781351076760

CD7 CAR T Cells for the Therapy of Acute Myeloid Leukemia
Gomes-Silva, D, Atilla, E, Atilla, PA, Mo, F, Tashiro, H, Srinivasan, M, Lulla, P, Rouce, RH, Cabral, JMS, Ramos, CA, Brenner, M & Mamonkin, M 2018, Molecular Therapy. https://doi.org/10.1016/j.ymthe.2018.10.001

C-MPL provides tumor-Targeted T-cell receptor-Transgenic T cells with costimulation and cytokine signals
Nishimura, CD, Brenner, DA, Mukherjee, M, Hirsch, RA, Ott, L, Wu, MF, Liu, H, Dakhova, O, Orange, JS, Brenner, M, Lin, CY & Arber, C 2017, Blood, vol. 130, no. 25, pp. 2739-2749. https://doi.org/10.1182/blood-2017-02-769463

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