Malcolm Brenner, MD, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Biography

Dr. Brenner completed his postdoctoral training in 1981 and joined the Clinical Research Centre of Northwick Park Hospital in London, England as a MRC Clinical Scientist and Honorary Senior Registrar. He also began lecturing in Haematology at the Royal Free Hospital and Hospital for Sick Children, also in London.

Dr. Brenner joined the faculty at the University of Tennessee in Memphis as a Professor in the Departments of Pediatrics and Medicine in 1990. He also became the Director of the Bone Marrow Transplant Division of the St. Jude Children's Research Hospital that same year. He later directed the Cell and Gene Therapy Program at St. Jude's from 1994 until 1997, when he assumed his current positions at the Baylor College of Medicine.

Description of Research

Dr. Brenner's research focuses on gene transfer to stem cells and to effector cells of the immune system. His research group was one of the first to use gene transfer in human subjects, establishing the feasibility of tracking human stem cells and their progeny in subjects with cancer. Dr. Brenner also develops tumor vaccines for pediatric and hematological malignancies, using genetic modification with retroviral and adenoviral vectors.

Areas Of Expertise

Stem cells Gene therapy Cell therapy Vectors
Education & Training

PhD, Cambridge University
Publications

Oncolytic adeno-immunotherapy modulates the immune system enabling CAR T-cells to cure pancreatic tumors
Rosewell Shaw, A, Porter, CE, Yip, T, Mah, WC, McKenna, MK, Dysthe, M, Jung, Y, Parihar, R, Brenner, MK & Suzuki, M 2021, , Communications Biology, vol. 4, no. 1, 368. https://doi.org/10.1038/s42003-021-01914-8

Clinical effects of administering leukemia-specific donor T cells to patients with AML/MDS after allogeneic transplant
Lulla, PD, Naik, S, Vasileiou, S, Tzannou, I, Watanabe, A, Kuvalekar, M, Lulla, S, Carrum, G, Ramos, CA, Kamble, R, Hill, LQ, Randhawa, J, Gottschalk, S, Krance, R, Wang, T, Wu, M, Robertson, C, Gee, AP, Chung, B, Grilley, B, Brenner, MK, Heslop, HE, Vera, JF & Leen, AM 2021, , Blood, vol. 137, no. 19, pp. 2585-2597. https://doi.org/10.1182/blood.2020009471

Oncolytic adenovirus and gene therapy with EphA2-BiTE for the treatment of pediatric high-grade gliomas
Arnone, CM, Polito, VA, Mastronuzzi, A, Carai, A, Diomedi, FC, Antonucci, L, Petrelli, LL, Vinci, M, Ferrari, F, Salviato, E, Scarsella, M, De Stefanis, C, Weber, G, Quintarelli, C, De Angelis, B, Brenner, MK, Gottschalk, S, Hoyos, V, Locatelli, F, Caruana, I & Del Bufalo, F 2021, , Journal for immunotherapy of cancer, vol. 9, no. 5, e001930. https://doi.org/10.1136/jitc-2020-001930

T-Cell Therapy for Lymphoma Using Nonengineered Multiantigen-Targeted T Cells Is Safe and Produces Durable Clinical Effects
Vasileiou, S, Lulla, PD, Tzannou, I, Watanabe, A, Kuvalekar, M, Callejas, WL, Bilgi, M, Wang, T, Wu, MJ, Kamble, R, Ramos, CA, Rouce, RH, Zeng, Z, Gee, AP, Grilley, BJ, Vera, JF, Bollard, CM, Brenner, M, Heslop, HE, Rooney, CM, Leen, AM & Carrum, G 2021, , Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol. 39, no. 13, pp. 1415-1425. https://doi.org/10.1200/JCO.20.02224

Reversal of exhaustion in engineered T cells
Mamonkin, M & Brenner, MK 2021, , Science, vol. 372, no. 6537, pp. 34-35. https://doi.org/10.1126/science.abh0583

Taking T-Cell Oncotherapy Off-the-Shelf
Mo, F, Mamonkin, M, Brenner, MK & Heslop, HE 2021, , Trends in Immunology, vol. 42, no. 3, pp. 261-272. https://doi.org/10.1016/j.it.2021.01.004

Mesenchymal stromal cell delivery of oncolytic immunotherapy improves CAR-T cell antitumor activity
McKenna, MK, Englisch, A, Brenner, B, Smith, T, Hoyos, V, Suzuki, M & Brenner, MK 2021, , Molecular Therapy, vol. 29, no. 5, pp. 1808-1820. https://doi.org/10.1016/j.ymthe.2021.02.004

Anti-CD30 CAR-T Cell Therapy in Relapsed and Refractory Hodgkin Lymphoma
Ramos, CA, Grover, NS, Beaven, AW, Lulla, PD, Wu, MF, Ivanova, A, Wang, T, Shea, TC, Rooney, CM, Dittus, C, Park, SI, Gee, AP, Eldridge, PW, McKay, KL, Mehta, B, Cheng, CJ, Buchanan, FB, Grilley, BJ, Morrison, K, Brenner, MK, Serody, JS, Dotti, G, Heslop, HE & Savoldo, B 2020, , Journal of Clinical Oncology, vol. 38, no. 32, pp. 3794-3804. https://doi.org/10.1200/JCO.20.01342

Transgenic CD8aß co-receptor rescues endogenous TCR function in TCR-transgenic virus-specific T cells
Bajwa, G, Lanz, I, Cardenas, M, Brenner, MK & Arber, C 2020, , Journal for immunotherapy of cancer, vol. 8, no. 2, e001487. https://doi.org/10.1136/jitc-2020-001487

Modulating tnfa activity allows transgenic il15-expressing cll-1 car t cells to safely eliminate acute myeloid leukemia
Ataca Atilla, P, McKenna, MK, Tashiro, H, Srinivasan, M, Mo, F, Watanabe, N, Simons, BW, McLean Stevens, A, Redell, MS, Heslop, HE, Mamonkin, M, Brenner, MK & Atilla, E 2020, , Journal for immunotherapy of cancer, vol. 8, no. 2, e001229. https://doi.org/10.1136/jitc-2020-001229

The safety and clinical effects of administering a multiantigen-targeted T cell therapy to patients with multiple myeloma
Lulla, PD, Tzannou, I, Vasileiou, S, Carrum, G, Ramos, CA, Kamble, R, Wang, T, Wu, M, Bilgi, M, Gee, AP, Mukhi, S, Chung, B, Wang, L, Watanabe, A, Kuvalekar, M, Jeong, M, Li, Y, Ketkar, S, French-Kim, M, Grilley, B, Brenner, MK, Heslop, HE, Vera, JF & Leen, AM 2020, , Science translational medicine, vol. 12, no. 554, eaaz3339. https://doi.org/10.1126/SCITRANSLMED.AAZ3339

Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma
Hegde, M, Joseph, SK, Pashankar, F, DeRenzo, C, Sanber, K, Navai, S, Byrd, TT, Hicks, J, Xu, ML, Gerken, C, Kalra, M, Robertson, C, Zhang, H, Shree, A, Mehta, B, Dakhova, O, Salsman, VS, Grilley, B, Gee, A, Dotti, G, Heslop, H, Brenner, MK, Wels, WS, Gottschalk, S & Ahmed, N 2020, , Nature Communications, vol. 11, no. 1, 3549. https://doi.org/10.1038/s41467-020-17175-8

Oncolytic Adenovirus Armed with BiTE, Cytokine, and Checkpoint Inhibitor Enables CAR T Cells to Control the Growth of Heterogeneous Tumors
Porter, CE, Rosewell Shaw, A, Jung, Y, Yip, T, Castro, PD, Sandulache, VC, Sikora, A, Gottschalk, S, Ittman, MM, Brenner, M & Suzuki, M 2020, , Molecular Therapy, vol. 28, no. 5, pp. 1251-1262. https://doi.org/10.1016/j.ymthe.2020.02.016

Engineered off-the-shelf therapeutic T cells resist host immune rejection
Mo, F, Watanabe, N, McKenna, MK, Hicks, MJ, Srinivasan, M, Gomes-Silva, D, Atilla, E, Smith, T, Ataca Atilla, P, Ma, R, Quach, D, Heslop, HE, Brenner, MK & Mamonkin, M 2021, , Nature Biotechnology, vol. 39, no. 1, pp. 56-63. https://doi.org/10.1038/s41587-020-0601-5

T-cell receptor stimulation enhances the expansion and function of CD19 chimeric antigen receptor–expressing T cells
Lapteva, N, Gilbert, M, Diaconu, I, Rollins, LA, Al-Sabbagh, M, Naik, S, Krance, RA, Tripic, T, Hiregange, M, Raghavan, D, Dakhova, O, Rouce, RH, Liu, H, Omer, B, Savoldo, B, Dotti, G, Cruz, CR, Sharpe, K, Gates, M, Orozco, A, Durett, A, Pacheco, E, Gee, AP, Ramos, CA, Heslop, H, Brenner, M & Rooney, CM 2019, , Clinical Cancer Research, vol. 25, no. 24, pp. 7340-7350. https://doi.org/10.1158/1078-0432.CCR-18-3199

Allogeneic hematopoietic stem cell transplant for relapsed and refractory non-Hodgkin lymphoma in pediatric patients
Naik, S, Martinez, CA, Omer, B, Sasa, G, Yassine, K, Allen, CE, Kamdar, K, Orth, R, Wu, M, Leung, K, Gottschalk, S, Brenner, MK, Heslop, H & Krance, RA 2019, , Blood Advances, vol. 3, no. 18, pp. 2689-2695. https://doi.org/10.1182/bloodadvances.2018026203

Erratum: Tandem CAR T cells targeting HER2 and IL13Ra2 mitigate tumor antigen escape Trivalent CAR T cells overcome interpatient antigenic variability in glioblastoma (Journal of Clinical Investigation (2019) 129:8 (3464) DOI:10.1172/JCI131246)
Hegde, M, Mukherjee, M, Grada, Z, Pignata, A, Landi, D, Navai, SA, Wakefield, A, Fousek, K, Bielamowicz, K, Chow, KKH, Brawley, VS, Byrd, TT, Krebs, S, Gottschalk, S, Wels, WS, Baker, ML, Dotti, G, Mamonkin, M, Brenner, MK, Orange, JS & Ahmed, N 2019, , Journal of Clinical Investigation, vol. 129, no. 8, pp. 3464. https://doi.org/10.1172/JCI131245

Adoptive Cell Therapy for Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia
Lulla, PD, Mamonkin, M & Brenner, MK 2019, , Cancer Journal (United States), vol. 25, no. 3, pp. 199-207. https://doi.org/10.1097/PPO.0000000000000376

Adoptive Cell Therapy: ACT-Up or ACT-Out?
Brenner, MK 2019, , Molecular Therapy, vol. 27, no. 4, pp. 693-694. https://doi.org/10.1016/j.ymthe.2019.02.017

Chimeric antigen receptors for T-cell malignancies
Scherer, LD, Brenner, M & Mamonkin, M 2019, , Frontiers in Oncology, vol. 9, no. MAR, 126. https://doi.org/10.3389/fonc.2019.00126