Maen Abdelrahim, MD, PhD, B Pharm

Associate Professor of Medicine in Oncology, Academic Institute
Director, Cockrell Center for Advanced Therapeutics; Associate Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Abdelrahim completed pharmacy training followed by graduate work in the field of pharmacology and toxicology. Upon completion of his graduate work, clinical training as a medical oncologist fueled his motivation and expertise in the field of anticancer drug discovery.

His translational research focus is on the discovery and development of new anticancer drugs. He has identified for the first time a new structural class of compounds that can target selective transcription factor called Sp proteins. Transcription factors are now recognized as targets for the development of new anticancer drugs. 

Description of Research

  • Targeted therapy in GI cancer
  • Immunotherapy
  • T cell therapy 

Dr. Abdelrahim's research has pinpointed few compounds that inhibit tumor growth and angiogenesis in-part by inducing proteasome-dependent degradation of selected Sp proteins in cancer cells and tumors. The lead compound of this class (Tolfenamic acid) has reached Phase I Clinical Trial to treat patients with advanced and metastatic pancreatic cancer in combination with gemcitabine and radiation therapy. Dr. Abdelrahim has a patent application submitted for the new use of these compounds in GI cancers. In prior research, he was the first to find that Sp4 protein is over expressed in GI cancers including pancreatic cancer and that the role of Sp4 can be equally important as Sp1 in some type of GI cancers.

Researchers in cancer have the ultimate responsibility of taking their findings to the clinic which is described as translational research. By seeing GI cancer patients in his practice, collaborating with translational scientist in the lab and conducting and directing clinical trials, Dr. Abdelrahim hopes to continue to fuel the translational research cycle from lab to clinic and back to the lab.

 

Areas Of Expertise

Clinical trials Gastrointestinal cancer Clinical research Translation research
Education & Training

Internship, Baylor College of Medicine
Fellow, Duke University Medical Center
MD, Texas A&M Health Science Center College of Medicine
PhD, Texas A&M University
B Pharm, Isra University
Publications

Utilization of Immunotherapy for the Treatment of Hepatocellular Carcinoma in the Peri-Transplant Setting: Transplant Oncology View
Abdelrahim, M, Esmail, A, Saharia, A, Abudayyeh, A, Abdel-Wahab, N, Diab, A, Murakami, N, Kaseb, AO, Chang, JC, Gaber, AO & Ghobrial, RM 2022, , Cancers, vol. 14, no. 7, 1760. https://doi.org/10.3390/cancers14071760

Pancreatic head vs pancreatic body/tail cancer: Are they different?
Sun, K, Mylavarapu, C, Crenshaw, A, Zhang, Y, Hsu, E, Xu, J, Niravath, M, Jones, SL, Ordonez, A & Abdelrahim, M 2022, , World journal of gastrointestinal oncology, vol. 14, no. 3, pp. 716-723. https://doi.org/10.4251/wjgo.v14.i3.716

Transarterial Chemoembolization (TACE) Plus Sorafenib Compared to TACE Alone in Transplant Recipients with Hepatocellular Carcinoma: An Institution Experience
Abdelrahim, M, Victor, D, Esmail, A, Kodali, S, Graviss, EA, Nguyen, DT, Moore, LW, Saharia, A, McMillan, R, Fong, JN, Uosef, A, Elshawwaf, M, Heyne, K & Ghobrial, RM 2022, , Cancers, vol. 14, no. 3, 650. https://doi.org/10.3390/cancers14030650

Utility of Cell-Free DNA Detection in Transplant Oncology
Reddy, T, Esmail, A, Chang, JC, Ghobrial, RM & Abdelrahim, M 2022, , Cancers, vol. 14, no. 3, 743. https://doi.org/10.3390/cancers14030743

What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2020–2021?—Report of the Basic and Translational Research Committee of the International Liver Transplantation Society
Czigany, Z, Brüggenwirth, IMA, Ekser, B, Abdelrahim, M, Bhat, M, Bonaccorsi-Riani, E, Chen, A, Emamaullee, J, Eymard, C, Ho, CM, Mas, VR, Zarrinpar, A, Yuksel, M, Martins, PN & Selzner, M 2022, , Transplantation, vol. 106, no. 2, pp. 227-233. https://doi.org/10.1097/TP.0000000000004003

Emerging Concepts in Managing Malignancy in Kidney Transplant Patients
Schreiber, B, Abdelrahim, M, Abudayyeh, A & Murakami, N 2022, , Seminars in nephrology. https://doi.org/10.1016/j.semnephrol.2022.01.003

Triple-Regimen of Vemurafenib, Irinotecan, and Cetuximab for the Treatment of BRAFV600E-Mutant CRC: A Case Report and Review
Cho, SM, Esmail, A & Abdelrahim, M 2021, , Frontiers in Pharmacology, vol. 12, 795381. https://doi.org/10.3389/fphar.2021.795381

Transcription factors specificity protein and nuclear receptor 4A1 in pancreatic cancer
Safe, S, Mohankumar, K, Howard, M, Shrestha, R, Hedrick, E & Abdelrahim, M 2021, , World Journal of Gastroenterology, vol. 27, no. 38, pp. 6387-6398. https://doi.org/10.3748/wjg.v27.i38.6387

Transplant oncology: An evolving field in cancer care
Abdelrahim, M, Esmail, A, Abudayyeh, A, Murakami, N, Saharia, A, McMillan, R, Victor, D, Kodali, S, Shetty, A, Fong, JVN, Moore, LW, Heyne, K, Gaber, AO & Ghobrial, RM 2021, , Cancers, vol. 13, no. 19, 4911. https://doi.org/10.3390/cancers13194911

Clinical Outcomes Among Patients With Metastatic Pancreatic Ductal Adenocarcinoma Treated With Liposomal Irinotecan
Yu, KH, Hendifar, AE, Alese, OB, Draper, A, Abdelrahim, M, Burns, E, Khan, G, Cockrum, P, Bhak, RH, Nguyen, C, DerSarkissian, M, Duh, MS & Bahary, N 2021, , Frontiers in Oncology, vol. 11, pp. 678070. https://doi.org/10.3389/fonc.2021.678070

Clinical Outcomes Among Patients With Metastatic Pancreatic Ductal Adenocarcinoma Treated With Liposomal Irinotecan
Yu, KH, Hendifar, AE, Alese, OB, Draper, A, Abdelrahim, M, Burns, E, Khan, G, Cockrum, P, Bhak, RH, Nguyen, C, DerSarkissian, M, Duh, MS & Bahary, N 2021, , Frontiers in Oncology, vol. 11, 678070. https://doi.org/10.3389/fonc.2021.678070

Incidence, predictors, and survival impact of acute kidney injury in patients with melanoma treated with immune checkpoint inhibitors: a 10-year single-institution analysis
Abdelrahim, M, Mamlouk, O, Lin, H, Lin, J, Page, V, Abdel-Wahab, N, Swan, JT, Selamet, U, Yee, C, Diab, A, Suki, W & Abudayyeh, A 2021, , OncoImmunology, vol. 10, no. 1, 1927313. https://doi.org/10.1080/2162402X.2021.1927313

Incidence, predictors, and survival impact of acute kidney injury in patients with melanoma treated with immune checkpoint inhibitors: a 10-year single-institution analysis
Abdelrahim, M, Mamlouk, O, Lin, H, Lin, J, Page, V, Abdel-Wahab, N, Swan, J, Selamet, U, Yee, C, Diab, A, Suki, W & Abudayyeh, A 2021, , OncoImmunology, vol. 10, no. 1, 1927313, pp. 1927313. https://doi.org/10.1080/2162402X.2021.1927313

Hepatitis B Virus Reactivation in Cancer Patients Treated with Immune Checkpoint Inhibitors
Burns, EA, Muhsen, IN, Anand, K, Xu, J, Umoru, G, Arain, AN & Abdelrahim, M 2021, , Journal of Immunotherapy, vol. 44, no. 3, pp. 132-139. https://doi.org/10.1097/CJI.0000000000000358

The latest advancement in pancreatic ductal adenocarcinoma therapy: A review article for the latest guidelines and novel therapies
Elsayed, M & Abdelrahim, M 2021, , Biomedicines, vol. 9, no. 4, 389. https://doi.org/10.3390/biomedicines9040389

New Breakthroughs for Liver Transplantation of Cholangiocarcinoma
McMillan, RR, Saharia, A, Abdelrahim, M & Ghobrial, RM 2021, , Current Transplantation Reports, vol. 8, no. 1, pp. 21-27. https://doi.org/10.1007/s40472-021-00313-6

Infliximab for the treatment of patients with checkpoint inhibitor–associated acute tubular interstitial nephritis
Lin, JS, Mamlouk, O, Selamet, U, Tchakarov, A, Glass, WF, Sheth, RA, Layman, RM, Dadu, R, Abdelwahab, N, Abdelrahim, M, Diab, A, Yee, C & Abudayyeh, A 2021, , OncoImmunology, vol. 10, no. 1, 1877415. https://doi.org/10.1080/2162402X.2021.1877415

A multi-center study on safety and efficacy of immune checkpoint inhibitors in cancer patients with kidney transplant
Immune Checkpoint Inhibitors in Solid Organ Transplant Consortium 2021, , Kidney international, vol. 100, no. 1, pp. 196-205. https://doi.org/10.1016/j.kint.2020.12.015

Survival following liver transplantation for locally advanced, unresectable intrahepatic cholangiocarcinoma
McMillan, RR, Javle, M, Kodali, S, Saharia, A, Mobley, C, Heyne, K, Hobeika, MJ, Lunsford, KE, Victor, DW, Shetty, A, McFadden, RS, Abdelrahim, M, Kaseb, A, Divatia, M, Yu, N, Nolte Fong, J, Moore, LW, Nguyen, DT, Graviss, EA, Gaber, AO, Vauthey, JN & Ghobrial, RM 2022, , American Journal of Transplantation, vol. 22, no. 3, pp. 823-832. https://doi.org/10.1111/ajt.16906

Renal Toxicity
Abdelrahim, M & Abudayyeh, A 2021, . in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1342, Springer, pp. 389-397. https://doi.org/10.1007/978-3-030-79308-1_16