Luping Huang

Luping Huang, MD, PhD

Assistant Research Professor of Transplant Immunology in Surgery, Academic Institute
Houston Methodist
Weill Cornell Medical College


lhuang3@houstonmethodist.org
Biography

Dr. Luping Huang earned her MD in Southeast University School of Medicine and Ph.D. in Tokushima University School of Medicine. She held faculty appointments at Baylor College of Medicine in Houston, Texas and Wright State University in Dayton, Ohio before becoming a member of Houston Methodist Research Institute in 2018.

Description of Research

Dr. Huang’s research interests are to determine the underlying mechanisms of TDRD1in prostate cancer and to develop a mouse monoclonal antibody that recognizes human TDRD1 protein with exceptional specificity and sensitivity which may contribute to diagnosis and prognosis of prostate cancer, she also interest to develop immunotherapy drugs and CAR-T which may benefit for prostate cancer treatment in the future.

 

Areas Of Expertise

Prostate cancer Immunotherapy Biomarker CAR-T Lung and renal injury and inflammation
Education & Training

Postdoctoral Fellowship, Baylor College of Medicine
Postdoctoral Fellowship, Tulane University School of Medicine
PhD, Tokushima University School of Medicine
MD, Southeast University School of Medicine
Publications

The cancer testis antigen TDRD1 regulates prostate cancer proliferation by associating with the snRNP biogenesis machinery
Kim, H, Barua, A, Huang, L, Zhou, T, Bolaji, M, Zachariah, S, Mitra, A, Jung, SY, He, B & Feng, Q 2023, , Oncogene, vol. 42, no. 22, pp. 1821-1831. https://doi.org/10.1038/s41388-023-02690-x

From bench to bedside: the history and progress of CAR T cell therapy
Mitra, A, Barua, A, Huang, L, Ganguly, S, Feng, Q & He, B 2023, , Frontiers in immunology, vol. 14, 1188049, pp. 1188049. https://doi.org/10.3389/fimmu.2023.1188049

Potential Mechanisms Involved in Chronic Kidney Disease of Unclear Etiology
Holliday, MW, Li, Q, Bustamante, EG, Niu, J, Huang, L, Espina, IM, Dominguez, JR, Truong, L, Murray, KO, Fan, L, Anumudu, SJ, Shah, M, Fischer, RSB, Vangala, C, Mandayam, S, Perez, J, Pan, JS, Ali, S, Awan, AA & Sheikh-Hamad, D 2022, , Clinical Journal of the American Society of Nephrology, vol. 17, no. 9, pp. 1293-1304. https://doi.org/10.2215/CJN.16831221

Multi-walled carbon nanotube carpets as scaffolds for U87MG glioblastoma multiforme cell growth
Parikh, SD, Dave, S, Huang, L, Wang, W, Mukhopadhyay, SM & Mayes, DA 2019, , Materials Science and Engineering C. https://doi.org/10.1016/j.msec.2019.110345

N-acetylcysteine modulation of mitochondrial respiration and blood brain barrier permeability is time depedent and cell type specific
El Amouri, SS, Waker, C, Huang, L, Smith, C & Mayes, DA 2018, , International Journal of Molecular Biology: Open Access, vol. 3, no. 6. <http://www.medcrave.com/articles/det/17052/N-acetylcysteine-modulation-of-mitochondrial-respiration-and-blood-brain-barrier-permeability-is-time-dependent-and-cell-type-specific>

Gender- and region-specific changes in estrogen signaling in aging rat brain mitochondria
Evola, CM, Hudson, TL, Huang, L, Corbett, AM & Mayes, DA 2018, , Aging, vol. 10, no. 8, pp. 2148-2169. https://doi.org/10.18632/aging.101538

Stanniocalcin-1 inhibits thrombin-induced signaling and protects from bleomycin-induced lung injury
Huang, L, Zhang, L, Ju, H, Li, Q, Pan, JSC, Al-Lawati, Z & Sheikh-Hamad, D 2015, , Scientific Reports, vol. 5, 18117. https://doi.org/10.1038/srep18117

Severe nephrotoxic nephritis following conditional and kidney-specific knockdown of stanniocalcin-1
Huang, L, Lou, Y, Ju, H, Zhang, L, Pan, JSC, Ross, A, Sun, Y, Truong, L & Sheikh-Hamad, D 2015, , PLoS ONE, vol. 10, no. 9, e0138440. https://doi.org/10.1371/journal.pone.0138440

Stanniocalcin-1 inhibits renal ischemia/reperfusion injury via an AMP-activated protein kinase-dependent pathway
Pan, JSC, Huang, L, Belousova, T, Lu, L, Yang, Y, Reddel, R, Chang, A, Ju, H, DiMattia, G, Tong, Q & Sheikh-Hamad, D 2015, , Journal of the American Society of Nephrology, vol. 26, no. 2, pp. 364-378. https://doi.org/10.1681/ASN.2013070703

AKI after conditional and kidney-specific knockdown of stanniocalcin-1
Huang, L, Belousova, T, Pan, JSC, Du, J, Ju, H, Lu, L, Zhang, P, Truong, L, Nuotio-Antar, A & Sheikh-Hamad, D 2014, , Journal of the American Society of Nephrology, vol. 25, no. 10, pp. 2303-2315. https://doi.org/10.1681/ASN.2013070690

Overexpression of stanniocalcin-1 inhibits reactive oxygen species and renal ischemia/reperfusion injury in mice
Huang, L, Belousova, T, Chen, M, Dimattia, G, Liu, D & Sheikh-Hamad, D 2012, , Kidney international, vol. 82, no. 8, pp. 867-877. https://doi.org/10.1038/ki.2012.223

Human stanniocalcin-1 suppresses angiotensin II-induced superoxide generation in cardiomyocytes through UCP3-mediated anti-oxidant pathway
Liu, D, Huang, L, Wang, Y, Wang, W, Wehrens, XHT, Belousova, T, Abdelrahim, M, Dimattia, G & Sheikh-Hamad, D 2012, , PLoS ONE, vol. 7, no. 5, e36994. https://doi.org/10.1371/journal.pone.0036994

Stanniocalcin-1 suppresses superoxide generation in macrophages through induction of mitochondrial UCP2
Wang, Y, Huang, L, Abdelrahim, M, Cai, Q, Truong, A, Bick, R, Poindexter, B & Sheikh-Hamad, D 2009, , Journal of Leukocyte Biology, vol. 86, no. 4, pp. 981-988. https://doi.org/10.1189/jlb.0708454

Anti-Inflammatory and renal protective actions of stanniocalcin-1 in a model of anti-glomerular basement membrane glomerulonephritis
Huang, L, Garcia, G, Lou, Y, Zhou, Q, Truong, L, Dimattia, G, Lan, XR, Lan, HY, Wang, Y & Sheikh-Hamad, D 2009, , American Journal of Pathology, vol. 174, no. 4, pp. 1368-1378. https://doi.org/10.2353/ajpath.2009.080476

Marinobufagenin interferes with the function of the mineralocorticoid receptor
Smith, CL, He, Q, Huang, L, Foster, E & Puschett, JB 2007, , Biochemical and Biophysical Research Communications, vol. 356, no. 4, pp. 930-934. https://doi.org/10.1016/j.bbrc.2007.03.085

The pure estrogen receptor antagonist ICI 182,780 promotes a novel interaction of estrogen receptor-a with the 3',5'-cyclic adenosine monophosphate response element-binding protein-binding protein/p300 coactivators
Jaber, BM, Gao, T, Huang, L, Karmakar, S & Smith, CL 2006, , Molecular Endocrinology, vol. 20, no. 11, pp. 2695-2710. https://doi.org/10.1210/me.2005-0218

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