Luan Truong, MD

Professor of Pathology and Genomic Medicine, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


After completing his training in renal pathology in 1984, Dr. Truong joined the Department of Pathology at Baylor College of Medicine. He was promoted to Associate Professor in 1990, and Professor in 1996. He currently holds full-time faculty appointment in the Department of Pathology, Weill Medical College of Cornell University and in the Houston Methodist Research Institute. He also hold adjunct faculty appointment in the Departments of Pathology and Medicine, Baylor College of Medicine. He has been the attending pathologist for the Harris County Hospital District and Houton Methodist since 1984, and has served as Chief of Nephropathology since 1989. Dr. Truong also serves as the Director of the Pathology Core for the interdepartmental NIH-funded O’Brien Research Center on Renal Inflammation. Well recognized in the area of nephropathology, Dr. Truong actively participates in scholarly activities in this field as section editor and peer-reviewer for many scientific journals, as leader in professional societies, and as lecturer in national and international scientific meetings. 

Description of Research

Dr. Truong´s research interests involve surgical pathology and nephropathology. In the area of surgical pathology, he is interested in using morphology to define new diseases and to improve the diagnostic accuracy of known diseases. He combines traditional clinicopathologic observation with novel immunohistochemical techniques to study case materials drawn from more than 30,000 surgical pathology specimens submitted to the Department of Pathology and Genomic Medicine annually. In the area of clinical nephropathology, Dr. Truong is interested in assessing the pathogenesis and natural behavior of several specific renal diseases using a clinico-pathologic approach, and has access to more than 10,000 renal biopsies accumulated in the renal pathology laboratory suitable for this purpose. In the area of experimental nephropathology, Dr. Truong’s research focuses on the pathogenesis of primary chronic tubulointerstitial nephritis. He has established a model of chronic obstructive uropathy by unilateral ligation of the ureter and has focused on cell cycle abnormality, including apoptosis and cell proliferation of tubular cells and interstitial cells as a crucial element in chronic tubulointerstitial injury. He is currently investigating preconditioning as a mechanism to attenuate acute tubular cell injury. He recently made the novel observation that activation of cell survival mechanisms, including the PI3 kinase pathway and survivin, may serve as important protective mechanisms. He also collaborates extensively with other investigators in the Texas Medical Center and elsewhere in terms of morphologic support and structure-function correlation studies on various renal diseases.

Areas Of Expertise

Kidney diseases Acute tubular cell injury chronic tubulointerstitial injury Renal transplantation Renal neoplasms
Education & Training

Residency, Baylor College of Medicine
MD, Pennsylvania State University College of Medicine

Disease different effects of global osteopontin and macrophage osteopontin in glomerular injury
Trostel, J, Truong, LD, Roncal-Jimenez, C, Miyazaki, M, Miyazaki-Anzai, S, Kuwabara, M, McMahan, R, Andres-Hernando, A, Sato, Y, Jensen, T, Lanaspa, MA, Johnson, RJ & Garcia, GE 2018, American Journal of Physiology - Renal Physiology, vol. 315, no. 4, pp. F759-F768. DOI: 10.1152/ajprenal.00458.2017

Clinical and pathologic outcomes of incidental IgA glomerular deposits (IgAGD) in donated kidneys in an ethnically diverse region of the USA
Gaber, LW, Khan, F, Barrios, R, Truong, L, Graviss, E, Nguyen, DTM & Suki, W 2018, Transplantation, vol. 102.

Kidney disease in the setting of HIV infection: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
Conference Participants 2018, Kidney International, vol. 93, no. 3, pp. 753-760. DOI: 10.1016/j.kint.2017.11.007

Spheroid-type of AL amyloid deposition associated with colonic adenocarcinoma: A case report with literature review
Kim, MJ, McCroskey, Z, Piao, Y, Belcheva, A, Truong, L, Kurtin, PJ & Ro, JY 2018, Pathology International, vol. 68, no. 2, pp. 123-127. DOI: 10.1111/pin.12618

Diagnostic histochemistry in medical diseases of the kidney
Cathro, HP, Shen, SS & Truong, LD 2018, Seminars in Diagnostic Pathology. DOI: 10.1053/j.semdp.2018.10.001

Sarcoid-like granulomas in renal cell carcinoma: The Houston Methodist Hospital experience
Arora, K, Divatia, MK, Truong, L, Shen, SS, Ayala, AG & Ro, JY 2017, Annals of Diagnostic Pathology, vol. 31, pp. 62-65. DOI: 10.1016/j.anndiagpath.2017.07.003

Complement activation: an atypical presentation of an atypical syndrome
Iardino, A, Bunin, V, Truong, LD & Preti, HA 2017, BMJ case reports, vol. 2017. DOI: 10.1136/bcr-2017-221798

Role of renal drug exposure in polymyxin B-induced nephrotoxicity
Manchandani, P, Zhou, J, Babic, JT, Ledesma, KR, Truong, LD & Tama, VH 2017, Antimicrobial agents and chemotherapy, vol. 61, no. 4, 02391-16. DOI: 10.1128/AAC.02391-16

Early detection of acute tubulointerstitial nephritis in the genesis of Mesoamerican nephropathy
Fischer, RSB, Vangala, C, Truong, L, Mandayam, S, Chavarria, D, Granera Llanes, OM, Fonseca Laguna, MU, Guerra Baez, A, Garcia, F, García-Trabanino, R & Murray, KO 2017, Kidney International. DOI: 10.1016/j.kint.2017.09.012

Role of mechanistic target of rapamycin (mTOR) in renal function and ischaemia–reperfusion induced kidney injury
Alshaman, R, Truong, L & Oyekan, A 2016, Clinical and Experimental Pharmacology and Physiology, vol. 43, no. 11, pp. 1087-1096. DOI: 10.1111/1440-1681.12648

Macrophage A2A Adenosine Receptors Are Essential to Protect from Progressive Kidney Injury
Truong, LD, Trostel, J, McMahan, R, Chen, JF & Garcia, GE 2016, American Journal of Pathology, vol. 186, no. 10, pp. 2601-2613. DOI: 10.1016/j.ajpath.2016.06.017

MiR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy
Badal, SS, Wang, Y, Long, J, Corcoran, DL, Chang, BH, Truong, LD, Kanwar, YS, Overbeek, PA & Danesh, FR 2016, Nature communications, vol. 7, 12076. DOI: 10.1038/ncomms12076

Characterization of polymyxin B biodistribution and disposition in an animal model
Manchandani, P, Zhou, J, Ledesma, KR, Truong, LD, Chow, DSL, Eriksen, JL & Tam, VH 2016, Antimicrobial agents and chemotherapy, vol. 60, no. 2, pp. 1029-1034. DOI: 10.1128/AAC.02445-15

Enigma (partially) resolved: Phospholipase A2 receptor is the cause of “idiopathic” membranous glomerulonephritis
Truong, LD & Seshan, SV 2015, American Journal of Physiology - Renal Physiology, vol. 309, no. 12, pp. F1000-F1002. DOI: 10.1152/ajprenal.00264.2015

Obstructive nephropathy: What the surgical pathologist should know
Truong, L & Mai, K 2015, Pathology Case Reviews, vol. 20, no. 6, pp. 250-255. DOI: 10.1097/PCR.0000000000000118

Severe nephrotoxic nephritis following conditional and kidney-specific knockdown of stanniocalcin-1
Huang, L, Lou, Y, Ju, H, Zhang, L, Pan, JSC, Ross, A, Sun, Y, Truong, LD & Sheikh-Hamad, D 2015, PLoS ONE, vol. 10, no. 9, e0138440. DOI: 10.1371/journal.pone.0138440

Invasive urothelial carcinoma exhibiting basal cell immunohistochemical markers: A variant of urothelial carcinoma associated with aggressive features
Mai, KT, Truong, LD, Ball, CG, Williams, P, Flood, TA & Belanger, EC 2015, Pathology Research and Practice, vol. 211, no. 8, pp. 610-618. DOI: 10.1016/j.prp.2015.05.005

Absence of nicotinic acetylcholine receptor a7 subunit amplifies inflammation and accelerates onset of fibrosis: An inflammatory kidney model
Truong, LD, Trostel, J & Garcia, GE 2015, FASEB Journal, vol. 29, no. 8, pp. 3558-3570. DOI: 10.1096/fj.14-262493

Kidney injury associated with telavancin dosing regimen in an animal model
Tam, VH, Ledesma, KR, Bowers, DR, Zhou, J & Truong, LD 2015, Antimicrobial agents and chemotherapy, vol. 59, no. 5, pp. 2930-2933. DOI: 10.1128/AAC.05002-14

Loss of PTEN promotes podocyte cytoskeletal rearrangement, aggravating diabetic nephropathy
Lin, JS, Shi, Y, Peng, H, Shen, X, Thomas, S, Wang, Y, Truong, LD, Dryer, SE, Hu, Z & Xu, J 2015, Journal of Pathology, vol. 236, no. 1, pp. 30-40. DOI: 10.1002/path.4508