Luan Truong, MD

Professor of Pathology and Genomic Medicine, Academic Institute
Houston Methodist
Weill Cornell Medical College


Biography

After completing his training in renal pathology in 1984, Dr. Truong joined the Department of Pathology at Baylor College of Medicine. He was promoted to Associate Professor in 1990, and Professor in 1996. He currently holds full-time faculty appointment in the Department of Pathology, Weill Medical College of Cornell University and in the Houston Methodist Research Institute. He also hold adjunct faculty appointment in the Departments of Pathology and Medicine, Baylor College of Medicine. He has been the attending pathologist for the Harris County Hospital District and Houston Methodist since 1984, and has served as Chief of Nephropathology since 1989. Dr. Truong also serves as the Director of the Pathology Core for the interdepartmental NIH-funded O’Brien Research Center on Renal Inflammation. Well recognized in the area of nephropathology, Dr. Truong actively participates in scholarly activities in this field as section editor and peer-reviewer for many scientific journals, as leader in professional societies, and as lecturer in national and international scientific meetings. 

Description of Research

Dr. Truong´s research interests involve surgical pathology and nephropathology. In the area of surgical pathology, he is interested in using morphology to define new diseases and to improve the diagnostic accuracy of known diseases. He combines traditional clinicopathologic observation with novel immunohistochemical techniques to study case materials drawn from more than 30,000 surgical pathology specimens submitted to the Department of Pathology and Genomic Medicine annually. In the area of clinical nephropathology, Dr. Truong is interested in assessing the pathogenesis and natural behavior of several specific renal diseases using a clinico-pathologic approach, and has access to more than 10,000 renal biopsies accumulated in the renal pathology laboratory suitable for this purpose. In the area of experimental nephropathology, Dr. Truong’s research focuses on the pathogenesis of primary chronic tubulointerstitial nephritis. He has established a model of chronic obstructive uropathy by unilateral ligation of the ureter and has focused on cell cycle abnormality, including apoptosis and cell proliferation of tubular cells and interstitial cells as a crucial element in chronic tubulointerstitial injury. He is currently investigating preconditioning as a mechanism to attenuate acute tubular cell injury. He recently made the novel observation that activation of cell survival mechanisms, including the PI3 kinase pathway and survivin, may serve as important protective mechanisms. He also collaborates extensively with other investigators in the Texas Medical Center and elsewhere in terms of morphologic support and structure-function correlation studies on various renal diseases.

Areas Of Expertise

Kidney diseases Acute tubular cell injury chronic tubulointerstitial injury Renal transplantation Renal neoplasms
Education & Training

Residency, Baylor College of Medicine
MD, Pennsylvania State University College of Medicine
Publications

Monocytes and Macrophages in Kidney Disease and Homeostasis
Nachiappa Ganesh, R, Garcia, G & Truong, L 2024, , International journal of molecular sciences, vol. 25, no. 7, 3763. https://doi.org/10.3390/ijms25073763

Reproducibility and prognostic ability of chronicity parameters in kidney biopsy – Comprehensive evaluation comparing microscopy and artificial intelligence in digital pathology
Nachiappa Ganesh, R, Graviss, EA, Nguyen, D, El-Zaatari, Z, Gaber, L, Barrios, R, Truong, L & Farris, AB 2024, , Human Pathology, vol. 146, pp. 75-85. https://doi.org/10.1016/j.humpath.2024.04.006

Vancomycin nephrotoxicity: A comprehensive clinico-pathological study
Ganesh, RN, Edwards, A, Zaatari, ZE, Gaber, L, Barrios, R & Truong, LD 2024, , PLoS ONE, vol. 19, no. 3 March, e0295136. https://doi.org/10.1371/journal.pone.0295136

A Woman with Bilateral Pheochromocytoma and Tuberous Sclerosis Complex
Zahid, M, Koshy, S, Shakil, J, Khadra, HS, Truong, LD & Sadhu, AR 2024, , AACE Clinical Case Reports, vol. 10, no. 2, pp. 41-44. https://doi.org/10.1016/j.aace.2023.12.001

Myoglobin Cast Nephropathy Diagnosed on Renal Biopsy in a Patient Treated for Malarial Infection
Varadarajan, R, Patel, A, Salah, H, Sutaria, N, Barrios, R, Truong, L, Gaber, L & El-Zaatari, ZM 2024, , Case Reports in Nephrology, vol. 2024, 6764335, pp. 6764335. https://doi.org/10.1155/2024/6764335

Recurrent Pleural Effusion Associated With Candida Albicans Infection in Transplanted Kidney: A Case Report
Siddiqui, A, Truong, L & Shakil, J 2024, , Transplantation Proceedings, vol. 56, no. 6, pp. 1509-1512. https://doi.org/10.1016/j.transproceed.2024.05.021

Zileuton ameliorates aminoglycoside and polymyxin-associated acute kidney injury in an animal model
Hudson, CS, Smith, JE, Eales, BM, Kajiji, S, Liu, X, Truong, LD & Tam, VH 2023, , Journal of Antimicrobial Chemotherapy, vol. 78, no. 10, pp. 2435-2441. https://doi.org/10.1093/jac/dkad246

Renal oncocytoma with vacuolated cells and giant mitochondria: Report of a rare tumor and review of the literature
Patel, A, Aland, J, Salah, H, Truong, LD, Goldfarb, DW & El-Zaatari, ZM 2023, , Human Pathology Reports, vol. 33, 300719. https://doi.org/10.1016/j.hpr.2023.300719

Increased Diagnostic Specificity of Congo Red Stain for Amyloid: The Potential Role of Texas Red–Filtered Fluorescence Microscopy
Shehabeldin, A, Hussey, C, Aggad, R & Truong, L 2023, , Archives of Pathology and Laboratory Medicine, vol. 147, no. 8, pp. 907-915. https://doi.org/10.5858/ARPA.2021-0512-OA

Graft Microthrombus Formation in Postreperfusion Biopsies: Comprehensive Morphologic Characterization and Impact on Graft Outcome
Nachiappa Ganesh, R, Graviss, EA, Nguyen, DT, El-Zaatari, Z, Gaber, L, Barrios, R & Truong, L 2023, , Kidney International Reports, vol. 8, no. 7, pp. 1439-1444. https://doi.org/10.1016/j.ekir.2023.04.008

Proliferative glomerulonephritis with monoclonal IgG deposits: a unique case with a clinical course of over 46 years
James, T, Afrouzian, M, Truong, L, Aleter, O, Badalamenti, J & Kassem, H 2023, , BMC Nephrology, vol. 24, no. 1, 109, pp. 109. https://doi.org/10.1186/s12882-023-03178-2

Notch Blockade Specifically in Bone Marrow-Derived FSP-1-Positive Cells Ameliorates Renal Fibrosis
Wu, Y, Liang, M, Huang, F, Cheng, OH, Xiao, X, Lee, TH, Truong, L & Cheng, J 2023, , Cells, vol. 12, no. 2, 214. https://doi.org/10.3390/cells12020214

Graft Microthrombus Formation in Postreperfusion Biopsies: Comprehensive Morphologic Characterization and Impact on Graft Outcome
Nachiappa Ganesh, R, Graviss, EA, Nguyen, DT, El-Zaatari, Z, Gaber, L, Barrios, R & Truong, L 2023, , Kidney International Reports, vol. 8, no. 7, pp. 1439-1444. https://doi.org/10.1016/j.ekir.2023.04.008

Delphi: A Democratic and Cost-Effective Method of Consensus Generation in Transplantation
Afrouzian, M, Kozakowski, N, Liapis, H, Broecker, V, Truong, L, Avila-Casado, C, Regele, H, Seshan, S, Ambruzs, JM, Farris, AB, Buob, D, Chander, PN, Cheraghvandi, L, Clahsen-van Groningen, MC, de Almeida Araujo, S, Ertoy Baydar, D, Formby, M, Galesic Ljubanovic, D, Herrera Hernandez, L, Honsova, E, Mohamed, N, Ozluk, Y, Rabant, M, Royal, V, Stevenson, HL, Toniolo, MF & Taheri, D 2023, , Transplant International, vol. 36, 11589. https://doi.org/10.3389/ti.2023.11589

Corrigendum: Delphi: A Democratic and Cost-Effective Method of Consensus Generation in Transplantation
Afrouzian, M, Kozakowski, N, Liapis, H, Broecker, V, Truong, L, Avila-Casado, C, Regele, H, Seshan, S, Ambruzs, JM, Farris, AB, Buob, D, Chander, PN, Cheraghvandi, L, Clahsen-van Groningen, MC, de Almeida Araujo, S, Baydar, DE, Formby, M, Ljubanovic, DG, Hernandez, LH, Honsova, E, Mohamed, N, Ozluk, Y, Rabant, M, Royal, V, Stevenson, HL, Toniolo, MF & Taheri, D 2023, , Transplant International, vol. 36, pp. 12046. https://doi.org/10.3389/ti.2023.12046

De Novo Fibrinogen A Alpha Chain Amyloidosis in a Kidney Transplant Patient: Case Report and Literature Review
Khaja, T, Truong, L & Nassar, G 2023, , Canadian Journal of Kidney Health and Disease, vol. 10, pp. 20543581231209207. https://doi.org/10.1177/20543581231209207

Thrombotic Microangiopathy in the Renal Allograft: Results of the TMA Banff Working Group Consensus on Pathologic Diagnostic Criteria
Afrouzian, M, Kozakowski, N, Liapis, H, Broecker, V, Truong, L, Avila-Casado, C, Regele, H, Seshan, S, Ambruzs, JM, Farris, AB, Buob, D, Chander, PN, Cheraghvandi, L, Clahsen-van Groningen, MC, de Almeida Araujo, S, Ertoy Baydar, D, Formby, M, Galesic Ljubanovic, D, Herrera Hernandez, L, Honsova, E, Mohamed, N, Ozluk, Y, Rabant, M, Royal, V, Stevenson, HL, Toniolo, MF & Taheri, D 2023, , Transplant International, vol. 36, 11590. https://doi.org/10.3389/ti.2023.11590

Corrigendum: Thrombotic Microangiopathy in the Renal Allograft: Results of the TMA Banff Working Group Consensus on Pathologic Diagnostic Criteria
Afrouzian, M, Kozakowski, N, Liapis, H, Broecker, V, Truong, L, Avila-Casado, C, Regele, H, Seshan, S, Ambruzs, JM, Farris, AB, Buob, D, Chander, PN, Cheraghvandi, L, Clahsen-van Groningen, MC, de Almeida Araujo, S, Baydar, DE, Formby, M, Ljubanovic, DG, Hernandez, LH, Honsova, E, Mohamed, N, Ozluk, Y, Rabant, M, Royal, V, Stevenson, HL, Toniolo, MF & Taheri, D 2023, , Transplant International, vol. 36, pp. 12047. https://doi.org/10.3389/ti.2023.12047

Temporal regulation of notch activation improves arteriovenous fistula maturation
Guo, Q, Chen, G, Cheng, H, Qing, Y, Truong, L, Ma, Q, Wang, Y & Cheng, J 2022, , Journal of Translational Medicine, vol. 20, no. 1, 543. https://doi.org/10.1186/s12967-022-03727-7

Papillary renal cell carcinoma with malakoplakia: A unique case
Roth, AA, Patel, A, Salah, H, Truong, LD & El-Zaatari, ZM 2022, , Human Pathology Reports, vol. 30, 300681. https://doi.org/10.1016/j.hpr.2022.300681