Luan Truong, MD

Professor of Pathology and Genomic Medicine, Academic Institute
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


After completing his training in renal pathology in 1984, Dr. Truong joined the Department of Pathology at Baylor College of Medicine. He was promoted to Associate Professor in 1990, and Professor in 1996. He currently holds full-time faculty appointment in the Department of Pathology, Weill Medical College of Cornell University and in the Houston Methodist Research Institute. He also hold adjunct faculty appointment in the Departments of Pathology and Medicine, Baylor College of Medicine. He has been the attending pathologist for the Harris County Hospital District and Houston Methodist since 1984, and has served as Chief of Nephropathology since 1989. Dr. Truong also serves as the Director of the Pathology Core for the interdepartmental NIH-funded O’Brien Research Center on Renal Inflammation. Well recognized in the area of nephropathology, Dr. Truong actively participates in scholarly activities in this field as section editor and peer-reviewer for many scientific journals, as leader in professional societies, and as lecturer in national and international scientific meetings. 

Description of Research

Dr. Truong´s research interests involve surgical pathology and nephropathology. In the area of surgical pathology, he is interested in using morphology to define new diseases and to improve the diagnostic accuracy of known diseases. He combines traditional clinicopathologic observation with novel immunohistochemical techniques to study case materials drawn from more than 30,000 surgical pathology specimens submitted to the Department of Pathology and Genomic Medicine annually. In the area of clinical nephropathology, Dr. Truong is interested in assessing the pathogenesis and natural behavior of several specific renal diseases using a clinico-pathologic approach, and has access to more than 10,000 renal biopsies accumulated in the renal pathology laboratory suitable for this purpose. In the area of experimental nephropathology, Dr. Truong’s research focuses on the pathogenesis of primary chronic tubulointerstitial nephritis. He has established a model of chronic obstructive uropathy by unilateral ligation of the ureter and has focused on cell cycle abnormality, including apoptosis and cell proliferation of tubular cells and interstitial cells as a crucial element in chronic tubulointerstitial injury. He is currently investigating preconditioning as a mechanism to attenuate acute tubular cell injury. He recently made the novel observation that activation of cell survival mechanisms, including the PI3 kinase pathway and survivin, may serve as important protective mechanisms. He also collaborates extensively with other investigators in the Texas Medical Center and elsewhere in terms of morphologic support and structure-function correlation studies on various renal diseases.

Areas Of Expertise

Kidney diseases Acute tubular cell injury chronic tubulointerstitial injury Renal transplantation Renal neoplasms
Education & Training

Residency, Baylor College of Medicine
MD, Pennsylvania State University College of Medicine

Vancomycin-Associated Tubular Casts and Vancomycin Nephrotoxicity
Tantranont, N, Luque, Y, Hsiao, M, Haute, C, Gaber, L, Barrios, R, Adrogue, HE, Niasse, A & Truong, LD 2021, , Kidney International Reports, vol. 6, no. 7, pp. 1912-1922.

PDGFRA in vascular adventitial MSCs promotes neointima formation in arteriovenous fistula in chronic kidney disease
Song, K, Qing, Y, Guo, Q, Peden, EK, Chen, C, Mitch, WE, Truong, L & Cheng, J 2020, , JCI insight, vol. 5, no. 21, e137298.

Prevalence, Characteristics, and Outcomes of Incidental IgA Glomerular Deposits in Donor Kidneys
Gaber, LW, Khan, FN, Graviss, EA, Nguyen, DT, Moore, LW, Truong, LD, Barrios, RJ & Suki, WN 2020, , Kidney International Reports, vol. 5, no. 11, pp. 1914-1924.

Prevalence, Characteristics, and Outcomes of Incidental IgA Glomerular Deposits in Donor Kidneys
Gaber, LW, Khan, FN, Graviss, EA, Nguyen, DT, Moore, LW, Truong, LD, Barrios, RJ & Suki, WN 2020, , Kidney International Reports, vol. 5, no. 11, pp. 1914-1924.

A global Slc7a7 knockout mouse model demonstrates characteristic phenotypes of human lysinuric protein intolerance
Stroup, BM, Marom, R, Li, X, Hsu, CW, Chang, CY, Truong, LD, Dawson, B, Grafe, I, Chen, Y, Jiang, MM, Lanza, D, Green, JR, Sun, Q, Barrish, JP, Ani, S, Christiansen, AE, Seavitt, JR, Dickinson, ME, Kheradmand, F, Heaney, JD, Lee, B & Burrage, LC 2020, , Human Molecular Genetics, vol. 29, no. 13, pp. 2171-2184.

A Case Report of Recurrent Lupus Nephritis 15 Days After Renal Transplantation
Romero Karam, LA, Patel, AM, Truong, L & Gonzalez, JM 2020, , Transplantation Proceedings, vol. 52, no. 2, pp. 614-618.

Outcomes of Kidney Transplantation using Deceased Donors with History of Diabetes
Khan, FN, Truong, LD, Nguyen, DT, Graviss, EA, Bhatti, MI, Frost, AE, Gaber, AO & Suki, WN 2019, , Clinical Transplantation, pp. e13775.

A Systematic Review of Interpathologist Agreement in Histologic Classification of Lupus Nephritis
Dasari, S, Chakraborty, A, Truong, L & Mohan, C 2019, , Kidney International Reports, vol. 4, no. 10, pp. 1420-1425.

Kidney donors with diabetes: Renal biopsy findings at time of transplantation and their significance
Truong, L, Suki, WN, Gaber, LW, Gaber, AO & Khan, F 2019, , Transplantation Direct, vol. 5, no. 7, e465.

Notch signaling in bone marrow–derived FSP-1 cells initiates neointima formation in arteriovenous fistulas
Liang, M, Guo, Q, Huang, F, Han, G, Song, K, Luo, J, Cheng, H, Hu, H, Peden, EK, Chen, C, Mitch, WE, Du, J, Fu, X, Truong, L & Cheng, J 2019, , Kidney international, vol. 95, no. 6, pp. 1347-1358.

Donor-related diabetic nephropathy: a comprehensive clinicopathological study
Truong, LD, Gaber, LW & Khan, F 2019, , Human Pathology, vol. 85, pp. 136-144.

Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice
Galvan, DL, Long, J, Green, N, Chang, BH, Lin, JS, Schumacker, P, Truong, L, Overbeek, P & Danesh, FR 2019, , Journal of Clinical Investigation, vol. 129, no. 7, pp. 2807-2823.

Rapidly Progressive Glomerulonephritis Secondary to IgA Nephropathy in a Patient with Systemic Lupus Erythematosus
Patel, AM, Karam, LAR, Rojas, SCF, Redfearn, WE, Truong, LD & Gonzalez, JM 2019, , Case Reports in Nephrology, vol. 2019, 8354823.

Disease different effects of global osteopontin and macrophage osteopontin in glomerular injury
Trostel, J, Truong, LD, Roncal-Jimenez, C, Miyazaki, M, Miyazaki-Anzai, S, Kuwabara, M, McMahan, R, Andres-Hernando, A, Sato, Y, Jensen, T, Lanaspa, MA, Johnson, RJ & Garcia, GE 2018, , American Journal of Physiology - Renal Physiology, vol. 315, no. 4, pp. F759-F768.

Clinical and pathologic outcomes of incidental IgA glomerular deposits (IgAGD) in donated kidneys in an ethnically diverse region of the USA
Gaber, LW, Khan, F, Barrios, R, Truong, L, Graviss, E, Nguyen, DTM & Suki, W 2018, Transplantation, vol. 102.

Kidney disease in the setting of HIV infection: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
Conference Participants 2018, , Kidney international, vol. 93, no. 3, pp. 545-559.

Spheroid-type of AL amyloid deposition associated with colonic adenocarcinoma: A case report with literature review
Kim, MJ, McCroskey, Z, Piao, Y, Belcheva, A, Truong, L, Kurtin, PJ & Ro, JY 2018, , Pathology International, vol. 68, no. 2, pp. 123-127.

Diagnostic histochemistry in medical diseases of the kidney
Cathro, HP, Shen, S & Truong, L 2018, , Seminars in Diagnostic Pathology, vol. 35, no. 6, pp. 360-369.

Sarcoid-like granulomas in renal cell carcinoma: The Houston Methodist Hospital experience
Arora, K, Divatia, MK, Truong, L, Shen, S, Ayala, A & Ro, J 2017, , Annals of Diagnostic Pathology, vol. 31, pp. 62-65.

Complement activation: an atypical presentation of an atypical syndrome
Iardino, A, Bunin, V, Truong, LD & Preti, HA 2017, , BMJ Case Reports, vol. 2017.