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Longhou Fang, PhD

Associate Professor of Cardiovascular Sciences, Academic Institute
Associate Member, Research Institute
Houston Methodist
Weill Cornell Medical College

Description of Research

The Fang lab employ zebrafish and mouse models to studying the role of lipid metabolism in angiogenesis and lymphangiogenesis. During his postdoctoral studies at UC San Diego, Dr. Fang discovered that apolipoprotein (apoA-I) binding protein (AIBP) controls angiogenesis via regulation of cholesterol homeostasis.Based upon the findings, the Fang laboratory will be focusing on the role of AIBP-regulated lipid metabolism in angiogenesis and lymphangiogenesis. We will use a plethora of disease models such as heart hypertrophy, heart ischemia and reperfusion, peripheral artery ischemia and reperfusion, corneal angiogenesis, and tumorigenesis in mice as well as in zebrafish heart regeneration. Both zebrafish and mouse model will be used to study the role of AIBP in lymphangiogenesis.

Areas Of Expertise

Angiogenesis Lymphangiogenesis hematopoiesis cholesterol metabolism
Education & Training

Postdoctoral Associate, University of California, San Diego
BS, Anhui Normal University
PhD, CAS - Shanghai Institute of Biochemistry and Cell Biology

Hematopoiesis is regulated by cholesterol efflux pathways and lipid rafts: Connections with cardiovascular diseases
Morgan, PK, Fang, L, Lancaster, GI & Murphy, AJ 2020, Journal of lipid research, vol. 61, no. 5, pp. 667-675.

Regulation of lipid rafts, angiogenesis and inflammation by AIBP
Fang, L & Miller, YI 2019, Current opinion in lipidology, vol. 30, no. 3, pp. 218-223.

AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate
Gu, Q, Yang, X, Lv, J, Zhang, J, Xia, B, Kim, JD, Wang, R, Xiong, F, Meng, S, Clements, TP, Tandon, B, Wagner, DS, Diaz, MF, Wenzel, PL, Miller, YI, Traver, D, Cooke, JP, Li, W, Zon, LI, Chen, K, Bai, Y & Fang, L 2019, , Science, pp. eaav1749.

TBX20 Regulates Angiogenesis Through the Prokineticin 2-Prokineticin Receptor 1 Pathway
Meng, S, Gu, Q, Yang, X, Lv, J, Owusu, I, Matrone, G, Chen, K, Cooke, JP & Fang, L 2018, Circulation, vol. 138, no. 9, pp. 913-928.

AIBP augments cholesterol efflux from alveolar macrophages to surfactant and reduces acute lung inflammation
Choi, SH, Wallace, AM, Schneider, DA, Burg, E, Kim, J, Alekseeva, E, Ubags, ND, Cool, CD, Fang, L, Suratt, BT & Miller, YI 2018, JCI insight, vol. 3, no. 16.

AIBP protects against metabolic abnormalities and atherosclerosis
Schneider, DA, Choi, SH, Agatisa-Boyle, C, Zhu, L, Kim, J, Pattison, J, Sears, DD, Gordts, PLSM, Fang, L & Miller, YI 2018, , Journal of lipid research, vol. 59, no. 5, pp. 854-863.

A minimally invasive approach to induce myocardial infarction in mice without thoracotomy
Sun, Q, Wang, KK, Pan, M, Zhou, JP, Qiu, XT, Wang, ZY, Yang, Z, Chen, Y, Shen, H, Gu, QL, Fang, L, Zhang, GG & Bai, YP 2018, , Journal of Cellular and Molecular Medicine, vol. 22, no. 11, pp. 5208-5219.

Lmo2 (LIM-Domain-Only 2) Modulates Sphk1 (Sphingosine Kinase) and Promotes Endothelial Cell Migration
Matrone, G, Meng, S, Gu, Q, Lv, J, Fang, L, Chen, K & Cooke, JP 2017, , Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 37, no. 10, pp. 1860-1868.

AIBP Limits Angiogenesis Through ?-Secretase-Mediated Upregulation of Notch Signaling
Mao, R, Meng, S, Gu, Q, Araujo-Gutierrez, R, Kumar, S, Yan, Q, Almazan, F, Youker, KA, Fu, Y, Pownall, HJ, Cooke, JP, Miller, YI & Fang, L 2017, , Circulation Research, vol. 120, no. 11, pp. 1727-1739.

AIBP: A Novel Molecule at the Interface of Cholesterol Transport, Angiogenesis, and Atherosclerosis
Zhu, L & Fang, L 2015, , Methodist DeBakey cardiovascular journal, vol. 11, no. 3, pp. 160-165.

Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development
Yang, H, Fang, L, Zhan, R, Hegarty, JM, Ren, J, Hsiai, TK, Gleeson, JG, Miller, YI, Trejo, JA & Chi, NC 2015, , Developmental Biology, vol. 404, no. 2, pp. 49-60.

Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia
Liu, C, Gates, KP, Fang, L, Amar, MJ, Schneider, DA, Geng, H, Huang, W, Kim, J, Pattison, J, Zhang, J, Witztum, JL, Remaley, AT, Dong, PD & Miller, YI 2015, , DMM Disease Models and Mechanisms, vol. 8, no. 8, pp. 989-998.

Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of MicroRNA-92a
Chen, Z, Wen, L, Martin, M, Hsu, CY, Fang, L, Lin, FM, Lin, TY, Geary, MJ, Geary, GG, Zhao, Y, Johnson, DA, Chen, JW, Lin, SJ, Chien, S, Huang, HD, Miller, YI, Huang, PH & Shyy, JYJ 2015, , Circulation, vol. 131, no. 9, pp. 805-814.

Zebrafish models of dyslipidemia: Relevance to atherosclerosis and angiogenesis
Fang, L, Liu, C & Miller, YI 2014, , Translational Research, vol. 163, no. 2, pp. 99-108.

Targeted cholesterol efflux
Fang, L & Miller, YI 2013, , Cell Cycle, vol. 12, no. 21, pp. 3345-3346.

Control of angiogenesis by AIBP-mediated cholesterol efflux
Fang, L, Choi, SH, Baek, JS, Liu, C, Almazan, F, Ulrich, F, Wiesner, P, Taleb, A, Deer, E, Pattison, J, Torres-Vázquez, J, Li, AC & Miller, YI 2013, , Nature, vol. 498, no. 7452, pp. 118-122.

Emerging applications for zebrafish as a model organism to study oxidative mechanisms and their roles in inflammation and vascular accumulation of oxidized lipids
Fang, L & Miller, YI 2012, , Free Radical Biology and Medicine, vol. 53, no. 7, pp. 1411-1420.

Ezetimibe and simvastatin reduce cholesterol levels in zebrafish larvae fed a high-cholesterol diet
Baek, JS, Fang, L, Li, AC & Miller, YI 2012, , Cholesterol, vol. 2012, 564705.

In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish
Fang, L, Green, SR, Baek, JS, Lee, SH, Ellett, F, Deer, E, Lieschke, GJ, Witztum, JL, Tsimikas, S & Miller, YI 2011, , Journal of Clinical Investigation, vol. 121, no. 12, pp. 4861-4869.

Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity
Miller, YI, Choi, SH, Wiesner, P, Fang, L, Harkewicz, R, Hartvigsen, K, Boullier, A, Gonen, A, Diehl, CJ, Que, X, Montano, E, Shaw, PX, Tsimikas, S, Binder, CJ & Witztum, JL 2011, Circulation Research, vol. 108, no. 2, pp. 235-248.