Li Lai, PhD

Assistant Research Professor of Cardiovascular Sciences, Academic Institute
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Transflammation in tissue regeneration and response to injury: How cell-autonomous inflammatory signaling mediates cell plasticity
Cooke, JP & Lai, L 2023, , Advanced Drug Delivery Reviews, vol. 203, 115118. https://doi.org/10.1016/j.addr.2023.115118

Epigenetic Regulation of Angiogenesis in Peripheral Artery Disease
Lai, L, Chen, Z, Malhi, NK & Southerland, KW 2023, , Methodist DeBakey cardiovascular journal, vol. 19, no. 5, pp. 47-57. https://doi.org/10.14797/mdcvj.1294

Role of angiogenic transdifferentiation in vascular recovery
Cooke, JP & Lai, L 2023, , Frontiers in Cardiovascular Medicine, vol. 10, 1155835, pp. 1155835. https://doi.org/10.3389/fcvm.2023.1155835

Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression
Lin, Q, He, Y, Wang, X, Zhang, Y, Hu, M, Guo, W, He, Y, Zhang, T, Lai, L, Sun, Z, Yi, Z, Liu, M & Chen, Y 2020, , Advanced Science, vol. 7, no. 9, 1903483. https://doi.org/10.1002/advs.201903483

Glycolytic Switch Is Required for Transdifferentiation to Endothelial Lineage
Lai, L, Reineke, EL, Hamilton, DJ & Cooke, JP 2019, , Circulation, vol. 139, no. 1, pp. 119-133. https://doi.org/10.1161/CIRCULATIONAHA.118.035741, https://doi.org/10.1161/CIRCULATIONAHA.118.035741

Aberrant FGFR tyrosine kinase signaling enhances the warburg effect by reprogramming LDH Isoform expression and activity in prostate cancer
Liu, J, Chen, G, Liu, Z, Liu, S, Cai, Z, You, P, Ke, Y, Lai, L, Huang, Y, Gao, H, Zhao, L, Pelicano, H, Huang, P, McKeehan, WL, Wu, CL, Wang, C, Zhong, W & Wang, F 2018, , Cancer research, vol. 78, no. 16, pp. 4459-4470. https://doi.org/10.1158/0008-5472.CAN-17-3226

LGR4 modulates breast cancer initiation, metastasis, and cancer stem cells
Yue, Z, Yuan, Z, Zeng, L, Wang, Y, Lai, L, Li, J, Sun, P, Xue, X, Qi, J, Yang, Z, Zheng, Y, Fang, Y, Li, D, Siwko, S, Li, Y, Luo, J & Liu, M 2018, , FASEB Journal, vol. 32, no. 5, pp. 2422-2437. https://doi.org/10.1096/fj.201700897R

Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis
Suh, JH, Lai, L, Nam, D, Kim, J, Jo, J, Taffet, GE, Kim, E, Kaelber, JT, Lee, HK, Entman, ML, Cooke, JP & Reineke, EL 2017, , Journal of Biological Chemistry, vol. 292, no. 52, pp. 21643-21652. https://doi.org/10.1074/jbc.M117.804740

Modulating DDAH/NOS Pathway to Discover Vasoprotective Insulin Sensitizers
Lai, L & Ghebremariam, YT 2016, , Journal of Diabetes Research, vol. 2016, 1982096. https://doi.org/10.1155/2016/1982096

PKA turnover by the REG?-proteasome modulates FoxO1 cellular activity and VEGF-induced angiogenesis
Liu, S, Lai, L, Zuo, Q, Dai, F, Wu, L, Wang, Y, Zhou, Q, Liu, J, Liu, J, Li, L, Lin, Q, Creighton, CJ, Costello, MG, Huang, S, Jia, C, Liao, L, Luo, H, Fu, J, Liu, M, Yi, Z, Xiao, J & Li, X 2014, , Journal of Molecular and Cellular Cardiology, vol. 72, pp. 28-38. https://doi.org/10.1016/j.yjmcc.2014.02.007

Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2
Wang, Y, Dong, J, Li, D, Lai, L, Siwko, S, Li, Y & Liu, M 2013, , STEM CELLS, vol. 31, no. 9, pp. 1921-1931. https://doi.org/10.1002/stem.1438

Lgr4 in ocular development and glaucoma
Siwko, S, Lai, L, Weng, J & Liu, M 2013, , Journal of Ophthalmology, vol. 2013, 987494. https://doi.org/10.1155/2013/987494

A Natural Small Molecule Harmine Inhibits Angiogenesis and Suppresses Tumour Growth through Activation of p53 in Endothelial Cells
Dai, F, Chen, Y, Song, Y, Huang, L, Zhai, D, Dong, Y, Lai, L, Zhang, T, Li, D, Pang, X, Liu, M & Yi, Z 2012, , PLoS ONE, vol. 7, no. 12, e52162. https://doi.org/10.1371/journal.pone.0052162

Cucurbitacin e inhibits breast tumor metastasis by suppressing cell migration and invasion
Zhang, T, Li, J, Dong, Y, Zhai, D, Lai, L, Dai, F, Deng, H, Chen, Y, Liu, M & Yi, Z 2012, , Breast Cancer Research and Treatment, vol. 135, no. 2, pp. 445-458. https://doi.org/10.1007/s10549-012-2175-5

Plumbagin inhibits tumour angiogenesis and tumour growth through the Ras signalling pathway following activation of the VEGF receptor-2
Lai, L, Liu, J, Zhai, D, Lin, Q, He, L, Dong, Y, Zhang, J, Lu, B, Chen, Y, Yi, Z & Liu, M 2012, , British Journal of Pharmacology, vol. 165, no. 4 B, pp. 1084-1096. https://doi.org/10.1111/j.1476-5381.2011.01532.x

1'-Acetoxychavicol acetate suppresses angiogenesis-mediated human prostate tumor growth by targeting VEGF-mediated Src-FAK-Rho GTPase-signaling pathway
Pang, X, Zhang, L, Lai, L, Chen, J, Wu, Y, Yi, Z, Zhang, J, Qu, W, Aggarwal, BB & Liu, M 2011, , Carcinogenesis, vol. 32, no. 6, pp. 904-912. https://doi.org/10.1093/carcin/bgr052