Unknown

Lewis W. Francis, PhD

Adjunct Associate Professor of Medicine, Academic Institute
Houston Methodist


Publications

Transcriptomic analysis reveals the anti-cancer effect of gestational mesenchymal stem cell secretome
Vaiasicca, S, Melone, G, James, DW, Quintela, M, Xiao, J, Yao, S, Finnell, RH, Conlan, RS, Francis, LW & Corradetti, B 2024, , Stem Cells Translational Medicine, vol. 13, no. 7, pp. 693-710. https://doi.org/10.1093/stcltm/szae024

Homeobox regulator Wilms Tumour 1 is displaced by androgen receptor at cis-regulatory elements in the endometrium of PCOS patients
James, DW, Quintela, M, Lucini, L, Alkafri, NK, Healey, GD, Younas, K, Bunkheila, A, Margarit, L, Francis, LW, Gonzalez, D & Conlan, RS 2024, , Frontiers in Endocrinology, vol. 15, 1368494, pp. 1368494. https://doi.org/10.3389/fendo.2024.1368494

Microneedle-Assisted Transfersomes as a Transdermal Delivery System for Aspirin
Rahbari, R, Francis, L, Guy, OJ, Sharma, S, Von Ruhland, C & Xia, Z 2023, , Pharmaceutics, vol. 16, no. 1, 57. https://doi.org/10.3390/pharmaceutics16010057

Elucidating Novel Targets for Ovarian Cancer Antibody–Drug Conjugate Development: Integrating In Silico Prediction and Surface Plasmon Resonance to Identify Targets with Enhanced Antibody Internalization Capacity
Onyido, EK, James, D, Garcia-Parra, J, Sinfield, J, Moberg, A, Coombes, Z, Worthington, J, Williams, N, Francis, LW, Conlan, RS & Gonzalez, D 2023, , Antibodies, vol. 12, no. 4, 65. https://doi.org/10.3390/antib12040065

Transcriptomic analysis of stem cells from chorionic villi uncovers the impact of chromosomes 2, 6 and 22 in the clinical manifestations of Down syndrome
Vaiasicca, S, Melone, G, James, DW, Quintela, M, Preziuso, A, Finnell, RH, Conlan, RS, Francis, LW & Corradetti, B 2023, , Stem Cell Research and Therapy, vol. 14, no. 1, 265, pp. 265. https://doi.org/10.1186/s13287-023-03503-4

Selenium nanoparticles modulate histone methylation via lysine methyltransferase activity and S-adenosylhomocysteine depletion
Toubhans, B, Alkafri, N, Quintela, M, James, DW, Bissardon, C, Gazze, S, Knodel, F, Proux, O, Gourlan, AT, Rathert, P, Bohic, S, Gonzalez, D, Francis, LW, Charlet, L & Conlan, RS 2023, , Redox Biology, vol. 61, 102641, pp. 102641. https://doi.org/10.1016/j.redox.2023.102641

Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells
Quintela, M, James, DW, Pociute, A, Powell, L, Edwards, K, Coombes, Z, Garcia, J, Garton, N, Das, N, Lutchman-Singh, K, Margarit, L, Beynon, AL, Rioja, I, Prinjha, RK, Harker, NR, Gonzalez, D, Conlan, RS & Francis, LW 2023, , Clinical Epigenetics, vol. 15, no. 1, 63, pp. 63. https://doi.org/10.1186/s13148-023-01477-x

Alginate oligosaccharides enhance the antifungal activity of nystatin against candidal biofilms
Powell, LC, Adams, JYM, Quoraishi, S, Py, C, Oger, A, Gazze, SA, Francis, LW, von Ruhland, C, Owens, D, Rye, PD, Hill, KE, Pritchard, MF & Thomas, DW 2023, , Frontiers in cellular and infection microbiology, vol. 13, 1122340. https://doi.org/10.3389/fcimb.2023.1122340

In silico enhancer mining reveals SNS-032 and EHMT2 inhibitors as therapeutic candidates in high-grade serous ovarian cancer
Quintela, M, James, DW, Garcia, J, Edwards, K, Margarit, L, Das, N, Lutchman-Singh, K, Beynon, AL, Rioja, I, Prinjha, RK, Harker, NR, Gonzalez, D, Steven Conlan, R & Francis, LW 2023, , British Journal of Cancer, vol. 129, no. 1, pp. 163-174. https://doi.org/10.1038/s41416-023-02274-2

Dinaciclib as an effective pan-cyclin dependent kinase inhibitor in platinum resistant ovarian cancer
Howard, D, James, D, Garcia-Parra, J, Pan-Castillo, B, Worthington, J, Williams, N, Coombes, Z, Rees, SC, Lutchman-Singh, K, Francis, LW, Rees, P, Margarit, L, Conlan, RS & Gonzalez, D 2022, , Frontiers in Oncology, vol. 12, 1014280, pp. 1014280. https://doi.org/10.3389/fonc.2022.1014280

Topical, immunomodulatory epoxy-tiglianes induce biofilm disruption and healing in acute and chronic skin wounds
Powell, LC, Cullen, JK, Boyle, GM, De Ridder, T, Yap, PY, Xue, W, Pierce, CJ, Pritchard, MF, Menzies, GE, Abdulkarim, M, Adams, JYM, Stokniene, J, Francis, LW, Gumbleton, M, Johns, J, Hill, KE, Jones, AV, Parsons, PG, Reddell, P & Thomas, DW 2022, , Science translational medicine, vol. 14, no. 662, abn3758. https://doi.org/10.1126/scitranslmed.abn3758

Complimentary protein extraction methods increase the identification of the Park Grass Experiment metaproteome
Quinn, GA, Abdelhameed, A, Banat, IM, Berrar, D, Doerr, SH, Dudley, E, Francis, LW, Gazze, SA, Hallin, I, Matthews, GP, Swain, MT, Whalley, WR & van Keulen, G 2022, , Applied Soil Ecology, vol. 173, 104388. https://doi.org/10.1016/j.apsoil.2022.104388

Mechanomimetic 3D Scaffolds as a Humanized In Vitro Model for Ovarian Cancer
Paradiso, F, Lenna, S, Gazze, SA, Parra, JG, Murphy, K, Margarit, L, Gonzalez, D, Francis, L & Taraballi, F 2022, , Cells, vol. 11, no. 5, 824. https://doi.org/10.3390/cells11050824

Studying Activated Fibroblast Phenotypes and Fibrosis-Linked Mechanosensing Using 3D Biomimetic Models
Paradiso, F, Quintela, M, Lenna, S, Serpelloni, S, James, D, Caserta, S, Conlan, S, Francis, L & Taraballi, F 2022, , Macromolecular Bioscience, vol. 22, no. 4, 2100450, pp. e2100450. https://doi.org/10.1002/mabi.202100450

Hyaluronic acid-functionalized nanomicelles enhance saha efficacy in 3d endometrial cancer models
Edwards, K, Yao, S, Pisano, S, Feltracco, V, Brusehafer, K, Samanta, S, Oommen, OP, Gazze, SA, Paravati, R, Maddison, H, Li, C, Gonzalez, D, Conlan, RS & Francis, L 2021, , Cancers, vol. 13, no. 16, 4032. https://doi.org/10.3390/cancers13164032

Jellyfish collagen: A biocompatible collagen source for 3d scaffold fabrication and enhanced chondrogenicity
Ahmed, Z, Powell, LC, Matin, N, Mearns-Spragg, A, Thornton, CA, Khan, IM & Francis, LW 2021, , Marine Drugs, vol. 19, no. 8, 405. https://doi.org/10.3390/md19080405

Functional analysis of non-genetic resistance to platinum in epithelial ovarian cancer reveals a role for the mbd3-nurd complex in resistance development
Bauer, TL, Collmar, K, Kaltofen, T, Loeffler, AK, Decker, L, Mueller, J, Pinter, S, Eisler, SA, Mahner, S, Fraungruber, P, Kommoss, S, Staebler, A, Francis, L, Conlan, RS, Zuber, J, Jeschke, U, Trillsch, F & Rathert, P 2021, , Cancers, vol. 13, no. 15, 3801. https://doi.org/10.3390/cancers13153801

High content, quantitative AFM analysis of the scalable biomechanical properties of extracellular vesicles
Gazze, SA, Thomas, SJ, Garcia-Parra, J, James, DW, Rees, P, Marsh-Durban, V, Corteling, R, Gonzalez, D, Conlan, RS & Francis, LW 2021, , Nanoscale, vol. 13, no. 12, pp. 6129-6141. https://doi.org/10.1039/d0nr09235e

Dinaciclib, a bimodal agent effective against endometrial cancer
Howard, D, James, D, Murphy, K, Garcia-Parra, J, Pan-Castillo, B, Rex, S, Moul, A, Jones, E, Bilbao-Asensio, M, Michue-Seijas, S, Lutchman-Singh, K, Margarit, L, Francis, LW, Rees, P, Gonzalez, D & Conlan, RS 2021, , Cancers, vol. 13, no. 5, 1135, pp. 1-17. https://doi.org/10.3390/cancers13051135

Highly glycosylated MUC1 mediates high affinity L-selectin binding at the human endometrial surface
Francis, LW, Yao, SN, Powell, LC, Griffiths, S, Berquand, A, Piasecki, T, Howe, W, Gazze, AS, Farach-Carson, MC, Constantinou, P, Carson, D, Margarit, L, Gonzalez, D & Conlan, RS 2021, , Journal of Nanobiotechnology, vol. 19, no. 1, 50, pp. 50. https://doi.org/10.1186/s12951-021-00793-9

VIEW FULL PUBLICATIONS