Lawrence Rice, MD

Dottie and Jimmy C. Adair Distinguished Chair in Hematology, Department of Medicine
Professor of Medicine, Institute for Academic Medicine
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

After completing an Internal Medicine Internship, Residency, and Hematology fellowship at Baylor College of Medicine, Dr. Rice was appointed to the faculty and became a Professor of Medicine and Professor of Thrombosis Research. For more than 20 years, he served as the Hematology Program Director and Director of the required medical student Hematology/Oncology course.

In 2007, his primary affiliation changed to Chief of Hematology at Houston Methodist Hospital and Professor of Medicine at Weill Cornell Medical College. He has maintained an active Consultative Hematology practice at Houston Methodist for more than 30 years. This program is distinguished by the depth and breadth of the blood disorders managed, including Congenital TTP, paroxysmal nocturnal hemoglobinuria and Evans' syndrome. Two-thirds of his patients have "benign" hematologic disorders and one-third have hematologic malignancies.

Dr. Rice actively teaches medical students, residents and subspecialty fellows, and has received numerous teaching awards, including induction in the inaugural class of the Baylor Medicine Educator Hall of Fame. In 2009-2010, he received the Edward C. Lynch Outstanding Teacher Award from Houston Methodist Internal Medicine residents, the Houston Methodist GME Teacher of the Year Award, the Hematology Honorary Fellow (Outstanding Teacher) Award from graduating MD Anderson Hematology/Oncology fellows, and the Hematology Educator of the Year from Baylor Hematology/Oncology fellows. Dr. Rice frequently gives lectures and chairs national educational symposia and CME events.

Description of Research

Dr. Rice's research interests include:

-Thrombocytopenic disorders (ITP, TTP and HIT)
-Bleeding, clotting and anticoagulation problems
-Anemias, erythropoietin actions and iron metabolism
Recent clinical studies include participation in pivotal trials of novel platelet-stimulating hormones, anticoagulants, and iron-chelators.

Areas Of Expertise

Hematology Anemias Thrombocytopenias Anticoagulants Erythropoietin
Education & Training

Residency, Baylor College of Medicine
Clinical Fellowship, Baylor College of Medicine
MD, Emory University
Publications

HITs and misses in 100 years of heparin
Rice, L 2017, Hematology, vol 2017, no. 1, pp. 667-673. DOI: 10.1182/asheducation-2017.1.667

Recombinant ADAMTS-13: First-in-human pharmacokinetics and safety in congenital thrombotic thrombocytopenic purpura
Scully, M, Knöbl, P, Kentouche, K, Rice, L, Windyga, J, Schneppenheim, R, Kremer Hovinga, JA, Kajiwara, M, Fujimura, Y, Maggiore, C, Doralt, J, Hibbard, C, Martell, L & Ewenstein, B 2017, Blood, vol 130, no. 19, pp. 2055-2063. DOI: 10.1182/blood-2017-06-788026

Intravenous Immunoglobulin for Heparin-Induced Thrombocytopenia
Ibrahim, IF & Rice, L 2017, Chest, vol 152, no. 4, pp. 906-907. DOI: 10.1016/j.chest.2017.05.043

Leukapheresis reduces 4-week mortality in acute myeloid leukemia patients with hyperleukocytosis – a retrospective study from a tertiary center
Nan, X, Qin, Q, Gentille, C, Ensor, J, Leveque, C, Pingali, R, Phan, AT, Rice, L & Iyer, S 2017, Leukemia and Lymphoma, pp. 1-11. DOI: 10.1080/10428194.2016.1277386

Adult Hemophagocytic Lymphohistiocytosis: More Data; Even More Questions
Rice, L & Pacheco, J 2016, Critical Care Medicine, vol 44, no. 11, pp. 2119-2121. DOI: 10.1097/CCM.0000000000001946

Sickle Cell Trait and Rhabdomyolysis among U.S. Army Soldiers
Ibrahim, IF & Rice, L 2016, The New England journal of medicine, vol 375, no. 17, pp. 1695-6. DOI: 10.1056/NEJMc1611135

To the Editor
Ibrahim, IF & Rice, L 2016, New England Journal of Medicine, vol 375, no. 17, pp. 1695-1696. DOI: 10.1056/NEJMc1611135

Nonmalignant leukocyte disorders
Rice, L & Teruya, M 2016, . in Nonmalignant Hematology: Expert Clinical Review: Questions and Answers. Springer International Publishing, pp. 563-573. DOI: 10.1007/978-3-319-30352-9_48

Antiplatelet and anticoagulant agents
Ibrahim, IF & Rice, L 2016, . in Management of Bleeding Patients. Springer International Publishing, pp. 227-238. DOI: 10.1007/978-3-319-30726-8_25

Primary thyroid lymphoma presenting as dermatomyositis: A first case and review of the literature
Nan, X, Adike, A, Rice, L & Bunin, VM 2016, BMJ Case Reports, vol 2016, 215057. DOI: 10.1136/bcr-2016-215057

A need for a systematic genetic evaluation of hereditary polyuric patients
Bichet, DG, Rice, L & Levallois-Gignac, J 2016, Clinical Kidney Journal, vol 9, no. 2, pp. 177-179. DOI: 10.1093/ckj/sfw006

How low is too low: Statin induced hemolysis
Pacheco, JM, Yilmaz, M & Rice, L 2016, American Journal of Hematology, vol 91, no. 2, pp. 267. DOI: 10.1002/ajh.24105

Polycythemia vera: An appraisal of the biology and management 10 years after the discovery of JAK2 V617F
Stein, BL, Oh, ST, Berenzon, D, Hobbs, GS, Kremyanskaya, M, Rampal, RK, Abboud, CN, Adler, K, Heaney, ML, Jabbour, EJ, Komrokji, RS, Moliterno, AR, Ritchie, EK, Rice, L, Mascarenhas, J & Hoffman, R 2015, Journal of Clinical Oncology, vol 33, no. 33, pp. 3953-3960. DOI: 10.1200/JCO.2015.61.6474

There is no such thing as a "positive" antibody test: Diagnosing heparin-induced thrombocytopenia in 2015
Rice, L 2015, Chest, vol 148, no. 1, pp. 1-3. DOI: 10.1378/chest.15-0737

Sickle cell patients face death in the ICU
Rice, L & Teruya, M 2014, Critical Care Medicine, vol 42, no. 7, pp. 1730-1731. DOI: 10.1097/CCM.0000000000000387

Progressive anemia and left upper quadrant pain in a patient with polycythemia vera
Roberts, JA, Morales, M & Rice, L 2014, JAMA: The Journal of the American Medical Association, vol 311, no. 21, pp. 2227-2228. DOI: 10.1001/jama.2014.117

Fatal cardiac and renal allograft rejection with lenalidomide therapy for light-chain amyloidosis
Meyers, DE, Adu-Gyamfi, B, Segura, AM, Buja, LM, Mallidi, HR, Frazier, OH & Rice, L 2013, American Journal of Transplantation, vol 13, no. 10, pp. 2730-2733. DOI: 10.1111/ajt.12391

Successful long-term treatment of philadelphia chromosome-negative myeloproliferative neoplasms with combination of hydroxyurea and anagrelide
Ahn, IE, Natelson, E & Rice, L 2013, Clinical Lymphoma, Myeloma and Leukemia, vol 13, no. SUPPL. 2. DOI: 10.1016/j.clml.2013.05.015

PF4/heparin antibody testing and treatment of heparin-induced thrombocytopenia in the intensive care unit
Wanat, M, Fitousis, K, Hall, J & Rice, L 2013, Clinical and Applied Thrombosis/Hemostasis, vol 19, no. 3, pp. 297-302. DOI: 10.1177/1076029612438709

The amyloidoses: clinical features, diagnosis and treatment.
Baker, KR & Rice, L 2012, Houston Methodist DeBakey Cardiovascular Journal, vol 8, no. 3, pp. 3-7.