Lan Zhou

Lan Zhou, PhD, MD

Professor of Pathology and Laboratory Medicine, Academic Institute
Full Member, Research Institute
Vice-Chair for Research, Department of Pathology & Genomic Medicine
Houston Methodist
Weill Cornell Medical College


Publications

Loss of GSK3ß in hematopoietic stem cells results in normal hematopoiesis in mice
Lee, G, Franklin, J, Gupta, K, Liu, R, Zhou, L, Ryder, C, Sobieraj, L, Molitor, L, Abiona, O, Meyerson, H, Das, I, Jackson, Z & Wald, DN 2023, , Blood Advances, vol. 7, no. 23, pp. 7185-7189. https://doi.org/10.1182/bloodadvances.2022008094

Loss of HES1 expression is associated with extracellular matrix remodeling and tumor immune suppression in KRAS mutant colon adenocarcinomas
Wang, L, Gu, W, Zou, B, Kalady, M, Xin, W & Zhou, L 2023, , Scientific Reports, vol. 13, no. 1, 15999, pp. 15999. https://doi.org/10.1038/s41598-023-42234-7

Late Recurrence of Colorectal Carcinoma in Patients with Malignant Polyp and Risk Factors
Cui, M, Sadri, N, Awadallah, A, Zhou, L & Xin, W 2023, , International Journal of Surgical Pathology, vol. 31, no. 6, pp. 967-974. https://doi.org/10.1177/10668969221113498

Targeting CRABP-II overcomes pancreatic cancer drug resistance by reversing lipid raft cholesterol accumulation and AKT survival signaling
Yu, S, Wang, L, Che, D, Zhang, M, Li, M, Naito, M, Xin, W & Zhou, L 2022, , Journal of Experimental and Clinical Cancer Research, vol. 41, no. 1, 88. https://doi.org/10.1186/s13046-022-02261-0

Organoids as a Model System for Studying Notch Signaling in Intestinal Epithelial Homeostasis and Intestinal Cancer
Dou, Y, Pizarro, T & Zhou, L 2022, , American Journal of Pathology, vol. 192, no. 10, pp. 1347-1357. https://doi.org/10.1016/j.ajpath.2022.06.008

Endothelial PERK-ATF4-JAG1 axis activated by T-ALL remodels bone marrow vascular niche
Liu, C, Chen, Q, Shang, Y, Chen, L, Myers, J, Awadallah, A, Sun, J, Yu, S, Umphred-Wilson, K, Che, D, Dou, Y, Li, L, Wearsch, P, Ramírez-Bergeron, D, Beck, R, Xin, W, Jin, G, Adoro, S & Zhou, L 2022, , Theranostics, vol. 12, no. 6, pp. 2894-2907. https://doi.org/10.7150/thno.67710

O-Fucose and Fringe-modified NOTCH1 extracellular domain fragments as decoys to release niche-lodged hematopoietic progenitor cells
Yu, S, Wang, W, Albakri, M, Yu, X, Majihail, G, Lim, S, Lopilato, RK, Ito, A, Letterio, J, Haltiwanger, RS & Zhou, L 2021, , Glycobiology, vol. 31, no. 5, pp. 582-592. https://doi.org/10.1093/glycob/cwaa113

Notch-regulated dendritic cells restrain inflammation-associated colorectal carcinogenesis
Wang, L, Yu, S, Chan, ER, Chen, KY, Liu, C, Che, D, Awadallah, A, Myers, J, Askew, D, Huang, AY, Maillard, I, Huang, D, Xin, W & Zhou, L 2021, , Cancer immunology research, vol. 9, no. 3, pp. 348-361. https://doi.org/10.1158/2326-6066.CIR-20-0428

Peritumoral/vascular expression of PSMA as a diagnostic marker in hepatic lesions
Chen, W, Lee, Z, Awadallah, A, Zhou, L & Xin, W 2020, , Diagnostic Pathology, vol. 15, no. 1, 92. https://doi.org/10.1186/s13000-020-00982-4

A Review of Advances in Hematopoietic Stem Cell Mobilization and the Potential Role of Notch2 Blockade
Albakri, M, Tashkandi, H & Zhou, L 2020, , Cell Transplantation, vol. 29. https://doi.org/10.1177/0963689720947146

Systemic Notch downregulation promotes KrasG12D-induced myeloproliferative neoplasm
You, X, Wen, Z, Chang, YI, Ranheim, EA, Zhou, Y, Zhou, L, Kong, G & Zhang, J 2019, , British Journal of Haematology, vol. 186, no. 3, pp. e52-e56. https://doi.org/10.1111/bjh.15893

Downregulating Notch counteracts Kras G12D -induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm
Kong, G, You, X, Wen, Z, Chang, YI, Qian, S, Ranheim, EA, Letson, C, Zhang, X, Zhou, Y, Liu, Y, Rajagopalan, A, Zhang, J, Stieglitz, E, Loh, M, Hofmann, I, Yang, D, Zhong, X, Padron, E, Zhou, L, Pear, WS & Zhang, J 2019, , Leukemia, vol. 33, no. 3, pp. 671-685. https://doi.org/10.1038/s41375-018-0248-0

Kit-independent mast cell adhesion mediated by Notch
Murata, A, Hikosaka, M, Yoshino, M, Zhou, L & Hayashi, SI 2019, , International Immunology, vol. 31, no. 2, pp. 69-79. https://doi.org/10.1093/intimm/dxy067

Comparison of targeted next generation sequencing (NGS) versus isolated BRAF V600E analysis in patients with metastatic melanoma
Zhu, ML, Zhou, L & Sadri, N 2018, , Virchows Archiv, vol. 473, no. 3, pp. 371-377. https://doi.org/10.1007/s00428-018-2393-2

Notch2 blockade enhances hematopoietic stem cell mobilization and homing
Wang, W, Yu, S, Myers, J, Wang, Y, Xin, WW, Albakri, M, Xin, AW, Li, M, Huang, AY, Xin, W, Siebel, CW, Lazarus, HM & Zhou, L 2017, , Haematologica, vol. 102, no. 10, pp. 1785-1795. https://doi.org/10.3324/haematol.2017.168674

CRABP-II enhances pancreatic cancer cell migration and invasion by stabilizing interleukin 8 expression
Yu, S, Parameswaran, N, Li, M, Wang, Y, Jackson, MW, Liu, H, Xin, W & Zhou, L 2017, , Oncotarget, vol. 8, no. 32, pp. 52432-52444. https://doi.org/10.18632/oncotarget.14194

Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma
Wang, Y, Huang, D, Chen, KY, Cui, M, Wang, W, Huang, X, Awadellah, A, Li, Q, Friedman, A, Xin, WW, Di Martino, L, Cominelli, F, Miron, A, Chan, R, Fox, JG, Xu, Y, Shen, X, Kalady, MF, Markowitz, S, Maillard, I, Lowe, JB, Xin, W & Zhou, L 2017, , Gastroenterology, vol. 152, no. 1, pp. 193-205.e10. https://doi.org/10.1053/j.gastro.2016.09.004

Cellular Prion Protein Mediates Pancreatic Cancer Cell Survival and Invasion through Association with and Enhanced Signaling of Notch1
Wang, Y, Yu, S, Huang, D, Cui, M, Hu, H, Zhang, L, Wang, W, Parameswaran, N, Jackson, M, Osborne, B, Bedogni, B, Li, C, Sy, MS, Xin, W & Zhou, L 2016, , American Journal of Pathology, vol. 186, no. 11, pp. 2945-2956. https://doi.org/10.1016/j.ajpath.2016.07.010

Evaluation of Quantitative Real-Time PCR as a Hepatitis C Virus Supplementary Test After RIBA Discontinuation
Gong, S, Schmotzer, CL & Zhou, L 2016, , Journal of Clinical Laboratory Analysis, vol. 30, no. 5, pp. 418-423. https://doi.org/10.1002/jcla.21873

Aberrant notch signaling in the bone marrow microenvironment of acute lymphoid leukemia suppresses osteoblast-mediated support of hematopoietic niche function
Wang, W, Zimmerman, G, Huang, X, Yu, S, Myers, J, Wang, Y, Moreton, S, Nthale, J, Awadallah, A, Beck, R, Xin, W, Wald, D, Huang, AY & Zhou, L 2016, , Cancer research, vol. 76, no. 6, pp. 1641-1652. https://doi.org/10.1158/0008-5472.CAN-15-2092

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