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Kyuson Yun, PhD

Assistant Member, Research Institute
Assistant Professor of Neurology, Academic Institute
Houston Methodist
Weill Cornell Medical College


Yun Lab


Areas Of Expertise

Cancer stem cells Glioblastoma Brain cancer Medulloblastoma Targeted therapy Diagnostic device Signaling pathways
Education & Training

PhD, California Institute of Technology
BS, California Institute of Technology
Patents

Yap1 inhibitors and methods

Patent Number: WO 2017/197104 Al, Nov 16 2017

Publications

Glioblastoma Myeloid-Derived Suppressor Cell Subsets Express Differential Macrophage Migration Inhibitory Factor Receptor Profiles That Can Be Targeted to Reduce Immune Suppression
Alban, TJ, Bayik, D, Otvos, B, Rabljenovic, A, Leng, L, Jia-Shiun, L, Roversi, G, Lauko, A, Momin, AA, Mohammadi, AM, Peereboom, DM, Ahluwalia, MS, Matsuda, K, Yun, K, Bucala, R, Vogelbaum, MA & Lathia, JD 2020, Frontiers in immunology, vol. 11, 1191. https://doi.org/10.3389/fimmu.2020.01191

Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity
von Roemeling, CA, Wang, Y, Qie, Y, Yuan, H, Zhao, H, Liu, X, Yang, Z, Yang, M, Deng, W, Bruno, KA, Chan, CK, Lee, AS, Rosenfeld, SS, Yun, K, Johnson, AJ, Mitchell, DA, Jiang, W & Kim, BYS 2020, Nature Communications, vol. 11, no. 1, 1508. https://doi.org/10.1038/s41467-020-15129-8

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation
Yang, Z, Shi, J, Xie, J, Wang, Y, Sun, J, Liu, T, Zhao, Y, Zhao, X, Wang, X, Ma, Y, Malkoc, V, Chiang, C, Deng, W, Chen, Y, Fu, Y, Kwak, KJ, Fan, Y, Kang, C, Yin, C, Rhee, J, Bertani, P, Otero, J, Lu, W, Yun, K, Lee, AS, Jiang, W, Teng, L, Kim, BYS & Lee, LJ 2020, Nature Biomedical Engineering, vol. 4, no. 1, pp. 69-83. https://doi.org/10.1038/s41551-019-0485-1

MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes
Dhar, SS, Zhao, D, Lin, T, Gu, B, Pal, K, Wu, SJ, Alam, H, Lv, J, Yun, K, Gopalakrishnan, V, Flores, ER, Northcott, PA, Rajaram, V, Li, W, Shilatifard, A, Sillitoe, RV, Chen, K & Lee, MG 2018, , Molecular Cell, vol. 70, no. 5, pp. 825-841.e6. https://doi.org/10.1016/j.molcel.2018.04.028

Yap1 inhibitors and methods
Yun, K & Zhai, H-X May. 11 2017, , Patent No. WO 2017/197104 Al, IPC No. A61K 31/409 (2006.01) C07D 487/22 (2006.01).

S100A4 Is a Biomarker and Regulator of Glioma Stem Cells That Is Critical for Mesenchymal Transition in Glioblastoma
Chow, K-H, Park, HJ, George, J, Yamamoto, K, Gallup, AD, Graber, JH, Chen, Y, Jiang, W, Steindler, DA, Neilson, EG, Kim, BYS & Yun, K 2017, , Cancer research. https://doi.org/10.1158/0008-5472.CAN-17-1294

Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy
Yuan, H, Jiang, W, von Roemeling, CA, Qie, Y, Liu, X, Chen, Y, Wang, Y, Wharen, RE, Yun, K, Bu, G, Knutson, KL & Kim, BYS 2017, Nature Nanotechnology. https://doi.org/10.1038/nnano.2017.69

Expression and function of ABCG2 and XIAP in glioblastomas
Emery, IF, Gopalan, A, Wood, S, Chow, KH, Battelli, C, George, J, Blaszyk, H, Florman, J & Yun, K 2017, , Journal of Neuro-Oncology, pp. 1-11. https://doi.org/10.1007/s11060-017-2422-z

High prevalence of TP53 mutations is associated with poor survival and an EMT signature in gliosarcoma patients
Cho, SY, Park, C, Na, D, Han, JY, Lee, J, Park, OK, Zhang, C, Sung, CO, Moon, HE, Kim, Y, Kim, JH, Kim, JJ, Khang, SK, Nam, DH, Choi, JW, Suh, YL, Kim, DG, Park, SH, Youn, H, Yun, K, Kim, JI, Lee, C, Paek, SH & Park, H 2017, , Experimental and Molecular Medicine, vol. 49, no. 4, e317, pp. e317. https://doi.org/10.1038/emm.2017.9

S100a4 is a novel biomarker and regulator of glioma stem cells that is critical for mesenchymal transition in glioblastomas
Yun, K 2017, Cancer Research.

Cell-autonomous and non-autonomous functions of s100a4 in regulating stemness, mesenchymal transition, and metastasis
Nirala, B, Baskin, D & Yun, K 2017, , Oncoscience, vol. 4, no. 11-12, pp. 166-167. https://doi.org/10.18632/oncoscience.377

Addressing intra-tumoral heterogeneity and therapy resistance
Rybinski, B & Yun, K 2016, Oncotarget, vol. 7, no. 44, pp. 72322-72342. https://doi.org/10.18632/oncotarget.11875

ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype
Junankar, S, Baker, LA, Roden, DL, Nair, R, Elsworth, B, Gallego-Ortega, D, Lacaze, P, Cazet, A, Nikolic, I, Teo, WS, Yang, J, McFarland, A, Harvey, K, Naylor, MJ, Lakhani, SR, Simpson, PT, Raghavendra, A, Saunus, J, Madore, J, Kaplan, W, Ormandy, C, Millar, EKA, OToole, S, Yun, K & Swarbrick, A 2015, , Nature Communications, vol. 6, pp. 6548. https://doi.org/10.1038/ncomms7548

Epigenetic states of cells of origin and tumor evolution drive tumor-initiating cell phenotype and tumor heterogeneity
Chow, K-H, Shin, D-M, Jenkins, MH, Miller, EE, Shih, DJ, Choi, S, Low, BE, Philip, V, Rybinski, B, Bronson, RT, Taylor, MD & Yun, K 2014, , Cancer research, vol. 74, no. 17, pp. 4864-74. https://doi.org/10.1158/0008-5472.CAN-13-3293

Novel insights into embryonic stem cell self-renewal revealed through comparative human and mouse systems biology networks
Dowell, KG, Simons, AK, Bai, H, Kell, B, Wang, ZZ, Yun, K & Hibbs, MA 2014, Stem cells (Dayton, Ohio), vol. 32, no. 5, pp. 1161-72. https://doi.org/10.1002/stem.1612

Prom1 function in development, intestinal inflammation, and intestinal tumorigenesis
Karim, BO, Rhee, K-J, Liu, G, Yun, K & Brant, SR 2014, Frontiers in Oncology, vol. 4, pp. 323. https://doi.org/10.3389/fonc.2014.00323

Notch1-induced brain tumor models the sonic hedgehog subgroup of human medulloblastoma
Natarajan, S, Li, Y, Miller, EE, Shih, DJ, Taylor, MD, Stearns, TM, Bronson, RT, Ackerman, SL, Yoon, JK & Yun, K 2013, , Cancer research, vol. 73, no. 17, pp. 5381-90. https://doi.org/10.1158/0008-5472.CAN-13-0033

Elevated Id2 expression results in precocious neural stem cell depletion and abnormal brain development
Park, HJ, Hong, M, Bronson, RT, Israel, MA, Frankel, WN & Yun, K 2013, Stem cells (Dayton, Ohio), vol. 31, no. 5, pp. 1010-21. https://doi.org/10.1002/stem.1351

Cell-type-specific predictive network yields novel insights into mouse embryonic stem cell self-renewal and cell fate
Dowell, KG, Simons, AK, Wang, ZZ, Yun, K & Hibbs, MA 2013, PLoS ONE, vol. 8, no. 2, pp. e56810. https://doi.org/10.1371/journal.pone.0056810

Imaging glioma initiation in vivo through a polished and reinforced thin-skull cranial window
Zhang, L, Lapierre, A, Roy, B, Lim, M, Zhu, J, Wang, W, Sampson, SB, Yun, K, Lyons, B, Li, Y & Lin, D-T 2012, Journal of visualized experiments : JoVE, no. 69. https://doi.org/10.3791/4201