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Kyuson Yun, PhD

Assistant Professor of Neurosurgery, Institute for Academic Medicine
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College

Yun Lab

Areas Of Expertise

Cancer stem cells Glioblastoma Brain cancer Medulloblastoma Targeted therapy Diagnostic device Signaling pathways
Education & Training

PhD, California Institute of Technology
BS, California Institute of Technology
Postdoctoral Fellowship
Postdoctoral Associate

Yap1 inhibitors and methods

Patent Number: WO 2017/197104 Al, Nov 16 2017


MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes
Dhar, SS, Zhao, D, Lin, T, Gu, B, Pal, K, Wu, SJ, Alam, H, Lv, J, Yun, K, Gopalakrishnan, V, Flores, ER, Northcott, PA, Rajaram, V, Li, W, Shilatifard, A, Sillitoe, RV, Chen, K & Lee, MG 2018, Molecular Cell.

Yap1 inhibitors and methods
Yun, K & Zhai, H-X May. 11 2017, , Patent No. WO 2017/197104 Al, IPC No. A61K 31/409 (2006.01) C07D 487/22 (2006.01).

S100A4 Is a Biomarker and Regulator of Glioma Stem Cells That Is Critical for Mesenchymal Transition in Glioblastoma
Chow, K-H, Park, HJ, George, J, Yamamoto, K, Gallup, AD, Graber, JH, Chen, Y, Jiang, W, Steindler, DA, Neilson, EG, Kim, BYS & Yun, K 2017, Cancer Research.

Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy
Yuan, H, Jiang, W, von Roemeling, CA, Qie, Y, Liu, X, Chen, Y, Wang, Y, Wharen, RE, Yun, K, Bu, G, Knutson, KL & Kim, BYS 2017, Nature Nanotechnology.

Expression and function of ABCG2 and XIAP in glioblastomas
Emery, IF, Gopalan, A, Wood, S, Chow, KH, Battelli, C, George, J, Blaszyk, H, Florman, J & Yun, K 2017, Journal of Neuro-Oncology, pp. 1-11.

High prevalence of TP53 mutations is associated with poor survival and an EMT signature in gliosarcoma patients
Cho, SY, Park, C, Na, D, Han, JY, Lee, J, Park, OK, Zhang, C, Sung, CO, Moon, HE, Kim, Y, Kim, JH, Kim, JJ, Khang, SK, Nam, DH, Choi, JW, Suh, YL, Kim, DG, Park, SH, Youn, H, Yun, K, Kim, JI, Lee, C, Paek, SH & Park, H 2017, Experimental and Molecular Medicine, vol. 49, no. 4, e317, pp. e317.

S100a4 is a novel biomarker and regulator of glioma stem cells that is critical for mesenchymal transition in glioblastomas
Yun, K 2017, Cancer Research.

Cell-autonomous and non-autonomous functions of s100a4 in regulating stemness, mesenchymal transition, and metastasis
Nirala, B, Baskin, D & Yun, K 2017, Oncoscience, vol. 4, no. 11-12, pp. 166-167.

Addressing intra-tumoral heterogeneity and therapy resistance
Rybinski, B & Yun, K 2016, Oncotarget, vol. 7, no. 44, pp. 72322-72342.

ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype
Junankar, S, Baker, LA, Roden, DL, Nair, R, Elsworth, B, Gallego-Ortega, D, Lacaze, P, Cazet, A, Nikolic, I, Teo, WS, Yang, J, McFarland, A, Harvey, K, Naylor, MJ, Lakhani, SR, Simpson, PT, Raghavendra, A, Saunus, J, Madore, J, Kaplan, W, Ormandy, C, Millar, EKA, OToole, S, Yun, K & Swarbrick, A 2015, Nature communications, vol. 6, pp. 6548.

Epigenetic states of cells of origin and tumor evolution drive tumor-initiating cell phenotype and tumor heterogeneity
Chow, K-H, Shin, D-M, Jenkins, MH, Miller, EE, Shih, DJ, Choi, S, Low, BE, Philip, V, Rybinski, B, Bronson, RT, Taylor, MD & Yun, K 2014, Cancer Research, vol. 74, no. 17, pp. 4864-74.

Novel insights into embryonic stem cell self-renewal revealed through comparative human and mouse systems biology networks
Dowell, KG, Simons, AK, Bai, H, Kell, B, Wang, ZZ, Yun, K & Hibbs, MA 2014, Stem cells (Dayton, Ohio), vol. 32, no. 5, pp. 1161-72.

Prom1 function in development, intestinal inflammation, and intestinal tumorigenesis
Karim, BO, Rhee, K-J, Liu, G, Yun, K & Brant, SR 2014, Frontiers in Oncology, vol. 4, pp. 323.

Notch1-induced brain tumor models the sonic hedgehog subgroup of human medulloblastoma
Natarajan, S, Li, Y, Miller, EE, Shih, DJ, Taylor, MD, Stearns, TM, Bronson, RT, Ackerman, SL, Yoon, JK & Yun, K 2013, Cancer Research, vol. 73, no. 17, pp. 5381-90.

Elevated Id2 expression results in precocious neural stem cell depletion and abnormal brain development
Park, HJ, Hong, M, Bronson, RT, Israel, MA, Frankel, WN & Yun, K 2013, Stem cells (Dayton, Ohio), vol. 31, no. 5, pp. 1010-21.

Cell-type-specific predictive network yields novel insights into mouse embryonic stem cell self-renewal and cell fate
Dowell, KG, Simons, AK, Wang, ZZ, Yun, K & Hibbs, MA 2013, PLoS ONE, vol. 8, no. 2, pp. e56810.

Imaging glioma initiation in vivo through a polished and reinforced thin-skull cranial window
Zhang, L, Lapierre, A, Roy, B, Lim, M, Zhu, J, Wang, W, Sampson, SB, Yun, K, Lyons, B, Li, Y & Lin, D-T 2012, Journal of visualized experiments : JoVE, no. 69.

Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1
Li, Y, Hibbs, MA, Gard, AL, Shylo, NA & Yun, K 2012, Stem cells (Dayton, Ohio), vol. 30, no. 4, pp. 741-52.

Cancer stem cells are enriched in the side population cells in a mouse model of glioma
Harris, MA, Yang, H, Low, BE, Mukherjee, J, Mukherje, J, Guha, A, Bronson, RT, Shultz, LD, Israel, MA & Yun, K 2008, Cancer Research, vol. 68, no. 24, pp. 10051-9.

Cancer stem cells
Yun, K & Tennent, B 2008, Drug Discovery Today: Disease Models, vol. 4, no. 2, pp. 47-52.

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