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Kyuson Yun, PhD

Assistant Member, Research Institute
Assistant Professor of Neurology, Academic Institute
Houston Methodist
Weill Cornell Medical College

Yun Lab

Areas Of Expertise

Cancer stem cells Glioblastoma Brain cancer Medulloblastoma Targeted therapy Diagnostic device Signaling pathways
Education & Training

PhD, California Institute of Technology
BS, California Institute of Technology

Yap1 inhibitors and methods

Patent Number: WO 2017/197104 Al, Nov 16 2017


A cloud-based platform for the analysis of single cell RNA sequencing data
Joshy, N & Yun, K 2020, , Unknown Journal.

Glioblastoma Myeloid-Derived Suppressor Cell Subsets Express Differential Macrophage Migration Inhibitory Factor Receptor Profiles That Can Be Targeted to Reduce Immune Suppression
Alban, TJ, Bayik, D, Otvos, B, Rabljenovic, A, Leng, L, Jia-Shiun, L, Roversi, G, Lauko, A, Momin, AA, Mohammadi, AM, Peereboom, DM, Ahluwalia, MS, Matsuda, K, Yun, K, Bucala, R, Vogelbaum, MA & Lathia, JD 2020, , Frontiers in immunology, vol. 11, 1191.

Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity
von Roemeling, CA, Wang, Y, Qie, Y, Yuan, H, Zhao, H, Liu, X, Yang, Z, Yang, M, Deng, W, Bruno, KA, Chan, CK, Lee, AS, Rosenfeld, SS, Yun, K, Johnson, AJ, Mitchell, DA, Jiang, W & Kim, BYS 2020, , Nature Communications, vol. 11, no. 1, 1508.

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation
Yang, Z, Shi, J, Xie, J, Wang, Y, Sun, J, Liu, T, Zhao, Y, Zhao, X, Wang, X, Ma, Y, Malkoc, V, Chiang, C, Deng, W, Chen, Y, Fu, Y, Kwak, KJ, Fan, Y, Kang, C, Yin, C, Rhee, J, Bertani, P, Otero, J, Lu, W, Yun, K, Lee, AS, Jiang, W, Teng, L, Kim, BYS & Lee, LJ 2020, , Nature Biomedical Engineering, vol. 4, no. 1, pp. 69-83.

Glioblastoma myeloid-derived suppressor cell subsets express differential macrophage migration inhibitory factor receptor profiles that can be targeted to reduce immune suppression
Alban, TJ, Bayik, D, Otvos, B, Rabljenovic, A, Leng, L, Jia-Shiun, L, Roversi, G, Lauko, A, Momin, A, Mohammadi, AM, Peereboom, DM, Ahluwalia, MS, Matsuda, K, Yun, K, Bucala, R, Vogelbaum, MA & Lathia, JD 2019, , Unknown Journal.

MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes
Dhar, SS, Zhao, D, Lin, T, Gu, B, Pal, K, Wu, SJ, Alam, H, Lv, J, Yun, K, Gopalakrishnan, V, Flores, ER, Northcott, PA, Rajaram, V, Li, W, Shilatifard, A, Sillitoe, RV, Chen, K & Lee, MG 2018, , Molecular Cell, vol. 70, no. 5, pp. 825-841.e6.

Yap1 inhibitors and methods
Yun, K & Zhai, H-X Nov. 16 2017, , Patent No. WO 2017/197104 Al, IPC No. A61K 31/409 (2006.01) C07D 487/22 (2006.01).

S100A4 Is a Biomarker and Regulator of Glioma Stem Cells That Is Critical for Mesenchymal Transition in Glioblastoma
Chow, K-H, Park, HJ, George, J, Yamamoto, K, Gallup, AD, Graber, JH, Chen, Y, Jiang, W, Steindler, DA, Neilson, EG, Kim, BYS & Yun, K 2017, , Cancer research.

Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy
Yuan, H, Jiang, W, von Roemeling, CA, Qie, Y, Liu, X, Chen, Y, Wang, Y, Wharen, RE, Yun, K, Bu, G, Knutson, KL & Kim, BYS 2017, , Nature Nanotechnology.

Expression and function of ABCG2 and XIAP in glioblastomas
Emery, IF, Gopalan, A, Wood, S, Chow, KH, Battelli, C, George, J, Blaszyk, H, Florman, J & Yun, K 2017, , Journal of Neuro-Oncology, pp. 1-11.

High prevalence of TP53 mutations is associated with poor survival and an EMT signature in gliosarcoma patients
Cho, SY, Park, C, Na, D, Han, JY, Lee, J, Park, OK, Zhang, C, Sung, CO, Moon, HE, Kim, Y, Kim, JH, Kim, JJ, Khang, SK, Nam, DH, Choi, JW, Suh, YL, Kim, DG, Park, SH, Youn, H, Yun, K, Kim, JI, Lee, C, Paek, SH & Park, H 2017, , Experimental and Molecular Medicine, vol. 49, no. 4, e317, pp. e317.

S100a4 is a novel biomarker and regulator of glioma stem cells that is critical for mesenchymal transition in glioblastomas
Yun, K 2017, Cancer Research.

Cell-autonomous and non-autonomous functions of s100a4 in regulating stemness, mesenchymal transition, and metastasis
Nirala, B, Baskin, D & Yun, K 2017, , Oncoscience, vol. 4, no. 11-12, pp. 166-167.

Addressing intra-tumoral heterogeneity and therapy resistance
Rybinski, B & Yun, K 2016, , Oncotarget, vol. 7, no. 44, pp. 72322-72342.

ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype
Junankar, S, Baker, LA, Roden, DL, Nair, R, Elsworth, B, Gallego-Ortega, D, Lacaze, P, Cazet, A, Nikolic, I, Teo, WS, Yang, J, McFarland, A, Harvey, K, Naylor, MJ, Lakhani, SR, Simpson, PT, Raghavendra, A, Saunus, J, Madore, J, Kaplan, W, Ormandy, C, Millar, EKA, OToole, S, Yun, K & Swarbrick, A 2015, , Nature Communications, vol. 6, pp. 6548.

Epigenetic states of cells of origin and tumor evolution drive tumor-initiating cell phenotype and tumor heterogeneity
Chow, K-H, Shin, D-M, Jenkins, MH, Miller, EE, Shih, DJ, Choi, S, Low, BE, Philip, V, Rybinski, B, Bronson, RT, Taylor, MD & Yun, K 2014, , Cancer research, vol. 74, no. 17, pp. 4864-74.

Novel insights into embryonic stem cell self-renewal revealed through comparative human and mouse systems biology networks
Dowell, KG, Simons, AK, Bai, H, Kell, B, Wang, ZZ, Yun, K & Hibbs, MA 2014, , Stem cells (Dayton, Ohio), vol. 32, no. 5, pp. 1161-72.

Prom1 function in development, intestinal inflammation, and intestinal tumorigenesis
Karim, BO, Rhee, K-J, Liu, G, Yun, K & Brant, SR 2014, , Frontiers in Oncology, vol. 4, pp. 323.

Notch1-induced brain tumor models the sonic hedgehog subgroup of human medulloblastoma
Natarajan, S, Li, Y, Miller, EE, Shih, DJ, Taylor, MD, Stearns, TM, Bronson, RT, Ackerman, SL, Yoon, JK & Yun, K 2013, , Cancer research, vol. 73, no. 17, pp. 5381-90.

Elevated Id2 expression results in precocious neural stem cell depletion and abnormal brain development
Park, HJ, Hong, M, Bronson, RT, Israel, MA, Frankel, WN & Yun, K 2013, , Stem cells (Dayton, Ohio), vol. 31, no. 5, pp. 1010-21.