Kyuson Yun

Kyuson Yun, PhD

Associate Professor of Neurology, Academic Institute
Associate Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Yun Lab


Areas Of Expertise

Cancer stem cells Immunotherapy Glioblastoma Brain cancer Medulloblastoma Diagnostic device tumor microenvironment immune suppression mechanism
Education & Training

PhD, California Institute of Technology
BS, California Institute of Technology
Patents

Yap1 inhibitors and methods

Patent Number: WO 2017/197104 Al, Nov 16 2017

Publications

A prognostic matrix code defines functional glioblastoma phenotypes and niches
Vishnoi, M, Dereli, Z, Yin, Z, Kong, EK, Kinali, M, Thapa, K, Babur, O, Yun, K, Abdelfattah, N, Li, X, Bozorgui, B, Rostomily, RC & Korkut, A 2023, , bioRxiv. https://doi.org/10.1101/2023.06.06.543903

Identification of Kinase Targets for Enhancing the Antitumor Activity of Eribulin in Triple-Negative Breast Cell Lines
Xie, X, Lee, J, Fuson, JA, Liu, H, Iwase, T, Yun, K, Margain, C, Tripathy, D & Ueno, NT 2023, , Biomedicines, vol. 11, no. 3, 735. https://doi.org/10.3390/biomedicines11030735

Cancer stem cells, not bulk tumor cells, determine mechanisms of resistance to SMO inhibitors
George, J, Chen, Y, Abdelfattah, N, Yamamoto, K, Gallup, TD, Adamson, SI, Rybinski, B, Srivastava, A, Kumar, P, Lee, MG, Baskin, DS, Jiang, W, Choi, JM, Flavahan, W, Chuang, JH, Kim, BY, Xu, J, Jung, SY & Yun, K 2022, , Cancer research communications, vol. 2, no. 6, pp. 402-416. https://doi.org/10.1158/2767-9764.crc-22-0124

Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target
Abdelfattah, N, Kumar, P, Wang, C, Leu, JS, Flynn, WF, Gao, R, Baskin, DS, Pichumani, K, Ijare, OB, Wood, SL, Powell, SZ, Haviland, DL, Parker Kerrigan, BC, Lang, FF, Prabhu, SS, Huntoon, KM, Jiang, W, Kim, BYS, George, J & Yun, K 2022, , Nature Communications, vol. 13, no. 1, 767, pp. 767. https://doi.org/10.1038/s41467-022-28372-y, https://doi.org/10.1038/s41467-022-28372-y

Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target
Abdelfattah, N, Kumar, P, Wang, C, Leu, JS, Flynn, WF, Gao, R, Baskin, DS, Pichumani, K, Ijare, OB, Wood, SL, Powell, SZ, Haviland, DL, Parker Kerrigan, BC, Lang, FF, Prabhu, SS, Huntoon, KM, Jiang, W, Kim, BYS, George, J & Yun, K 2022, , Nature Communications, vol. 13, no. 1, 767. https://doi.org/10.1038/s41467-022-28372-y

Author Correction: Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation
Yang, Z, Shi, J, Xie, J, Wang, Y, Sun, J, Liu, T, Zhao, Y, Zhao, X, Wang, X, Ma, Y, Malkoc, V, Chiang, C, Deng, W, Chen, Y, Fu, Y, Kwak, KJ, Fan, Y, Kang, C, Yin, C, Rhee, J, Bertani, P, Otero, J, Lu, W, Yun, K, Lee, AS, Jiang, W, Teng, L, Kim, BYS & Lee, LJ 2021, , Nature Biomedical Engineering, vol. 5, no. 8, pp. 944-945. https://doi.org/10.1038/s41551-021-00725-w

DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases
Zhang, N, Bewick, B, Schultz, J, Tiwari, A, Krencik, R, Zhang, A, Adachi, K, Xia, G, Yun, K, Sarkar, P & Ashizawa, T 2021, , Neurotherapeutics, vol. 18, no. 3, pp. 1710-1728. https://doi.org/10.1007/s13311-021-01075-w

A cloud-based platform for the analysis of single cell RNA sequencing data
Joshy, N & Yun, K 2020, , Unknown Journal. https://doi.org/10.1101/2020.09.28.317719

Glioblastoma Myeloid-Derived Suppressor Cell Subsets Express Differential Macrophage Migration Inhibitory Factor Receptor Profiles That Can Be Targeted to Reduce Immune Suppression
Alban, TJ, Bayik, D, Otvos, B, Rabljenovic, A, Leng, L, Jia-Shiun, L, Roversi, G, Lauko, A, Momin, AA, Mohammadi, AM, Peereboom, DM, Ahluwalia, MS, Matsuda, K, Yun, K, Bucala, R, Vogelbaum, MA & Lathia, JD 2020, , Frontiers in immunology, vol. 11, 1191, pp. 1191. https://doi.org/10.3389/fimmu.2020.01191

Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity
von Roemeling, CA, Wang, Y, Qie, Y, Yuan, H, Zhao, H, Liu, X, Yang, Z, Yang, M, Deng, W, Bruno, KA, Chan, CK, Lee, AS, Rosenfeld, SS, Yun, K, Johnson, AJ, Mitchell, DA, Jiang, W & Kim, BYS 2020, , Nature Communications, vol. 11, no. 1, 1508. https://doi.org/10.1038/s41467-020-15129-8

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation
Yang, Z, Shi, J, Xie, J, Wang, Y, Sun, J, Liu, T, Zhao, Y, Zhao, X, Wang, X, Ma, Y, Malkoc, V, Chiang, C, Deng, W, Chen, Y, Fu, Y, Kwak, KJ, Fan, Y, Kang, C, Yin, C, Rhee, J, Bertani, P, Otero, J, Lu, W, Yun, K, Lee, AS, Jiang, W, Teng, L, Kim, BYS & Lee, LJ 2020, , Nature Biomedical Engineering, vol. 4, no. 1, pp. 69-83. https://doi.org/10.1038/s41551-019-0485-1

Glioblastoma myeloid-derived suppressor cell subsets express differential macrophage migration inhibitory factor receptor profiles that can be targeted to reduce immune suppression
Alban, TJ, Bayik, D, Otvos, B, Rabljenovic, A, Leng, L, Jia-Shiun, L, Roversi, G, Lauko, A, Momin, A, Mohammadi, AM, Peereboom, DM, Ahluwalia, MS, Matsuda, K, Yun, K, Bucala, R, Vogelbaum, MA & Lathia, JD 2019, , Unknown Journal. https://doi.org/10.1101/2019.12.19.882555

MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes
Dhar, SS, Zhao, D, Lin, T, Gu, B, Pal, K, Wu, SJ, Alam, H, Lv, J, Yun, K, Gopalakrishnan, V, Flores, ER, Northcott, PA, Rajaram, V, Li, W, Shilatifard, A, Sillitoe, RV, Chen, K & Lee, MG 2018, , Molecular Cell, vol. 70, no. 5, pp. 825-841.e6. https://doi.org/10.1016/j.molcel.2018.04.028

Yap1 inhibitors and methods
Yun, K & Zhai, H-X Nov. 16 2017, , Patent No. WO 2017/197104 Al, IPC No. A61K 31/409 (2006.01) C07D 487/22 (2006.01).

S100A4 Is a Biomarker and Regulator of Glioma Stem Cells That Is Critical for Mesenchymal Transition in Glioblastoma
Chow, K-H, Park, HJ, George, J, Yamamoto, K, Gallup, AD, Graber, JH, Chen, Y, Jiang, W, Steindler, DA, Neilson, EG, Kim, BYS & Yun, K 2017, , Cancer research. https://doi.org/10.1158/0008-5472.CAN-17-1294

Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy
Yuan, H, Jiang, W, von Roemeling, CA, Qie, Y, Liu, X, Chen, Y, Wang, Y, Wharen, RE, Yun, K, Bu, G, Knutson, KL & Kim, BYS 2017, , Nature Nanotechnology. https://doi.org/10.1038/nnano.2017.69

Expression and function of ABCG2 and XIAP in glioblastomas
Emery, IF, Gopalan, A, Wood, S, Chow, KH, Battelli, C, George, J, Blaszyk, H, Florman, J & Yun, K 2017, , Journal of Neuro-Oncology, pp. 1-11. https://doi.org/10.1007/s11060-017-2422-z

High prevalence of TP53 mutations is associated with poor survival and an EMT signature in gliosarcoma patients
Cho, SY, Park, C, Na, D, Han, JY, Lee, J, Park, OK, Zhang, C, Sung, CO, Moon, HE, Kim, Y, Kim, JH, Kim, JJ, Khang, SK, Nam, DH, Choi, JW, Suh, YL, Kim, DG, Park, SH, Youn, H, Yun, K, Kim, JI, Lee, C, Paek, SH & Park, H 2017, , Experimental and Molecular Medicine, vol. 49, no. 4, e317, pp. e317. https://doi.org/10.1038/emm.2017.9

S100a4 is a novel biomarker and regulator of glioma stem cells that is critical for mesenchymal transition in glioblastomas
Yun, K 2017, Cancer Research.

Cell-autonomous and non-autonomous functions of s100a4 in regulating stemness, mesenchymal transition, and metastasis
Nirala, B, Baskin, D & Yun, K 2017, , Oncoscience, vol. 4, no. 11-12, pp. 166-167. https://doi.org/10.18632/oncoscience.377