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Kumar Pichumani, PhD

Associate Research Professor of Neurosurgery, Academic Institute
Associate Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College

Baskin Lab

Kumar Pichumani, PhD, is a research scientist at the Neurosurgery Research Laboratory and Associate Research Member at Houston Methodist Research Institute. Dr. Pichumani is an NMR physicist and has worked in NMR spectroscopy since 1990. He developed new methods using first principles of NMR spin relaxation to increase both resolution and sensitivity so that complex biomacromolecules of larger molecular mass can be studied by NMR Spectroscopy. These research publications were cited by two Nobel Laureates in NMR spectroscopy.

Description of Research

Dr. Pichumani's most recent research involves investigating in-vivo cancer metabolism using non- radioactive 13C enriched nutrients as infusion substrates (glucose, acetate, fatty acids), studying the fate of these substrates via high-resolution 13C NMR spectroscopy of surgically resected tumor tissues extracts. In a recent article published in CELL, he demonstrated that acetate acts as an alternate energy source for cancer cells in human glioblastoma patients and mouse models. He studied in India, Sweden and the US, gaining a diverse background spanning physics, mathematics, electronics, physical chemistry, NMR, Cancer Metabolism and biophysics.

Areas Of Expertise

Molecular imaging Cancer metabolism NMR spectroscopy
Education & Training

PhD, Indian Institute of Science Bangalore
Postdoctoral Fellowship, Indiana University Bloomington
BSc, Madurai Kamaraj University
MSc, Madurai Kamaraj University
Postdoctoral Fellowship, Stockholm University

Elevated levels of circulating betahydroxybutyrate in pituitary tumor patients may differentiate prolactinomas from other immunohistochemical subtypes
Ijare, OB, Holan, C, Hebert, J, Sharpe, MA, Baskin, DS & Pichumani, K 2020, , Scientific Reports, vol. 10, no. 1, 1334.

Proton magnetic resonance spectroscopy characterization of Rathke’s cleft cysts (RCCs): Relevance to the differential diagnosis of pituitary adenomas and RCCs
Ijare, OB, Sharpe, MA, Baskin, DS & Pichumani, K 2020, Cancers, vol. 12, no. 2, 360.

Metabolic fate of glucose in atypical meningioma studied by 13C NMR isotopomer analysis
Pichumani, K, Ijare, OB & Baskin, DS 2019, . in Metabolic fate of glucose in atypical meningioma studied by 13C NMR isotopomer. Proc. Intl. Soc. Mag. Reson. Med. 27 (2019) 2507 edn, vol. 27, Internatioal Society for magnetic resonance in medicine, pp. 2507.

Ex Vivo 1 H NMR study of pituitary adenomas to differentiate various immunohistochemical subtypes
Ijare, OB, Baskin, DS & Pichumani, K 2019, , Scientific Reports, vol. 9, no. 1, 3007.

Tracking Metabolic Rewiring of Cancer Metabolism in Humans Using Isotope-Resolved NMR
Pichumani, K 2019, . in Methods in Molecular Biology. Methods in Molecular Biology, vol. 2037, Humana Press, pp. 169-186.

Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency
Jakkamsetti, V, Marin-Valencia, I, Ma, Q, Good, LB, Terrill, T, Rajasekaran, K, Pichumani, K, Khemtong, C, Hooshyar, MA, Sundarrajan, C, Patel, MS, Bachoo, RM, Malloy, CR & Pascual, JM 2019, , Science translational medicine, vol. 11, no. 480, aan0457.

Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo
Courtney, KD, Bezwada, D, Mashimo, T, Pichumani, K, Vemireddy, V, Funk, AM, Wimberly, J, McNeil, SS, Kapur, P, Lotan, Y, Margulis, V, Cadeddu, JA, Pedrosa, I, DeBerardinis, RJ, Malloy, CR, Bachoo, RM & Maher, EA 2018, , Cell Metabolism, vol. 28, no. 5, pp. 793-800.e2.

Metabolism of fructose in B-cells: A 13C NMR spectroscopy based stable isotope tracer study
Ijare, OB, Baskin, DS, Sharpe, MA & Pichumani, K 2018, Analytical Biochemistry, vol. 552, pp. 110-117.

Measurement of 13C turnover into glutamate and glutamine pools in brain tumor patients
Pichumani, K, Mashimo, T, Vemireddy, V, Ijare, OB, Mickey, BE, Malloy, CR, Marin-Valencia, I, Baskin, DS, Bachoo, RM & Maher, EA 2017, , FEBS Letters, vol. 591, no. 21, pp. 3548-3554.

Elucidating the structural organization of a novel low-density lipoprotein nanoparticle reconstituted with docosahexaenoic acid
Mulik, RS, Zheng, H, Pichumani, K, Ratnakar, J, Jiang, Q-X & Corbin, IR 2017, Chemistry and Physics of Lipids, vol. 204, pp. 65-75.

Hepatic gluconeogenesis influences (13)C enrichment in lactate in human brain tumors during metabolism of [1,2-(13)C]acetate
Pichumani, K, Mashimo, T, Vemireddy, V, Kovacs, Z, Ratnakar, J, Mickey, B, Malloy, CR, DeBerardinis, RJ, Bachoo, RM & Maher, EA 2016, Neurochemistry International, vol. 97, pp. 133-6.

Novel application of complimentary imaging techniques to examine in vivo glucose metabolism in the kidney
Hato, T, Friedman, AN, Mang, HE, Plotkin, Z, Dube, S, Hutchins, GD, Territo, PR, McCarthy, BP, Riley, AA, Pichumani, K, Malloy, CR, Harris, RA, Dagher, PC & Sutton, TA 2016, American journal of physiology. Renal physiology, pp. ajprenal.00535.2015.

Conditions for 13C NMR detection of 2-hydroxyglutarate in tissue extracts from isocitrate dehydrogenase-mutated gliomas
Pichumani, K, Mashimo, T, Baek, HM, Ratnakar, J, Mickey, B, DeBerardinis, RJ, Maher, EA, Bachoo, RM, Malloy, CR & Kovacs, Z 2015, , Analytical Biochemistry, vol. 481, pp. 4-6.

Effects of hydrogen bonding on amide-proton chemical shift anisotropy in a proline-containing model peptide
Pichumani, K, George, G, Hebbar, S, Chatterjee, B & Raghothama, S 2015, , Chemical Physics Letters, vol. 627, 32894, pp. 126-129.

The ratio of acetate-to-glucose oxidation in astrocytes from a single 13C NMR spectrum of cerebral cortex
Marin-Valencia, I, Hooshyar, MA, Pichumani, K, Sherry, AD & Malloy, CR 2015, , Journal of Neurochemistry, vol. 132, no. 1, pp. 99-109.

Acetate is a bioenergetic substrate for human glioblastoma and brain metastases
Mashimo, T, Pichumani, K, Vemireddy, V, Hatanpaa, KJ, Singh, DK, Sirasanagandla, S, Nannepaga, S, Piccirillo, SG, Kovacs, Z, Foong, C, Huang, Z, Barnett, S, Mickey, BE, Deberardinis, RJ, Tu, BP, Maher, EA & Bachoo, RM 2014, , Cell, vol. 159, no. 7, pp. 1603-1614.

A comparative study of short- and long-TE 1H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors
Choi, C, Ganji, S, Hulsey, K, Madan, A, Kovacs, Z, Dimitrov, I, Zhang, S, Pichumani, K, Mendelsohn, D, Mickey, B, Malloy, C, Bachoo, R, Deberardinis, R & Maher, E 2013, , NMR in Biomedicine, vol. 26, no. 10, pp. 1242-1250.

Determination of 15N chemical shift anisotropy from a membrane-bound protein by NMR spectroscopy
Pandey, MK, Vivekanandan, S, Ahuja, S, Pichumani, K, Im, SC, Waskell, L & Ramamoorthy, A 2012, , Journal of Physical Chemistry B, vol. 116, no. 24, pp. 7181-7189.

Magnetic resonance spectroscopy with longitudinal multispin orders
Velan, SS, Pichumani, K, Murray, D, Raylman, RR, Scott, T, Manivannan, A & Halliburton, L 2008, , Current Analytical Chemistry, vol. 4, no. 1, pp. 40-54.

Determination of the anomeric configuration in carbohydrates by longitudinal cross-correlated relaxation studies: Application to mono- And disaccharides
Pichumani, K, Zou, X, Chandra, T & Brown, KL 2007, , Magnetic Resonance in Chemistry, vol. 45, no. 9, pp. 734-738.