Keith A. Youker

Keith A. Youker, PhD

Associate Research Professor of Cardiovascular Sciences, Academic Institute
Associate Research Member, Research Institute
Houston Methodist


Biography

Dr. Keith Youker earned his Ph.D. in Cardiovascular Sciences from Baylor College of Medicine and was the first graduate from this program. The program initially used a broad knowledge approach to training including course work from medical school, graduate school, and cardiovascular core courses designed for basic scientists to work in clinical cardiovascular research. His dissertation work earned him a nomination for the Sigma Xi “Excellence in Science Dissertation Award”. Since graduation, Dr. Youker has been a faculty member in both the departments of Medicine and Surgery at Baylor College of Medicine prior to joining Houston Methodist Hospital. He has served as an ad hoc reviewer for the journals of Circulation, American Journal of Pathology, ASAIO and the Journal of Heart and Lung Transplantation. Dr. Youker’s primary focus has been in heart failure with a particular interest in inflammation and its role in the progression of heart failure. Dr. Youker prefers a hands-on approach in the laboratory and is expert in many areas from electron microscopy to molecular biology techniques and has earned a reputation of excellence in cardiovascular immunopathology research.

Description of Research

Dr. Youker focuses on research of the immune system in heart failure and metabolism in heart failure.

Areas Of Expertise

Transplantation LVAD Immunology Cardiac Heart Failure
Education & Training

PhD, Baylor College of Medicine
Publications

An In Vitro Platform to Study Reversible Endothelial-to-Mesenchymal Transition
Krishnamoorthi, MK, Thandavarayan, RA, Youker, KA & Bhimaraj, A 2022, , Frontiers in Pharmacology, vol. 13, 912660. https://doi.org/10.3389/fphar.2022.912660

Cleavage stimulating factor 64 depletion mitigates cardiac fibrosis through alternative polyadenylation
Neupane, R, Youker, K, Yalamanchili, HK, Cieslik, KA, Karmouty-quintana, H, Guha, A & Thandavarayan, RA 2022, , Biochemical and Biophysical Research Communications, vol. 597, pp. 109-114. https://doi.org/10.1016/j.bbrc.2022.01.093

Long term development of diastolic dysfunction and heart failure with preserved left ventricular ejection fraction in heart transplant recipients
Vejpongsa, P, Torre-Amione, G, Marcos-Abdala, HG, Kumar, S, Youker, K, Bhimaraj, A & Nagueh, SF 2022, , Scientific Reports, vol. 12, no. 1, 3834. https://doi.org/10.1038/s41598-022-07888-9

Role of Endothelial and Mesenchymal Cell Transitions in Heart Failure and Recovery Thereafter
Wang, G, Cruz, AS, Youker, K, Marcos-Abdala, HG, Thandavarayan, RA, Cooke, JP, Torre-Amione, G, Chen, K & Bhimaraj, A 2021, , Frontiers in Genetics, vol. 11, 609262, pp. 609262. https://doi.org/10.3389/fgene.2020.609262

Endothelial Dysfunction-related Neurological Bleeds with Continuous Flow-Left Ventricular Assist Devices Measured by Digital Thermal Monitor
Ali, A, Uribe, C, Araujo-Gutierrez, R, Cruz-Solbes, AS, Marcos-Abdala, HG, Youker, KA, Guha, A, Torre-Amione, G, Nguyen, DT, Graviss, EA, Cooke, JP & Bhimaraj, A 2021, , ASAIO Journal, pp. 561-566. https://doi.org/10.1097/MAT.0000000000001281

Endothelial Dysfunction-related Neurological Bleeds with Continuous Flow-Left Ventricular Assist Devices Measured by Digital Thermal Monitor
Ali, A, Uribe, C, Araujo-Gutierrez, R, Cruz-Solbes, AS, Marcos-Abdala, HG, Youker, KA, Guha, A, Torre-Amione, G, Nguyen, DT, Graviss, EA, Cooke, JP & Bhimaraj, A 2021, , ASAIO Journal, vol. 67, no. 5, pp. 561-566. https://doi.org/10.1097/MAT.0000000000001281

Platelet rich plasma concentration improves biologic mesh incorporation and decreases multinucleated giant cells in a dose dependent fashion
Araujo-Gutierrez, R, Van Eps, JL, Scherba, JC, Anastasio, AT, Cabrera, F, Vatsaas, CJ, Youker, K & Fernandez Moure, JS 2021, , Journal of Tissue Engineering and Regenerative Medicine, vol. 15, no. 11, pp. 1037-1046. https://doi.org/10.1002/term.3247

Nanovaccine for Heart Failure
Youker, KA, Torre-Amione, G & Shen, H May. 27 2021, , Patent No. WO2021101968.

Endothelial Dysfunction-related Neurological Bleeds with Continuous Flow-Left Ventricular Assist Devices Measured by Digital Thermal Monitor
Ali, A, Uribe, C, Araujo-Gutierrez, R, Cruz-Solbes, AS, Marcos-Abdala, HG, Youker, KA, Guha, A, Torre-Amione, G, Nguyen, DT, Graviss, EA, Cooke, JP & Bhimaraj, A 2020, , ASAIO journal (American Society for Artificial Internal Organs : 1992). https://doi.org/10.1097/MAT.0000000000001281

Vulnerable Atherosclerotic Plaque Imaging by Small-Molecule High-Affinity Positron Emission Tomography Radiopharmaceutical
Yang, Z, Li, F, Yelamanchili, D, Zeng, Z, Rosales, C, Youker, KA, Shen, H, Ferrari, M, Mahmarian, J, Pownall, HJ, Hamilton, DJ & Li, Z 2019, , advanced therapeutics, vol. 2, no. 8. https://doi.org/10.1002/adtp.201900005

Erratum: Inducible lung epithelial resistance requires multisource reactive oxygen species generation to protect against viral infections (mBio, (2018) 9(3), e00696-18, 10.1128/mBio.00696-18)
Kirkpatrick, CT, Wang, Y, Leiva Juarez, MM, Shivshankar, P, Pantaleón García, J, Plumer, AK, Kulkarni, VV, Ware, HH, Gulraiz, F, Chavez Cavasos, MA, Martinez Zayas, G, Wali, S, Rice, AP, Liu, H, Tour, JM, Sikkema, WKA, Cruz Solbes, AS, Youker, KA, Tuvim, MJ, Dickey, BF & Evans, SE 2019, , mBio, vol. 10, no. 2, e00496-19. https://doi.org/10.1128/mBio.00496-19

Mitochondrial hyperacetylation in the failing hearts of obese patients mediated partly by a reduction in SIRT3: The involvement of the mitochondrial permeability transition pore
García-Rivas, G, Castillo, EC, Morales, JA, Chapoy-Villanueva, H, Silva-Platas, C, Treviño-Saldaña, N, Guerrero-Beltrán, CE, Bernal-Ramírez, J, Torres-Quintanilla, A, García, N, Youker, K & Torre-Amione, G 2019, , Cellular Physiology and Biochemistry, vol. 53, no. 3, pp. 465-479. https://doi.org/10.33594/000000151

Vulnerable Atherosclerotic Plaque Imaging by Small-Molecule High-Affinity Positron Emission Tomography Radiopharmaceutical
Yang, Z, Li, F, Yelamanchili, D, Zeng, Z, Rosales, C, Youker, KA, Shen, H, Ferrari, M, Mahmarian, J, Pownall, HJ, Hamilton, DJ & Li, Z 2019, , Advanced Therapeutics, vol. 2, no. 8, 1900005. https://doi.org/10.1002/adtp.201900005

Small molecule disruption of G protein ß? subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats
Karuppagounder, V, Bajpai, A, Meng, S, Arumugam, S, Sreedhar, R, Giridharan, VV, Guha, A, Bhimaraj, A, Youker, KA, Palaniyandi, SS, Karmouty-Quintana, H, Kamal, F, Spiller, KL, Watanabe, K & Thandavarayan, RA 2018, , PLoS ONE, vol. 13, no. 7, e0200697. https://doi.org/10.1371/journal.pone.0200697

Efficacy of sustained delivery of GC-1 from a Nanofluidic system in a spontaneously obese non-human primate: a case study
Filgueira, CS, Bruno, G, Smith, ZW, Chua, CYX, Ballerini, A, Folci, M, Gilbert, AL, Jain, P, Sastry, JK, Nehete, PN, Shelton, KA, Hill, LR, Ali, A, Youker, KA & Grattoni, A 2018, , Biomedical Microdevices, vol. 20, no. 2, 49. https://doi.org/10.1007/s10544-018-0296-2

Inducible lung epithelial resistance requires multisource reactive oxygen species generation to protect against viral infections
Kirkpatrick, CT, Wang, Y, Leiva Juarez, MM, Shivshankar, P, Pantaleón García, J, Plumer, AK, Kulkarni, VV, Ware, HH, Gulraiz, F, Chavez Cavasos, MA, Martinez Zayes, G, Wali, S, Rice, AP, Liu, H, Tour, JM, Sikkema, WKA, Cruz Solbes, AS, Youker, KA, Tuvim, MJ, Dickey, BF & Evans, SE 2018, , mBio, vol. 9, no. 3, e00696-18. https://doi.org/10.1128/mBio.00696-18

Functionally redundant control of cardiac hypertrophic signaling by inositol 1,4,5-trisphosphate receptors
Garcia, MI, Karlstaedt, A, Chen, JJ, Amione-Guerra, J, Youker, KA, Taegtmeyer, H & Boehning, D 2017, , Journal of Molecular and Cellular Cardiology, vol. 112, pp. 95-103. https://doi.org/10.1016/j.yjmcc.2017.09.006

Rapamycin nanoparticles localize in diseased lung vasculature and prevent pulmonary arterial hypertension
Segura-Ibarra, V, Amione-Guerra, J, Cruz-Solbes, AS, Cara, FE, Iruegas-Nunez, DA, Wu, S, Youker, KA, Bhimaraj, A, Torre-Amione, G, Ferrari, M, Karmouty-Quintana, H, Guha, A & Blanco, E 2017, , International Journal of Pharmaceutics, vol. 524, no. 1-2, pp. 257-267. https://doi.org/10.1016/j.ijpharm.2017.03.069

AIBP Limits Angiogenesis Through ?-Secretase-Mediated Upregulation of Notch Signaling
Mao, R, Meng, S, Gu, Q, Araujo-Gutierrez, R, Kumar, S, Yan, Q, Almazan, F, Youker, KA, Fu, Y, Pownall, HJ, Cooke, JP, Miller, YI & Fang, L 2017, , Circulation Research, vol. 120, no. 11, pp. 1727-1739. https://doi.org/10.1161/CIRCRESAHA.116.309754

Epithelial to mesenchymal transition (EMT) and endothelial to mesenchymal transition (EndMT): Role and implications in kidney fibrosis
Cruz-Solbes, AS & Youker, K 2017, . in RK Miller (ed.), Kidney Development and Disease. Results and Problems in Cell Differentiation, vol. 60, Springer-Verlag, pp. 345-372. https://doi.org/10.1007/978-3-319-51436-9_13