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Junhua Mai, PhD

Instructor in Nanomedicine, Institute for Academic Medicine
Instructor, Research Institute
Houston Methodist


jmai@houstonmethodist.org
Publications

PTGER3 induces ovary tumorigenesis and confers resistance to cisplatin therapy through up-regulation Ras-MAPK/Erk-ETS1-ELK1/CFTR1 axis
Rodriguez-Aguayo, C, Bayraktar, E, Ivan, C, Aslan, B, Mai, J, He, G, Mangala, LS, Jiang, D, Nagaraja, AS, Ozpolat, B, Chavez-Reyes, A, Ferrari, M, Mitra, R, Siddik, ZH, Shen, H, Yang, X, Sood, AK & Lopez-Berestein, G 2019, EBioMedicine. https://doi.org/10.1016/j.ebiom.2018.11.045

Chemotherapy sensitizes therapy-resistant cells to mild hyperthermia by suppressing heat shock protein 27 expression in triple-negative breast cancer
Mu, C, Wu, X, Zhou, X, Wolfram, J, Shen, J, Zhang, D, Mai, J, Xia, X, Holder, AM, Ferrari, M, Liu, X & Shen, H 2018, Clinical Cancer Research, vol. 24, no. 19, pp. 4900-4912. https://doi.org/10.1158/1078-0432.CCR-17-3872

DNA Thioaptamer with Homing Specificity to Lymphoma Bone Marrow Involvement
Mai, J, Li, X, Zhang, G, Huang, Y, Xu, R, Shen, Q, Lokesh, GL, Thiviyanathan, V, Chen, L, Liu, H, Zu, Y, Ma, X, Volk, DE, Gorenstein, DG, Ferrari, M & Shen, H 2018, Molecular Pharmaceutics, vol. 15, no. 5, pp. 1814-1825. https://doi.org/10.1021/acs.molpharmaceut.7b01169

SMAD4 gene mutation renders pancreatic cancer resistance to radiotherapy through promotion of autophagy
Wang, F, Xia, X, Yang, C, Shen, J, Mai, J, Kim, HC, Kirui, D, Kang, Y, Fleming, JB, Koay, EJ, Mitra, S, Ferrari, M & Shen, H 2018, Clinical Cancer Research, vol. 24, no. 13, pp. 3176-3185. https://doi.org/10.1158/1078-0432.CCR-17-3435

A novel DNA aptamer for dual targeting of polymorphonuclear myeloid-derived suppressor cells and tumor cells
Liu, H, Mai, J, Shen, J, Wolfram, J, Li, Z, Zhang, G, Xu, R, Li, Y, Mu, C, Zu, Y, Li, X, Lokesh, GL, Thiviyanathan, V, Volk, DE, Gorenstein, DG, Ferrari, M, Hu, Z & Shen, H 2018, Theranostics, vol. 8, no. 1, pp. 31-44. https://doi.org/10.7150/thno.21342

Targeting autocrine CCL5-CCR5 axis reprograms immunosuppressive myeloid cells and reinvigorates antitumor immunity
Ban, Y, Mai, J, Li, X, Mitchell-Flack, M, Zhang, T, Zhang, L, Chouchane, L, Ferrari, M, Shen, H & Ma, X 2017, Cancer Research, vol. 77, no. 11, pp. 2857-2868. https://doi.org/10.1158/0008-5472.CAN-16-2913

A Liposome Encapsulated Ruthenium Polypyridine Complex as a Theranostic Platform for Triple-Negative Breast Cancer
Shen, J, Kim, HC, Wolfram, J, Mu, C, Zhang, W, Liu, H, Xie, Y, Mai, J, Zhang, H, Li, Z, Guevara, M, Mao, ZW & Shen, H 2017, Nano Letters, vol. 17, no. 5, pp. 2913-2920. https://doi.org/10.1021/acs.nanolett.7b00132

Lipopolyplex potentiates anti-tumor immunity of mRNA-based vaccination
Persano, S, Guevara, ML, Li, Z, Mai, J, Ferrari, M, Pompa, PP & Shen, H 2017, Biomaterials, vol. 125, pp. 81-89. https://doi.org/10.1016/j.biomaterials.2017.02.019

An injectable nanoparticle generator enhances delivery of cancer therapeutics
Xu, R, Zhang, G, Mai, J, Deng, X, Segura-Ibarra, V, Wu, S, Shen, J, Liu, H, Hu, Z, Chen, L, Huang, Y, Koay, E, Huang, Y, Liu, J, Ensor, JE, Blanco, E, Liu, X, Ferrari, M & Shen, H 2016, Nature Biotechnology, vol. 34, no. 4, pp. 414-418. https://doi.org/10.1038/nbt.3506

Porous Silicon Microparticle Potentiates Anti-Tumor Immunity by Enhancing Cross-Presentation and Inducing Type I Interferon Response
Xia, X, Mai, J, Xu, R, Perez, JET, Guevara, ML, Shen, Q, Mu, C, Tung, HY, Corry, DB, Evans, SE, Liu, X, Ferrari, M, Zhang, Z, Li, XC, Wang, RF & Shen, H 2015, Cell Reports, vol. 11, no. 6, pp. 957-966. https://doi.org/10.1016/j.celrep.2015.04.009

Recent advances in discovering the role of CCL5 in metastatic breast cancer
Khalid, A, Wolfram, J, Ferrari, I, Mu, C, Mai, J, Yang, Z, Zhao, Y, Ferrari, M, Ma, X & Shen, H 2015, Mini-Reviews in Medicinal Chemistry, vol. 15, no. 13, pp. 1063-1072. https://doi.org/10.2174/138955751513150923094709#sthash.vVMryxxP.dpuf

Bone marrow endothelium-targeted therapeutics for metastatic breast cancer
Mai, J, Huang, Y, Mu, C, Zhang, G, Xu, R, Guo, X, Xia, X, Volk, DE, Lokesh, GL, Thiviyanathan, V, Gorenstein, DG, Liu, X, Ferrari, M & Shen, H 2014, Journal of Controlled Release, vol. 187, pp. 22-29. https://doi.org/10.1016/j.jconrel.2014.04.057

Transient mild hyperthermia induces e-selectin mediated localization of mesoporous silicon vectors in solid tumors
Kirui, DK, Mai, J, Palange, AL, Qin, G, Van De Ven, AL, Liu, X, Shen, H & Ferrari, M 2014, PLoS ONE, vol. 9, no. 2, e86489. https://doi.org/10.1371/journal.pone.0086489

Multifunctional gold nanorods for siRNA gene silencing and photothermal therapy
Shen, J, Kim, HC, Mu, C, Gentile, E, Mai, J, Wolfram, J, Ji, LN, Ferrari, M, Mao, ZW & Shen, H 2014, Advanced Healthcare Materials, vol. 3, no. 10, pp. 1629-1637. https://doi.org/10.1002/adhm.201400103

XBP1 promotes triple-negative breast cancer by controlling the HIF1a pathway
Chen, X, Iliopoulos, D, Zhang, Q, Tang, Q, Greenblatt, MB, Hatziapostolou, M, Lim, E, Tam, WL, Ni, M, Chen, Y, Mai, J, Shen, H, Hu, DZ, Adoro, S, Hu, B, Song, M, Tan, C, Landis, MD, Ferrari, M, Shin, SJ, Brown, M, Chang, JC, Liu, XS & Glimcher, LH 2014, Nature, vol. 508, no. 1, pp. 103-107. https://doi.org/10.1038/nature13119

Cyclodextrin and polyethylenimine functionalized mesoporous silica nanoparticles for delivery of siRNA cancer therapeutics
Shen, J, Kim, HC, Su, H, Wang, F, Wolfram, J, Kirui, D, Mai, J, Mu, C, Ji, LN, Mao, ZW & Shen, H 2014, Theranostics, vol. 4, no. 5, pp. 487-497. https://doi.org/10.7150/thno.8263

High capacity nanoporous silicon carrier for systemic delivery of gene silencing therapeutics
Shen, J, Xu, R, Mai, J, Kim, HC, Guo, X, Qin, G, Yang, Y, Wolfram, J, Mu, C, Xia, X, Gu, J, Liu, X, Mao, ZW, Ferrari, M & Shen, H 2013, ACS Nano, vol. 7, no. 11, pp. 9867-9880. https://doi.org/10.1021/nn4035316

Multistage Vectored siRNA Targeting Ataxia-Telangiectasia Mutated for Breast Cancer Therapy
Xu, R, Huang, Y, Mai, J, Zhang, G, Guo, X, Xia, X, Koay, EJ, Qin, G, Erm, DR, Li, Q, Liu, X, Ferrari, M & Shen, H 2013, Small, vol. 9, no. 9-10, pp. 1799-1808. https://doi.org/10.1002/smll.201201510

Enhancing chemotherapy response with sustained EphA2 silencing using multistage vector delivery
Shen, H, Rodriguez-Aguayo, C, Xu, R, Gonzalez-Villasana, V, Mai, J, Huang, Y, Zhang, G, Guo, X, Bai, L, Qin, G, Deng, X, Li, Q, Erm, DR, Aslan, B, Liu, X, Sakamoto, J, Chavez-Reyes, A, Han, HD, Sood, AK, Ferrari, M & Lopez-Berestein, G 2013, Clinical Cancer Research, vol. 19, no. 7, pp. 1806-1815. https://doi.org/10.1158/1078-0432.CCR-12-2764

RAFTsomes containing epitope-MHC-II complexes mediated CD4+ T cell activation and antigen-specific immune responses.
Ding, Q, Chen, J, Wei, X, Sun, W, Mai, J, Yang, Y & Xu, Y 2013, Pharmaceutical research, vol. 30, no. 1, pp. 60-69.

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