Juan "Jon" Toledo Atucha , MD, PhD

Assistant Professor of Neurology, Academic Institute
Assistant Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Publications

Association of Intensive vs Standard Blood Pressure Control With Regional Changes in Cerebral Small Vessel Disease Biomarkers: Post Hoc Secondary Analysis of the SPRINT MIND Randomized Clinical Trial
Rashid, T, Li, K, Toledo, JB, Nasrallah, I, Pajewski, NM, Dolui, S, Detre, J, Wolk, DA, Liu, H, Heckbert, SR, Bryan, RN, Williamson, J, Davatzikos, C, Seshadri, S, Launer, LJ & Habes, M 2023, , JAMA Network Open, vol. 6, no. 3, pp. e231055. https://doi.org/10.1001/jamanetworkopen.2023.1055

Association of Intensive vs Standard Blood Pressure Control with Regional Changes in Cerebral Small Vessel Disease Biomarkers: Post Hoc Secondary Analysis of the SPRINT MIND Randomized Clinical Trial
Rashid, T, Li, K, Toledo, JB, Nasrallah, I, Pajewski, NM, Dolui, S, Detre, J, Wolk, DA, Liu, H, Heckbert, SR, Bryan, RN, Williamson, J, Davatzikos, C, Seshadri, S, Launer, LJ & Habes, M 2023, , JAMA Network Open, vol. 6, no. 3, pp. E231055. https://doi.org/10.1001/jamanetworkopen.2023.1055

Double blind, nonrandomized crossover study of active recharge biphasic deep brain stimulation for primary dystonia
Wong, JK, Lopes, JMLJ, Hu, W, Wang, A, Au, KLK, Stiep, T, Frey, J, Toledo, JB, Raike, RS, Okun, MS & Almeida, L 2023, , Parkinsonism and Related Disorders, vol. 109, pp. 105328. https://doi.org/10.1016/j.parkreldis.2023.105328

Clinical outcome measures in dementia with Lewy bodies trials: critique and recommendations
the Lewy Body Dementias Clinical Trials Workgroup from the Lewy Body Dementias Professional Interest Area - Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART)+ 2022, , Translational Neurodegeneration, vol. 11, no. 1, 24. https://doi.org/10.1186/s40035-022-00299-w

Correction: Clinical outcome measures in dementia with Lewy bodies trials: critique and recommendations (Translational Neurodegeneration, (2022), 11, 1, (24), 10.1186/s40035-022-00299-w)
the Lewy Body Dementias Clinical Trials Workgroup from the Lewy Body Dementias Professional Interest Area - Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART)+ 2022, , Translational Neurodegeneration, vol. 11, no. 1, 29. https://doi.org/10.1186/s40035-022-00306-0

SPARE-Tau: A flortaucipir machine-learning derived early predictor of cognitive decline
Toledo, JB, Rashid, T, Liu, H, Launer, L, Shaw, LM, Heckbert, SR, Weiner, M, Seshadri, S & Habes, M 2022, , PLoS ONE, vol. 17, no. 11 November, e0276392. https://doi.org/10.1371/journal.pone.0276392

Subacute tremor and ataxia: Diligence in pursuit of a diagnosis
Frey, J, Toledo, JB, Ramirez-Zamora, A & Malaty, IA 2022, , Parkinsonism and Related Disorders, vol. 104, pp. 129-131. https://doi.org/10.1016/j.parkreldis.2022.05.016

Clinical outcome measures in dementia with Lewy bodies trials: critique and recommendations
Lewy Body Dementias Clinical Trials Workgroup from the Lewy Body Dementias Professional Interest Area - Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (ISTAART)+ 2022, , Translational Neurodegeneration, vol. 11, no. 1, pp. 24. https://doi.org/10.1186/s40035-022-00299-w

A randomized clinical trial of burst vs. spaced physical therapy for Parkinsons disease
Au, KLK, Lopes, JLMLJ, Kraus, A, Patton, K, Warren, L, Gao, H, Wong, JK, Moore, K, Toledo, JB, Stiep, T, Frey, J, Tholanikunnel, T, Hess, C, Almeida, L, Ramirez-Zamora, A & Okun, MS 2022, , Parkinsonism and Related Disorders, vol. 97, pp. 57-62. https://doi.org/10.1016/j.parkreldis.2022.02.021

Disentangling tau and brain atrophy cluster heterogeneity across the Alzheimer's disease continuum
for the Alzheimer’s Disease Neuroimaging Initiative 2022, , Alzheimers and Dementia: Translational Research and Clinical Interventions, vol. 8, no. 1, e12305. https://doi.org/10.1002/trc2.12305

Dementia with Lewy bodies: Impact of co-pathologies and implications for clinical trial design
the ISTAART Lewy body dementias Trial Methods Working Group 2022, , Alzheimers and Dementia, vol. 19, no. 1, pp. 318-332. https://doi.org/10.1002/alz.12814

Collaborative Clustering Based on Adaptive Laplace Modeling for Neuroimaging Data Analysis
Liu, H, Li, K, Toledo, JB & Habes, M 2022, . in IEEE International Symposium on Circuits and Systems, ISCAS 2022. Proceedings - IEEE International Symposium on Circuits and Systems, vol. 2022-May, Institute of Electrical and Electronics Engineers Inc. pp. 1630-1634, 2022 IEEE International Symposium on Circuits and Systems, ISCAS 2022, Austin, United States, 5/27/22. https://doi.org/10.1109/ISCAS48785.2022.9937245

ADCoC: Adaptive Distribution Modeling Based Collaborative Clustering for Disentangling Disease Heterogeneity from Neuroimaging Data
Liu, H, Grothe, MJ, Rashid, T, Labrador-Espinosa, MA, Toledo, JB & Habes, M 2022, , IEEE Transactions on Emerging Topics in Computational Intelligence. https://doi.org/10.1109/TETCI.2021.3136587

Disentangling tau and brain atrophy cluster heterogeneity across the Alzheimer's disease continuum
for the Alzheimer’s Disease Neuroimaging Initiative 2022, , Alzheimers and Dementia: Translational Research and Clinical Interventions, vol. 8, no. 1, pp. e12305. https://doi.org/10.1002/trc2.12305

Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease
EUROPAR and the International Parkinson and Movement Disorders Society Non-Motor Parkinson’s Disease Study Group 2021, , npj Parkinsons Disease, vol. 7, no. 1, 48. https://doi.org/10.1038/s41531-021-00174-x

Neurofilament Light Chain Related to Longitudinal Decline in Frontotemporal Lobar Degeneration
Zhang, JV, Irwin, DJ, Blennow, K, Zetterberg, H, Lee, EB, Shaw, LM, Rascovsky, K, Massimo, L, McMillan, CT, Chen-Plotkin, A, Elman, L, Lee, VM-Y, McCluskey, L, Toledo, JB, Weintraub, D, Wolk, D, Trojanowski, JQ & Grossman, M 2021, , Neurology: Clinical Practice, vol. 11, no. 2, pp. 105-116. https://doi.org/10.1212/CPJ.0000000000000959

Neurofilament Light Chain Related to Longitudinal Decline in Frontotemporal Lobar Degeneration
Zhang, JV, Irwin, DJ, Blennow, K, Zetterberg, H, Lee, EB, Shaw, LM, Rascovsky, K, Massimo, L, McMillan, CT, Chen-Plotkin, A, Elman, L, Lee, VM-Y, McCluskey, L, Toledo, JB, Weintraub, D, Wolk, D, Trojanowski, JQ & Grossman, M 2021, , Neurology: Clinical Practice, vol. 11, no. 2, pp. 105-116. https://doi.org/10.1212/CPJ.0000000000000959

Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study
Attems, J, Toledo, JB, Walker, L, Gelpi, E, Gentleman, S, Halliday, G, Hortobagyi, T, Jellinger, K, Kovacs, GG, Lee, EB, Love, S, McAleese, KE, Nelson, PT, Neumann, M, Parkkinen, L, Polvikoski, T, Sikorska, B, Smith, C, Grinberg, LT, Thal, DR, Trojanowski, JQ & McKeith, IG 2021, , Acta Neuropathologica, vol. 141, no. 2, pp. 159-172. https://doi.org/10.1007/s00401-020-02255-2

The Brain Chart of Aging: Machine-learning analytics reveals links between brain aging, white matter disease, amyloid burden, and cognition in the iSTAGING consortium of 10,216 harmonized MR scans
for the iSTAGING consortium, the Preclinical AD consortium, the ADNI, and the CARDIA studies 2021, , Alzheimers and Dementia, vol. 17, no. 1, pp. 89-102. https://doi.org/10.1002/alz.12178

Sex and APOE e4 genotype modify the Alzheimer’s disease serum metabolome
Arnold, M, Nho, K, Kueider-Paisley, A, Massaro, T, Huynh, K, Brauner, B, MahmoudianDehkordi, S, Louie, G, Moseley, MA, Thompson, JW, John-Williams, LS, Tenenbaum, JD, Blach, C, Chang, R, Brinton, RD, Baillie, R, Han, X, Trojanowski, JQ, Shaw, LM, Martins, R, Weiner, MW, Trushina, E, Toledo, JB, Meikle, PJ, Bennett, DA, Krumsiek, J, Doraiswamy, PM, Saykin, AJ, Kaddurah-Daouk, R & Kastenmüller, G 2020, , Nature Communications, vol. 11, no. 1, 1148. https://doi.org/10.1038/s41467-020-14959-w